Scott Bailey

Associate Professor

20012018
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Clustered Regularly Interspaced Short Palindromic Repeats Medicine & Life Sciences
RNA Medicine & Life Sciences
DNA Medicine & Life Sciences
CRISPR-Cas Systems Medicine & Life Sciences
DNA Cleavage Medicine & Life Sciences
Escherichia coli Medicine & Life Sciences
Caenorhabditis elegans Medicine & Life Sciences
bis(5'-nucleosyl)tetraphosphatase (asymmetrical) Medicine & Life Sciences

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Research Output 2001 2018

Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis

Singh, D., Wang, Y., Mallon, J., Yang, O., Fei, J., Poddar, A., Ceylan, D., Bailey, S. & Ha, T. Apr 1 2018 In : Nature Structural and Molecular Biology. 25, 4, p. 347-354 8 p.

Research output: Contribution to journalArticle

Guide RNA
DNA Cleavage
Streptococcus pyogenes
DNA
Base Pairing

Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a)

Singh, D., Mallon, J., Poddar, A., Wang, Y., Tippana, R., Yang, O., Bailey, S. & Ha, T. May 22 2018 In : Proceedings of the National Academy of Sciences of the United States of America. 115, 21, p. 5444-5449 6 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Guide RNA
Endonucleases
DNA Cleavage
Observation

Microbiology: The case of the mysterious messenger

Johnson, K. & Bailey, S. Aug 31 2017 In : Nature. 548, 7669, p. 527-528 2 p.

Research output: Contribution to journalShort survey

molecular analysis
prokaryote
microbiology
immune system
immunity

Mycobacterium abscessus L,D-transpeptidases are susceptible to inactivation by carbapenems and cephalosporins but not penicillins

Kumar, P., Chauhan, V., Silva, J. R. A., Lameira, J., D’Andrea, F. B., Li, S. G., Ginell, S. L., Freundlich, J. S., Alves, C. N., Bailey, S., Cohen, K. A. & Lamichhane, G. Oct 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 10, e00866

Research output: Contribution to journalArticle

Peptidyl Transferases
Lactams
Carbapenems
Cephalosporins
Mycobacterium

Altered stoichiometry Escherichia coli Cascade complexes with shortened CRISPR RNA spacers are capable of interference and primed adaptation

Kuznedelov, K., Mekler, V., Lemak, S., Tokmina-Lukaszewska, M., Datsenko, K. A., Jain, I., Savitskaya, E., Mallon, J., Shmakov, S., Bothner, B., Bailey, S., Yakunin, A. F., Severinov, K. & Semenova, E. Dec 1 2016 In : Nucleic acids research. 44, 22, p. 10849-10861 13 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
RNA
Escherichia coli
CRISPR-Cas Systems
Nucleotides