Research Output 1984 2017

2017
Antigen Presentation
Epitopes
Antigens
Proteins
Immunodominant Epitopes

Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis

Darrah, E., Kim, A., Zhang, X., Boronina, T., Cole, R. N., Fava, A., Giles, J. T., Bingham, C. O., Chalmers, M. J., Griffin, P. R., Sadegh-Nasseri, S. & Rosen, A. Jan 6 2017 In : Journal of Proteome Research. 16, 1, p. 355-365 11 p.

Research output: Contribution to journalArticle

Granzymes
Proteolysis
Epitopes
Rheumatoid Arthritis
Omsk Hemorrhagic Fever
2016
Antigen Presentation
Helper-Inducer T-Lymphocytes
Major Histocompatibility Complex
Epitopes
Proteins
2015

Determinants of immunodominance for CD4 T cells

Kim, A. & Sadegh-Nasseri, S. Jun 1 2015 In : Current Opinion in Immunology. 34, p. 9-15 7 p.

Research output: Contribution to journalArticle

Antigen Presentation
T-Lymphocytes
Epitopes
Proteins
Antigens

Exogenous antigens bind MHC class II first, and are processed by cathepsins later

Sadegh-Nasseri, S. & Kim, A. Jul 8 2015 In : Molecular Immunology. 68

Research output: Contribution to journalArticle

Cathepsins
Antigen Presentation
Antigens
Epitopes
T-Lymphoid Precursor Cells

MHC class II auto-antigen presentation is unconventional

Sadegh-Nasseri, S. & Kim, A. 2015 In : Frontiers in Immunology. 6, JUL, 372

Research output: Contribution to journalArticle

Histocompatibility Antigens Class II
Antigen Presentation
Epitopes
MHC Class II Genes
Peptide Fragments
2014

Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources

Kim, A., Hartman, I. Z., Poore, B., Boronina, T., Cole, R. N., Song, N., Ciudad, M. T., Caspi, R. R., Jaraquemada, D. & Sadegh-Nasseri, S. 2014 In : Nature Communications. 5, 5369

Research output: Contribution to journalArticle

Immunodominant Epitopes
Epitopes
Cathepsins
pathogens
antigens
2013

HLA-DO and its role in MHC class II antigen presentation

Poluektov, Y. O., Kim, A. & Sadegh-Nasseri, S. 2013 In : Frontiers in Immunology. 4, AUG, Article 260

Research output: Contribution to journalArticle

Histocompatibility Antigens Class II
Antigen Presentation
Major Histocompatibility Complex
T-Lymphocytes
Antigens

HLA-DO as the Optimizer of Epitope Selection for MHC Class II Antigen Presentation

Poluektov, Y. O., Kim, A. R., Hartman, I. Z. & Sadegh-Nasseri, S. Aug 8 2013 In : PLoS One. 8, 8, e71228

Research output: Contribution to journalArticle

Histocompatibility Antigens Class II
Antigen Presentation
Epitopes
Peptides
peptides

Mix to validate: A facile, reversible pegylation for fast screening of potential therapeutic proteins in vivo

Kim, T. H., Swierczewska, M., Oh, Y., Kim, A., Jo, D. G., Park, J. H., Byun, Y., Sadegh-Nasseri, S., Pomper, M. G., Lee, K. C. & Lee, S. Jul 1 2013 In : Angewandte Chemie - International Edition. 52, 27, p. 6880-6884 5 p.

Research output: Contribution to journalArticle

Proteins
Caprylates
Anthralin
Porphobilinogen Synthase
Dental Materials

Studying MHC class II peptide loading and editing in vitro

Kim, A., Ishizuka, I., Hartman, I., Poluektov, Y., Narayan, K. & Sadegh-Nasseri, S. 2013 Methods in Molecular Biology. Humana Press Inc., Vol. 960, p. 447-459 13 p. (Methods in Molecular Biology; vol. 960)

Research output: Chapter in Book/Report/Conference proceedingChapter

Major Histocompatibility Complex
Peptides
In Vitro Techniques
Immunodominant Epitopes
Surface Plasmon Resonance
2012

How HLA-DM molecules work: Recognition of MHC II conformational heterogeneity

Sadegh-Nasseri, S., Chou, C. L., Hartman, I. Z., Kim, A. & Narayan, K. Jun 1 2012 In : Frontiers in Bioscience - Scholar. 4 S, 4, p. 1325-1332 8 p.

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Epitopes
T-Lymphocytes
Antigens
Peptides
2011

Resolution of infection promotes a state of dormancy and long survival of CD4 memory T cells

Dalai, S. K., Khoruzhenko, S., Drake, C. G., Jie, C. C. & Sadegh-Nasseri, S. Nov 2011 In : Immunology and Cell Biology. 89, 8, p. 870-881 12 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Infection
Antigens
Autoimmunity
B-Lymphocytes
2010

A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes

Hartman, I. Z., Kim, A., Cotter, R. J., Walter, K., Dalai, S. K., Boronina, T., Griffith, W., Lanar, D. E., Schwenk, R., Krzych, U., Cole, R. N. & Sadegh-Nasseri, S. Nov 2010 In : Nature Medicine. 16, 11, p. 1333-1340 8 p.

Research output: Contribution to journalArticle

Immunodominant Epitopes
Histocompatibility Antigens Class II
Antigen Presentation
Major Histocompatibility Complex
Epitopes

Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection

Sadegh-Nasseri, S., Natarajan, S., Chou, C. L., Hartman, I. Z., Narayan, K. & Kim, A. Jul 2010 In : Immunologic Research. 47, 1-3, p. 56-64 9 p.

Research output: Contribution to journalArticle

Antigen Presentation
Major Histocompatibility Complex
Epitopes
Peptides
T-Lymphocytes

Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy

Sadegh-Nasseri, S., Dalai, S. K., Korb Ferris, L. C. & Mirshahidi, S. Jan 2010 In : Immunology. 129, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Ligands
T-Lymphocytes
Peptides
2009

HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1

Narayan, K., Su, K. W., Chou, C. L., Khoruzhenko, S. & Sadegh-Nasseri, S. Sep 2009 In : Molecular Immunology. 46, 15, p. 3157-3162 6 p.

Research output: Contribution to journalArticle

HLA-DR1 Antigen
Peptides
Superantigens
Antigen-Presenting Cells
Viscosity

Staphylococcal enterotoxin A induces small clusters of HLA-DR1 on B cells

Narayan, K., Perkins, E. M., Murphy, G. E., Dalai, S. K., Edidin, M., Subramaniam, S. & Sadegh-Nasseri, S. Jul 9 2009 In : PLoS One. 4, 7, e6188

Research output: Contribution to journalArticle

HLA-DR1 Antigen
Enterotoxins
B-Lymphocytes
B-lymphocytes
Castration
2008

Anergy in memory CD4+ T cells is induced by B cells

Dalai, S. K., Mirshahidi, S., Morrot, A., Zavala, F. & Sadegh-Nasseri, S. Sep 1 2008 In : Journal of Immunology. 181, 5, p. 3221-3231 11 p.

Research output: Contribution to journalArticle

B-Lymphocytes
T-Lymphocytes
Dendritic Cells
Graft Rejection
Transgenic Mice

Short peptide sequences mimic HLA-DM functions

Chou, C. L., Mirshahidi, S., Su, K. W., Kim, A., Narayan, K., Khoruzhenko, S., Xu, M. & Sadegh-Nasseri, S. Apr 2008 In : Molecular Immunology. 45, 7, p. 1935-1943 9 p.

Research output: Contribution to journalArticle

Peptides
HLA-DR1 Antigen
T-Lymphocytes
B-Lymphocytes
In Vitro Techniques

The convergent roles of tapasin and HLA-DM in antigen presentation

Sadegh-Nasseri, S., Chen, M., Narayan, K. & Bouvier, M. Mar 2008 In : Trends in Immunology. 29, 3, p. 141-147 7 p.

