Senthilkumar Karuppagounder

Research Associate

20062020

Research output per year

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Research Output

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Article
2020

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

Pirooznia, S. K., Yuan, C., Khan, M. R., Karuppagounder, S. S., Wang, L., Xiong, Y., Kang, S. U., Lee, Y., Dawson, V. L. & Dawson, T. M., Mar 5 2020, In : Molecular neurodegeneration. 15, 1, 17.

Research output: Contribution to journalArticle

Open Access
2019

FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors

Lei, X., Liu, L., Terrillion, C. E., Karuppagounder, S. S., Cisternas, P., Lay, M., Martinelli, D. C., Aja, S., Dong, X., Pletnikov, M. V. & Wong, G. W., Dec 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 14734-14747 14 p.

Research output: Contribution to journalArticle

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease

Brahmachari, S., Lee, S., Kim, S., Yuan, C., Karuppagounder, S. S., Ge, P., Shi, R., Kim, E. J., Liu, A., Kim, D., Quintin, S., Jiang, H., Kumar, M., Yun, S. P., Kam, T. I., Mao, X., Lee, Y., Swing, D. A., Tessarollo, L., Ko, H. S. & 2 others, Dawson, V. L. & Dawson, T. M., Aug 1 2019, In : Brain. 142, 8, p. 2380-2401 22 p.

Research output: Contribution to journalArticle

Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Xue, Y., Zhan, X., Sun, S., Karuppagounder, S. S., Xia, S., Dawson, V. L., Dawson, T. M., Laterra, J., Zhang, J. & Ying, M., Feb 1 2019, In : Stem Cells Translational Medicine. 8, 2, p. 112-123 12 p.

Research output: Contribution to journalArticle

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease

Kim, S., Kwon, S. H., Kam, T. I., Panicker, N., Karuppagounder, S. S., Lee, S., Lee, J. H., Kim, W. R., Kook, M., Foss, C. A., Shen, C., Lee, H., Kulkarni, S., Pasricha, P. J., Lee, G., Pomper, M. G., Dawson, V. L., Dawson, T. M. & Ko, H. S., Aug 21 2019, In : Neuron. 103, 4, p. 627-641.e7

Research output: Contribution to journalArticle

2018

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Yun, S. P., Kam, T. I., Panicker, N., Kim, S., Oh, Y., Park, J. S., Kwon, S. H., Park, Y. J., Karuppagounder, S. S., Park, H., Kim, S., Oh, N., Kim, N. A., Lee, S., Brahmachari, S., Mao, X., Lee, J. H., Kumar, M., An, D., Kang, S. U. & 13 others, Lee, Y., Lee, K. C., Na, D. H., Kim, D., Lee, S. H., Roschke, V. V., Liddelow, S. A., Mari, Z., Barres, B. A., Dawson, V. L., Lee, S., Dawson, T. M. & Ko, H. S., Jul 1 2018, In : Nature medicine. 24, 7, p. 931-938 8 p.

Research output: Contribution to journalArticle

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

Kim, S., Yun, S. P., Lee, S., Umanah, G., Bandaru, V. V. R., Yin, X., Rhee, P., Karuppagounder, S., Kwon, S. H., Lee, H., Mao, X., Kim, D., Pandey, A., Lee, G., Dawson, V., Dawson, T. M. & Ko, H. S., Jan 23 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. 798-803 6 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease

Kam, T-I., Mao, X., Park, H., Chou, S. C., Karuppagounder, S., Umanah, G., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A., Ko, H. S., Rosenthal, L. I. S. & 2 others, Dawson, T. M. & Dawson, V., Nov 2 2018, In : Science. 362, 6414, eaat8407.

Research output: Contribution to journalArticle

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Xiong, Y., Neifert, S., Karuppagounder, S. S., Liu, Q., Stankowski, J. N., Lee, B. D., Ko, H. S., Lee, Y., Grima, J. C., Mao, X., Jiang, H., Kang, S. U., Swing, D. A., Iacovitti, L., Tessarollo, L., Dawson, T. M. & Dawson, V. L., Feb 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1635-1640 6 p.

Research output: Contribution to journalArticle

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

Yun, S. P., Kim, D., Kim, S., Kim, S., Karuppagounder, S., Kwon, S. H., Lee, S., Kam, T-I., Lee, S., Ham, S., Park, J. H., Dawson, V., Dawson, T. M., Lee, Y. & Ko, H. S., Jan 8 2018, In : Molecular Neurodegeneration. 13, 1, 1.

Research output: Contribution to journalArticle

2017

Overexpression of Parkinson’s disease-associated mutation LRRK2 G2019S in mouse forebrain induces behavioral deficits and α-synuclein pathology

Xiong, Y., Neifert, S., Karuppagounder, S. S., Stankowski, J. N., Lee, B. D., Grima, J. C., Chen, G., Ko, H. S., Lee, Y., Swing, D., Tessarollo, L., Dawson, T. M. & Dawson, V. L., Jan 1 2017, In : eNeuro. 4, 2, e0004.

