Saraswati Sukumar

Professor

1979 …2020

Research output per year

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Research Output

Article

A biologic scaffold-associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy

Wolf, M. T., Ganguly, S., Wang, T. L., Anderson, C. W., Sadtler, K., Narain, R., Cherry, C., Parrillo, A. J., Park, B. V., Wang, G., Pan, F., Sukumar, S., Pardoll, D. M. & Elisseeff, J. H., Jan 30 2019, In : Science translational medicine. 11, 477, aat7973.

Research output: Contribution to journalArticle

A breast cancer cell microarray (CMA) as a rapid method to characterize candidate biomarkers

Wu, X., Zahari, M. S., Renuse, S., Jacob, H. K. C., Sakamuri, S., Singal, M., Gabrielson, E., Sukumar, S. & Pandey, A., Dec 1 2014, In : Cancer Biology and Therapy. 15, 12, p. 1593-1599 7 p.

Research output: Contribution to journalArticle

Absence of TSG101 transcript abnormalities in human cancers

Trink, B., Pai, S. I., Spunt, S. L., Raman, V., Cairns, P., Jen, J., Gabrielson, E., Sukumar, S. & Sidransky, D., May 28 1998, In : Oncogene. 16, 21, p. 2815-2818 4 p.

Research output: Contribution to journalArticle

Open Access

Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine.

Sukumar, S., Perantoni, A., Reed, C., Rice, J. M. & Wenk, M. L., Jul 1986, In : Molecular and cellular biology. 6, 7, p. 2716-2720 5 p.

Research output: Contribution to journalArticle

Open Access

Activation of diverse signalling pathways by oncogenic PIK3CA mutations

Wu, X., Renuse, S., Sahasrabuddhe, N. A., Zahari, M. S., Chaerkady, R., Kim, M. S., Nirujogi, R. S., Mohseni, M., Kumar, P., Raju, R., Zhong, J., Yang, J., Neiswinger, J., Jeong, J. S., Newman, R., Powers, M. A., Somani, B. L., Gabrielson, E., Sukumar, S., Stearns, V. & 5 others, Qian, J., Zhu, H., Vogelstein, B., Park, B. H. & Pandey, A., 2014, In : Nature communications. 5, 4961.

Research output: Contribution to journalArticle

Activation of H-ras-1 oncogenes by chemical carcinogens.

Zarbl, H., Sukumar, S., Arthur, A. L., Martin-Zanca, D. & Barbacid, M., 1986, In : Basic life sciences. 38, p. 385-397 13 p.

Research output: Contribution to journalArticle

Activation of H-ras oncogenes in preneoplastic mouse mammary tissues

Kumar, R., Medina, D. & Sukumar, S., Sep 5 1990, In : Oncogene. 5, 8, p. 1271-1277 7 p.

Research output: Contribution to journalArticle

Activation of methionine synthase by insulin-like growth factor-1 and dopamine: A target for neurodevelopmental toxins and thimerosal

Waly, M., Olteanu, H., Banerjee, R., Choi, S. W., Mason, J. B., Parker, B. S., Sukumar, S., Shim, S., Sharma, A., Benzecry, J. M., Power-Charnitsky, V. A. & Deth, R. C., Apr 1 2004, In : Molecular psychiatry. 9, 4, p. 358-370 13 p.

Research output: Contribution to journalArticle

Activation of ras oncogenes by chemical carcinogens.

Barbacid, M., Sukumar, S. & Zarbl, H., 1986, In : Gene amplification and analysis. 4, p. 21-38 18 p.

Research output: Contribution to journalArticle

Activation of ras oncogenes preceding the onset of neoplasia

Kumar, R., Sukumar, S. & Barbacid, M., 1990, In : Science. 248, 4959, p. 1101-1104 4 p.

Research output: Contribution to journalArticle

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

Sengupta, S., Nagalingam, A., Muniraj, N., Bonner, M. Y., Mistriotis, P., Afthinos, A., Kuppusamy, P., Lanoue, D., Cho, S., Korangath, P., Shriver, M., Begum, A., Merino, V. F., Huang, C. Y., Arbiser, J. L., Matsui, W., Györffy, B., Konstantopoulos, K., Sukumar, S., Marignani, P. A. & 2 others, Saxena, N. K. & Sharma, D., Oct 12 2017, In : Oncogene. 36, 41, p. 5709-5721 13 p.

