Saraswati Sukumar

Professor

1979 …2020

Research output per year

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Research Output

2014

Do breast cancer cell lines provide a relevant model of the patient tumor methylome?

Cope, L. M., Fackler, M. J., Lopez-Bujanda, Z., Wolff, A. C., Visvanathan, K., Gray, J. W., Sukumar, S. & Umbricht, C. B., Aug 26 2014, In : PloS one. 9, 8, e105545.

Research output: Contribution to journalArticle

Genetic and phenotypic diversity in breast tumor metastases

Almendro, V., Kim, H. J., Cheng, Y. K., Gonen, M., Itzkovitz, S., Argani, P., Van Oudenaarden, A., Sukumar, S., Michor, F. & Polyak, K., Mar 1 2014, In : Cancer Research. 74, 5, p. 1338-1348 11 p.

Research output: Contribution to journalArticle

Novel methylated biomarkers and a robust assay to detect circulating tumor dna in metastatic breast cancer

Fackler, M. J., Bujanda, Z. L., Umbricht, C., Teo, W. W., Cho, S., Zhang, Z., Visvanathan, K., Jeter, S., Argani, P., Wang, C., Lyman, J. P., De Brot, M., Ingle, J. N., Boughey, J., McGuire, K., King, T. A., Carey, L. A., Cope, L., Wolff, A. C. & Sukumar, S., Apr 15 2014, In : Cancer Research. 74, 8, p. 2160-2170 11 p.

Research output: Contribution to journalArticle

Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation

Barrio-Real, L., Benedetti, L. G., Engel, N., Tu, Y., Cho, S., Sukumar, S. & Kazanietz, M. G., Sep 24 2014, In : Breast Cancer Research. 16, 5, p. 1-13 13 p., 441.

Research output: Contribution to journalArticle

The Notch pathway inhibits TGFβ signaling in breast cancer through HEYL-mediated crosstalk

Han, L., Diehl, A., Nguyen, N. K., Korangath, P., Teo, W., Cho, S., Kominsky, S., Huso, D. L., Feigenbaum, L., Rein, A., Argani, P., Landberg, G., Gessler, M. & Sukumar, S., Nov 15 2014, In : Cancer Research. 74, 22, p. 6509-6518 10 p.

Research output: Contribution to journalArticle

Tissue specific DNA methylation in normal human breast epithelium and in breast cancer

Avraham, A., Cho, S. S., Uhlmann, R., Polak, M. L., Sandbank, J., Karni, T., Pappo, I., Halperin, R., Vaknin, Z., Sella, A., Sukumar, S. & Evron, E., Mar 20 2014, In : PloS one. 9, 3, e91805.

Research output: Contribution to journalArticle

2013

Big punches come in nanosizes for chemoprevention

Sharma, D. & Sukumar, S., Oct 2013, In : Cancer Prevention Research. 6, 10, p. 1007-1010 4 p.

Research output: Contribution to journalArticle

Biomarker modulation following short-term vorinostat in women with newly diagnosed primary breast cancer

Stearns, V., Jacobs, L. K., Fackler, M. J., Tsangaris, T. N., Rudek, M. A., Higgins, M., Lange, J., Cheng, Z., Slater, S. A., Jeter, S. C., Powers, P., Briest, S., Chao, C., Yoshizawa, C., Sugar, E., Espinoza-Delgado, I., Sukumar, S., Gabrielson, E. & Davidson, N. E., Jul 15 2013, In : Clinical Cancer Research. 19, 14, p. 4008-4016 9 p.

Research output: Contribution to journalArticle

Cytoplasmic mislocalization of overexpressed FOXF1 is associated with the malignancy and metastasis of colorectal adenocarcinomas

Lo, P. K., Lee, J. S., Chen, H., Reisman, D., Berger, F. G. & Sukumar, S., Feb 1 2013, In : Experimental and Molecular Pathology. 94, 1, p. 262-269 8 p.