Research output: Contribution to journalArticle

Antigen Presentation
Major Histocompatibility Complex
Peptides
Antigen-Presenting Cells
Helper-Inducer T-Lymphocytes
2007

HLA-DM targets the hydrogen bond between the histidine at position β81 and peptide to dissociate HLA-DR-peptide complexes

Narayan, K., Chou, C. L., Kim, A., Hartman, I. Z., Dalai, S., Khoruzhenko, S. & Sadegh-Nasseri, S. Jan 2007 In : Nature Immunology. 8, 1, p. 92-100 9 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Histidine
Hydrogen
Peptides
Histocompatibility
2004

The Magnitude of TCR Engagement is a Critical Predictor of T Cell Anergy or Activation

Mirshahidi, S., Korb Ferris, L. C. & Sadegh-Nasseri, S. May 1 2004 In : Journal of Immunology. 172, 9, p. 5346-5355 10 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Peptides
HLA-DR1 Antigen
Autoimmune Diseases
Clone Cells
2003

Synaptic PDZ domain-mediated protein interactions are disrupted by inhalational anesthetics

Fang, M., Tao, Y. X., He, F., Zhang, M., Levine, C. F., Mao, P., Tao, F., Chou, C. L., Sadegh-Nasseri, S. & Johns, R. A. Sep 19 2003 In : Journal of Biological Chemistry. 278, 38, p. 36669-36675 7 p.

Research output: Contribution to journalArticle

PDZ Domains
Anesthetics
Proteins
Nitric Oxide Synthase Type I
Neurotransmitter Receptor
2001

Anergy in peripheral memory CD4+ T cells induced by low avidity engagement of T cell receptor

Mirshahidi, S., Huang, C. & Sadegh-Nasseri, S. Sep 17 2001 In : Journal of Experimental Medicine. 194, 6, p. 719-731 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
CTLA-4 Antigen
Peptides
Blocking Antibodies
2000

Determinants of the peptide-induced conformational change in the human class II major histocompatibility complex protein HLA-DR1

Sato, A. K., Zarutskie, J. A., Rushe, M. M., Lomakin, A., Natarajan, S. K., Sadegh-Nasseri, S., Benedek, G. B. & Stern, L. J. Jan 21 2000 In : Journal of Biological Chemistry. 275, 3, p. 2165-2173 9 p.

Research output: Contribution to journalArticle

HLA-DR1 Antigen
Major Histocompatibility Complex
Peptides
Proteins
Birth Injuries

HLA-DM recognizes the flexible conformation of major histocompatibility complex class II

Chou, C. L. & Sadegh-Nasseri, S. Dec 18 2000 In : Journal of Experimental Medicine. 192, 12, p. 1697-1706 10 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens
HLA Antigens
Major Histocompatibility Complex
Peptides
1999

Induction of T cell anergy by low numbers of agonist ligands

Korb, L. C., Mirshahidi, S., Ramyar, K., Sadighi Akha, A. A. & Sadegh-Nasseri, S. Jun 1 1999 In : Journal of Immunology. 162, 11, p. 6401-6409 9 p.

Research output: Contribution to journalArticle

Ligands
T-Lymphocytes
Peptides
T-Cell Antigen Receptor-CD3 Complex
Calcineurin

Sodium dodecyl sulfate stability of HLA-DR1 complexes correlates with burial of hydrophobic residues in pocket 1

Natarajan, S. K., Stern, L. J. & Sadegh-Nasseri, S. Mar 15 1999 In : Journal of Immunology. 162, 6, p. 3463-3470 8 p.

Research output: Contribution to journalArticle

HLA-DR1 Antigen
Sodium Dodecyl Sulfate
Peptides
Hemagglutinins
Biosensing Techniques
Peptides
HLA-DR1 Antigen
Hemagglutinins
1997
HLA-DR1 Antigen
Superantigens
Major Histocompatibility Complex
Peptides
In Vitro Techniques
1996

Processing and presentation of endocytically acquired protein antigens by MHC class II and class I molecules

Germain, R. N., Castellino, F., Han, R., Reis E Sousa, C., Romagnoli, P., Sadegh-Nasseri, S. & Zhong, G. M. 1996 In : Immunological Reviews. 151, p. 5-30 26 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens Class II
Proteins
HLA-DR1 Antigen
Peptides
peptides
Molecules
Complementary DNA
1995

Accuracy of a structural homology model for a class ii

Nauss, J. L. & Sadegh-Nasseri, S. 1995 In : Journal of Biomolecular Structure and Dynamics. 12, 6, p. 1213-1233 21 p.

