Samuel R Denmeade

Professor

1985 …2019
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Research Output 1985 2019

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2019

An IL-2 proaerolysin fusion toxin that selectively eliminates regulatory t cells to enhance antitumor immune response

Rogers, O., Yen, H., Solomon, A., Drake, C. & Denmeade, S. R., Jul 1 2019, In : Prostate. 79, 10, p. 1071-1078 8 p.

Research output: Contribution to journalArticle

Interleukin-2
Immunosuppressive Agents
Hemagglutinins
Neoplasms
Prostatic Neoplasms

A phase II randomized placebo-controlled double-blind study of salvage radiation therapy plus placebo versus SRT plus enzalutamide with high-risk PSA-recurrent prostate cancer after radical prostatectomy (SALV-ENZA)

Kapoor, R., Deek, M. P., McIntyre, R., Raman, N., Kummerlowe, M., Chen, I., Gaver, M., Wang, H., Denmeade, S., Lotan, T., Paller, C., Markowski, M., Carducci, M., Eisenberger, M., Beer, T. M., Song, D. Y., Deweese, T. L., Hearn, J. W., Greco, S., Deville, C. & 7 others, Desai, N. B., Heath, E. I., Liauw, S., Spratt, D. E., Hung, A. Y., Antonarakis, E. S. & Tran, P. T., Jun 13 2019, In : BMC cancer. 19, 1, 572.

Research output: Contribution to journalArticle

Open Access
Salvage Therapy
Prostatectomy
Double-Blind Method
Prostatic Neoplasms
Radiotherapy

A Phase I Study of Alpha-1,3-Galactosyltransferase-Expressing Allogeneic Renal Cell Carcinoma Immunotherapy in Patients with Refractory Metastatic Renal Cell Carcinoma

Hahn, A. W., Drake, C., Denmeade, S. R., Zakharia, Y., Maughan, B. L., Kennedy, E., Link, C., Vahanian, N., Hammers, H. & Agarwal, N., Jan 1 2019, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access
Renal Cell Carcinoma
Immunotherapy
Kidney
Salvage Therapy
N-acetyllactosaminide alpha-1,3-galactosyltransferase
Open Access
Mesenchymal Stromal Cells
Prostatic Neoplasms
Bone Marrow
Safety
Neoplasms

A pilot study of prostate-specific membrane antigen (PSMA) dynamics in men undergoing treatment for advanced prostate cancer

Paller, C., Piana, D., Eshleman, J., Riel, S., Denmeade, S. R., Isaacsson Velho, P., Rowe, S., Pomper, M. G., Antonarakis, E., Luo, J. & Eisenberger, M., Jan 1 2019, In : Prostate. 79, 14, p. 1597-1603 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Circulating Neoplastic Cells
Therapeutics
Castration
Prostate-Specific Antigen
Renal Cell Carcinoma
2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid
Neoplasms
Prospective Studies
Neoplasm Metastasis
Open Access
radiation therapy
Prostatic Neoplasms
Radiotherapy
cancer
progressions
Placebos
Neoplasm Metastasis
Prednisone
Prostatic Neoplasms
Confidence Intervals

Supraphysiological androgens suppress prostate cancer growth through androgen receptor-mediated DNA damage

Chatterjee, P., Schweizer, M. T., Lucas, J. M., Coleman, I., Nyquist, M. D., Frank, S. B., Tharakan, R., Mostaghel, E., Luo, J., Pritchard, C. C., Lam, H. M., Corey, E., Antonarakis, E. S., Denmeade, S. R. & Nelson, P. S., Jul 16 2019, In : The Journal of clinical investigation. 130

Research output: Contribution to journalArticle

Open Access
Androgen Receptors
Androgens
DNA Damage
Prostatic Neoplasms
Growth
Wnt Signaling Pathway
Castration
Prostatic Neoplasms
Mutation
Prostate-Specific Antigen
2018
Radium
Castration
Prostatic Neoplasms
Alkaline Phosphatase
Bone and Bones

Muscadine grape skin extract (MPX) in men with biochemically recurrent prostate cancer: A randomized, multicenter, placebo-controlled clinical trial

Paller, C., Zhou, X. C., Heath, E. I., Taplin, M. E., Mayer, T., Stein, M. N., Bubley, G. J., Pili, R., Hudson, T., Kakarla, R., Abbas, M. M., Anders, N., Dowling, D., King, S., Bruns, A. B., Wagner, W. D., Drake, C. G., Antonarakis, E., Eisenberger, M., Denmeade, S. R. & 3 others, Rudek-Renaut, M., Rosner, G. & Carducci, M. A., Jan 15 2018, In : Clinical Cancer Research. 24, 2, p. 306-315 10 p.