Research output: Contribution to journalArticle

Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning

Pignatelli, M., Umanah, G., Ribeiro, S. P., Chen, R., Karuppagounder, S., Yau, H. J., Eacker, S., Dawson, V., Dawson, T. M. & Bonci, A., Jan 18 2017, In : Neuron. 93, 2, p. 425-440 16 p.

Research output: Contribution to journalArticle

2016

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration

Brahmachari, S., Ge, P., Lee, S. H., Kim, D., Karuppagounder, S., Kumar, M., Mao, X., Shin, J. H., Lee, Y., Pletnikova, O., Troncoso, J. C., Dawson, V., Dawson, T. M. & Ko, H. S., Aug 1 2016, In : Journal of Clinical Investigation. 126, 8, p. 2970-2988 19 p.

Research output: Contribution to journalArticle

Adult conditional knockout of PGC-1α leads to loss of dopamine neurons

Jiang, H., Kang, S., Zhang, S., Karuppagounder, S., Xu, J., Lee, Y. K., Kang, B. G., Lee, Y., Zhang, J., Pletnikova, O., Troncoso, J. C., Pirooznia, S., Andrabi, S. A., Dawson, V. & Dawson, T. M., 2016, In : eNeuro. 3, 4, e0183-16.2016.

Research output: Contribution to journalArticle

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

Karuppagounder, S. S., Xiong, Y., Lee, Y., Lawless, M. C., Kim, D., Nordquist, E., Martin, I., Ge, P., Brahmachari, S., Jhaldiyal, A., Kumar, M., Andrabi, S. A., Dawson, T. M. & Dawson, V. L., Oct 1 2016, In : Journal of Chemical Neuroanatomy. 76, p. 90-97 8 p.

Research output: Contribution to journalArticle

Methamphetamine-induced dopaminergic toxicity prevented owing to the neuroprotective effects of salicylic acid

Thrash-Williams, B., Karuppagounder, S., Bhattacharya, D., Ahuja, M., Suppiramaniam, V. & Dhanasekaran, M., Jun 1 2016, In : Life Sciences. 154, p. 24-29 6 p.

Research output: Contribution to journalArticle

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3

Mao, X., Ou, M. T., Karuppagounder, S., Kam, T-I., Yin, X., Xiong, Y., Ge, P., Umanah, G., Brahmachari, S., Shin, J. H., Kang, H. C., Zhang, J., Xu, J., Chen, R., Park, H., Andrabi, S. A., Kang, S., Gonçalves, R. A., Liang, Y., Zhang, S. & 12 others, Qi, C., Lam, S., Keiler, J. A., Tyson, J., Kim, D., Panicker, N., Yun, S. P., Workman, C. J., Vignali, D. A. A., Dawson, V., Ko, H. S. & Dawson, T. M., Sep 30 2016, In : Science. 353, 6307, aah3374.

Research output: Contribution to journalArticle

2014

Elucidating the neurotoxic effects of MDMA and its analogs

Karuppagounder, S. S., Bhattacharya, D., Ahuja, M., Suppiramaniam, V., Deruiter, J., Clark, R. & Dhanasekaran, M., Apr 17 2014, In : Life Sciences. 101, 1-2, p. 37-42 6 p.

Research output: Contribution to journalArticle

Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinsons-like movement disorder

Lu, W., Karuppagounder, S. S., Springer, D. A., Allen, M. D., Zheng, L., Chao, B., Zhang, Y., Dawson, V. L., Dawson, T. M. & Lenardo, M., 2014, In : Nature communications. 5, 4930.

Research output: Contribution to journalArticle

MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway

Xiao, J., Li, Y., Prandovszky, E., Karuppagounder, S. S., Talbot, C. C., Dawson, V. L., Dawson, T. M. & Yolken, R. H., May 30 2014, In : Neuroscience. 268, p. 128-138 11 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

Andrabi, S. A., Umanah, G. K. E., Chang, C., Stevens, D. A., Karuppagounder, S. S., Gagné, J. P., Poirier, G. G., Dawson, V. L. & Dawson, T. M., Jul 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. 10209-10214 6 p.

Research output: Contribution to journalArticle

2013

Assessment of therapeutic potential of amantadine in methamphetamine induced neurotoxicity

Thrash-Williams, B., Ahuja, M., Karuppagounder, S. S., Uthayathas, S., Suppiramaniam, V. & Dhanasekaran, M., Oct 1 2013, In : Neurochemical Research. 38, 10, p. 2084-2094 11 p.

Research output: Contribution to journalArticle

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

Lee, Y., Karuppagounder, S. S., Shin, J. H., Lee, Y. I., Ko, H. S., Swing, D., Jiang, H., Kang, S. U., Lee, B. D., Kang, H. C., Kim, D., Tessarollo, L., Dawson, V. L. & Dawson, T. M., Oct 1 2013, In : Nature neuroscience. 16, 10, p. 1392-1400 9 p.

Research output: Contribution to journalArticle

Selective inhibition of phosphodiesterase 5 enhances glutamatergic synaptic plasticity and memory in mice

Uthayathas, S., Parameshwaran, K., Karuppagounder, S. S., Ahuja, M., Dhanasekaran, M. & Suppiramaniam, V., Nov 1 2013, In : Synapse. 67, 11, p. 741-747 7 p.

