19962020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1996 2020

Filter
Article
2020

Blocking cellular N-glycosylation suppresses human cytomegalovirus entry in human fibroblasts

Zheng, L., Li, H., Fu, L., Liu, S., Yan, Q. & Leng, S. X., Jan 2020, In : Microbial Pathogenesis. 138, 103776.

Research output: Contribution to journalArticle

Cytomegalovirus
Glycosylation
Fibroblasts
Cytomegalovirus Infections
Integrins
2019

Impaired glucose tolerance predicts all-cause mortality among older men at high risk for cardiovascular disease in China

Fang, F., Wang, N., Yan, S., Wang, L., Lu, Y., Li, J., Li, H., Pham, G., Li, C., Leng, S. & Tian, H., Jan 1 2019, In : Primary Care Diabetes.

Research output: Contribution to journalArticle

Glucose Intolerance
China
Cardiovascular Diseases
Mortality
Glucose
Synucleins
Toll-Like Receptor 3
Toll-Like Receptor 2
Astrocytes
Interferons
Geriatrics
Industry
Health

Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a MIR-22/SIRT-1 Pathway

Mao, G. X., Xu, X. G., Wang, S. Y., Li, H., Zhang, J., Zhang, Z. S., Su, H. L., Chen, S. S., Xing, W. M., Wang, Y. Z., Dai, J. H., Wang, G. F., Leng, S. & Yan, J., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 5276096.

Research output: Contribution to journalArticle

Open Access
Cell Aging
Organelle Biogenesis
Fibroblasts
Rhodiola
rhodioloside
2018

Clinic-pathologic features and prognostic analysis of thyroid cancer in the older adult: A SEER based study

Shi, L. Y., Liu, J., Yu, L. J., Lei, Y. M., Leng, S. & Zhang, H. Y., Jan 1 2018, In : Journal of Cancer. 9, 15, p. 2744-2750 7 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Epidemiology
Neoplasms
Thyroidectomy
Proportional Hazards Models

Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults

Keshtkar-Jahromi, M., Ouyang, M., Keshtkarjahromi, M., Almed, S., Li, H., Walston, J. D., Rios, R. & Leng, S., Apr 12 2018, In : Vaccine. 36, 16, p. 2220-2225 6 p.

Research output: Contribution to journalArticle

tumor necrosis factors
Influenza Vaccines
influenza
Vaccination
apoptosis
Geriatrics
Industry
Health

Relationship between T-Cell responses to CMV, markers of inflammation, and frailty in HIV-uninfected and HIV-infected men in the multicenter AIDS cohort study

Margolick, J. B., Bream, J., Nilles, T. L., Li, H., Langan, S. J., Deng, S., Wang, R., Wada, N. & Leng, S., Jun 20 2018, In : Journal of Infectious Diseases. 218, 2, p. 249-258 10 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Acquired Immunodeficiency Syndrome
Cohort Studies
HIV
Inflammation

Reply to: Update on Aging Statistics and Geriatrics Development in China

Li, X., Fan, L. & Leng, S., Jan 1 2018, (Accepted/In press) In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Geriatrics
China

Reply to: Comments on the Aging Tsunami and Senior Healthcare Development in China

Li, X., Fan, L. & Leng, S., Jan 1 2018, (Accepted/In press) In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Tsunamis
China
Delivery of Health Care

The Aging Tsunami and Senior Healthcare Development in China

Li, X., Fan, L. & Leng, S., Jan 1 2018, (Accepted/In press) In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Tsunamis
Geriatrics
China
Delivery of Health Care
Health Care Reform

The association of single nucleotide polymorphism rs189037C>T in ATM gene with coronary artery disease in Chinese Han populations

Ding, X., He, Y., Hao, Q., Chen, S., Yang, M., Leng, S., Yue, J. & Dong, B., Jan 1 2018, In : Medicine (United States). 97, 4, e9747.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Single Nucleotide Polymorphism
Coronary Artery Disease
Genotype
Population

α-Synuclein activates innate immunity but suppresses interferon-γ expression in murine astrocytes

Wang, J., Chen, Z., Walston, J. D., Gao, P., Gao, M. & Leng, S., Jul 1 2018, In : European Journal of Neuroscience. 48, 1, p. 1583-1599 17 p.

Research output: Contribution to journalArticle

Synucleins
Interleukin-1
Innate Immunity
Astrocytes
Interferons
2017

Clinical-pathological characteristics and prognostic factors for papillary thyroid microcarcinoma in the elderly

Tang, J., Liu, H. B., Yu, L., Meng, X., Leng, S. & Zhang, H., Jan 1 2017, In : Journal of Cancer. 9, 2, p. 256-262 7 p.