Research output: Contribution to journalArticle

HMGA1: A Master Regulator of Tumor Progression in Triple-Negative Breast Cancer Cells

Shah, S. N., Cope, L., Poh, W., Belton, A., Roy, S., Talbot, C. C., Sukumar, S., Huso, D. L. & Resar, L. M. S., May 2 2013, In : PloS one. 8, 5, e63419.

Research output: Contribution to journalArticle

HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression

Shah, N., Jin, K., Cruz, L. A., Park, S., Sadik, H., Cho, S., Goswami, C. P., Nakshatri, H., Gupta, R., Chang, H. Y., Zhang, Z., Cimino-Mathews, A., Cope, L., Umbricht, C. & Sukumar, S., Sep 1 2013, In : Cancer Research. 73, 17, p. 5449-5458 10 p.

Research output: Contribution to journalArticle

Modeling precision treatment of breast cancer

Daemen, A., Griffith, O. L., Heiser, L. M., Wang, N. J., Enache, O. M., Sanborn, Z., Pepin, F., Durinck, S., Korkola, J. E., Griffith, M., Hur, J. S., Huh, N., Chung, J., Cope, L., Fackler, M. J., Umbricht, C., Sukumar, S., Seth, P., Sukhatme, V. P., Jakkula, L. R. & 7 others, Lu, Y., Mills, G. B., Cho, R. J., Collisson, E. A., van't Veer, L. J., Spellman, P. T. & Gray, J. W., Dec 10 2013, In : Genome biology. 14, 10, R110.

Research output: Contribution to journalArticle

Open Access

Molecular pathways: Current role and future directions of the retinoic acid pathway in cancer prevention and treatment

Connolly, R. M., Nguyen, N. K. & Sukumar, S., Apr 1 2013, In : Clinical Cancer Research. 19, 7, p. 1651-1959 309 p.

Research output: Contribution to journalReview article

Molecular profiling of human mammary gland links breast cancer risk to a p27+ cell population with progenitor characteristics

Choudhury, S., Almendro, V., Merino, V. F., Wu, Z., Maruyama, R., Su, Y., Martins, F. C., Jo Fackler, M., Bessarabova, M., Kowalczyk, A., Conway, T., Beresford-Smith, B., Macintyre, G., Cheng, Y. K., Lopez-Bujanda, Z., Kaspi, A., Hu, R., Robens, J., Nikolskaya, T., Haakensen, V. D. & 25 others, Schnitt, S. J., Argani, P., Ethington, G., Panos, L., Grant, M., Clark, J., Herlihy, W., Lin, S. J., Chew, G., Thompson, E. W., Greene-Colozzi, A., Richardson, A. L., Rosson, G. D., Pike, M., Garber, J. E., Nikolsky, Y., Blum, J. L., Au, A., Hwang, E. S., Tamimi, R. M., Michor, F., Haviv, I., Liu, X. S., Sukumar, S. & Polyak, K., Jul 3 2013, In : Cell stem cell. 13, 1, p. 117-130 14 p.

Research output: Contribution to journalArticle

Novel insights into breast cancer genetic variance through RNA sequencing

Horvath, A., Pakala, S. B., Mudvari, P., Reddy, S. D. N., Ohshiro, K., Casimiro, S., Pires, R., Fuqua, S. A. W., Toi, M., Costa, L., Nair, S. S., Sukumar, S. & Kumar, R., Jul 25 2013, In : Scientific reports. 3, 2256.

Research output: Contribution to journalArticle

2012

ADP ribosylation by PARP-1 suppresses HOXB7 transcriptional activity

Wu, X., Ellmann, S., Rubin, E., Gil, M., Jin, K., Han, L., Chen, H., Kwon, E. M., Guo, J., Ha, H. C. & Sukumar, S., Jul 23 2012, In : PloS one. 7, 7, e40644.

Research output: Contribution to journalArticle

Altered antisense-to-sense transcript ratios in breast cancer

Maruyama, R., Shipitsin, M., Choudhury, S., Wu, Z., Protopopov, A., Yao, J., Lo, P. K., Bessarabova, M., Ishkin, A., Nikolsky, Y., Liu, X. S., Sukumar, S. & Polyak, K., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 2820-2824 5 p.

