Saraswati Sukumar

Professor

1979 …2020

Research output per year

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Research Output

2004

Very High Frequency of Hypermethylated Genes in Breast Cancer Metastasis to the Bone, Brain, and Lung

Mehrotra, J., Vali, M., McVeigh, M., Kominsky, S. L., Fackler, M. J., Lahti-Domenici, J., Polyak, K., Sacchi, N., Garrett-Mayer, E., Argani, P. & Sukumar, S., May 1 2004, In : Clinical Cancer Research. 10, 9, p. 3104-3109 6 p.

Research output: Contribution to journalArticle

2003

An isoform of the Wilms' tumor suppressor gene potentiates granulocytic differentiation

Loeb, D. M., Summers, J. L., Burwell, E. A., Korz, D., Friedman, A. D. & Sukumar, S., Jan 1 2003, In : Leukemia. 17, 5, p. 965-971 7 p.

Research output: Contribution to journalArticle

Distant metastasis in breast cancer: Molecular mechanisms and a search for therapeutic targets

Parker, B. S. & Sukumar, S., Jan 1 2003, In : Cancer Biology and Therapy. 2, 1, p. 14-21 8 p.

Research output: Contribution to journalReview article

DNA methylation of RASSF1A, HIN-1, RAR-β, cyclin D2 and twist in in situ and invasive lobular breast carcinoma

Fackler, M. J., McVeigh, M., Evron, E., Garrett, E., Mehrotra, J., Polyak, K., Sukumar, S. & Argani, P., Dec 20 2003, In : International Journal of Cancer. 107, 6, p. 970-975 6 p.

Research output: Contribution to journalArticle

HOX genes: Emerging stars in cancer

Chen, H. & Sukumar, S., Sep 1 2003, In : Cancer Biology and Therapy. 2, 5, p. 524-525 2 p.

Research output: Contribution to journalComment/debate

Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast

Kominsky, S. L., Argani, P., Korz, D., Evron, E., Raman, V., Garrett, E., Rein, A., Sauter, G., Kallioniemi, O. P. & Sukumar, S., Apr 3 2003, In : Oncogene. 22, 13, p. 2021-2033 13 p.

Research output: Contribution to journalArticle

Methylation Profiling of Benign and Malignant Breast Lesions and Its Application to Cytopathology

Pu, R. T., Laitala, L. E., Alli, P. M., Fackler, M. J., Sukumar, S. & Clark, D. P., Nov 1 2003, In : Modern Pathology. 16, 11, p. 1095-1101 7 p.

Research output: Contribution to journalArticle

Mitoxantrone mediates demethylation and reexpression of cyclin D2, estrogen receptor and 14.3.3σ in breast cancer cells

Parker, B. S., Cutts, S. M., Nudelman, A., Rephaeli, A., Phillips, D. R. & Sukumar, S., May 1 2003, In : Cancer Biology and Therapy. 2, 3, p. 259-263 5 p.

Research output: Contribution to journalArticle

Novel Agents for Chemoprevention, Screening Methods, and Sampling Issues

Fackler, M. J., Evron, E., Khan, S. A. & Sukumar, S., Jan 1 2003, In : Journal of Mammary Gland Biology and Neoplasia. 8, 1, p. 75-89 15 p.

Research output: Contribution to journalReview article

Role of Homeobox Genes in Normal Mammary Gland Development and Breast Tumorigenesis

Chen, H. & Sukumar, S., Apr 1 2003, In : Journal of Mammary Gland Biology and Neoplasia. 8, 2, p. 159-175 17 p.

Research output: Contribution to journalReview article

2002

Cyclin E is a target of WT1 transcriptional repression

Loeb, D. M., Korz, D., Katsnelson, M., Burwell, E. A., Friedman, A. D. & Sukumar, S., May 31 2002, In : Journal of Biological Chemistry. 277, 22, p. 19627-19632 6 p.

Research output: Contribution to journalArticle

In this issue

Sukumar, S., Jan 1 2002, In : Cancer Biology and Therapy. 1, 2, p. 88-89 2 p.

Research output: Contribution to journalEditorial

Open Access

The role of WT1 in oncogenesis: Tumor suppressor or oncogene?

Loeb, D. M. & Sukumar, S., Aug 1 2002, In : International journal of hematology. 76, 2, p. 117-126 10 p.

