Sergey Akimov

Research Associate

19962019
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Fingerprint Dive into the research topics where Sergey Akimov is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Transglutaminases Medicine & Life Sciences
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Research Output 1996 2019

Cysteamine Protects Neurons from Mutant Huntingtin Toxicity

Arbez, N., Roby, E., Akimov, S., Eddings, C., Ren, M., Wang, X. & Ross, C. A., Jan 1 2019, In : Journal of Huntington's Disease. 8, 2, p. 129-143 15 p.

Research output: Contribution to journalArticle

Cysteamine
Neurons
Brain-Derived Neurotrophic Factor
Neuroprotective Agents
Cysteine

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

Eddings, C. R., Arbez, N., Akimov, S., Geva, M., Hayden, M. R. & Ross, C. A., Sep 1 2019, In : Neurobiology of Disease. 129, p. 118-129 12 p.

Research output: Contribution to journalArticle

Neurons
Huntington Disease
Neuroprotective Agents
Endoplasmic Reticulum
trkB Receptor

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease

Gomez-Pastor, R., Burchfiel, E. T., Neef, D. W., Jaeger, A. M., Cabiscol, E., McKinstry, S. U., Doss, A., Aballay, A., Lo, D. C., Akimov, S., Ross, C. A., Eroglu, C. & Thiele, D. J., Feb 13 2017, In : Nature Communications. 8, 14405.

Research output: Contribution to journalArticle

Transcription factors
Huntington Disease
Transcription Factors
shock
degradation

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

The HD iPSC Consortium, May 1 2017, In : Nature Neuroscience. 20, 5, p. 648-660 13 p.

Research output: Contribution to journalArticle

Huntington Disease
Pharmacology
Histone Code
Genes
Isoxazoles

PPARΔ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

Dickey, A. S., Sanchez, D. N., Arreola, M., Sampat, K. R., Fan, W., Arbez, N., Akimov, S., Van Kanegan, M. J., Ohnishi, K., Gilmore-Hall, S. K., Flores, A. L., Nguyen, J. M., Lomas, N., Hsu, C. L., Lo, D. C., Ross, C. A., Masliah, E., Evans, R. M. & La Spada, A. R., Dec 6 2017, In : Science Translational Medicine. 9, 419, eaal2332.

Research output: Contribution to journalArticle

Peroxisomes
Huntington Disease
Quality Control
Energy Metabolism
Homeostasis