Saraswati Sukumar

Professor

1979 …2020

Research output per year

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Research Output

2009

PIK3CA somatic mutations in breast cancer: Mechanistic insights from Langevin dynamics simulations

Mankoo, P. K., Sukumar, S. & Karchin, R., May 1 2009, In : Proteins: Structure, Function and Bioinformatics. 75, 2, p. 499-508 10 p.

Research output: Contribution to journalArticle

2008

A PET rat model for assessing the effectiveness of new chemotherapies

Winnard, P. T. & Sukumar, S., Apr 2008, In : Cancer Biology and Therapy. 7, 4, p. 538-539 2 p.

Research output: Contribution to journalComment/debate

Open Access

Cell type-specific DNA methylation patterns in the human breast

Bloushtain-Qimron, N., Yao, J., Snyder, E. L., Shipitsin, M., Campbell, L. L., Mani, S. A., Hu, M., Chen, H., Ustyansky, V., Antosiewicz, J. E., Argani, P., Halushka, M. K., Thomson, J. A., Pharoah, P., Porgador, A., Sukumar, S., Parsons, R., Richardson, A. L., Stampfer, M. R., Gelman, R. S. & 3 others, Nikolskaya, T., Nikolsky, Y. & Polyak, K., Sep 16 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 37, p. 14076-14081 6 p.

Research output: Contribution to journalArticle

Epigenomics and breast cancer

Lo, P. K. & Sukumar, S., Dec 1 2008, In : Pharmacogenomics. 9, 12, p. 1879-1902 24 p.

Research output: Contribution to journalReview article

Heterogeneity of breast cancer metastases: Comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases

Wu, J. M., Fackler, M. J., Halushka, M. K., Molavi, D. W., Taylor, M. E., Wei, W. T., Griffin, C., Fetting, J., Davidson, N. E., De Marzo, A. M., Hicks, J. L., Chitale, D., Ladanyi, M., Sukumar, S. & Argani, P., Apr 1 2008, In : Clinical Cancer Research. 14, 7, p. 1938-1946 9 p.

Research output: Contribution to journalArticle

Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis

Chen, H., Ji, S. L., Liang, X., Zhang, H., Zhu, T., Zhang, Z., Taylor, M. E., Zahnow, C., Feigenbaum, L., Rein, A. & Sukumar, S., May 15 2008, In : Cancer Research. 68, 10, p. 3637-3644 8 p.

Research output: Contribution to journalArticle

Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer

Suijkerbuijk, K. P. M., Fackler, M. J., Sukumar, S., Van gils, C. H., Van laar, T., Van der wall, E., Vooijs, M. & Van Diest, P. J., Nov 3 2008, In : Annals of Oncology. 19, 11, p. 1870-1874 5 p.

Research output: Contribution to journalArticle

Quantitative promoter hypermethylation profiles of ductal carcinoma in situ in north american and korean women: Potential applications for diagnosis

Ji, S. L., Fackler, M. J., Wei, W. T., Jae, H. L., Choi, C., Min, H. P., Jung, H. Y., Zhang, Z., Argani, P. & Sukumar, S., Sep 2008, In : Cancer Biology and Therapy. 7, 9, p. 1400-1408 9 p.

Research output: Contribution to journalArticle

Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9

Cao, D., Polyak, K., Halushka, M. K., Nassar, H., Kouprina, N., Iacobuzio-Donahue, C., Wu, X., Sukumar, S., Hicks, J., De Marzo, A. & Argani, P., Oct 27 2008, In : Breast Cancer Research. 10, 5, R91.

Research output: Contribution to journalArticle

SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium

Marlow, R., Strickland, P., Ji, S. L., Wu, X., PeBenito, M., Binnewies, M., Le, E. K., Moran, A., Macias, H., Cardiff, R. D., Sukumar, S. & Hinck, L., Oct 1 2008, In : Cancer Research. 68, 19, p. 7819-7827 9 p.