Research output: Contribution to journalArticle

Sulfhydration mediates neuroprotective actions of parkin

Vandiver, M. S., Paul, B. D., Xu, R., Karuppagounder, S., Rao, F., Snowman, A. M., Seok Ko, H., Il Lee, Y., Dawson, V. L., Dawson, T. M., Sen, N. & Snyder, S. H., Apr 11 2013, In : Nature communications. 4, 1626.

Research output: Contribution to journalArticle

2012

Central insulin resistance and synaptic dysfunction in intracerebroventricular-streptozotocin injected rodents

Shonesy, B. C., Thiruchelvam, K., Parameshwaran, K., Rahman, E. A., Karuppagounder, S. S., Huggins, K. W., Pinkert, C. A., Amin, R., Dhanasekaran, M. & Suppiramaniam, V., Feb 2012, In : Neurobiology of Aging. 33, 2, p. 430.e5-430.e18

Research output: Contribution to journalArticle

Developmental nicotine exposure induced alterations in behavior and glutamate receptor function in hippocampus

Parameshwaran, K., Buabeid, M. A., Karuppagounder, S. S., Uthayathas, S., Thiruchelvam, K., Shonesy, B., Dityatev, A., Escobar, M. C., Dhanasekaran, M. & Suppiramaniam, V., Mar 1 2012, In : Cellular and Molecular Life Sciences. 69, 5, p. 829-841 13 p.

Research output: Contribution to journalArticle

Investigate the chronic neurotoxic effects of diquat

Karuppagounder, S. S., Ahuja, M., Buabeid, M., Parameshwaran, K., Abdel-Rehman, E., Suppiramaniam, V. & Dhanasekaran, M., May 1 2012, In : Neurochemical Research. 37, 5, p. 1102-1111 10 p.

Research output: Contribution to journalArticle

2010

Neurotoxic effects of methamphetamine

Thrash, B., Karuppagounder, S. S., Uthayathas, S., Suppiramaniam, V. & Dhanasekaran, M., Jan 1 2010, In : Neurochemical Research. 35, 1, p. 171-179 9 p.

Research output: Contribution to journalArticle

2008

Effect of dopaminergic neurotoxin MPTP/MPP+ on coenzyme Q content

Dhanasekaran, M., Karuppagounder, S. S., Uthayathas, S., Wold, L. E., Parameshwaran, K., Jayachandra Babu, R., Suppiramaniam, V. & Brown-Borg, H., Jul 18 2008, In : Life Sciences. 83, 3-4, p. 92-95 4 p.

Research output: Contribution to journalArticle

Role of lipoamide dehydrogenase and metallothionein on 1-methyl-4-phenyl-1, 2,3,6- tetrahydropyridine-induced neurotoxicity

Dhanasekaran, M., Albano, C. B., Pellet, L., Karuppagounder, S. S., Uthayathas, S., Suppiramaniam, V., Brown-Borg, H. & Ebadi, M., Jun 1 2008, In : Neurochemical Research. 33, 6, p. 980-984 5 p.

Research output: Contribution to journalArticle

2007

Evaluation of neuroprotective and anti-fatigue effects of sildenafil

Uthayathas, S., Karuppagounder, S. S., Tamer, S. I., Parameshwaran, K., Degim, T., Suppiramaniam, V. & Dhanasekaran, M., Sep 1 2007, In : Life Sciences. 81, 12, p. 988-992 5 p.

Research output: Contribution to journalArticle

Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism

Senthilkumar, K. S., Saravanan, K. S., Chandra, G., Sindhu, K. M., Jayakrishnan, A. & Mohanakumar, K. P., Nov 22 2007, In : Behavioural Brain Research. 184, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

2006

Acute intranigral homocysteine administration produces stereotypic behavioral changes and striatal dopamine depletion in Sprague-Dawley rats

Chandra, G., Gangopadhyay, P. K., Senthil Kumar, K. S. & Mohanakumar, K. P., Feb 23 2006, In : Brain research. 1075, 1, p. 81-92 12 p.

Research output: Contribution to journalArticle

Ebselen effects on MPTP-induced neurotoxicity

Dhanasekaran, M., Uthayathas, S., Karuppagounder, S. S., Parameshwaran, K., Suppiramaniam, V., Ebadi, M. & Brown-Borg, H. M., Nov 6 2006, In : Brain research. 1118, 1, p. 251-254 4 p.

Research output: Contribution to journalArticle

l-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats

Saravanan, K. S., Sindhu, K. M., Senthilkumar, K. S. & Mohanakumar, K. P., Jul 1 2006, In : Neurochemistry International. 49, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

Rats with unilateral median forebrain bundle, but not striatal or nigral, lesions by the neurotoxins MPP+ or rotenone display differential sensitivity to amphetamine and apomorphine

Sindhu, K. M., Banerjee, R., Senthilkumar, K. S., Saravanan, K. S., Raju, B. C., Rao, J. M. & Mohanakumar, K. P., Jun 1 2006, In : Pharmacology Biochemistry and Behavior. 84, 2, p. 321-329 9 p.

Research output: Contribution to journalArticle