Scott Kominsky

Associate Professor

19982018
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Research Output 1998 2018

2018

CITED2 attenuates macrophage recruitment concordant with the downregulation of CCL20 in breast cancer cells

Jayaraman, S., Doucet, M. & Kominsky, S. L. Jan 1 2018 In : Oncology Letters. 15, 1, p. 871-878 8 p.

Research output: Contribution to journalArticle

Down-Regulation
Macrophages
Breast Neoplasms
Conditioned Culture Medium
Neoplasms

Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterations

Zhang, C., Winnard, P. T., Dasari, S., Kominsky, S. L., Doucet, M., Jayaraman, S., Raman, V. & Barman, I. Jan 1 2018 In : Chemical Science. 9, 3, p. 743-753 11 p.

Research output: Contribution to journalArticle

Beryllium minerals
Pathology
Risk assessment
Raman spectroscopy
Labels
2017

Down-regulation of CITED2 attenuates breast tumor growth, vessel formation and TGF-β-induced expression of VEGFA

Jayaraman, S., Doucet, M. & Kominsky, S. L. 2017 In : Oncotarget. 8, 4, p. 6169-6178 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta
Down-Regulation
Breast Neoplasms
Growth
Neoplasms
2016

CCL20/CCR6 Signaling Regulates Bone Mass Accrual in Mice

Doucet, M., Jayaraman, S., Swenson, E., Tusing, B., Weber, K. L. & Kominsky, S. L. Jul 1 2016 In : Journal of Bone and Mineral Research. 31, 7, p. 1381-1390 10 p.

Research output: Contribution to journalArticle

Osteoblasts
Bone and Bones
CCR6 Receptors
Macrophage Inflammatory Proteins
G-Protein-Coupled Receptors

CITED2 Modulates Breast Cancer Metastatic Ability through Effects on IKKα

Jayaraman, S., Doucet, M., Lau, W. M. & Kominsky, S. L. Aug 1 2016 In : Molecular Cancer Research. 14, 8, p. 730-739 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Nude Mice
Interleukin-11
Bone and Bones
2014

The Notch pathway inhibits TGFβ signaling in breast cancer through HEYL-mediated crosstalk

Han, L., Diehl, A., Nguyen, N. K., Korangath, P., Teo, W., Cho, S., Kominsky, S., Huso, D. L., Feigenbaum, L., Rein, A., Argani, P., Landberg, G., Gessler, M. & Sukumar, S. Nov 15 2014 In : Cancer Research. 74, 22, p. 6509-6518 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Human Mammary Glands
Basic Helix-Loop-Helix Transcription Factors
Transgenic Mice
Carcinogenesis
2013

CITED2 modulates estrogen receptor transcriptional activity in breast cancer cells

Lau, W. M., Doucet, M., Huang, D., Weber, K. L. & Kominsky, S. L. Jul 26 2013 In : Biochemical and Biophysical Research Communications. 437, 2, p. 261-266 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Cells
Breast Neoplasms
Tumors

Concepts and Surgical Treatment of Metastatic Bone Disease

Weber, K. & Kominsky, S. L. Jul 19 2013 Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. 760-765 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone Diseases
Bone
Bone and Bones
Spine
Kyphoplasty

Enpp1: A Potential Facilitator of Breast Cancer Bone Metastasis

Lau, W. M., Doucet, M., Stadel, R., Huang, D., Weber, K. L. & Kominsky, S. L. Jul 5 2013 In : PLoS One. 8, 7, e66752

Research output: Contribution to journalArticle

Bone Neoplasms
metastasis
breast neoplasms
Bone
bones
2012

MIP-1δ activates NFATc1 and enhances osteoclastogenesis: Involvement of both PLCγ2 and NFκB signaling

Weber, K. L., Doucet, M., Shaner, A., Hsu, N., Huang, D., Fogel, J. & Kominsky, S. L. Jul 9 2012 In : PLoS One. 7, 7, e40799

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
osteoclasts
Osteogenesis
Osteoclasts
Bone
2011

Breast cancer: Preclinical and clinical evaluation of intraductally administered agents in early breast cancer

Stearns, V., Mori, T., Jacobs, L. K., Khouri, N. F., Gabrielson, E., Yoshida, T., Kominsky, S. L., Huso, D. L., Jeter, S., Powers, P., Tarpinian, K., Brown, R. J., Lange, J. R., Rudek, M. A., Zhang, Z., Tsangaris, T. N. & Sukumar, S. Oct 26 2011 In : Science Translational Medicine. 3, 106, 106ra108

Research output: Contribution to journalArticle

Breast Neoplasms
Mastectomy
Breast
Clinical Trials
Methylnitrosourea
2010

Identification of prospective factors promoting osteotropism in breast cancer: A potential role for CITED2

