Sergey Akimov

Research Associate

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Research Output 1996 2017

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease

Gomez-Pastor, R., Burchfiel, E. T., Neef, D. W., Jaeger, A. M., Cabiscol, E., McKinstry, S. U., Doss, A., Aballay, A., Lo, D. C., Akimov, S. S., Ross, C. A., Eroglu, C. & Thiele, D. J., Feb 13 2017, In : Nature Communications. 8, 14405

Research output: Contribution to journalArticle

Transcription factors
Huntington Disease
Transcription Factors

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

The HD iPSC Consortium, May 1 2017, In : Nature Neuroscience. 20, 5, p. 648-660 13 p.

Research output: Contribution to journalArticle

Huntington Disease
Histone Code

PPARΔ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

Dickey, A. S., Sanchez, D. N., Arreola, M., Sampat, K. R., Fan, W., Arbez, N., Akimov, S., Van Kanegan, M. J., Ohnishi, K., Gilmore-Hall, S. K., Flores, A. L., Nguyen, J. M., Lomas, N., Hsu, C. L., Lo, D. C., Ross, C. A., Masliah, E., Evans, R. M. & La Spada, A. R., Dec 6 2017, In : Science Translational Medicine. 9, 419, eaal2332

Research output: Contribution to journalArticle

Huntington Disease
Quality Control
Energy Metabolism
Retinoid X Receptors

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

Dickey, A. S. , Pineda, V. V. , Tsunemi, T. , Liu, P. P. , Miranda, H. C. , Gilmore-Hall, S. K. , Lomas, N. , Sampat, K. R. , Buttgereit, A. , Torres, M. J. M. , Flores, A. L. , Arreola, M. , Arbez, N. , Akimov, S. S. , Gaasterland, T. , Lazarowski, E. R. , Ross, C. A. , Yeo, G. W. , Sopher, B. L. , Magnuson, G. K. & 3 others Pinkerton, A. B., Masliah, E. & La Spada, A. R., Jan 1 2016, In : Nature Medicine. 22, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

PPAR delta
Huntington Disease
Chemical activation
Transcriptional Activation

HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity

Mattis, V. B., Tom, C., Akimov, S., Saeedian, J., Østergaard, M. E., Southwell, A. L., Doty, C. N., Ornelas, L., Sahabian, A., Lenaeus, L., Mandefro, B., Sareen, D., Arjomand, J., Hayden, M. R., Ross, C. A. & Svendsen, C. N., Dec 15 2014, In : Human Molecular Genetics. 24, 11, p. 3257-3271 15 p., ddv080

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Huntington Disease
Brain-Derived Neurotrophic Factor
Glutamic Acid
trkB Receptor