Research output: Contribution to journalArticle

Active specific immunotherapy of guinea pigs with visceral tumor implants

Yarkoni, E., Hunter, J. T., Sukumar, S. & Rapp, H. J., Apr 1 1982, In : Cancer Immunology Immunotherapy. 12, 3, p. 273-275 3 p.

Research output: Contribution to journalArticle

ADP ribosylation by PARP-1 suppresses HOXB7 transcriptional activity

Wu, X., Ellmann, S., Rubin, E., Gil, M., Jin, K., Han, L., Chen, H., Kwon, E. M., Guo, J., Ha, H. C. & Sukumar, S., Jul 23 2012, In : PloS one. 7, 7, e40644.

Research output: Contribution to journalArticle

Advances in intraductal therapy for breast cancer prevention and treatment

Chen, C., Wang, G., Sukumar, S., Wang, Y. & Sun, S., 2017, In : Chinese Journal of Clinical Oncology. 44, 4, p. 177-180 4 p.

Research output: Contribution to journalArticle

Alterations in the Ha-ras-1 and the p53 pathway genes in the progression of N-methyl-N-nitrosourea-induced rat mammary tumors

McKenzie, K. E., Armstrong, B. A., Chen, Y., Nagarajan, M., Aldaz, C. M. & Sukumar, S., Oct 1997, In : Molecular Carcinogenesis. 20, 2, p. 194-203 10 p.

Research output: Contribution to journalArticle

Alterations in vascular gene expression in invasive breast carcinoma

Parker, B. S., Argani, P., Cook, B. P., Liangfeng, H., Chartrand, S. D., Zhang, M., Saha, S., Bardelli, A., Jiang, Y., St. Martin, T. B., Nacht, M., Teicher, B. A., Klinger, K. W., Sukumar, S. & Madden, S. L., Nov 1 2004, In : Cancer Research. 64, 21, p. 7857-7866 10 p.

Research output: Contribution to journalArticle

Altered antisense-to-sense transcript ratios in breast cancer

Maruyama, R., Shipitsin, M., Choudhury, S., Wu, Z., Protopopov, A., Yao, J., Lo, P. K., Bessarabova, M., Ishkin, A., Nikolsky, Y., Liu, X. S., Sukumar, S. & Polyak, K., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 2820-2824 5 p.

Research output: Contribution to journalArticle

Altered WAF1 genes do not play a role in abnormal cell cycle regulation in breast cancers lacking p53 mutations

McKenzie, K. E., Siva, A., Maier, S., Runnebaum, I. B., Seshadri, R. & Sukumar, S., Sep 1 1997, In : Clinical Cancer Research. 3, 9, p. 1669-1673 5 p.

Research output: Contribution to journalArticle

Animal models for breast cancer

Sukumar, S., McKenzie, K. & Chen, Y., Dec 1995, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 333, 1-2, p. 37-44 8 p.

Research output: Contribution to journalArticle

An isoform of the Wilms' tumor suppressor gene potentiates granulocytic differentiation

Loeb, D. M., Summers, J. L., Burwell, E. A., Korz, D., Friedman, A. D. & Sukumar, S., Jan 1 2003, In : Leukemia. 17, 5, p. 965-971 7 p.

Research output: Contribution to journalArticle

Antigenic Variants Isolated from a Mutagen-treated Guinea Pig Fibrosarcoma

Zbar, B., Sukumar, S., Tanio, Y., Terata, N. & Hovis, J., Nov 1 1984, In : Cancer Research. 44, 11, p. 5079-5085 7 p.

Research output: Contribution to journalArticle

A pivotal role for HOXB7 protein in endocrine resistant breast cancer

Jin, K. & Sukumar, S., Jan 1 2015, In : Oncoscience. 2, 11, p. 917-919 3 p.

Research output: Contribution to journalArticle

A rodent model for Wilms tumors: Embryonal kidney neoplasms induced by N- nitroso-N'-methylurea

Sharma, P. M., Bowman, M., Yu, B. F. & Sukumar, S., 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 21, p. 9931-9935 5 p.