Research output: Contribution to journalArticle

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., Raman, V., Zhen, L., Mitzner, W. A., Sukumar, S. & Semenza, G. L., Apr 5 2012, In : Oncogene. 31, 14, p. 1757-1770 14 p.

Research output: Contribution to journalArticle

Intraductal administration of a polymeric nanoparticle formulation of curcumin (NanoCurc) significantly attenuates incidence of mammary tumors in a rodent chemical carcinogenesis model: Implications for breast cancer chemoprevention in at-risk populations

Chun, Y. S., Bisht, S., Chenna, V., Pramanik, D., Yoshida, T., Hong, S. M., De wilde, R. F., Zhang, Z., Huso, D. L., Zhao, M., Rudek, M. A., Stearns, V., Maitra, A. & Sukumar, S., Nov 2012, In : Carcinogenesis. 33, 11, p. 2242-2249 8 p.

Research output: Contribution to journalArticle

Intraductally administered pegylated liposomal doxorubicin reduces mammary stem cell function in the mammary gland but in the long term, induces malignant tumors

Chun, Y. S., Yoshida, T., Mori, T., Huso, D. L., Zhang, Z., Stearns, V., Perkins, B., Jones, R. J. & Sukumar, S., Aug 2012, In : Breast Cancer Research and Treatment. 135, 1, p. 201-208 8 p.

Research output: Contribution to journalArticle

Loperamide, an FDA-Approved antidiarrhea drug, effectively reverses the resistance of multidrug resistant MCF-7/MDR1 human breast cancer cells to doxorubicin-induced cytotoxicity

Zhou, Y., Sridhar, R., Shan, L., Sha, W., Gu, X. & Sukumar, S., Feb 1 2012, In : Cancer Investigation. 30, 2, p. 119-125 7 p.

Research output: Contribution to journalArticle

MYC gene amplification is often acquired in lethal distant breast cancer metastases of unamplified primary tumors

Singhi, A. D., Cimino-Mathews, A., Jenkins, R. B., Lan, F., Fink, S. R., Nassar, H., Vang, R., Fetting, J. H., Hicks, J., Sukumar, S., De Marzo, A. M. & Argani, P., Mar 2012, In : Modern Pathology. 25, 3, p. 378-387 10 p.

Research output: Contribution to journalArticle

Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition

Gao, D., Joshi, N., Choi, H., Ryu, S., Hahn, M., Catena, R., Sadik, H., Argani, P., Wagner, P., Vahdat, L. T., Port, J. L., Stiles, B., Sukumar, S., Altorki, N. K., Rafii, S. & Mittal, V., Mar 15 2012, In : Cancer Research. 72, 6, p. 1384-1394 11 p.

Research output: Contribution to journalArticle

Serum DNA methylation for monitoring response to neoadjuvant chemotherapy in breast cancer patients

Avraham, A., Uhlmann, R., Shperber, A., Birnbaum, M., Sandbank, J., Sella, A., Sukumar, S. & Evron, E., Oct 1 2012, In : International Journal of Cancer. 131, 7, p. E1166-E1172

Research output: Contribution to journalArticle

Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

Jiao, X., Wood, L. D., Lindman, M., Jones, S., Buckhaults, P., Polyak, K., Sukumar, S., Carter, H., Kim, D., Karchin, R. & Sjöblom, T., May 2012, In : Genes Chromosomes and Cancer. 51, 5, p. 480-489 10 p.

Research output: Contribution to journalArticle

The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway

Jin, K., Kong, X., Shah, T., Penet, M. F., Wildes, F., Sgroi, D. C., Ma, X. J., Huang, Y., Kallioniemi, A., Landberg, G., Bieche, I., Wu, X., Lobie, P. E., Davidson, N. E., Bhujwalla, Z. M., Zhu, T. & Sukumar, S., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 2736-2741 6 p.

Research output: Contribution to journalArticle

The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function

Lo, P. K., Lee, J. S. & Sukumar, S., Jan 1 2012, In : Cellular Signalling. 24, 1, p. 316-324 9 p.

