Scott Bailey

Associate Professor

20012019

Research output per year

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Research Output

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2019

Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding

Okafor, I. C., Singh, D., Wang, Y., Jung, M., Wang, H., Mallon, J., Bailey, S., Lee, J. K. & Ha, T., Dec 16 2019, In : Nucleic acids research. 47, 22, p. 11880-11888 9 p.

Research output: Contribution to journalArticle

Open Access

Target sequence requirements of a type III-B CRISPR-Cas immune system

Johnson, K., Learn, B. A., Estrella, M. A. & Bailey, S., Jan 1 2019, In : Journal of Biological Chemistry. 294, 26, p. 10290-10299 10 p.

Research output: Contribution to journalArticle

2018

Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis

Singh, D., Wang, Y., Mallon, J., Yang, O., Fei, J., Poddar, A., Ceylan, D., Bailey, S. & Ha, T., Apr 1 2018, In : Nature Structural and Molecular Biology. 25, 4, p. 347-354 8 p.

Research output: Contribution to journalArticle

2017

Mycobacterium abscessus L,D-transpeptidases are susceptible to inactivation by carbapenems and cephalosporins but not penicillins

Kumar, P., Chauhan, V., Silva, J. R. A., Lameira, J., D’Andrea, F. B., Li, S. G., Ginell, S. L., Freundlich, J. S., Alves, C. N., Bailey, S., Cohen, K. & Lamichhane, G., Oct 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 10, e00866.

Research output: Contribution to journalArticle

2016

Cas9, poised for DNA cleavage: Structural rearrangements explain how Cas9 cuts DNA

Chen, H. & Bailey, S., Feb 19 2016, In : Science. 351, 6275, p. 811-812 2 p.

Research output: Contribution to journalArticle

RNA-activated DNA cleavage by the Type III-B CRISPR–Cas effector complex

Estrella, M. A., Kuo, F. T. & Bailey, S., Feb 15 2016, In : Genes & development. 30, 4, p. 460-470 11 p.

Research output: Contribution to journalArticle

Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli

Hayes, R. P., Xiao, Y., Ding, F., Van Erp, P. B. G., Rajashankar, K., Bailey, S., Wiedenheft, B. & Ke, A., Feb 25 2016, In : Nature. 530, 7591, p. 499-503 5 p.

Research output: Contribution to journalArticle

2015

Mechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli

Van Erp, P. B. G., Jackson, R. N., Carter, J., Golden, S. M., Bailey, S. & Wiedenheft, B., Sep 30 2015, In : Nucleic Acids Research. 43, 17, p. 8381-8391 11 p.

Research output: Contribution to journalArticle

2014

Cut site selection by the two nuclease domains of the Cas9 RNA-guided endonuclease

Chen, H., Choi, J. & Bailey, S., 2014, In : Journal of Biological Chemistry. 289, 19, p. 13284-13294 11 p.

Research output: Contribution to journalArticle

Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target.

Mulepati, S., Héroux, A. & Bailey, S., 2014, In : Science. 345, 6203, p. 1479-1484 6 p.

Research output: Contribution to journalArticle

2013

The Cmr complex: An RNA-guided endoribonuclease

Bailey, S., Dec 2013, In : Biochemical Society Transactions. 41, 6, p. 1464-1467 4 p.

Research output: Contribution to journalArticle

2012

Crystal structure of the largest subunit of a bacterial RNA-guided immune complex and its role in DNA target binding

Mulepati, S., Orr, A. & Bailey, S., Jun 29 2012, In : Journal of Biological Chemistry. 287, 27, p. 22445-22449 5 p.

Research output: Contribution to journalArticle

2011
2009

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

Yin, F. F., Bailey, S., Innis, C. A., Ciubotaru, M., Kamtekar, S., Steitz, T. A. & Schatz, D. G., May 2009, In : Nature structural & molecular biology. 16, 5, p. 499-508 10 p.

Research output: Contribution to journalArticle

2008

The structure of a transcribing T7 RNA polymerase in transition from initiation to elongation

Durniak, K. J., Bailey, S. & Steitz, T. A., Oct 24 2008, In : Science. 322, 5901, p. 553-557 5 p.

Research output: Contribution to journalArticle

The structure of LepA, the ribosomal back translocase

Evans, R. N., Blaha, G., Bailey, S. & Steitz, T. A., Mar 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 12, p. 4673-4678 6 p.

Research output: Contribution to journalArticle

2007

Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase

Bailey, S., Eliason, W. K. & Steitz, T. A., Oct 19 2007, In : Science. 318, 5849, p. 459-463 5 p.

Research output: Contribution to journalArticle

The crystal structure of the Thermus aquaticus DnaB helicase monomer

Bailey, S., Eliason, W. K. & Steitz, T. A., Jul 2007, In : Nucleic Acids Research. 35, 14, p. 4728-4736 9 p.

Research output: Contribution to journalArticle

2006

The Structure of T. aquaticus DNA Polymerase III Is Distinct from Eukaryotic Replicative DNA Polymerases

Bailey, S., Wing, R. A. & Steitz, T. A., Sep 8 2006, In : Cell. 126, 5, p. 893-904 12 p.

Research output: Contribution to journalArticle

2003

Analysis of the catalytic and binding residues of the diadenosine tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans by site-directed mutagenesis

Abdelghany, H. M., Bailey, S., Blackburn, G. M., Rafferty, J. B. & McLennan, A. G., Feb 14 2003, In : Journal of Biological Chemistry. 278, 7, p. 4435-4439 5 p.

Research output: Contribution to journalArticle

Crystallization of the Bacillus subtilis SPP1 bacteriophage helicase loader protein G39P

Bailey, S., Sedelnikova, S. E., Mesa, P., Ayora, S., Alonso, J. C. & Rafferty, J. B., Jun 1 2003, In : Acta Crystallographica Section D: Biological Crystallography. 59, 6, p. 1090-1092 3 p.

Research output: Contribution to journalArticle

Structural analysis of Bacillus subtilis SPP1 phage helicase loader protein G39P

Bailey, S., Sedelnikova, S. E., Mesa, P., Ayora, S., Waltho, J. P., Ashcroft, A. E., Baron, A. J., Alonso, J. C. & Rafferty, J. B., Apr 25 2003, In : Journal of Biological Chemistry. 278, 17, p. 15304-15312 9 p.

Research output: Contribution to journalArticle

2002

Crystallization of a complex of Caenorhabditis elegans diadenosine tetraphosphate hydrolase and a non-hydrolysable substrate analogue, AppCH2ppA

Bailey, S., Sedelnikova, S. E., Blackburn, G. M., Abdelghany, H. M., McLennan, A. G. & Rafferty, J. B., 2002, In : Acta Crystallographica Section D: Biological Crystallography. 58, 3, p. 526-528 3 p.

Research output: Contribution to journalArticle

The Crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms

Bailey, S., Sedelnikova, S. E., Blackburn, G. M., Abdelghany, H. M., Baker, P. J., McLennan, A. G. & Rafferty, J. B., 2002, In : Structure. 10, 4, p. 589-600 12 p.

Research output: Contribution to journalArticle

2001

Cloning, characterisation and crystallisation of a diadenosine 5′,5‴-P1,P4-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans

Abdelghany, H. M., Gasmi, L., Cartwright, J. L., Bailey, S., Rafferty, J. B. & McLennan, A. G., Nov 26 2001, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1550, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle