Saraswati Sukumar

Professor

1979 …2020

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2020

DNA methylation markers predict recurrence-free interval in triple-negative breast cancer

Fackler, M. J., Cho, S., Cope, L., Gabrielson, E., Visvanathan, K., Wilsbach, K., Meir-Levi, D., Lynch, C. F., Marks, J., Geradts, J., Regan, M. M., Viale, G., Wolff, A. C., Sukumar, S. & Umbricht, C. B., Dec 1 2020, In : npj Breast Cancer. 6, 1, 3.

Research output: Contribution to journalArticle

Open Access

Nanoparticle interactions with immune cells dominate tumor retention and induce T cell–mediated tumor suppression in models of breast cancer

Korangath, P., Barnett, J. D., Sharma, A., Henderson, E. T., Stewart, J., Yu, S. H., Kandala, S. K., Yang, C. T., Caserto, J. S., Hedayati, M., Armstrong, T. D., Jaffee, E., Gruettner, C., Zhou, X. C., Fu, W., Hu, C., Sukumar, S., Simons, B. W. & Ivkov, R., Jan 1 2020, In : Science Advances. 6, 13, eaay1601.

Research output: Contribution to journalArticle

Open Access

Targeted nanopore sequencing with Cas9-guided adapter ligation

Gilpatrick, T., Lee, I., Graham, J. E., Raimondeau, E., Bowen, R., Heron, A., Downs, B., Sukumar, S., Sedlazeck, F. J. & Timp, W., Apr 1 2020, In : Nature biotechnology. 38, 4, p. 433-438 6 p.

Research output: Contribution to journalArticle

2019

A biologic scaffold-associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy

Wolf, M. T., Ganguly, S., Wang, T. L., Anderson, C. W., Sadtler, K., Narain, R., Cherry, C., Parrillo, A. J., Park, B. V., Wang, G., Pan, F., Sukumar, S., Pardoll, D. M. & Elisseeff, J. H., Jan 30 2019, In : Science Translational Medicine. 11, 477, aat7973.

Research output: Contribution to journalArticle

Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays

Guo, Z., Cheng, Z., Wang, J., Liu, W., Peng, H., Wang, Y., Rao, A. V. S., Li, R. J., Ying, X., Korangath, P., Liberti, M. V., Li, Y., Xie, Y., Hong, S. Y., Schiene-Fischer, C., Fischer, G., Locasale, J. W., Sukumar, S., Zhu, H. & Liu, J. O., Nov 25 2019, In : Angewandte Chemie - International Edition. 58, 48, p. 17158-17162 5 p.

Research output: Contribution to journalArticle

DNA methylation markers for breast cancer detection in the developing world

Downs, B. M., Mercado-Rodriguez, C., Cimino-Mathews, A., Chen, C., Yuan, J. P., Van Den Berg, E., Cope, L. M., Schmitt, F., Tse, G. M., Ali, S. Z., Meir-Levi, D., Sood, R., Li, J., Richardson, A. L., Mosunjac, M. B., Rizzo, M., Tulac, S., Kocmond, K. J., De Guzman, T., Lai, E. W. & 9 others, Rhees, B., Bates, M., Wolff, A. C., Gabrielson, E., Harvey, S. C., Umbricht, C. B., Visvanathan, K., Fackler, M. J. & Sukumar, S., Nov 1 2019, In : Clinical Cancer Research. 25, 21, p. 6357-6367 11 p.

Research output: Contribution to journalArticle

Intraductal fulvestrant for therapy of ERα-positive ductal carcinoma in situ of the breast: A preclinical study

Wang, G., Chen, C., Pai, P., Korangath, P., Sun, S., Merino, V. F., Yuan, J., Li, S., Nie, G., Stearns, V. & Sukumar, S., Jul 1 2019, In : Carcinogenesis. 40, 7, p. 903-913 11 p.

Research output: Contribution to journalArticle

Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ

Ding, L., Su, Y., Fassl, A., Hinohara, K., Qiu, X., Harper, N. W., Huh, S. J., Bloushtain-Qimron, N., Jovanović, B., Ekram, M., Zi, X., Hines, W. C., Alečković, M., Gil del Alcazar, C., Caulfield, R. J., Bonal, D. M., Nguyen, Q. D., Merino, V. F., Choudhury, S., Ethington, G. & 28 others, Panos, L., Grant, M., Herlihy, W., Au, A., Rosson, G. D., Argani, P., Richardson, A. L., Dillon, D., Allred, D. C., Babski, K., Kim, E. M. H., McDonnell, C. H., Wagner, J., Rowberry, R., Bobolis, K., Kleer, C. G., Hwang, E. S., Blum, J. L., Cristea, S., Sicinski, P., Fan, R., Long, H. W., Sukumar, S., Yeon Park, S., Garber, J. E., Bissell, M., Yao, J. & Polyak, K., Dec 1 2019, In : Nature communications. 10, 1, 4182.

Research output: Contribution to journalArticle

Open Access

Validation of a low-cost, carbon dioxide-based cryoablation system for percutaneous tumor ablation

Surtees, B., Young, S., Hu, Y., Wang, G., McChesney, E., Kuroki, G., Acree, P., Thomas, S., Blair, T., Rastogi, S., Kraitchman, D., Weiss, C., Sukumar, S., Harvey, S. C. & Durr, N. J., Jan 1 2019, In : PloS one. 14, 7, e0207107.

Research output: Contribution to journalArticle

Open Access
2018

Breast hormone concentrations in random fine-needle aspirates of healthy women associate with cytological atypia and gene methylation

Lee, O., Heinz, R. E., Ivancic, D., Muzzio, M., Chatterton, R. T., Zalles, C. M., Keeney, K., Phan, B., Liu, D., Scholtens, D., Fackler, M. J., Stearns, V., Sukumar, S. & Khan, S. A., Sep 1 2018, In : Cancer Prevention Research. 11, 9, p. 557-567 11 p.

Research output: Contribution to journalArticle

Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer

Merino, V., Cho, S., Nguyen, N., Sadik, H., Narayan, A., Talbot, C., Cope, L., Zhou, X. C., Zhang, Z., Gyorffy, B. & Sukumar, S., Nov 28 2018, In : Breast Cancer Research. 20, 1, 1068.

Research output: Contribution to journalArticle

Quantitative phosphoproteomic analysis reveals reciprocal activation of receptor tyrosine kinases between cancer epithelial cells and stromal fibroblasts

Wu, X., Zahari, M. S., Renuse, S., Sahasrabuddhe, N. A., Chaerkady, R., Kim, M. S., Fackler, M. J., Stampfer, M., Gabrielson, E., Sukumar, S. & Pandey, A., Jun 15 2018, In : Clinical Proteomics. 15, 1, 21.

Research output: Contribution to journalArticle

2017

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

Sengupta, S., Nagalingam, A., Muniraj, N., Bonner, M. Y., Mistriotis, P., Afthinos, A., Kuppusamy, P., Lanoue, D., Cho, S., Korangath, P., Shriver, M., Begum, A., Merino, V., Huang, C. Y., Arbiser, J. L., Matsui, W., Györffy, B., Konstantopoulos, K., Sukumar, S., Marignani, P. A. & 2 others, Saxena, N. K. & Sharma, D., Oct 12 2017, In : Oncogene. 36, 41, p. 5709-5721 13 p.

Research output: Contribution to journalArticle

Advances in intraductal therapy for breast cancer prevention and treatment

Chen, C., Wang, G., Sukumar, S., Wang, Y. & Sun, S., 2017, In : Chinese Journal of Clinical Oncology. 44, 4, p. 177-180 4 p.

Research output: Contribution to journalArticle

Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis

Zhang, Y., Wei, J., Liu, S., Wang, J., Han, X., Qin, H., Lang, J., Cheng, K., Li, Y., Qi, Y., Anderson, G. J., Sukumar, S., Li, S. & Nie, G., 2017, In : Theranostics. 7, 5, p. 1062-1071 10 p.

Research output: Contribution to journalArticle

Inhibitors of STAT3, β-catenin, and IGF-1R sensitize mouse PIK3CA-mutant breast cancer to PI3K inhibitors

Merino, V., Cho, S., Liang, X., Park, S., Jin, K., Chen, Q., Pan, D., Zahnow, C., Rein, A. R. & Sukumar, S., May 1 2017, In : Molecular Oncology. 11, 5, p. 552-566 15 p.

Research output: Contribution to journalArticle

Monitoring of serum DNA methylation as an early independent marker of response and survival in metastatic breast cancer: TBCRC 005 prospective biomarker study

Visvanathan, K., Fackler, M. S., Zhang, Z., Lopez-Bujanda, Z. A., Jeter, S. C., Sokoll, L. J., Garrett-Mayer, E., Cope, L. M., Umbricht, C. B., Euhus, D. M., Forero, A., Storniolo, A. M., Nanda, R., Lin, N. U., Carey, L. A., Ingle, J. N., Sukumar, S. & Wolff, A. C., Mar 1 2017, In : Journal of Clinical Oncology. 35, 7, p. 751-758 8 p.

Research output: Contribution to journalArticle

The non-receptor tyrosine kinase TNK2/ACK1 is a novel therapeutic target in triple negative breast cancer

Wu, X., Zahari, M. S., Renuse, S., Kelkar, D. S., Bharbuiya, M. A., Rojas, P. L., Stearns, V., Gabrielson, E., Malla, P., Sukumar, S., Mahajan, N. P. & Pandey, A., Jan 1 2017, In : Oncotarget. 8, 2, p. 2971-2983 13 p.

Research output: Contribution to journalArticle

Tumor and serum DNA methylation in women receiving preoperative chemotherapy with or without vorinostat in TBCRC008

Connolly, R., Fackler, M. J., Zhang, Z., Zhou, X. C., Goetz, M. P., Boughey, J. C., Walsh, B., Carpenter, J. T., Storniolo, A. M., Watkins, S. P., Gabrielson, E., Stearns, V. & Sukumar, S., Sep 16 2017, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-10 10 p.

Research output: Contribution to journalArticle

2016

A self-folding hydrogel in vitro model for ductal carcinoma

Kwag, H. R., Serbo, J. V., Korangath, P., Sukumar, S., Romer, L. & Gracias, D. H., Apr 1 2016, In : Tissue Engineering - Part C: Methods. 22, 4, p. 398-407 10 p.

Research output: Contribution to journalArticle

Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple-negative breast cancer

Merino, V., Nguyen, N., Jin, K., Sadik, H., Cho, S., Korangath, P., Han, L., Foster, Y. M. N., Zhou, X. C., Zhang, Z., Connolly, R., Stearns, V., Ali, S. Z., Adams, C., Chen, Q., Pan, D., Huso, D. L., Ordentlich, P., Brodie, A. & Sukumar, S., Apr 1 2016, In : Cancer Research. 76, 7, p. 2013-2024 12 p.

Research output: Contribution to journalArticle

DNA promoter hypermethylation in nipple fluid: A potential tool for early breast cancer detection

de Groot, J. S., Moelans, C. B., Elias, S. G., Fackler, M. J., van Domselaar, R., Suijkerbuijk, K. P. M., Witkamp, A. J., Sukumar, S., van Diest, P. J. & van der Wall, E., Apr 26 2016, In : Oncotarget. 7, 17, p. 24778-24791 14 p.