Research output: Contribution to journalArticle

2011

Breast cancer: Preclinical and clinical evaluation of intraductally administered agents in early breast cancer

Stearns, V., Mori, T., Jacobs, L. K., Khouri, N. F., Gabrielson, E., Yoshida, T., Kominsky, S. L., Huso, D. L., Jeter, S., Powers, P., Tarpinian, K., Brown, R. J., Lange, J. R., Rudek, M. A., Zhang, Z., Tsangaris, T. N. & Sukumar, S., Oct 26 2011, In : Science translational medicine. 3, 106, 106ra108.

Research output: Contribution to journalArticle

Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium

Maruyama, R., Choudhury, S., Kowalczyk, A., Bessarabova, M., Beresford-Smith, B., Conway, T., Kaspi, A., Wu, Z., Nikolskaya, T., Merino, V. F., Lo, P. K., Liu, X. S., Nikolsky, Y., Sukumar, S., Haviv, I. & Polyak, K., Apr 2011, In : PLoS genetics. 7, 4, e1001369.

Research output: Contribution to journalArticle

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

Hung, T., Wang, Y., Lin, M. F., Koegel, A. K., Kotake, Y., Grant, G. D., Horlings, H. M., Shah, N., Umbricht, C., Wang, P., Wang, Y., Kong, B., Langerød, A., Børresen-Dale, A. L., Kim, S. K., Van De Vijver, M., Sukumar, S., Whitfield, M. L., Kellis, M., Xiong, Y. & 2 others, Wong, D. J. & Chang, H. Y., Jul 2011, In : Nature genetics. 43, 7, p. 621-629 9 p.

Research output: Contribution to journalArticle

Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole

Sabnis, G. J., Goloubeva, O., Chumsri, S., Nguyen, N., Sukumar, S. & Brodie, A. M. H., Mar 1 2011, In : Cancer Research. 71, 5, p. 1893-1903 11 p.

Research output: Contribution to journalArticle

Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence

Fackler, M. J., Umbricht, C. B., Williams, D., Argani, P., Cruz, L. A., Merino, V. F., Teo, W. W., Zhang, Z., Huang, P., Visvananthan, K., Marks, J., Ethier, S., Gray, J. W., Wolff, A. C., Cope, L. M. & Sukumar, S., Oct 1 2011, In : Cancer Research. 71, 19, p. 6195-6207 13 p.

Research output: Contribution to journalArticle

Methylated genes in breast cancer: Associations with clinical and histopathological features in a familial breast cancer cohort

Swift-Scanlan, T., Vang, R., Blackford, A., Fackler, M. J. & Sukumar, S., May 15 2011, In : Cancer Biology and Therapy. 11, 10, p. 853-865 13 p.

Research output: Contribution to journalArticle

2010

Basal-like breast cancer displays distinct patterns of promoter methylation

Lee, J. S., Fackler, M. J., Lee, J. H., Choi, C., Park, M. H., Yoon, J. H., Zhang, Z. & Sukumar, S., Jun 15 2010, In : Cancer Biology and Therapy. 9, 12, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

BRCA1: Linking HOX to breast cancer suppression

Jin, K. & Sukumar, S., Jul 23 2010, In : Breast Cancer Research. 12, 4, 306.

Research output: Contribution to journalArticle

Clonal selection in tamoxifen resistance

Jin, K. & Sukumar, S., May 1 2010, In : Cancer Biology and Therapy. 9, 9, p. 725-727 3 p.

Research output: Contribution to journalComment/debate

Open Access

DNA methylation-related vitamin D receptor insensitivity in breast cancer

Marik, R., Fackler, M. J., Gabrielson, E., Zeiger, M. A., Sukumar, S., Stearns, V. & Umbricht, C. B., Jul 1 2010, In : Cancer Biology and Therapy. 10, 1, p. 44-53 10 p.

Research output: Contribution to journalArticle

Open Access

Epigenetic inactivation of the potential tumor suppressor gene FOXF1 in breast cancer

Lo, P. K., Lee, J. S., Liang, X., Han, L., Mori, T., Fackler, M. J., Sadik, H., Argani, P., Pandita, T. K. & Sukumar, S., Jul 15 2010, In : Cancer Research. 70, 14, p. 6047-6058 12 p.