Research output: Contribution to journalArticle

The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis

Gupta, A., Guerin-Peyrou, T. G., Sharma, G. G., Park, C., Agarwal, M., Ganju, R. K., Pandita, S., Choi, K., Sukumar, S., Pandita, R. K., Ludwig, T. & Pandita, T. K., Jan 2008, In : Molecular and cellular biology. 28, 1, p. 397-409 13 p.

Research output: Contribution to journalArticle

2007
Open Access

A role for the HOXB7 homeodomain protein in DNA repair

Rubin, E., Wu, X., Zhu, T., Cheung, J. C. Y., Chen, H., Lorincz, A., Pandita, R. K., Sharma, G. G., Hyo, C. H., Gasson, J., Hanakahi, L. A., Pandita, T. K. & Sukumar, S., Feb 15 2007, In : Cancer Research. 67, 4, p. 1527-1535 9 p.

Research output: Contribution to journalArticle

Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis

Kominsky, S. L., Tyler, B., Sosnowski, J., Brady, K., Doucet, M., Nell, D., Smedley, J. G., McClane, B., Brem, H. & Sukumar, S., Sep 1 2007, In : Cancer Research. 67, 17, p. 7977-7982 6 p.

Research output: Contribution to journalArticle

DNA methylation regulates microRNA expression

Han, L., Witmer, P. D., Casey, E., Valle, D. & Sukumar, S., Aug 2007, In : Cancer Biology and Therapy. 6, 8, p. 1290-1294 5 p.

Research output: Contribution to journalArticle

Open Access

ETS genes in breast cancer: A step in the right direction

Wu, X. & Sukumar, S., Jan 2007, In : Cancer Biology and Therapy. 6, 1, p. 83-84 2 p.

Research output: Contribution to journalComment/debate

Open Access

HOXA1-stimulated oncogenicity is mediated by selective upregulation of components of the p44/42 MAP kinase pathway in human mammary carcinoma cells

Mohankumar, K. M., Xu, X. Q., Zhu, T., Kannan, N., Miller, L. D., Liu, E. T., Gluckman, P. D., Sukumar, S., Emerald, B. S. & Lobie, P. E., Jun 7 2007, In : Oncogene. 26, 27, p. 3998-4008 11 p.

Research output: Contribution to journalArticle

HOXA5 acts directly downstream of retinoic acid receptor β and contributes to retinoic acid-induced apoptosis and growth inhibition

Chen, H., Zhang, H., Lee, J., Liang, X., Wu, X., Zhu, T., Lo, P. K., Zhang, X. & Sukumar, S., Sep 1 2007, In : Cancer Research. 67, 17, p. 8007-8013 7 p.

Research output: Contribution to journalArticle

Molecular Definition of Breast Tumor Heterogeneity

Shipitsin, M., Campbell, L. L., Argani, P., Weremowicz, S., Bloushtain-Qimron, N., Yao, J., Nikolskaya, T., Serebryiskaya, T., Beroukhim, R., Hu, M., Halushka, M. K., Sukumar, S., Parker, L. M., Anderson, K. S., Harris, L. N., Garber, J. E., Richardson, A. L., Schnitt, S. J., Nikolsky, Y., Gelman, R. S. & 1 others, Polyak, K., Mar 13 2007, In : Cancer cell. 11, 3, p. 259-273 15 p.

Research output: Contribution to journalArticle

The genomic landscapes of human breast and colorectal cancers

Wood, L. D., Parsons, D. W., Jones, S., Lin, J., Sjöblom, T., Leary, R. J., Shen, D., Boca, S. M., Barber, T., Ptak, J., Silliman, N., Szabo, S., Dezso, Z., Ustyanksky, V., Nikolskaya, T., Nikolsky, Y., Karchin, R., Wilson, P. A., Kaminker, J. S., Zhang, Z. & 22 others, Croshaw, R., Willis, J., Dawson, D., Shipitsin, M., Willson, J. K. V., Sukumar, S., Polyak, K., Ben, H. P., Pethiyagoda, C. L., Pant, P. V. K., Ballinger, D. G., Sparks, A. B., Hartigan, J., Smith, D. R., Suh, E., Papadopoulos, N., Buckhaults, P., Markowitz, S. D., Parmigiani, G., Kinzler, K. W., Velculescu, V. E. & Vogelstein, B., Nov 16 2007, In : Science. 318, 5853, p. 1108-1113 6 p.