Research output: Contribution to journalArticle

2001

CpG methylation as a basis for breast tumor-specific loss of NES1/kallikrein 10 expression

Li, B., Goyal, J., Dhar, S., Dimri, G., Evron, E., Sukumar, S., Wazer, D. E. & Band, V., Nov 1 2001, In : Cancer Research. 61, 21, p. 8014-8021 8 p.

Research output: Contribution to journalArticle

Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR

Evron, E., Dooley, W. C., Umbricht, C. B., Rosenthal, D., Sacchi, N., Gabrielson, E., Soito, A. B., Hung, D. T., Ljung, B. M., Davidson, N. E. & Sukumar, S., Apr 28 2001, In : Lancet. 357, 9265, p. 1335-1336 2 p.

Research output: Contribution to journalArticle

Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer.

Klus, G. T., Rokaeus, N., Bittner, M. L., Chen, Y., Korz, D. M., Sukumar, S., Schick, A. & Szallasi, Z., Jul 2001, In : International journal of oncology. 19, 1, p. 169-174 6 p.

Research output: Contribution to journalArticle

Hypermethylation of 14-3-3 σ (stratifin) is an early event in breast cancer

Umbricht, C. B., Evron, E., Gabrielson, E., Ferguson, A., Marks, J. & Sukumar, S., Jun 7 2001, In : Oncogene. 20, 26, p. 3348-3353 6 p.

Research output: Contribution to journalArticle

Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation

Evron, E., Umbricht, C. B., Korz, D., Raman, V., Loeb, D. M., Niranjan, B., Buluwela, L., Weitzman, S. A., Marks, J. & Sukumar, S., Mar 15 2001, In : Cancer Research. 61, 6, p. 2782-2787 6 p.

Research output: Contribution to journalArticle

Wilms’ tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation

Loeb, D. M., Evron, E., Patel, C. B., Sharma, P. M., Niranjan, B., Buluwela, L., Weitzman, S. A., Korz, D. & Sukumar, S., Feb 1 2001, In : Cancer Research. 61, 3, p. 921-925 5 p.

Research output: Contribution to journalArticle

2000

Compromised HOXA5 function can limit p53 expression in human breast tumours

Raman, V., Martenser, S. A., Reisman, D., Evron, E., Odenwald, W. F., Jaffee, E., Marks, J. & Sukumar, S., Jun 22 2000, In : Nature. 405, 6789, p. 974-978 5 p.

Research output: Contribution to journalArticle

Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor β2 promoter in breast cancer cells

Sirchia, S. M., Ferguson, A. T., Sironi, E., Subramanyan, S., Orlandi, R., Sukumar, S. & Sacchi, N., Mar 16 2000, In : Oncogene. 19, 12, p. 1556-1563 8 p.

Research output: Contribution to journalArticle

Open Access

High frequency of hypermethylation at the 14-3-3 σ locus leads to gene silencing in breast cancer

Ferguson, A. T., Evron, E., Umbricht, C. B., Pandita, T. K., Chan, T. A., Hermeking, H., Marks, J. R., Lambers, A. R., Futreal, P. A., Stampfer, M. R. & Sukumar, S., May 23 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 11, p. 6049-6054 6 p.

Research output: Contribution to journalArticle

HOXA5 regulates expression of the progesterone receptor

Raman, V., Tamori, A., Vali, M., Zeller, K., Korz, D. & Sukumar, S., Aug 25 2000, In : Journal of Biological Chemistry. 275, 34, p. 26551-26555 5 p.

Research output: Contribution to journalArticle

1999

Analysis of human transcriptomes [2]

Velculescu, V. E., Madden, S. L., Zhang, L., Lash, A. E., Yu, J., Rago, C., Lal, A., Wang, C. J., Beaudry, G. A., Ciriello, K. M., Cook, B. P., Dufault, M. R., Ferguson, A. T., Gao, Y., He, T. C., Hermeking, H., Hiraldo, S. K., Hwang, P. M., Lopez, M. A., Luderer, H. F. & 14 others, Mathews, B., Petroziello, J. M., Polyak, K., Zawel, L., Zhang, W., Zhang, X., Zhou, W., Haluska, F. G., Jen, J., Sukumar, S., Landes, G. M., Riggins, G. J., Vogelstein, B. & Kinzler, K. W., 1999, In : Nature genetics. 23, 4, p. 387-388 2 p.