Research output: Contribution to journalArticle

Evaluation of promoter hypermethylation detection in serum as a diagnostic tool for breast carcinoma in Korean women

Kim, J. H., Shin, M. H., Kweon, S. S., Park, M. H., Yoon, J. H., Lee, J. S., Choi, C., Fackler, M. J. & Sukumar, S., Aug 1 2010, In : Gynecologic oncology. 118, 2, p. 176-181 6 p.

Research output: Contribution to journalArticle

Gene expression profiling of human breast tissue samples using SAGE-Seq

Wu, Z. J., Meyer, C. A., Choudhury, S., Shipitsin, M., Maruyama, R., Bessarabova, M., Nikolskaya, T., Sukumar, S., Schwartzman, A., Liu, J. S., Polyak, K. & Liu, X. S., Dec 2010, In : Genome research. 20, 12, p. 1730-1739 10 p.

Research output: Contribution to journalArticle

Intraductal therapy for the prevention of breast cancer

Jacobs, L., Sukumar, S. & Stearns, V., Jun 1 2010, In : Current Opinion in Investigational Drugs. 11, 6, p. 646-652 7 p.

Research output: Contribution to journalReview article

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

Gupta, R. A., Shah, N., Wang, K. C., Kim, J., Horlings, H. M., Wong, D. J., Tsai, M. C., Hung, T., Argani, P., Rinn, J. L., Wang, Y., Brzoska, P., Kong, B., Li, R., West, R. B., Van De Vijver, M. J., Sukumar, S. & Chang, H. Y., Apr 15 2010, In : Nature. 464, 7291, p. 1071-1076 6 p.

Research output: Contribution to journalArticle

Proteomic characterization of Her2/neu-overexpressing breast cancer cells

Chen, H., Pimienta, G., Gu, Y., Sun, X., Hu, J., Kim, M. S., Chaerkady, R., Gucek, M., Cole, R. N., Sukumar, S. & Pandey, A., Nov 1 2010, In : Proteomics. 10, 21, p. 3800-3810 11 p.

Research output: Contribution to journalArticle

Quantitative assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens

Kim, J. H., Choi, Y. D., Lee, J. S., Lee, J. H., Nam, J. H., Choi, C., Kweon, S. S., Fackler, M. J. & Sukumar, S., Jul 1 2010, In : Virchows Archiv. 457, 1, p. 35-42 8 p.

Research output: Contribution to journalArticle

Store-independent activation of orai1 by SPCA2 in mammary tumors

Feng, M., Grice, D. M., Faddy, H. M., Nguyen, N., Leitch, S., Wang, Y., Muend, S., Kenny, P. A., Sukumar, S., Roberts-Thomson, S. J., Monteith, G. R. & Rao, R., Oct 2010, In : Cell. 143, 1, p. 84-98 15 p.

Research output: Contribution to journalArticle

The Hox genes and their roles in oncogenesis

Shah, N. & Sukumar, S., May 1 2010, In : Nature Reviews Cancer. 10, 5, p. 361-371 11 p.

Research output: Contribution to journalReview article

2009

Hypermethylated genes as biomarkers of cancer in women with pathologic nipple discharge

Fackler, M. J., Rivers, A., Wei, W. T., Mangat, A., Taylor, E., Zhang, Z., Goodman, S., Argani, P., Nayar, R., Susnik, B., Sukumar, S. & Khan, S. A., Jun 1 2009, In : Clinical Cancer Research. 15, 11, p. 3802-3811 10 p.

Research output: Contribution to journalArticle

MethySYBR, a novel quantitative PCR assay for the dual analysis of DNA methylation and CpG methylation density

Lo, P. K., Watanabe, H., Cheng, P. C., Wei, W. T., Liang, X., Argani, P., Ji, S. L. & Sukumar, S., Sep 2009, In : Journal of Molecular Diagnostics. 11, 5, p. 400-414 15 p.

Research output: Contribution to journalArticle