Research output: Contribution to journalArticle

2006

Benzoylphenylurea sulfur analogues with potent antitumor activity

Hallur, G., Jimeno, A., Dalrymple, S., Zhu, T., Jung, M. K., Hidalgo, M., Isaacs, J. T., Sukumar, S., Hamel, E. & Khan, S. R., Apr 6 2006, In : Journal of medicinal chemistry. 49, 7, p. 2357-2360 4 p.

Research output: Contribution to journalArticle

Ductal access for prevention and therapy of mammary tumors

Murata, S., Kominsky, S. L., Vali, M., Zhang, Z., Garrett-Mayer, E., Korz, D., Huso, D., Baker, S. D., Barber, J., Jaffee, E., Reilly, R. T. & Sukumar, S., Jan 15 2006, In : Cancer Research. 66, 2, p. 638-645 8 p.

Research output: Contribution to journalArticle

Epigenetic biomarkers and breast cancer: Cause for optimism

Visvanathan, K., Sukumar, S. & Davidson, N. E., Nov 15 2006, In : Clinical Cancer Research. 12, 22, p. 6591-6593 3 p.

Research output: Contribution to journalEditorial

Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer

Lo, P. K., Mehrotra, J., D'Costa, A., Fackler, M. J., Garrett-Mayer, E., Argani, P. & Sukumar, S., Mar 2006, In : Cancer Biology and Therapy. 5, 3, p. 281-286 6 p.

Research output: Contribution to journalArticle

Open Access

HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition

Wu, X., Chen, H., Parker, B., Rubin, E., Zhu, T., Lee, J. S., Argani, P. & Sukumar, S., Oct 1 2006, In : Cancer Research. 66, 19, p. 9527-9534 8 p.

Research output: Contribution to journalArticle

Molecular links between obesity and breast cancer

Lorincz, A. M. & Sukumar, S., Jun 1 2006, In : Endocrine-related cancer. 13, 2, p. 279-292 14 p.

Research output: Contribution to journalReview article

Mutational hotspot in exon 20 of PIK3CA in breast cancer among Singapore Chinese

Liang, X., Quek, C. L., Salto-Tellez, M., Putti, T. C., Loh, M. & Sukumar, S., May 2006, In : Cancer Biology and Therapy. 5, 5, p. 544-548 5 p.

Research output: Contribution to journalArticle

Open Access

Overexpression of glycosylphosphatidylinositol (GPI) transamidase subunits phosphatidylinositol glycan class T and/or GPI anchor attachment 1 induces tumorigenesis and contributes to invasion in human breast cancer

Wu, G., Guo, Z., Chatterjee, A., Huang, X., Rubin, E., Wu, F., Mambo, E., Chang, X., Osada, M., Kim, M. S., Moon, C., Califano, J. A., Ratovitski, E. A., Gollin, S. M., Sukumar, S., Sidransky, D. & Trink, B., Oct 15 2006, In : Cancer Research. 66, 20, p. 9829-9836 8 p.

Research output: Contribution to journalArticle

Polyamine analogues down-regulate estrogen receptor α expression in human breast cancer cells

Huang, Y., Keen, J. C., Pledgie, A., Marton, L. J., Zhu, T., Sukumar, S., Park, B. H., Blair, B., Brenner, K., Casero, R. A. & Davidson, N. E., Jul 14 2006, In : Journal of Biological Chemistry. 281, 28, p. 19055-19063 9 p.

Research output: Contribution to journalArticle

Quantitative multiplex methylation-specific PCR analysis doubles detection of tumor cells in breast ductal fluid

Fackler, M. J., Malone, K., Zhang, Z., Schilling, E., Garrett-Mayer, E., Swift-Scanlan, T., Lange, J., Nayar, R., Davidson, N. E., Khan, S. A. & Sukumar, S., Jun 1 2006, In : Clinical Cancer Research. 12, 11 I, p. 3306-3310 5 p.