Research output: Contribution to journalLetter

Applications of telomerase research in the fight against cancer

McKenzie, K. E., Umbricht, C. B. & Sukumar, S., Mar 1 1999, In : Molecular Medicine Today. 5, 3, p. 114-122 9 p.

Research output: Contribution to journalReview article

Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer

Nacht, M., Ferguson, A. T., Zhang, W., Petroziello, J. M., Cook, B. P., Gao, Y. H., Maguire, S., Riley, D., Coppola, G., Landes, G. M., Madden, S. L. & Sukumar, S., Nov 1 1999, In : Cancer Research. 59, 21, p. 5464-5470 7 p.

Research output: Contribution to journalArticle

High telomerase reverse transcriptase (hTERT) messenger RNA level correlates with tumor recurrence in patients with favorable histology Wilms' tumor

Dome, J. S., Chung, S., Bergemann, T., Umbricht, C. B., Saji, M., Carey, L. A., Grundy, P. E., Perlman, E. J., Breslow, N. E. & Sukumar, S., Sep 1 1999, In : Cancer Research. 59, 17, p. 4301-4307 7 p.

Research output: Contribution to journalArticle

Human telomerase reverse transcriptase (hTERT) gene expression in thyroid neoplasms

Saji, M., Xydas, S., Westra, W. H., Liang, C. K., Clark, D. P., Udelsman, R., Umbricht, C. B., Sukumar, S. & Zeiger, M. A., Jun 1 1999, In : Clinical Cancer Research. 5, 6, p. 1483-1489 7 p.

Research output: Contribution to journalArticle

Telomerase activity and prognosis in primary breast cancers

Carey, L. A., Kim, N. W., Goodman, S., Marks, J., Henderson, G., Umbricht, C. B., Dome, J. S., Dooley, W., Amshey, S. R. & Sukumar, S., Oct 1999, In : Journal of Clinical Oncology. 17, 10, p. 3075-3081 7 p.

Research output: Contribution to journalArticle

Telomerase activity as a measure for monitoring radiocurability of tumor cells

Sawant, S. G., Gregoire, V., Dhar, S., Umbricht, C. B., Cvilic, S., Sukumar, S. & Pandita, T. K., Jun 8 1999, In : FASEB Journal. 13, 9, p. 1047-1054 8 p.

Research output: Contribution to journalArticle

Telomerase activity in ductal carcinoma in situ and invasive breast cancer

Umbricht, C. B., Sherman, M. E., Dome, J., Carey, L. A., Marks, J., Kim, N. & Sukumar, S., Jun 3 1999, In : Oncogene. 18, 22, p. 3407-3414 8 p.

Research output: Contribution to journalArticle

1998

Absence of TSG101 transcript abnormalities in human cancers

Trink, B., Pai, S. I., Spunt, S. L., Raman, V., Cairns, P., Jen, J., Gabrielson, E., Sukumar, S. & Sidransky, D., May 28 1998, In : Oncogene. 16, 21, p. 2815-2818 4 p.

Research output: Contribution to journalArticle

Careful histological confirmation and microdissection reveal telomerase activity in otherwise telomerase-negative breast cancers

Carey, L. A., Hedican, C. A., Henderson, G. S., Umbricht, C. B., Dome, J. S., Varon, D. & Sukumar, S., Feb 1 1998, In : Clinical Cancer Research. 4, 2, p. 435-440 6 p.

Research output: Contribution to journalArticle

Molecular cloning and chromosomal localization of Chinese hamster telomeric protein chTRF1. Its potential role in chromosomal instability

Smilenov, L. B., Mellado, W., Rao, P. H., Sawant, S. G., Umbricht, C. B., Sukumar, S. & Pandita, T. K., Oct 22 1998, In : Oncogene. 17, 16, p. 2137-2142 6 p.

Research output: Contribution to journalArticle

Open Access
1997

Alterations in the Ha-ras-1 and the p53 pathway genes in the progression of N-methyl-N-nitrosourea-induced rat mammary tumors

McKenzie, K. E., Armstrong, B. A., Chen, Y., Nagarajan, M., Aldaz, C. M. & Sukumar, S., Oct 1997, In : Molecular Carcinogenesis. 20, 2, p. 194-203 10 p.

Research output: Contribution to journalArticle

Altered WAF1 genes do not play a role in abnormal cell cycle regulation in breast cancers lacking p53 mutations

McKenzie, K. E., Siva, A., Maier, S., Runnebaum, I. B., Seshadri, R. & Sukumar, S., Sep 1 1997, In : Clinical Cancer Research. 3, 9, p. 1669-1673 5 p.