Research output: Contribution to journalArticle

Open Access

A role for the HOXB7 homeodomain protein in DNA repair

Rubin, E., Wu, X., Zhu, T., Cheung, J. C. Y., Chen, H., Lorincz, A., Pandita, R. K., Sharma, G. G., Hyo, C. H., Gasson, J., Hanakahi, L. A., Pandita, T. K. & Sukumar, S., Feb 15 2007, In : Cancer Research. 67, 4, p. 1527-1535 9 p.

Research output: Contribution to journalArticle

A self-folding hydrogel in vitro model for ductal carcinoma

Kwag, H. R., Serbo, J. V., Korangath, P., Sukumar, S., Romer, L. H. & Gracias, D. H., Apr 1 2016, In : Tissue Engineering - Part C: Methods. 22, 4, p. 398-407 10 p.

Research output: Contribution to journalArticle

A transforming ras gene in tumorigenic guinea pig cell lines initiated by diverse chemical carcinogens

Sukumar, S., Pulciani, S., Doniger, J., Dipaolo, J. A., Evans, C. H., Zbar, B. & Barbacid, M., Jan 1 1984, In : Science. 223, 4641, p. 1199-1202 4 p.

Research output: Contribution to journalArticle

Basal-like breast cancer displays distinct patterns of promoter methylation

Lee, J. S., Fackler, M. J., Lee, J. H., Choi, C., Park, M. H., Yoon, J. H., Zhang, Z. & Sukumar, S., Jun 15 2010, In : Cancer Biology and Therapy. 9, 12, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

Benzoylphenylurea sulfur analogues with potent antitumor activity

Hallur, G., Jimeno, A., Dalrymple, S., Zhu, T., Jung, M. K., Hidalgo, M., Isaacs, J. T., Sukumar, S., Hamel, E. & Khan, S. R., Apr 6 2006, In : Journal of medicinal chemistry. 49, 7, p. 2357-2360 4 p.

Research output: Contribution to journalArticle

Big punches come in nanosizes for chemoprevention

Sharma, D. & Sukumar, S., Oct 2013, In : Cancer Prevention Research. 6, 10, p. 1007-1010 4 p.

Research output: Contribution to journalArticle

Biomarker modulation following short-term vorinostat in women with newly diagnosed primary breast cancer

Stearns, V., Jacobs, L. K., Fackler, M. J., Tsangaris, T. N., Rudek, M. A., Higgins, M., Lange, J., Cheng, Z., Slater, S. A., Jeter, S. C., Powers, P., Briest, S., Chao, C., Yoshizawa, C., Sugar, E., Espinoza-Delgado, I., Sukumar, S., Gabrielson, E. & Davidson, N. E., Jul 15 2013, In : Clinical Cancer Research. 19, 14, p. 4008-4016 9 p.

Research output: Contribution to journalArticle

BRCA1: Linking HOX to breast cancer suppression

Jin, K. & Sukumar, S., Jul 23 2010, In : Breast Cancer Research. 12, 4, 306.

Research output: Contribution to journalArticle

Breast cancer: Preclinical and clinical evaluation of intraductally administered agents in early breast cancer

Stearns, V., Mori, T., Jacobs, L. K., Khouri, N. F., Gabrielson, E., Yoshida, T., Kominsky, S. L., Huso, D. L., Jeter, S., Powers, P., Tarpinian, K., Brown, R. J., Lange, J. R., Rudek, M. A., Zhang, Z., Tsangaris, T. N. & Sukumar, S., Oct 26 2011, In : Science translational medicine. 3, 106, 106ra108.

Research output: Contribution to journalArticle

Breast hormone concentrations in random fine-needle aspirates of healthy women associate with cytological atypia and gene methylation

Lee, O., Heinz, R. E., Ivancic, D., Muzzio, M., Chatterton, R. T., Zalles, C. M., Keeney, K., Phan, B., Liu, D., Scholtens, D., Fackler, M. J., Stearns, V., Sukumar, S. & Khan, S. A., Sep 1 2018, In : Cancer Prevention Research. 11, 9, p. 557-567 11 p.

