Senthilkumar Karuppagounder

Research Associate

20062019
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Fingerprint Dive into the research topics where Senthilkumar Karuppagounder is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Parkinson Disease Medicine & Life Sciences
Synucleins Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Medicine & Life Sciences
Dopamine Medicine & Life Sciences
Neurotoxins Medicine & Life Sciences
Methamphetamine Medicine & Life Sciences
Corpus Striatum Medicine & Life Sciences

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Research Output 2006 2019

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease

Brahmachari, S., Lee, S., Kim, S., Yuan, C., Karuppagounder, S., Ge, P., Shi, R., Kim, E. J., Liu, A., Kim, D., Quintin, S., Jiang, H., Kumar, M., Yun, S. P., Kam, T-I., Mao, X., Lee, Y., Swing, D. A., Tessarollo, L., Ko, H. S. & 2 others, Dawson, V. & Dawson, T. M., Aug 1 2019, In : Brain : a journal of neurology. 142, 8, p. 2380-2401 22 p.

Research output: Contribution to journalArticle

Zinc Fingers
Synucleins
Parkinson Disease
Proteins
Amino Acyl-tRNA Synthetases

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease

Kim, S., Kwon, S. H., Kam, T-I., Panicker, N., Karuppagounder, S., Lee, S., Lee, J. H., Kim, W. R., Kook, M., Foss, C., Shen, C., Lee, H., Kulkarni, S., Pasricha, P. J., Lee, G., Pomper, M. G., Dawson, V., Dawson, T. M. & Ko, H. S., Aug 21 2019, In : Neuron. 103, 4, p. 627-641.e7

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Brain
Truncal Vagotomy
Pathology

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Yun, S. P., Kam, T-I., Panicker, N., Kim, S., Oh, Y., Park, J. S., Kwon, S. H., Park, Y. J., Karuppagounder, S., Park, H., Kim, S., Oh, N., Kim, N. A., Lee, S., Brahmachari, S., Mao, X., Lee, J. H., Kumar, M., An, D., Kang, S. & 13 others, Lee, Y., Lee, K. C., Na, D. H., Kim, D., Lee, S. H., Roschke, V. V., Liddelow, S. A., Mari, Z., Barres, B. A., Dawson, V., Lee, S., Dawson, T. M. & Ko, H. S., Jul 1 2018, In : Nature Medicine. 24, 7, p. 931-938 8 p.

Research output: Contribution to journalArticle

Microglia
Astrocytes
Parkinson Disease
Synucleins
Nervous System Diseases

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

Kim, S., Yun, S. P., Lee, S., Umanah, G., Bandaru, V. V. R., Yin, X., Rhee, P., Karuppagounder, S., Kwon, S. H., Lee, H., Mao, X., Kim, D., Pandey, A., Lee, G., Dawson, V., Dawson, T. M. & Ko, H. S., Jan 23 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. 798-803 6 p.

Research output: Contribution to journalArticle

Synucleins
Glucosylceramidase
Gaucher Disease
Glycosphingolipids
Dopaminergic Neurons

Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease

Kam, T-I., Mao, X., Park, H., Chou, S. C., Karuppagounder, S., Umanah, G., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A., Ko, H. S., Rosenthal, L. I. S. & 2 others, Dawson, T. M. & Dawson, V., Nov 2 2018, In : Science. 362, 6414, eaat8407.

Research output: Contribution to journalArticle

Synucleins
Poly Adenosine Diphosphate Ribose
Parkinson Disease
Adenosine
Poisons