Research output: Contribution to journalArticle

Differential effects of wilms tumor WT1 splice variants on the insulin receptor promoter

Webster, N. J. G., Kong, Y., Sharma, P., Haas, M., Sukumar, S. & Seely, B. L., Dec 1997, In : Biochemical and Molecular Medicine. 62, 2, p. 139-150 12 p.

Research output: Contribution to journalArticle

Telomerase activity: A marker to distinguish follicular thyroid adenoma from carcinoma

Umbricht, C. B., Saji, M., Westra, W. H., Udelsman, R., Zeiger, M. A. & Sukumar, S., Jun 1 1997, In : Cancer Research. 57, 11, p. 2144-2147 4 p.

Research output: Contribution to journalArticle

Telomerase activity in the differential diagnosis of papillary carcinoma of the thyroid

Saji, M., Westra, W. H., Chen, H., Umbricht, C. B., Tuttle, R. M., Box, M. F., Udelsman, R., Sukumar, S. & Zeiger, M. A., Dec 1997, In : Surgery. 122, 6, p. 1137-1140 4 p.

Research output: Contribution to journalArticle

Telomerase activity in the normal and neoplastic rat mammary gland

Varon, D., Jiang, C., Hedican, C., Dome, J. S., Umbricht, C. B., Carey, L. A., Thompson, H. J. & Sukumar, S., Dec 15 1997, In : Cancer Research. 57, 24, p. 5605-5609 5 p.

Research output: Contribution to journalArticle

1996

Breast cancer prevention strategies for the twenty first century

Sukumar, S. & Mackenzie, K., Jan 1 1996, In : Molecular Medicine Today. 2, 11, p. 453-459 7 p.

Research output: Contribution to journalComment/debate

Midkine in the progression of rat N-nitroso-N-methylurea-induced mammary tumors

Chen, Y., McKenzie, K. E., Aldaz, C. M. & Sukumar, S., Dec 17 1996, In : Molecular Carcinogenesis. 17, 3, p. 112-116 5 p.

Research output: Contribution to journalArticle

Molecular genetics of human breast cancer.

McKenzie, K. & Sukumar, S., 1996, In : Progress in clinical and biological research. 394, p. 183-209 27 p.

Research output: Contribution to journalReview article

1995

Animal models for breast cancer

Sukumar, S., McKenzie, K. & Chen, Y., Dec 1995, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 333, 1-2, p. 37-44 8 p.

Research output: Contribution to journalArticle

1994

A rodent model for Wilms tumors: Embryonal kidney neoplasms induced by N- nitroso-N'-methylurea

Sharma, P. M., Bowman, M., Yu, B. F. & Sukumar, S., 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 21, p. 9931-9935 5 p.

Research output: Contribution to journalArticle

Open Access

Frequent p53 Gene Mutations and Novel Alleles in Familial Breast Cancer1

Glebov, O. K., McKenzie, K. E. & Sukumar, S., Jul 1994, In : Cancer Research. 54, 14, p. 3703-3709 7 p.

Research output: Contribution to journalArticle

Molecular mechanisms of chemical carcinogenesis in rodent models.

McKenzie, K. & Sukumar, S., 1994, In : Cancer treatment and research. 71, p. 313-329 17 p.

Research output: Contribution to journalReview article

RNA editing in the Wilms' tumor susceptibility gene, WT1

Sharma, P. M., Bowman, M., Madden, S. L., Rauscher, F. J. & Sukumar, S., Mar 15 1994, In : Genes and Development. 8, 6, p. 720-731 12 p.

Research output: Contribution to journalArticle

Open Access

Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles

Runnebaum, I. B., Yee, J. K., Kieback, D. G., Sukumar, S. & Friedmann, T., 1994, In : Anticancer research. 14, 3 A, p. 1137-1144 8 p.

Research output: Contribution to journalArticle

1993

Mutationen des p53 Tumorsuppressor-Gens beim Mammakarzinom und Suppression des neoplastischen Phänotyps durch Wildtyp p53

Runnebaum, I. B., Kieback, D. G., Friedmann, T., Sukumar, S. & Kreienberg, R., Dec 1993, In : Archives of Gynecology and Obstetrics. 254, 1-4, p. 834-836 3 p.

Research output: Contribution to journalArticle