Research output: Contribution to journalArticle

Controlled Clinical Trials
Vitis
Prostatic Neoplasms
Placebos
Skin
alpha-Macroglobulins
Peptide Hormones
Prostate-Specific Antigen
Macroglobulins
Prostatic Neoplasms

PSA-selective activation of cytotoxic human serine proteases within the tumor microenvironment as a therapeutic strategy to target prostate cancer

Rogers, O. C., Anthony, L., Rosen, D. M., Brennen, W. & Denmeade, S. R., Apr 27 2018, In : Oncotarget. 9, 32, p. 22436-22450 15 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Serine Proteases
Prostate-Specific Antigen
Prostatic Neoplasms
Peptide Hydrolases
2017

Androgen Receptor Splice Variants Are Not Substrates of Nonsense-Mediated Decay

Ajiboye, A. S., Esopi, D., Yegnasubramanian, S. & Denmeade, S. R., Jun 1 2017, In : Prostate. 77, 8, p. 829-837 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Cell Line
Castration
Androgen Receptor Antagonists
Emetine
Prodrugs
Prostate-Specific Antigen
Toxicity
Derivatives
Prostatic Neoplasms
Radiotherapy
Observation
Radiation
Androgens

Bipolar Androgen Therapy: A Paradoxical Approach for the Treatment of Castration-resistant Prostate Cancer

Schweizer, M. T., Antonarakis, E. & Denmeade, S. R., 2017, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Castration
Androgens
Prostatic Neoplasms
Testosterone
Therapeutics

Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide: An open-label, phase 2, multicohort study

Teply, B. A., Wang, H., Luber, B., Sullivan, R., Rifkind, I., Bruns, A., Spitz, A., DeCarli, M., Sinibaldi, V., Pratz, C. F., Lu, C., Silberstein, J. L., Luo, J., Schweizer, M. T., Drake, C. G., Carducci, M. A., Paller, C., Antonarakis, E., Eisenberger, M. & Denmeade, S. R., Jan 1 2017, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

Castration
Androgens
Prostatic Neoplasms
Therapeutics
MDV 3100
Circulating Neoplastic Cells
Castration
Androgen Receptors
Prostatic Neoplasms
Messenger RNA

Detection fidelity of AR mutations in plasma derived cell-free DNA

Goldstein, A., Toro, P. V., Lee, J., Silberstein, J. L., Nakazawa, M., Waters, I., Cravero, K., Chu, D., Cochran, R. L., Kim, M., Shinn, D., Torquato, S., Hughes, R. M., Pallavajjalla, A., Carducci, M. A., Paller, C., Denmeade, S. R., Kressel, B., Trock, B., Eisenberger, M. & 3 others, Antonarakis, E., Park, B. H. & Hurley, P., 2017, In : Oncotarget. 8, 9, p. 15651-15662 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Plasma Cells
Mutation
Castration
DNA

Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate

Brennen, W., Zhang, B., Kulac, I., Kisteman, L. N., Antony, L., Wang, H., Meeker, A. K., Demarzo, A. M., Garraway, I. P., Denmeade, S. R. & Isaacs, J. T., 2017, In : Oncotarget. 8, 29, p. 46710-46727 18 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Prostate
Prostatic Neoplasms
Chondrogenesis
Adipogenesis

Rationale for bipolar androgen therapy (BAT) for metastatic prostate cancer

Isaacs, J. T., Brennen, W. & Denmeade, S. R., Aug 24 2017, (Accepted/In press) In : Cell Cycle. p. 1-2 2 p.

Research output: Contribution to journalArticle

Androgens
Prostatic Neoplasms
Therapeutics
2016

A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer

Levy, O., Brennen, W., Han, E., Rosen, D. M., Musabeyezu, J., Safaee, H., Ranganath, S., Ngai, J., Heinelt, M., Milton, Y., Wang, H., Bhagchandani, S. H., Joshi, N., Bhowmick, N., Denmeade, S. R., Isaacs, J. T. & Karp, J. M., Jun 1 2016, In : Biomaterials. 91, p. 140-150 11 p.

Research output: Contribution to journalArticle

Prodrugs
Stem cells
Mesenchymal Stromal Cells
Prostatic Neoplasms
Prostate-Specific Antigen

Bipolar Androgen Therapy for Men With Androgen Ablation Naïve Prostate Cancer: Results From the Phase II BATMAN Study

Schweizer, M. T., Wang, H., Luber, B., Nadal, R., Spitz, A., Rosen, D. M., Cao, H., Antonarakis, E., Eisenberger, M., Carducci, M. A., Paller, C. & Denmeade, S. R., Sep 15 2016, In : Prostate. 76, 13, p. 1218-1226 9 p.

