Samarjit Das

Assistant Professor

20082019
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Research Output 2008 2019

2019

Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness

Tuday, E., Nomura, Y., Ruhela, D., Nakano, M., Fu, X., Shah, A., Roman, B., Yamaguchi, A., An, S. S., Steenbergen, C., Baraban, J. M., Berkowitz, D. E. & Das, S., Nov 1 2019, In : American journal of physiology. Heart and circulatory physiology. 317, 5, p. H1116-H1124

Research output: Contribution to journalArticle

Vascular Stiffness
MicroRNAs
Blood Vessels
Aorta
Vascular Smooth Muscle

Exosomal non-coding RNAs (Exo-ncRNAs) in cardiovascular health

Jaquenod De Giusti, C., Santalla, M. & Das, S., Dec 2019, In : Journal of Molecular and Cellular Cardiology. 137, p. 143-151 9 p.

Research output: Contribution to journalReview article

Exosomes
Untranslated RNA
Health
Biomarkers
MicroRNAs

The secret messages between mitochondria and nucleus in muscle cell biology

Soledad, R. B., Charles, S. & Das, S., May 15 2019, In : Archives of Biochemistry and Biophysics. 666, p. 52-62 11 p.

Research output: Contribution to journalReview article

Cytology
Mitochondria
Muscle Cells
Cell Biology
Muscle
2018

A microRNA’s journey to the center of the mitochondria

Macgregor-Das, A. M. & Das, S., Aug 1 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 2, p. H206-H215

Research output: Contribution to journalReview article

MicroRNAs
Mitochondria
Mitochondrial Genome
Webcasts
Regulator Genes

In vivo nanovector delivery of a heart-specific microrna-sponge

Kent, O. A., Steenbergen, C. J. & Das, S., Jun 15 2018, In : Journal of Visualized Experiments. 2018, 136, e57845.

Research output: Contribution to journalArticle

Porifera
MicroRNAs
Tissue
Cells
Oligonucleotides

The influence of MicroRNAs on mitochondrial calcium

De Giusti, C. J., Roman, B. & Das, S., Sep 21 2018, In : Frontiers in Physiology. 9, SEP, 1291.

Research output: Contribution to journalReview article

MicroRNAs
Calcium
Cytoplasm
Cell Death
Messenger RNA
2017

Divergent effects of miR-181 family members on myocardial function through protective cytosolic and detrimental mitochondrial microRNA targets

Das, S., Kohr, M., Dunkerly-Eyring, B., Lee, D., Bedja, D., Kent, O. A., Leung, A. K. L., Henao-Mejia, J., Flavell, R. A. & Steenbergen, C. J., 2017, In : Journal of the American Heart Association. 6, 3, e004694.

Research output: Contribution to journalArticle

MicroRNAs
Phosphoric Monoester Hydrolases
Porifera
Oxidative Stress
Gene Expression

Exosomal MicroRNA-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress

Kamalden, T. A., Macgregor-Das, A. M., Kannan, S. M., Dunkerly-Eyring, B., Khaliddin, N., Xu, Z., Fusco, A. P., Yazib, S. A., Chow, R. C., Duh, E. J., Halushka, M. K., Steenbergen, C. J. & Das, S., Nov 1 2017, In : Antioxidants and Redox Signaling. 27, 13, p. 913-930 18 p.

Research output: Contribution to journalArticle

Oxidative stress
Diabetes Complications
MicroRNAs
Pancreas
Medical problems

MiR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling

Hori, D., Dunkerly-Eyring, B., Nomura, Y., Biswas, D., Steppan, J., Henao-Mejia, J., Adachi, H., Santhanam, L., Berkowitz, D. E., Steenbergen, C. J., Flavell, R. A. & Das, S., Mar 1 2017, In : PLoS One. 12, 3, e0174108.

Research output: Contribution to journalArticle

Vascular Stiffness
Blood pressure
blood vessels
Losartan
Stiffness

Mitochondrial miRNAs in diabetes: Just the tip of the iceberg

Baradan, R., Hollander, J. M. & Das, S., 2017, In : Canadian Journal of Physiology and Pharmacology. 95, 10, p. 1156-1162 7 p.

Research output: Contribution to journalReview article

MicroRNAs
3' Untranslated Regions
Diabetes Mellitus
RNA-Induced Silencing Complex
RNA

MitomiRs keep the heart beating

Das, S., Vasanthi, H. R. & Parjapath, R., May 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 982. p. 431-450 20 p. (Advances in Experimental Medicine and Biology; vol. 982).