Research output: Contribution to journalArticle

RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer

Lau, Q. C., Raja, E., Salto-Tellez, M., Liu, Q., Ito, K., Inoue, M., Putti, T. C., Loh, M., Ko, T. K., Huang, C., Bhalla, K. N., Zhu, T., Ito, Y. & Sukumar, S., Jul 1 2006, In : Cancer Research. 66, 13, p. 6512-6520 9 p.

Research output: Contribution to journalArticle

Targeting early stage DCIS breast cancer directly in the ducts with intraductal chemotherapy

Sukumar, S., Murata, S., Kominsky, S., Vali, M., Zhang, Z., Garrett-Mayer, E., Korz, D., Huso, D., Baker, S. D., Barber, J., Jaffee, E. & Reilly, R. T., Mar 1 2006, In : Cancer Biology and Therapy. 5, 3, p. 249-250 2 p.

Research output: Contribution to journalComment/debate

Two-color quantitative multiplex methylation-specific PCR

Swift-Scanlan, T., Blackford, A., Argani, P., Sukumar, S. & Fackler, M. J., Feb 1 2006, In : BioTechniques. 40, 2, p. 210-219 10 p.

Research output: Contribution to journalArticle

2005

Identification of biomarkers for breast cancer in nipple aspiration and ductal lavage fluid

Li, J., Zhao, J., Yu, X., Lange, J., Kuerer, H., Krishnamurthy, S., Schilling, E., Khan, S. A., Sukumar, S. & Chan, D. W., Dec 1 2005, In : Clinical Cancer Research. 11, 23, p. 8312-8320 9 p.

Research output: Contribution to journalArticle

Identification of transcriptional targets of HOXA5

Chen, H., Rubin, E., Zhang, H., Chung, S., Jie, C. C., Garrett, E., Biswal, S. & Sukumar, S., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 19373-19380 8 p.

Research output: Contribution to journalArticle

Of Snail, mice, and women

Davidson, N. E. & Sukumar, S., Sep 1 2005, In : Cancer cell. 8, 3, p. 173-174 2 p.

Research output: Contribution to journalShort survey

Role of p53/p21Waf1/Cip1 in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells

Huang, Y., Pledgie, A., Rubin, E., Marton, L. J., Woster, P. M., Sukumar, S., Casero, R. A. & Davidson, N. E., Sep 2005, In : Cancer Biology and Therapy. 4, 9, p. 1006-1013 8 p.

Research output: Contribution to journalArticle

Open Access

Somatic mutation and gain of copy number of PIK3CA in human breast cancer

Wu, G., Xing, M., Mambo, E., Huang, X., Liu, J., Guo, Z., Chatterjee, A., Goldenberg, D., Gollin, S. M., Sukumar, S., Trink, B. & Sidransky, D., May 31 2005, In : Breast Cancer Research. 7, 5, R609.

Research output: Contribution to journalArticle

Open Access

Tumor-specific changes in mtDNA content in human cancer

Mambo, E., Chatterjee, A., Xing, M., Tallini, G., Haugen, B. R., Yeung, S. C. J., Sukumar, S. & Sidransky, D., Oct 10 2005, In : International Journal of Cancer. 116, 6, p. 920-924 5 p.

Research output: Contribution to journalArticle

2004

Activation of methionine synthase by insulin-like growth factor-1 and dopamine: A target for neurodevelopmental toxins and thimerosal

Waly, M., Olteanu, H., Banerjee, R., Choi, S. W., Mason, J. B., Parker, B. S., Sukumar, S., Shim, S., Sharma, A., Benzecry, J. M., Power-Charnitsky, V. A. & Deth, R. C., Apr 1 2004, In : Molecular psychiatry. 9, 4, p. 358-370 13 p.