Research output: Contribution to journalArticle

Androgens
Prostatic Neoplasms
Therapeutics
Quality of Life
Hormones
Biological Products
Dietary Supplements
Clinical Trials
United States Food and Drug Administration
Neoplasms

Clinical Applications of Molecular Imaging in the Management of Prostate Cancer

Gorin, M., Rowe, S. & Denmeade, S. R., 2016, (Accepted/In press) In : PET Clinics.

Research output: Contribution to journalArticle

Molecular Imaging
Prostatic Neoplasms
cancer
Neoplasms

Extreme Response to High-dose Testosterone in BRCA2- and ATM-mutated Prostate Cancer

Teply, B. A., Kachhap, S., Eisenberger, M. & Denmeade, S. R., 2016, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Testosterone
Prostatic Neoplasms

Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death

Na, R., Zheng, S. L., Han, M., Yu, H., Jiang, D., Shah, S., Ewing, C. M., Zhang, L., Novakovic, K., Petkewicz, J., Gulukota, K., Helseth, D. L., Quinn, M., Humphries, E., Wiley, K. E., Isaacs, S. D., Wu, Y., Liu, X., Zhang, N., Wang, C. H. & 17 others, Khandekar, J., Hulick, P. J., Shevrin, D. H., Cooney, K. A., Shen, Z., Partin, A. W., Carter, H. B., Carducci, M. A., Eisenberger, M., Denmeade, S. R., McGuire, M., Walsh, P., Helfand, B. T., Brendler, C. B., Ding, Q., Xu, J. & Isaacs, W. B., 2016, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Germ-Line Mutation
Prostatic Neoplasms
Mutation
Mutation Rate
Lethal Genes
Emetine
Dipeptidyl Peptidase 4
Prodrugs
Fibroblasts
Proteins

Mipsagargin, a novel thapsigargin-based PSMA-Activated prodrug: Results of a first-in-man phase i clinical trial in patients with refractory, advanced or metastatic solid tumours

Mahalingam, D., Wilding, G., Denmeade, S. R., Sarantopoulas, J., Cosgrove, D., Cetnar, J., Azad, N., Bruce, J., Kurman, M., Allgood, V. E. & Carducci, M. A., Apr 26 2016, In : British Journal of Cancer. 114, 9, p. 986-994 9 p.

Research output: Contribution to journalArticle

Thapsigargin
Prodrugs
Clinical Trials
Neoplasms
Exanthema

Mutational Analysis of Prostate-Specific Antigen Defines the Intrinsic Proteolytic Activity of the proPSA Zymogen

Sangster-Guity, N., Tu-Sekine, B., Raben, D. M., Denmeade, S. R. & Williams, S. A., Sep 15 2016, In : Prostate. 76, 13, p. 1203-1217 15 p.

Research output: Contribution to journalArticle

Enzyme Precursors
Prostate-Specific Antigen
Prostatic Neoplasms
Prostate
Tumor Biomarkers
Castration
Androgen Receptors
Prostatic Neoplasms
Disease-Free Survival
Antigens
docetaxel
Castration
Prednisone
Prostatic Neoplasms
Disease-Free Survival
2015
Castration
Androgen Receptors
Prostatic Neoplasms
Drug Therapy
Prostate-Specific Antigen

A phase i study of muscadine grape skin extract in men with biochemically recurrent prostate cancer: Safety, tolerability, and dose determination

Paller, C., Rudek-Renaut, M., Zhou, X. C., Wagner, W. D., Hudson, T. S., Anders, N., Hammers, H. J., Dowling, D., King, S., Antonarakis, E., Drake, C. G., Eisenberger, M., Denmeade, S. R., Rosner, G. & Carducci, M. A., Oct 1 2015, In : Prostate. 75, 14, p. 1518-1525 8 p.

Research output: Contribution to journalArticle

Vitis
Prostatic Neoplasms
Safety
Skin
Eructation

CCAAT/Enhancer binding protein β controls androgen-deprivation-induced senescence in prostate cancer cells

Barakat, D. J., Zhang, J., Barberi, T., Denmeade, S. R., Friedman, A. D. & Paz-Priel, I., Nov 26 2015, In : Oncogene. 34, 48, p. 5912-5922 11 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Androgens
Prostatic Neoplasms
Castration
Androgen Receptors

Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines

Akinboye, E., Bamji, Z. D., Kwabi-Addo, B., Ejeh, D., Copeland, R. L., Denmeade, S. R. & Bakare, O., Sep 1 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5839-5845 7 p.

Research output: Contribution to journalArticle

Emetine
Cytotoxicity
Inhibitory Concentration 50
Prostatic Neoplasms
Androgen Receptors
Castration
Androgens
Prostatic Neoplasms
Testosterone
Androgen Receptors

Protease-activated pore-forming peptides for the treatment and imaging of prostate cancer

LeBeau, A. M. & Denmeade, S. R., Mar 1 2015, In : Molecular Cancer Therapeutics. 14, 3, p. 659-668 10 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Peptide Hydrolases
Peptides
Antigens
Heterografts

Targeting thapsigargin towards tumors

Doan, N. T. Q., Paulsen, E. S., Sehgal, P., Møller, J. V., Nissen, P., Denmeade, S. R., Isaacs, J. T., Dionne, C. A. & Christensen, S. B., 2015, In : Steroids. 97, p. 2-7 6 p.