Lau, W. M., Weber, K. L., Doucet, M., Chou, Y. T., Brady, K., Kowalski, J., Tsai, H. L., Yang, J. & Kominsky, S. L. Feb 15 2010 In : International Journal of Cancer. 126, 4, p. 876-884 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Bone and Bones
Neoplasm Metastasis
Osteolysis
Bone Neoplasms
2009

Orthopedic Treatment of Metastatic Bone Disease

Weber, K. & Kominsky, S. Dec 23 2009 Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition. John Wiley & Sons, Inc., p. 407-410 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone Diseases
Orthopedics
Neoplasm Metastasis
Bone and Bones
2008

Macrophage inflammatory protein-1δ: A novel osteoclast stimulating factor secreted by renal cell carcinoma bone metastasis

Kominsky, S. L., Abdelmagid, S. M., Doucet, M., Brady, K. & Weber, K. L. Mar 1 2008 In : Cancer Research. 68, 5, p. 1261-1266 6 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Renal Cell Carcinoma
Osteoclasts
Neoplasm Metastasis
Bone and Bones

MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-β1

Kominsky, S. L., Doucet, M., Thorpe, M. & Weber, K. L. Dec 2008 In : Clinical and Experimental Metastasis. 25, 8, p. 865-870 6 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 13
Renal Cell Carcinoma
Neoplasm Metastasis
Bone and Bones
Matrix Metalloproteinase 1
2007

Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis

Kominsky, S. L., Tyler, B., Sosnowski, J., Brady, K., Doucet, M., Nell, D., Smedley, J. G., McClane, B., Brem, H. & Sukumar, S. Sep 1 2007 In : Cancer Research. 67, 17, p. 7977-7982 6 p.

Research output: Contribution to journalArticle

Claudin-3
Claudin-4
Neoplasm Metastasis
Brain
Breast Neoplasms

Renal cell carcinoma bone metastasis-elucidating the molecular targets

Weber, K., Doucet, M. & Kominsky, S. Dec 2007 In : Cancer and Metastasis Reviews. 26, 3-4, p. 691-704 14 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasm Metastasis
Bone and Bones
Transforming Growth Factor beta Receptors
Bone Neoplasms

TGF-β promotes the establishment of renal cell carcinoma bone metastasis

Kominsky, S. L., Doucet, M., Brady, K. & Weber, K. L. Jan 2007 In : Journal of Bone and Mineral Research. 22, 1, p. 37-44 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Transforming Growth Factor beta
Neoplasm Metastasis
Bone and Bones
Neoplasms
2006

A "bone" fide predictor of metastasis? Predicting breast cancer metastasis to bone

Kominsky, S. L. & Davidson, N. E. May 20 2006 In : Journal of Clinical Oncology. 24, 15, p. 2227-2229 3 p.

Research output: Contribution to journalArticle

Predictive Value of Tests
Bone Neoplasms
Radiopharmaceuticals
Diphosphonates
Gene Expression Profiling

Claudins: Emerging targets for cancer therapy

Kominsky, S. L. Aug 2006 In : Expert Reviews in Molecular Medicine. 8, 18, p. 1-11 11 p.

Research output: Contribution to journalArticle

Claudins
Tumors
Cell signaling
Toxicity
Neoplasms

Ductal access for prevention and therapy of mammary tumors

Murata, S., Kominsky, S. L., Vali, M., Zhang, Z., Garrett-Mayer, E., Korz, D., Huso, D., Baker, S. D., Barber, J., Jaffee, E., Reilly, R. T. & Sukumar, S. Jan 15 2006 In : Cancer Research. 66, 2, p. 638-645 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Antineoplastic Agents
Breast
Methylnitrosourea
Neoplasms

Targeting early stage DCIS breast cancer directly in the ducts with intraductal chemotherapy

Sukumar, S., Murata, S., Kominsky, S., Vali, M., Zhang, Z., Garrett-Mayer, E., Korz, D., Huso, D., Baker, S. D., Barber, J., Jaffee, E. & Reilly, R. T. Mar 2006 In : Cancer Biology and Therapy. 5, 3, p. 249-250 2 p.

Research output: Contribution to journalArticle

Animal Mammary Neoplasms
Clinical Trials, Phase I
Carcinoma, Intraductal, Noninfiltrating
Antineoplastic Agents
Breast Neoplasms
2005

Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer

Mironchik, Y., Winnard, P. T., Vesuna, F., Kato, Y., Wildes, F., Pathak, A. P., Kominsky, S., Artemov, D., Bhujwalla, Z., Van Diest, P., Burger, H., Glackin, C. & Raman, V. Dec 1 2005 In : Cancer Research. 65, 23, p. 10801-10809 9 p.

