Saurav Brahmachari


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Research Output 2006 2018

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Yun, S. P., Kam, T. I., Panicker, N., Kim, S., Oh, Y., Park, J. S., Kwon, S. H., Park, Y. J., Karuppagounder, S., Park, H., Kim, S., Oh, N., Kim, N. A., Lee, S., Brahmachari, S., Mao, X., Lee, J. H., Kumar, M., An, D., Kang, S. & 13 othersLee, Y., Lee, K. C., Na, D. H., Kim, D., Lee, S. H., Roschke, V. V., Liddelow, S. A., Mari, Z., Barres, B. A., Dawson, V., Lee, S., Dawson, T. M. & Ko, H. S., Jul 1 2018, In : Nature medicine. 24, 7, p. 931-938 8 p.

Research output: Contribution to journalArticle

Parkinson Disease
Nervous System Diseases

Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease

Kam, T. I., Mao, X., Park, H., Chou, S. C., Karuppagounder, S., Umanah, G., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A., Ko, H. S., Rosenthal, L. I. S. & 2 othersDawson, T. M. & Dawson, V., Nov 2 2018, In : Science. 362, 6414, eaat8407.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
Parkinson Disease
Adenosine Diphosphate Ribose

C-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential

Brahmachari, S., Karuppagounder, S., Ge, P., Lee, S., Dawson, V., Dawson, T. M. & Ko, H. S., 2017, In : Journal of Parkinson's Disease. 7, 4, p. 589-601 13 p.

Research output: Contribution to journalReview article

Parkinson Disease
Oxidative Stress
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Precursor Cell Lymphoblastic Leukemia-Lymphoma

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G., Kang, H., Ham, S., Kam, T. I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F. C., Springer, W., Dawson, V., Shin, J. H. & 1 othersDawson, T. M., Jan 24 2017, In : Cell Reports. 18, 4, p. 918-932 15 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Substantia Nigra

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration

Brahmachari, S., Ge, P., Lee, S. H., Kim, D., Karuppagounder, S., Kumar, M., Mao, X., Shin, J. H., Lee, Y., Pletnikova, O., Troncoso, J. C., Dawson, V., Dawson, T. M. & Ko, H. S., Aug 1 2016, In : Journal of Clinical Investigation. 126, 8, p. 2970-2988 19 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Parkinson Disease
abl Genes