Research output: Contribution to journalArticle

Thapsigargin
Prodrugs
Tumors
Thapsia
Sarcoplasmic Reticulum Calcium-Transporting ATPases
2014

AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer

Antonarakis, E., Lu, C., Wang, H., Luber, B., Nakazawa, M., Roeser, J. C., Chen, Y., Mohammad, T. A., Chen, Y., Fedor, H. L., Lotan, T., Zheng, Q., Demarzo, A. M., Isaacs, J. T., Isaacs, W. B., Nadal, R., Paller, C., Denmeade, S. R., Carducci, M. A., Eisenberger, M. & 1 others, Luo, J., Sep 11 2014, In : New England Journal of Medicine. 371, 11, p. 1028-1038 11 p.

Research output: Contribution to journalArticle

Prostate-Specific Antigen
Prostatic Neoplasms
Disease-Free Survival
Circulating Neoplastic Cells
Androgen Receptors

Clinical activity of enzalutamide in docetaxel-naïve and docetaxel-pretreated patients with metastatic castration-resistant prostate cancer

Nadal, R., Zhang, Z., Rahman, H., Schweizer, M. T., Denmeade, S. R., Paller, C., Carducci, M. A., Eisenberger, M. & Antonarakis, E., Nov 1 2014, In : Prostate. 74, 15, p. 1560-1568 9 p.

Research output: Contribution to journalArticle

docetaxel
Castration
Prostatic Neoplasms
Prostate-Specific Antigen
Disease-Free Survival

Pharmacokinetics and toxicology of a fibroblast activation protein (FAP)-Activated prodrug in murine xenograft models of human cancer

Brennen, W., Rosen, D. M., Chaux, A., Netto, G. J., Isaacs, J. T. & Denmeade, S. R., 2014, In : Prostate. 74, 13, p. 1308-1319 12 p.

Research output: Contribution to journalArticle

Prodrugs
Heterografts
Toxicology
Pharmacokinetics
Fibroblasts
Prostatic Neoplasms
Placebos
Randomized Controlled Trials
Therapeutics
Research Personnel
2013
Mesenchymal Stromal Cells
Prostate
Prostatic Neoplasms
Inflammation
Tropism

Prospective, randomized, double-blind, vehicle controlled, multicenter phase IIb clinical trial of the pore forming protein PRX302 for targeted treatment of symptomatic benign prostatic hyperplasia

Elhilali, M. M., Pommerville, P., Yocum, R. C., Merchant, R., Roehrborn, C. G. & Denmeade, S. R., Apr 2013, In : Journal of Urology. 189, 4, p. 1421-1426 6 p.

Research output: Contribution to journalArticle

Porins
Prostatic Hyperplasia
Prostate
Clinical Trials
Urine

Proteolysis of complement factors iC3b and C5 by the serine protease prostate-specific antigen in prostatic fluid and seminal plasma

Manning, M. L., Williams, S. A., Jelinek, C. A., Kostova, M. B. & Denmeade, S. R., Mar 15 2013, In : Journal of Immunology. 190, 6, p. 2567-2574 8 p.

Research output: Contribution to journalArticle

Complement C3b
Serine Proteases
Prostate-Specific Antigen
Semen
Proteolysis

Quantification of Mesenchymal Stem Cells (MSCs) at sites of human prostate cancer

Brennen, W., Chen, S., Denmeade, S. R. & Isaacs, J. T., 2013, In : Oncotarget. 4, 1, p. 106-117 12 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Prostatic Neoplasms
Bone Marrow
Stromal Cells
Prostatectomy

Single copies of mutant KRAS and mutant PIK3CA Cooperate in immortalized human epithelial cells to induce tumor formation

Wang, G. M., Wong, H. Y., Konishi, H., Blair, B. G., Abukhdeir, A. M., Gustin, J. P., Rosen, D. M., Denmeade, S. R., Rasheed, Z., Matsui, W., Garay, J. P., Mohseni, M., Higgins, M. J., Cidado, J., Jelovac, D., Croessmann, S., Cochran, R. L., Karnan, S., Konishi, Y., Ota, A. & 4 others, Hosokawa, Y., Argani, P., Lauring, J. & Park, B. H., Jun 1 2013, In : Cancer Research. 73, 11, p. 3248-3261 14 p.

Research output: Contribution to journalArticle

Epithelial Cells
Neoplasms
Mutation
1-Phosphatidylinositol 4-Kinase
Mitogen-Activated Protein Kinases