Research output: Contribution to journalArticle

Chromosomal Instability
Breast Neoplasms
Phenotype
Vascular Endothelial Growth Factor A
Magnetic Resonance Imaging
2004

Clostridium perfringens Enterotoxin Elicits Rapid and Specific Cytolysis of Breast Carcinoma Cells Mediated through Tight Junction Proteins Claudin 3 and 4

Kominsky, S. L., Vali, M., Korz, D., Gabig, T. G., Weitzman, S. A., Argani, P. & Sukumar, S. May 2004 In : American Journal of Pathology. 164, 5, p. 1627-1633 7 p.

Research output: Contribution to journalArticle

Claudin-3
Claudin-4
Tight Junction Proteins
Breast Neoplasms
Clostridium enterotoxin

Very High Frequency of Hypermethylated Genes in Breast Cancer Metastasis to the Bone, Brain, and Lung

Mehrotra, J., Vali, M., McVeigh, M., Kominsky, S. L., Fackler, M. J., Lahti-Domenici, J., Polyak, K., Sacchi, N., Garrett-Mayer, E., Argani, P. & Sukumar, S. May 1 2004 In : Clinical Cancer Research. 10, 9, p. 3104-3109 6 p.

Research output: Contribution to journalArticle

Gene Frequency
Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
Lung
2003

Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast

Kominsky, S. L., Argani, P., Korz, D., Evron, E., Raman, V., Garrett, E., Rein, A., Sauter, G., Kallioniemi, O. P. & Sukumar, S. Apr 3 2003 In : Oncogene. 22, 13, p. 2021-2033 13 p.

Research output: Contribution to journalArticle

Tight Junction Proteins
Carcinoma, Ductal, Breast
Carcinoma, Intraductal, Noninfiltrating
Claudins
Ductal Carcinoma
2001

Superantigen enhanced protection against a weak tumor-specific melanoma antigen: Implications for prophylactic vaccination against cancer

Kominsky, S. L., Torres, B. A., Hobeika, A. C., Lake, F. A. & Johnson, H. M. Dec 15 2001 In : International Journal of Cancer. 94, 6, p. 834-841 8 p.

Research output: Contribution to journalArticle

Melanoma-Specific Antigens
Superantigens
Vaccination
Neoplasms
T-Lymphocytes

Superantigens: The good, the bad, and the ugly

Torres, B. A., Kominsky, S., Perrin, G. Q., Hobeika, A. C. & Johnson, H. M. 2001 In : Experimental Biology and Medicine. 226, 3, p. 164-176 13 p.

Research output: Contribution to journalArticle

Superantigens
Tumors
T-cells
Immune System Diseases
Viruses
2000

Down-regulation of neu/HER-2 by interferon-γ in prostate cancer cells

Kominsky, S. L., Hobeika, A. C., Lake, F. A., Torres, B. A. & Johnson, H. M. Jul 15 2000 In : Cancer Research. 60, 14, p. 3904-3908 5 p.

Research output: Contribution to journalArticle

Interferon-gamma
Prostatic Neoplasms
Down-Regulation
Interferons
STAT1 Transcription Factor

Inhibition of the glioblastoma cell cycle by type I IFNs occurs at both the G1 and S phases and correlates with the upregulation of p21(WAF1/CIP1)

Tanabe, T., Kominsky, S. L., Subramaniam, P. S., Johnson, H. M. & Torres, B. A. 2000 In : Journal of Neuro-Oncology. 48, 3, p. 225-232 8 p.

Research output: Contribution to journalArticle

G1 Phase
Glioblastoma
S Phase
Cell Cycle
Up-Regulation

Inhibitory effects of IFN-γ and acyclovir on the glioblastoma cell cycle

Kominsky, S. L., Subramaniam, P. S., Johnson, H. M. & Torres, B. A. 2000 In : Journal of Interferon and Cytokine Research. 20, 5, p. 463-469 7 p.

Research output: Contribution to journalArticle

Acyclovir
Glioblastoma
Interferon-gamma
Cell Cycle
Astrocytes
1998

IFNγ inhibition of cell growth in glioblastomas correlates with increased levels of the cyclin dependent kinase inhibitor p21(WAF1/CIP1)

Kominsky, S., Johnson, H. M., Bryan, G., Tanabe, T., Hobeika, A. C., Subramaniam, P. S. & Torres, B. Dec 10 1998 In : Oncogene. 17, 23, p. 2973-2979 7 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase Inhibitor p21
Glioblastoma
Cell Line
Cyclin-Dependent Kinase 2
Growth