Research output: Contribution to journalArticle

Careful histological confirmation and microdissection reveal telomerase activity in otherwise telomerase-negative breast cancers

Carey, L. A., Hedican, C. A., Henderson, G. S., Umbricht, C. B., Dome, J. S., Varon, D. & Sukumar, S., Feb 1 1998, In : Clinical Cancer Research. 4, 2, p. 435-440 6 p.

Research output: Contribution to journalArticle

Cell type-specific DNA methylation patterns in the human breast

Bloushtain-Qimron, N., Yao, J., Snyder, E. L., Shipitsin, M., Campbell, L. L., Mani, S. A., Hu, M., Chen, H., Ustyansky, V., Antosiewicz, J. E., Argani, P., Halushka, M. K., Thomson, J. A., Pharoah, P., Porgador, A., Sukumar, S., Parsons, R., Richardson, A. L., Stampfer, M. R., Gelman, R. S. & 3 others, Nikolskaya, T., Nikolsky, Y. & Polyak, K., Sep 16 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 37, p. 14076-14081 6 p.

Research output: Contribution to journalArticle

Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis

Kominsky, S. L., Tyler, B., Sosnowski, J., Brady, K., Doucet, M., Nell, D., Smedley, J. G., McClane, B., Brem, H. & Sukumar, S., Sep 1 2007, In : Cancer Research. 67, 17, p. 7977-7982 6 p.

Research output: Contribution to journalArticle

Clostridium perfringens Enterotoxin Elicits Rapid and Specific Cytolysis of Breast Carcinoma Cells Mediated through Tight Junction Proteins Claudin 3 and 4

Kominsky, S. L., Vali, M., Korz, D., Gabig, T. G., Weitzman, S. A., Argani, P. & Sukumar, S., May 2004, In : American Journal of Pathology. 164, 5, p. 1627-1633 7 p.

Research output: Contribution to journalArticle

Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple-negative breast cancer

Merino, V. F., Nguyen, N., Jin, K., Sadik, H., Cho, S., Korangath, P., Han, L., Foster, Y. M. N., Zhou, X. C., Zhang, Z., Connolly, R. M., Stearns, V., Ali, S. Z., Adams, C., Chen, Q., Pan, D., Huso, D. L., Ordentlich, P., Brodie, A. & Sukumar, S., Apr 1 2016, In : Cancer Research. 76, 7, p. 2013-2024 12 p.

Research output: Contribution to journalArticle

Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer

Nacht, M., Ferguson, A. T., Zhang, W., Petroziello, J. M., Cook, B. P., Gao, Y. H., Maguire, S., Riley, D., Coppola, G., Landes, G. M., Madden, S. L. & Sukumar, S., Nov 1 1999, In : Cancer Research. 59, 21, p. 5464-5470 7 p.

Research output: Contribution to journalArticle

Compromised HOXA5 function can limit p53 expression in human breast tumours

Raman, V., Martenser, S. A., Reisman, D., Evron, E., Odenwald, W. F., Jaffee, E., Marks, J. & Sukumar, S., Jun 22 2000, In : Nature. 405, 6789, p. 974-978 5 p.

Research output: Contribution to journalArticle

CpG methylation as a basis for breast tumor-specific loss of NES1/kallikrein 10 expression

Li, B., Goyal, J., Dhar, S., Dimri, G., Evron, E., Sukumar, S., Wazer, D. E. & Band, V., Nov 1 2001, In : Cancer Research. 61, 21, p. 8014-8021 8 p.

Research output: Contribution to journalArticle

Cyclin E is a target of WT1 transcriptional repression

Loeb, D. M., Korz, D., Katsnelson, M., Burwell, E. A., Friedman, A. D. & Sukumar, S., May 31 2002, In : Journal of Biological Chemistry. 277, 22, p. 19627-19632 6 p.

Research output: Contribution to journalArticle

Cytoplasmic mislocalization of overexpressed FOXF1 is associated with the malignancy and metastasis of colorectal adenocarcinomas

Lo, P. K., Lee, J. S., Chen, H., Reisman, D., Berger, F. G. & Sukumar, S., Feb 1 2013, In : Experimental and Molecular Pathology. 94, 1, p. 262-269 8 p.

Research output: Contribution to journalArticle