Saurav Brahmachari

Research Associate

20062019

Research output per year

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Research Output

2019

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease

Brahmachari, S., Lee, S., Kim, S., Yuan, C., Karuppagounder, S. S., Ge, P., Shi, R., Kim, E. J., Liu, A., Kim, D., Quintin, S., Jiang, H., Kumar, M., Yun, S. P., Kam, T. I., Mao, X., Lee, Y., Swing, D. A., Tessarollo, L., Ko, H. S. & 2 others, Dawson, V. L. & Dawson, T. M., Aug 1 2019, In : Brain. 142, 8, p. 2380-2401 22 p.

Research output: Contribution to journalArticle

2018

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Yun, S. P., Kam, T. I., Panicker, N., Kim, S., Oh, Y., Park, J. S., Kwon, S. H., Park, Y. J., Karuppagounder, S. S., Park, H., Kim, S., Oh, N., Kim, N. A., Lee, S., Brahmachari, S., Mao, X., Lee, J. H., Kumar, M., An, D., Kang, S. U. & 13 others, Lee, Y., Lee, K. C., Na, D. H., Kim, D., Lee, S. H., Roschke, V. V., Liddelow, S. A., Mari, Z., Barres, B. A., Dawson, V. L., Lee, S., Dawson, T. M. & Ko, H. S., Jul 1 2018, In : Nature medicine. 24, 7, p. 931-938 8 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease

Kam, T-I., Mao, X., Park, H., Chou, S. C., Karuppagounder, S., Umanah, G., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A., Ko, H. S., Rosenthal, L. I. S. & 2 others, Dawson, T. M. & Dawson, V., Nov 2 2018, In : Science. 362, 6414, eaat8407.

Research output: Contribution to journalArticle

2017

C-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential

Brahmachari, S., Karuppagounder, S. S., Ge, P., Lee, S., Dawson, V. L., Dawson, T. M. & Ko, H. S., Jan 1 2017, In : Journal of Parkinson's Disease. 7, 4, p. 589-601 13 p.

Research output: Contribution to journalReview article

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G., Kang, H., Ham, S., Kam, T-I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F. C., Springer, W., Dawson, V., Shin, J. H. & 1 others, Dawson, T. M., Jan 24 2017, In : Cell Reports. 18, 4, p. 918-932 15 p.

Research output: Contribution to journalArticle

2016

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration

Brahmachari, S., Ge, P., Lee, S. H., Kim, D., Karuppagounder, S., Kumar, M., Mao, X., Shin, J. H., Lee, Y., Pletnikova, O., Troncoso, J. C., Dawson, V., Dawson, T. M. & Ko, H. S., Aug 1 2016, In : Journal of Clinical Investigation. 126, 8, p. 2970-2988 19 p.

Research output: Contribution to journalArticle

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

Karuppagounder, S. S., Xiong, Y., Lee, Y., Lawless, M. C., Kim, D., Nordquist, E., Martin, I., Ge, P., Brahmachari, S., Jhaldiyal, A., Kumar, M., Andrabi, S. A., Dawson, T. M. & Dawson, V. L., Oct 1 2016, In : Journal of Chemical Neuroanatomy. 76, p. 90-97 8 p.

Research output: Contribution to journalArticle

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3

Mao, X., Ou, M. T., Karuppagounder, S., Kam, T-I., Yin, X., Xiong, Y., Ge, P., Umanah, G., Brahmachari, S., Shin, J. H., Kang, H. C., Zhang, J., Xu, J., Chen, R., Park, H., Andrabi, S. A., Kang, S., Gonçalves, R. A., Liang, Y., Zhang, S. & 12 others, Qi, C., Lam, S., Keiler, J. A., Tyson, J., Kim, D., Panicker, N., Yun, S. P., Workman, C. J., Vignali, D. A. A., Dawson, V., Ko, H. S. & Dawson, T. M., Sep 30 2016, In : Science. 353, 6307, aah3374.

Research output: Contribution to journalArticle

2015

Cinnamon and its metabolite sodium benzoate attenuate the activation of p21rac and protect memory and learning in an animal model of Alzheimer's disease

Modi, K. K., Roy, A., Brahmachari, S., Rangasamy, S. B. & Pahan, K., Jun 23 2015, In : PloS one. 10, 6, e0130398.

Research output: Contribution to journalArticle

TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF

Nam, J. H., Park, E. S., Won, S. Y., Lee, Y. A., Kim, K. I., Jeong, J. Y., Baek, J. Y., Cho, E. J., Jin, M., Chung, Y. C., Lee, B. D., Kim, S. H., Kim, E. G., Byun, K., Lee, B., Woo, D. H., Lee, C. J., Kim, S. R., Bok, E., Kim, Y. S. & 8 others, Ahn, T. B., Ko, H. W., Brahmachari, S., Pletinkova, O., Troconso, J. C., Dawson, V. L., Dawson, T. M. & Jin, B. K., Dec 1 2015, In : Brain. 138, 12, p. 3610-3622 13 p.

Research output: Contribution to journalArticle

2014
2012

Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease

Roy, A., Ghosh, A., Jana, A., Liu, X., Brahmachari, S., Gendelman, H. E. & Pahan, K., Jun 18 2012, In : PloS one. 7, 6, e38113.

Research output: Contribution to journalArticle

2010

Myelin basic protein priming reduces the expression of Foxp3 in T cells via nitric oxide

Brahmachari, S. & Pahan, K., Feb 15 2010, In : Journal of Immunology. 184, 4, p. 1799-1809 11 p.

Research output: Contribution to journalArticle

2009

Inhibition of calpain attenuates encephalitogenicity of MBP-specific T cells

Guyton, M. K., Brahmachari, S., Das, A., Samantaray, S., Inoue, J., Azuma, M., Ray, S. K. & Banik, N. L., Sep 1 2009, In : Journal of Neurochemistry. 110, 6, p. 1895-1907 13 p.

Research output: Contribution to journalArticle

Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease

Ghosh, A., Roy, A., Matras, J., Brahmachari, S., Gendelman, H. E. & Pahan, K., Oct 28 2009, In : Journal of Neuroscience. 29, 43, p. 13543-13556 14 p.

Research output: Contribution to journalArticle

Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses

Brahmachari, S., Jana, A. & Pahan, K., Nov 1 2009, In : Journal of Immunology. 183, 9, p. 5917-5927 11 p.

Research output: Contribution to journalArticle

Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide

Brahmachari, S. & Pahan, K., Aug 1 2009, In : Journal of Immunology. 183, 3, p. 2045-2058 14 p.

Research output: Contribution to journalArticle

2008

Role of cytokine p40 family in multiple sclerosis

Brahmachari, S. & Pahan, K., Apr 1 2008, In : Minerva Medica. 99, 2, p. 105-118 14 p.

Research output: Contribution to journalReview article

2007
Open Access
2006

Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide

Brahmachari, S., Fung, Y. K. & Pahan, K., Sep 7 2006, In : Journal of Neuroscience. 26, 18, p. 4930-4939 10 p.

Research output: Contribution to journalArticle