Research output: Contribution to journalArticle

Survival
Thyroidectomy
Papillary Thyroid Microcarcinoma
Neoplasm Metastasis
Radio

Clinicopathologic features and prognostic factors for patients with colorectal cancer who are 75 years and older

Zhao, M., Liu, H., Tang, Y., Meng, X., Yu, J., Wang, Q., Zhou, Q., Leng, S. & Zhang, H., 2017, In : Oncotarget. 8, 45, p. 80002-80011 10 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Neoplasms
Marital Status
Social Support
Comorbidity
Virus Diseases
Drug Users
Tumor Necrosis Factor Receptors
HIV
Injections
Geriatrics
Industry
Health

Polymorphism rs189037C > T in the promoter region of the ATM gene may associate with reduced risk of T2DM in older adults in China: A case control study

Ding, X., Hao, Q., Yang, M., Chen, T., Chen, S., Yue, J., Leng, S. & Dong, B., Aug 14 2017, In : BMC Medical Genetics. 18, 1, 84.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Genetic Promoter Regions
Type 2 Diabetes Mellitus
Case-Control Studies
China

Recent advances in CMV tropism, latency, and diagnosis during aging

Leng, S., Kamil, J., Purdy, J. G., Lemmermann, N. A., Reddehase, M. J. & Goodrum, F. D., Jun 1 2017, In : GeroScience. 39, 3, p. 251-259 9 p.

Research output: Contribution to journalArticle

Tropism
Cytomegalovirus
Cytomegalovirus Infections
Muromegalovirus
Translational Medical Research
2016
HIV Infections
Hospitalization
Injections
Pharmaceutical Preparations
HIV
Geriatrics
Industry
Health

Longitudinal Changes over 10 Years in Free Testosterone among HIV-Infected and HIV-Uninfected Men

for the Multicenter AIDS Cohort Study (MACS) & Johnson-Hill, L., Jan 1 2016, In : Journal of Acquired Immune Deficiency Syndromes. 71, 1, p. 57-64 8 p.

Research output: Contribution to journalArticle

Testosterone
HIV
Confidence Intervals
Acquired Immunodeficiency Syndrome
Cohort Studies

Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats

Xue, Q. L., Yang, H., Li, H., Abadir, P., Burks, T. N., Koch, L. G., Britton, S. L., Carlson, J., Chen, L., Walston, J. D. & Leng, S., Apr 1 2016, In : Aging. 8, 4, p. 769-776 8 p.

Research output: Contribution to journalArticle

Hand Strength
Sirolimus
Running
Placebos
Diet
2015

Accelerated longitudinal gait speed decline in HIV-infected older men

for the Multicenter AIDS Cohort Study, Dec 1 2015, In : Journal of Acquired Immune Deficiency Syndromes. 70, 4, p. 370-376 7 p.

Research output: Contribution to journalArticle

HIV
Gait
Walking Speed
Acquired Immunodeficiency Syndrome
Cohort Studies

A novel flow cytometry-based tool for determining the efficiency of human cytomegalovirus infection in THP-1 derived macrophages

Li, H., Mao, G., Carlson, J. & Leng, S., Sep 1 2015, In : Journal of Virological Methods. 221, p. 127-130 4 p.

Research output: Contribution to journalArticle

Cytomegalovirus Infections
Flow Cytometry
Macrophages
Infection
Monoclonal Antibodies
Receptors, Tumor Necrosis Factor, Type II
Tumor Necrosis Factor Receptors
Drug Users
HIV Infections
Interleukin-6
Health Care Sector
Medical Societies
Geriatrics
China
Industry

Link between type 2 diabetes and Alzheimer’s disease: From epidemiology to mechanism and treatment

Li, X., Song, D. & Leng, S., Mar 10 2015, In : Clinical Interventions in Aging. 10, p. 549-560 12 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Alzheimer Disease
Epidemiology
Apolipoprotein E4
Insulin Resistance
Cytomegalovirus Infections
Cytomegalovirus
Reactive Oxygen Species
sirtinol
Galactosidases

Telomere length as an indicator of the robustness of B- and T-cell response to influenza in older adults

Najarro, K., Nguyen, H., Chen, G., Xu, M., Alcorta, S., Yao, X., Zukley, L., Metter, E. J., Truong, T., Lin, Y., Li, H., Oelke, M., Xu, X., Ling, S. M., Longo, D. L., Schneck, J. P., Leng, S., Ferrucci, L. & Weng, N. P., Oct 15 2015, In : Journal of Infectious Diseases. 212, 8, p. 1261-1269 9 p.

Research output: Contribution to journalArticle

Telomere
Human Influenza
T-Lymphocytes
Antibody Formation
Influenza Vaccines

Understanding Frailty, Aging, and Inflammation in HIV Infection

Leng, S. & Margolick, J. B., 2015, In : Current HIV/AIDS Reports. 12, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Geriatrics
HIV Infections
Inflammation
Cytomegalovirus Infections
Population
2014

Abstracts from the Third Chinese Congress on Gerontology and Health Industry, September 12-14, 2014, Suzhou, China

Leng, S., Hansen, J. C. H. & Li, X. Y., Sep 1 2014, In : Journal of the American Geriatrics Society. 62, p. S333-S395

Research output: Contribution to journalArticle

Health Services for the Aged
Geriatrics
China
Industry
Health

Frailty syndrome: An overview

Chen, X., Mao, G. & Leng, S., Mar 19 2014, In : Clinical Interventions in Aging. 9, p. 433-441 9 p.