Research output: Chapter in Book/Report/Conference proceedingChapter

MicroRNAs
Mitochondria
Set theory
Genes
2015

ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity

Belmonte, F., Das, S., Sysa-Shah, P., Sivakumaran, V., Stanley, B., Guo, X., Paolocci, N., Aon, M. A., Nagane, M., Kuppusamy, P., Steenbergen, C. J. & Gabrielson, K. L., 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 8, p. H1271-H1280

Research output: Contribution to journalArticle

Doxorubicin
Reactive Oxygen Species
Up-Regulation
Antioxidants
Enzymes

Extracellular vesicle microRNA transfer in cardiovascular disease

Das, S. & Halushka, M. K., Jul 1 2015, In : Cardiovascular Pathology. 24, 4, p. 199-206 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Cardiovascular Diseases
Endothelial Cells
Exosomes
Ischemic Preconditioning

Mitochondrial miRNA (MitomiR): A new player in cardiovascular health

Srinivasan, H. & Das, S., Jan 19 2015, In : Canadian Journal of Physiology and Pharmacology. 93, 10, p. 855-861 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Health
Mitochondria
Cardiovascular Diseases
Mitochondrial Genome
2014

miR-181c regulates the mitochondrial genome, bioenergetics, and propensity for heart failure in vivo

Das, S., Bedja, D., Campbell, N., Dunkerly, B., Chenna, V., Maitra, A. & Steenbergen, C. J., May 8 2014, In : PLoS One. 9, 5, e96820.

Research output: Contribution to journalArticle

Mitochondrial Genome
heart failure
MicroRNAs
microRNA
energy metabolism

The next generation of diagnostic biomarkers for type 2 diabetes

Das, S. & Kamalden, T. A., Jan 1 2014, Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms. Springer New York, p. 313-321 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biomarkers
Medical problems
MicroRNAs
Type 2 Diabetes Mellitus
Blood Vessels
2012

A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy

Pramanik, D., Campbell, N. R., Das, S., Gupta, S., Chenna, V., Bisht, S., Sysa-Shah, P., Bedja, D., Karikari, C., Steenbergen, C. J., Gabrielson, K. L., Maitra, A. & Maitra, A., Jun 2012, In : Oncotarget. 3, 6, p. 640-650 11 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Cardiomyopathies
Nanoparticles
Doxorubicin
Polymers

Application of systems biology principles to protein biomarker discovery: Urinary exosomal proteome in renal transplantation

Pisitkun, T., Gandolfo, M. T., Das, S., Knepper, M. A. & Bagnasco, S. M., Jun 2012, In : Proteomics - Clinical Applications. 6, 5-6, p. 268-278 11 p.

Research output: Contribution to journalArticle

Systems Biology
Biomarkers
Proteome
Kidney Transplantation
Mass spectrometry

Does the voltage dependent anion channel modulate cardiac ischemia-reperfusion injury?

Das, S., Steenbergen, C. J. & Murphy, E., Jun 2012, In : BBA - Biomembranes. 1818, 6, p. 1451-1456 6 p.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channels
Reperfusion Injury
Cell death
Cell Death
Adenine Nucleotides

Mitochondrial adenine nucleotide transport and cardioprotection

Das, S. & Steenbergen, C. J., Feb 2012, In : Journal of Molecular and Cellular Cardiology. 52, 2, p. 448-453 6 p.

Research output: Contribution to journalArticle

Adenine Nucleotides
Mitochondria
Myocardial Reperfusion Injury
Reperfusion Injury
Organelles

Nuclear miRNA regulates the mitochondrial genome in the heart

Das, S., Ferlito, M., Kent, O. A., Fox-Talbot, K., Wang, R., Liu, D., Raghavachari, N., Yang, Y., Wheelan, S., Murphy, E. & Steenbergen, C. J., Jun 8 2012, In : Circulation Research. 110, 12, p. 1596-1603 8 p.

Research output: Contribution to journalArticle

Mitochondrial Genome
MicroRNAs
Mitochondria
Messenger RNA
Electron Transport Complex IV
2009

Cardioprotection and altered mitochondrial adenine nucleotide transport

Steenbergen, C. J., Das, S., Su, J., Wong, R. & Murphy, E., 2009, In : Basic Research in Cardiology. 104, 2, p. 149-156 8 p.

Research output: Contribution to journalArticle

Adenine Nucleotides
Mitochondria
Reperfusion
Ischemia
Mitochondrial Membrane Potential
2008

Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation

Das, S., Wong, R., Rajapakse, N., Murphy, E. & Steenbergen, C. J., Oct 24 2008, In : Circulation Research. 103, 9, p. 983-991 9 p.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channels
Glycogen Synthase Kinase 3
Glycogen Synthase Kinases
Adenine Nucleotides
Phosphorylation