Research output: Contribution to journalArticle

Structural Models
Major Histocompatibility Complex
Peptides
HLA-DR1 Antigen
HLA-DR1 Antigen
Escherichia coli
Antigens
Peptides
Major Histocompatibility Complex
1994

MHC class II function preserved by low-affinity peptide interactions preceding stable binding

Sadegh-Nasseri, S., Stern, L. J., Wiley, D. C. & Germain, R. N. 1994 In : Nature. 370, 6491, p. 647-650 4 p.

Research output: Contribution to journalArticle

Peptides
HLA-DR1 Antigen
Major Histocompatibility Complex
Insects
Polyacrylamide Gel Electrophoresis
1993

The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition

Boehncke, W. H., Takeshita, T., Pendleton, C. D., Houghten, R. A., Sadegh-Nasseri, S., Racioppi, L., Berzofsky, J. A. & Germain, R. N. 1993 In : Journal of Immunology. 150, 2, p. 331-341 11 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Amino Acids
Peptides
Alanine
Glutamic Acid

The Importance of Dominant Negative Effects of Amino Acid Side Chain Substitution in Peptide-MHC Molecule Interactions and T Cell Recognition

Boehncke, W. H., Takeshita, T., Pendleton, C. D., Houghten, R. A., Sadegh-Nasseri, S., Racioppi, L., Berzofsky, J. A. & Germain, R. N. 1993 In : Journal of Immunology. 150, 2, p. 331341 1 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Amino Acids
Peptides
Alanine
Glutamic Acid
Bispecific Antibodies
Antigen Receptors
T-Cell Antigen Receptor
T-Lymphocytes
Interleukin-2
1992

How MHC class II molecules work: peptide-dependent completion of protein folding

Sadegh-Nasseri, S. & Germain, R. N. 1992 In : Immunology Today. 13, 2, p. 43-46 4 p.

Research output: Contribution to journalArticle

Protein Folding
Peptides
Proteins
1991

A role for peptide in determining MHC class II structure

Sadegh-Nasseri, S. & Germain, R. N. Sep 12 1991 In : Nature. 353, 6340, p. 167-170 4 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Peptides
Antigens
Proteins
1989

A kinetic intermediate in the reaction of an antigenic peptide and I-Ek

Sadegh-Nasseri, S. & McConnell, H. M. 1989 In : Nature. 337, 6204, p. 274-276 3 p.

Research output: Contribution to journalArticle

Peptides
Major Histocompatibility Complex
Genes
MHC Class II Genes
Ovalbumin
1988

Immunogenic presentation of an immunoglobulin 'tolerogen' requires interleukin 2

Sadegh-Nasseri, S. & Phipps, R. P. 1988 In : European Journal of Immunology. 18, 3, p. 417-423 7 p.

Research output: Contribution to journalArticle

Interleukin-2
Immunoglobulins
T-Lymphocytes
B-Lymphocytes
Lymphocytes
1987

The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant site.

Gammon, G., Shastri, N., Cogswell, J., Wilbur, S., Sadegh-Nasseri, S., Krzych, U., Miller, A. & Sercarz, E. Aug 1987 In : Immunological Reviews. 98, p. 53-73 21 p.

Research output: Contribution to journalArticle

T-Lymphocyte Epitopes
Antigens
Proteins
1986
Muramidase
Genes
MHC Class II Genes
Antigen Presentation
Concanavalin A
1985

The expressed specificity repertoire of T cells is uninfluenced by non-MHC in responder and non-responder H-2b mice

Sadegh-Nasseri, S., Shastri, N., Gammon, G. & Sercarz, E. 1985 In : Federation Proceedings. 44, 4

Research output: Contribution to journalArticle

T-Cell Antigen Receptor Specificity
1984

Non-H-2 reversal of MHC IR gene control of anti-lysozyme responsiveness

Sadegh-Nasseri, S., Kipp, D. & Shastri, N. 1984 In : Federation Proceedings. 43, 6

Research output: Contribution to journalArticle

Muramidase
Genes
Chromosomes, Human, Pair 2
Muramidase
Genes
Egg White
MHC Class II Genes