Research output: Contribution to journalArticle

Geriatric Assessment
Geriatrics
Exercise
Endocrine System
Virus Diseases

Heterogeneity of CD4+ and CD8+ T-cell responses to cytomegalovirus in HIV-infected and HIV-uninfected men who have sex with men

Li, H., Margolick, J. B., Bream, J., Nilles, T. L., Langan, S., Bui, H. T., Sylwester, A. W., Picker, L. J. & Leng, S., Aug 1 2014, In : Journal of Infectious Diseases. 210, 3, p. 400-404 5 p.

Research output: Contribution to journalArticle

Cytomegalovirus
HIV
T-Lymphocytes
Antigens
Open Reading Frames

The relationship of physical performance with HIV disease and mortality

Greene, M., Covinsky, K., Astemborski, J., Piggott, D. A., Brown, T. T., Leng, S., Galai, N., Mehta, S. H., Guralnik, J. & Kirk, G. D., 2014, In : AIDS. 28, 18, p. 2711-2719 9 p.

Research output: Contribution to journalArticle

HIV
Mortality
HIV Infections
Confidence Intervals
Odds Ratio
2013
Virus Diseases
Hepacivirus
C-Reactive Protein
HIV Infections
Interleukin-6

Frailty, HIV Infection, and Mortality in an Aging Cohort of Injection Drug Users

Piggott, D. A., Muzaale, A., Mehta, S. H., Brown, T. T., Patel, K. V., Leng, S. & Kirk, G. D., Jan 31 2013, In : PLoS One. 8, 1, e54910.

Research output: Contribution to journalArticle

drug injection
HIV infections
Drug Users
HIV Infections
Aging of materials

Serum chitotriosidase, a putative marker of chronically activated macrophages, increases with normal aging

Ramanathan, R., Kohli, A., Ingaramo, M. C., Jain, A., Leng, S., Punjabi, N. M., Walston, J. D. & Fedarko, N. S., Oct 2013, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 68, 10, p. 1303-1309 7 p.

Research output: Contribution to journalArticle

Macrophages
Serum
Acetylesterase
Neopterin
Granulocyte-Macrophage Colony-Stimulating Factor
2011
Independent Living
Neopterin
Serology
Cytomegalovirus
Monocytes

Frailty, inflammation, and immunity

Li, H., Manwani, B. & Leng, S., 2011, In : Aging and Disease. 2, 6, p. 466-473 8 p.

Research output: Contribution to journalArticle

Frail Elderly
Immunity
Inflammation
Human Influenza
Immune System
Independent Living
Inactivated Vaccines
inactivated vaccines
influenza
Human Influenza

Il-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults

Leng, S., Tian, X., Matteini, A., Li, H., Hughes, J., Jain, A., Walston, J. D. & Fedarko, N. S., Jul 2011, In : Age and Ageing. 40, 4, p. 475-481 7 p., afr047.

Research output: Contribution to journalArticle

Independent Living
Neopterin
Interleukin-6
Serum
Odds Ratio

Inflammation and Immune System Alterations in Frailty

Yao, X., Li, H. & Leng, S., Feb 2011, In : Clinics in Geriatric Medicine. 27, 1, p. 79-87 9 p.

Research output: Contribution to journalArticle

Immune System
Inflammation
T-Lymphocytes
Leukocyte Count
Geriatrics

Intrinsic aerobic capacity sets a divide for aging and longevity

Koch, L. G., Kemi, O. J., Qi, N., Leng, S., Bijma, P., Gilligan, L. J., Wilkinson, J. E., Wisløff, H., Høydal, M. A., Rolim, N., Abadir, P., Van Grevenhof, E. M., Smith, G. L., Burant, C. F., Ellingsen, Ø., Britton, S. L. & Wisløff, U., Oct 28 2011, In : Circulation Research. 109, 10, p. 1162-1172 11 p.

Research output: Contribution to journalArticle

Exercise
Premature Mortality
Running
Walking
Cardiovascular Diseases

Relationship between cytomegalovirus (CMV) IgG serology, detectable CMV DNA in peripheral monocytes, and CMV pp65 495-503-specific CD8 + T cells in older adults

Leng, S. X., Qu, T., Semba, R. D., Li, H., Yao, X., Nilles, T., Yang, X., Manwani, B., Walston, J. D., Ferrucci, L., Fried, L. P., Margolick, J. B. & Bream, J. H., Dec 2011, In : Age. 33, 4, p. 607-614 8 p.

Research output: Contribution to journalArticle

Serology
Cytomegalovirus
Monocytes
Immunoglobulin G
T-Lymphocytes
Cognition Disorders
Frail Elderly
Cytomegalovirus Infections
Activities of Daily Living
Inflammation
2010
Program Development
Geriatrics
China
Family Planning Policy
Medicine