Research output: Contribution to journalArticle

Effective treatment of ductal carcinoma in situ with a HER-2-targeted alpha-particle emitting radionuclide in a preclinical model of human breast cancer

Yoshida, T., Jin, K., Song, H., Park, S., Huso, D. L., Zhang, Z., Liangfeng, H., Zhu, C., Bruchertseifer, F., Morgenstern, A., Sgouros, G. & Sukumar, S., May 31 2016, In : Oncotarget. 7, 22, p. 33306-33315 10 p.

Research output: Contribution to journalArticle

Gene methylation and cytological atypia in random fine-needle aspirates for assessment of breast cancer risk

Stearns, V., Fackler, M. J., Hafeez, S., Bujanda, Z. L., Chatterton, R. T., Jacobs, L., Khouri, N. F., Ivancic, D., Kenney, K., Shehata, C., Jeter, S. C., Wolfman, J. A., Zalles, C. M., Huang, P., Khan, S. A. & Sukumar, S., Aug 1 2016, In : Cancer Prevention Research. 9, 8, p. 673-682 10 p.

Research output: Contribution to journalArticle

HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24

Teo, W. W., Merino, V. F., Cho, S., Korangath, P., Liang, X., Wu, R. C., Neumann, N. M., Ewald, A. J. & Sukumar, S., Oct 20 2016, In : Oncogene. 35, 42, p. 5539-5551 13 p.

Research output: Contribution to journalArticle

HOXC10 expression supports the development of chemotherapy resistance by fine tuning DNA repair in breast cancer cells

Sadik, H., Korangath, P., Nguyen, N. K., Gyorffy, B., Kumar, R., Hedayati, M., Teo, W. W., Park, S., Panday, H., Munoz, T. G., Menyhart, O., Shah, N., Pandita, R. K., Chang, J. C., DeWeese, T., Chang, H. Y., Pandita, T. K. & Sukumar, S., Aug 1 2016, In : Cancer Research. 76, 15, p. 4443-4456 14 p.

Research output: Contribution to journalArticle

The dual role of FOXF2 in regulation of DNA replication and the epithelial-mesenchymal transition in breast cancer progression

Lo, P. K., Lee, J. S., Liang, X. & Sukumar, S., Oct 1 2016, In : Cellular Signalling. 28, 10, p. 1502-1519 18 p.

Research output: Contribution to journalArticle

2015

A pivotal role for HOXB7 protein in endocrine resistant breast cancer

Jin, K. & Sukumar, S., Jan 1 2015, In : Oncoscience. 2, 11, p. 917-919 3 p.

Research output: Contribution to journalArticle

Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways

Wu, X., Zahari, M. S., Ma, B., Liu, R., Renuse, S., Sahasrabuddhe, N. A., Chen, L., Chaerkady, R., Kim, M. S., Zhong, J., Jelinek, C., Barbhuiya, M. A., Leal-Rojas, P., Yang, Y., Kashyap, M. K., Marimuthu, A., Ling, M., Fackler, M. J., Merino, V., Zhang, Z. & 7 others, Zahnow, C. A., Gabrielson, E., Stearns, V., Roa, J. C., Sukumar, S., Gill, P. S. & Pandey, A., Jan 1 2015, In : Oncotarget. 6, 30, p. 29143-29160 18 p.

Research output: Contribution to journalArticle

HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance

Jin, K., Park, S., Teo, W. W., Korangath, P., Cho, S. S., Yoshida, T., Győrffy, B., Goswami, C. P., Nakshatri, H., Cruz, L. A., Zhou, W., Ji, H., Su, Y., Ekram, M., Wu, Z., Zhu, T., Polyak, K. & Sukumar, S., Sep 1 2015, In : Cancer discovery. 5, 9, p. 944-959 16 p.

Research output: Contribution to journalArticle

HOXB7 promotes malignant progression by activating the TGFβ signaling pathway

Liu, S., Jin, K., Hui, Y., Fu, J., Jie, C., Feng, S., Reisman, D., Wang, Q., Fan, D., Sukumar, S. & Chen, H., Feb 15 2015, In : Cancer Research. 75, 4, p. 709-719 11 p.

Research output: Contribution to journalArticle

Improvement of stability and efficacy of C16Y therapeutic peptide via molecular self-assembly into tumor-responsive nanoformulation

Ding, Y., Ji, T., Zhao, Y., Zhang, Y., Zhao, X., Zhao, R., Lang, J., Zhao, X., Shi, J., Sukumar, S. & Nie, G., Oct 1 2015, In : Molecular cancer therapeutics. 14, 10, p. 2390-2400 11 p.

Research output: Contribution to journalArticle

Multiplexed detection of serological cancer markers with plasmon-enhanced Raman spectro-immunoassay

Li, M., Kang, J. W., Sukumar, S., Dasari, R. R. & Barman, I., Jul 1 2015, In : Chemical Science. 6, 7, p. 3906-3914 9 p.

Research output: Contribution to journalArticle

Phosphoproteomic analysis identifies focal adhesion kinase 2 (FAK2) as a potential therapeutic target for tamoxifen resistance in breast cancer

Wu, X., Zahari, M. S., Renuse, S., Nirujogi, R. S., Kim, M. S., Manda, S. S., Stearns, V., Gabrielson, E., Sukumar, S. & Pandey, A., Nov 2015, In : Molecular and Cellular Proteomics. 14, 11, p. 2887-2900 14 p.

Research output: Contribution to journalArticle

Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer

Su, Y., Subedee, A., Bloushtain-Qimron, N., Savova, V., Krzystanek, M., Li, L., Marusyk, A., Tabassum, D. P., Zak, A., Flacker, M. J., Li, M., Lin, J. J., Sukumar, S., Suzuki, H., Long, H., Szallasi, Z., Gimelbrant, A., Maruyama, R. & Polyak, K., Jun 16 2015, In : Cell Reports. 11, 10, p. 1549-1563 15 p.

Research output: Contribution to journalArticle

Targeting glutamine metabolism in breast cancer with aminooxyacetate

Korangath, P., Teo, W. W., Sadik, H., Han, L., Mori, N., Huijts, C. M., Wildes, F., Bharti, S., Zhang, Z., Santa-Maria, C. A., Tsai, H., Dang, C. V., Stearns, V., Bhujwalla, Z. M. & Sukumar, S., Jul 15 2015, In : Clinical Cancer Research. 21, 14, p. 3263-3273 11 p.

Research output: Contribution to journalArticle

2014

A breast cancer cell microarray (CMA) as a rapid method to characterize candidate biomarkers

Wu, X., Zahari, M. S., Renuse, S., Jacob, H. K. C., Sakamuri, S., Singal, M., Gabrielson, E., Sukumar, S. & Pandey, A., Dec 1 2014, In : Cancer Biology and Therapy. 15, 12, p. 1593-1599 7 p.

Research output: Contribution to journalArticle

Activation of diverse signalling pathways by oncogenic PIK3CA mutations

Wu, X., Renuse, S., Sahasrabuddhe, N. A., Zahari, M. S., Chaerkady, R., Kim, M. S., Nirujogi, R. S., Mohseni, M., Kumar, P., Raju, R., Zhong, J., Yang, J., Neiswinger, J., Jeong, J. S., Newman, R., Powers, M. A., Somani, B. L., Gabrielson, E., Sukumar, S., Stearns, V. & 5 others, Qian, J., Zhu, H., Vogelstein, B., Park, B. H. & Pandey, A., 2014, In : Nature communications. 5, 4961.

Research output: Contribution to journalArticle

Do breast cancer cell lines provide a relevant model of the patient tumor methylome?

Cope, L. M., Fackler, M. J., Lopez-Bujanda, Z., Wolff, A. C., Visvanathan, K., Gray, J. W., Sukumar, S. & Umbricht, C. B., Aug 26 2014, In : PloS one. 9, 8, e105545.

Research output: Contribution to journalArticle

Genetic and phenotypic diversity in breast tumor metastases

Almendro, V., Kim, H. J., Cheng, Y. K., Gonen, M., Itzkovitz, S., Argani, P., Van Oudenaarden, A., Sukumar, S., Michor, F. & Polyak, K., Mar 1 2014, In : Cancer Research. 74, 5, p. 1338-1348 11 p.

Research output: Contribution to journalArticle

Novel methylated biomarkers and a robust assay to detect circulating tumor dna in metastatic breast cancer

Fackler, M. J., Bujanda, Z. L., Umbricht, C., Teo, W. W., Cho, S., Zhang, Z., Visvanathan, K., Jeter, S., Argani, P., Wang, C., Lyman, J. P., De Brot, M., Ingle, J. N., Boughey, J., McGuire, K., King, T. A., Carey, L. A., Cope, L., Wolff, A. C. & Sukumar, S., Apr 15 2014, In : Cancer Research. 74, 8, p. 2160-2170 11 p.

Research output: Contribution to journalArticle

Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation

Barrio-Real, L., Benedetti, L. G., Engel, N., Tu, Y., Cho, S., Sukumar, S. & Kazanietz, M. G., Sep 24 2014, In : Breast Cancer Research. 16, 5, p. 1-13 13 p., 441.

Research output: Contribution to journalArticle

The Notch pathway inhibits TGFβ signaling in breast cancer through HEYL-mediated crosstalk

Han, L., Diehl, A., Nguyen, N. K., Korangath, P., Teo, W., Cho, S., Kominsky, S., Huso, D. L., Feigenbaum, L., Rein, A., Argani, P., Landberg, G., Gessler, M. & Sukumar, S., Nov 15 2014, In : Cancer Research. 74, 22, p. 6509-6518 10 p.

Research output: Contribution to journalArticle

Tissue specific DNA methylation in normal human breast epithelium and in breast cancer

Avraham, A., Cho, S. S., Uhlmann, R., Polak, M. L., Sandbank, J., Karni, T., Pappo, I., Halperin, R., Vaknin, Z., Sella, A., Sukumar, S. & Evron, E., Mar 20 2014, In : PloS one. 9, 3, e91805.

Research output: Contribution to journalArticle

2013

Big punches come in nanosizes for chemoprevention

Sharma, D. & Sukumar, S., Oct 1 2013, In : Cancer Prevention Research. 6, 10, p. 1007-1010 4 p.

Research output: Contribution to journalArticle

Biomarker modulation following short-term vorinostat in women with newly diagnosed primary breast cancer

Stearns, V., Jacobs, L. K., Fackler, M. J., Tsangaris, T. N., Rudek, M. A., Higgins, M., Lange, J., Cheng, Z., Slater, S. A., Jeter, S. C., Powers, P., Briest, S., Chao, C., Yoshizawa, C., Sugar, E., Espinoza-Delgado, I., Sukumar, S., Gabrielson, E. & Davidson, N. E., Jul 15 2013, In : Clinical Cancer Research. 19, 14, p. 4008-4016 9 p.

Research output: Contribution to journalArticle

Cytoplasmic mislocalization of overexpressed FOXF1 is associated with the malignancy and metastasis of colorectal adenocarcinomas

Lo, P. K., Lee, J. S., Chen, H., Reisman, D., Berger, F. G. & Sukumar, S., Feb 1 2013, In : Experimental and Molecular Pathology. 94, 1, p. 262-269 8 p.

Research output: Contribution to journalArticle

HMGA1: A Master Regulator of Tumor Progression in Triple-Negative Breast Cancer Cells

Shah, S. N., Cope, L., Poh, W., Belton, A., Roy, S., Talbot, C. C., Sukumar, S., Huso, D. L. & Resar, L. M. S., May 2 2013, In : PloS one. 8, 5, e63419.

Research output: Contribution to journalArticle