Research output: Contribution to journalArticle

Alterations in vascular gene expression in invasive breast carcinoma

Parker, B. S., Argani, P., Cook, B. P., Liangfeng, H., Chartrand, S. D., Zhang, M., Saha, S., Bardelli, A., Jiang, Y., St. Martin, T. B., Nacht, M., Teicher, B. A., Klinger, K. W., Sukumar, S. & Madden, S. L., Nov 1 2004, In : Cancer Research. 64, 21, p. 7857-7866 10 p.

Research output: Contribution to journalArticle

Clostridium perfringens Enterotoxin Elicits Rapid and Specific Cytolysis of Breast Carcinoma Cells Mediated through Tight Junction Proteins Claudin 3 and 4

Kominsky, S. L., Vali, M., Korz, D., Gabig, T. G., Weitzman, S. A., Argani, P. & Sukumar, S., May 2004, In : American Journal of Pathology. 164, 5, p. 1627-1633 7 p.

Research output: Contribution to journalArticle

Coupling the transcriptional regulatory action of Brn-3b to the cell cycle clock

Zhu, T. & Sukumar, S., Mar 2004, In : Cancer Biology and Therapy. 3, 3, p. 324-325 2 p.

Research output: Contribution to journalComment/debate

Open Access

Erratum: Alterations in vascular gene expression in invasive breast carcinoma (Cancer Research (November 1, 2004) 64, 1 (7857-7866))

Parker, B. S., Argani, P., Cook, B. P., Liangfeng, H., Chartrand, S. D., Zhang, M., Saha, S., Bardelli, A., Jiang, Y., St. Martin, T. B., Nacht, M., Teicher, B. A., Klinger, K. W., Sukumar, S. & Madden, S. L., Dec 1 2004, In : Cancer Research. 64, 23, 1 p.

Research output: Contribution to journalComment/debate

Estrogen Receptor/Progesterone Receptor-Negative Breast Cancers of Young African-American Women Have a Higher Frequency of Methylation of Multiple Genes than Those of Caucasian Women

Mehrotra, J., Ganpat, M. M., Kanaan, Y., Fackler, M. J., McVeigh, M., Lahti-Domenici, J., Polyak, K., Argani, P., Naab, T., Garrett, E., Parmigiani, G., Broome, C. & Sukumar, S., Mar 15 2004, In : Clinical Cancer Research. 10, 6, p. 2052-2057 6 p.

Research output: Contribution to journalArticle

HOXA5-Induced Apoptosis in Breast Cancer Cells Is Mediated by Caspases 2 and 8

Chen, H., Chung, S. & Sukumar, S., Jan 2004, In : Molecular and cellular biology. 24, 2, p. 924-935 12 p.

Research output: Contribution to journalArticle

Hypermethylation in histologically distinct classes of breast cancer

Bae, Y. K., Brown, A., Garrett, E., Bornman, D., Fackler, M. J., Sukumar, S., Herman, J. G. & Gabrielson, E., Sep 15 2004, In : Clinical Cancer Research. 10, 18 I, p. 5998-6005 8 p.

Research output: Contribution to journalArticle

Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer

Fackler, M. J., McVeigh, M., Mehrotra, J., Blum, M. A., Lange, J., Lapides, A., Garret, E., Argani, P., Sukumar, S. & D'Agostino, L., Sep 1 2004, In : Women's Oncology Review. 4, 3, p. 183-185 3 p.

Research output: Contribution to journalArticle

Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer

Fackler, M. J., McVeigh, M., Mehrotra, J., Blum, M. A., Lange, J., Lapides, A., Garrett, E., Argani, P. & Sukamar, S., Jul 1 2004, In : Cancer Research. 64, 13, p. 4442-4452 11 p.

Research output: Contribution to journalArticle

Significant allelic loss of ANX7region (10q21) in hormone receptor negative breast carcinomas

Leighton, X., Srikantan, V., Pollard, H. B., Sukumar, S. & Srivastava, M., Jul 16 2004, In : Cancer Letters. 210, 2, p. 239-244 6 p.

Research output: Contribution to journalArticle