S Yegnasubramanian

Associate Professor

19992019

Research output per year

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2019

A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs

Giovinazzo, H., Walker, D., Wyhs, N., Liu, J., Esopi, D. M., Vaghasia, A. M., Jain, Y., Bhamidipati, A., Zhou, J., Nelson, W. G. & Yegnasubramanian, S., Apr 30 2019, In : Oncotarget. 10, 32, p. 3040-3050 11 p.

Research output: Contribution to journalArticle

Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

Ando, M., Saito, Y., Xu, G., Bui, N. Q., Medetgul-Ernar, K., Pu, M., Fisch, K., Ren, S., Sakai, A., Fukusumi, T., Liu, C., Haft, S., Pang, J., Mark, A., Gaykalova, D., Guo, T., Favorov, A., Yegnasubramanian, S., Fertig, E., Ha, P. & 5 others, Tamayo, P., Yamasoba, T., Ideker, T., Messer, K. & Califano, J. A., Dec 1 2019, In : Nature communications. 10, 1, 2188.

Research output: Contribution to journalArticle

Open Access

Consequences of interleukin 1β-triggered chronic inflammation in the mouse prostate gland: Altered architecture associated with prolonged CD4 + infiltration mimics human proliferative inflammatory atrophy

Ashok, A., Keener, R. A., Rubenstein, M., Stookey, S., Bajpai, S., Hicks, J., Alme, A. K., Drake, C. G., Zheng, Q., Trabzonlu, L., Yegnasubramanian, S., Demarzo, A. M. & Bieberich, C. J., Jan 1 2019, In : Prostate.

Research output: Contribution to journalArticle

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

Kong, X., Chen, J., Xie, W., Brown, S. M., Cai, Y., Wu, K., Fan, D., Nie, Y., Yegnasubramanian, S., Tiedemann, R. L., Tao, Y., Yen, R-W., Topper, M. J., Zahnow, C., Easwaran, H., Rothbart, S. B., Xia, L. & Baylin, S. B., Apr 15 2019, In : Cancer cell. 35, 4, p. 633-648.e7

Research output: Contribution to journalArticle

Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition

Mao, W., Ghasemzadeh, A., Freeman, Z. T., Obradovic, A., Chaimowitz, M. G., Nirschl, T. R., McKiernan, E., Yegnasubramanian, S. & Drake, C. G., Oct 25 2019, In : Journal for immunotherapy of cancer. 7, 1, 277.

Research output: Contribution to journalArticle

Open Access

Lactoferrin CpG Island Hypermethylation and Decoupling of mRNA and Protein Expression in the Early Stages of Prostate Carcinogenesis

Porter, C. M., Haffner, M. C., Kulac, I., Maynard, J. P., Baena-Del Valle, J. A., Isaacs, W. B., Yegnasubramanian, S., De Marzo, A. M. & Sfanos, K. S., Nov 2019, In : American Journal of Pathology. 189, 11, p. 2311-2322 12 p.

Research output: Contribution to journalArticle

2018

Characterization of novel cell lines derived from a MYC-driven murine model of lethal metastatic adenocarcinoma of the prostate

Markowski, M., Hubbard, G. K., Hicks, J. L., Zheng, Q., King, A., Esopi, D., Rege, A., Yegnasubramanian, S., Bieberich, C. J. & Demarzo, A. M., Jan 1 2018, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer

Haffner, M. C., Guner, G., Taheri, D., Netto, G. J., Palsgrove, D. N., Zheng, Q., Guedes, L. B., Kim, K., Tsai, H., Esopi, D. M., Lotan, T., Sharma, R., Meeker, A. K., Chinnaiyan, A. M., Nelson, W. G., Yegnasubramanian, S., Luo, J., Mehra, R., Antonarakis, E., Drake, C. G. & 1 others, Demarzo, A. M., Jun 1 2018, In : American Journal of Pathology. 188, 6, p. 1478-1485 8 p.

Research output: Contribution to journalArticle

ETS2 is a prostate basal cell marker and is highly expressed in prostate cancers aberrantly expressing p63

Torres, A., Alshalalfa, M., Davicioni, E., Gupta, A., Yegnasubramanian, S., Wheelan, S., Epstein, J. I., Demarzo, A. M. & Lotan, T., Sep 1 2018, In : Prostate. 78, 12, p. 896-904 9 p.

Research output: Contribution to journalArticle

MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer

Baena-Del Valle, J. A., Zheng, Q., Esopi, D. M., Rubenstein, M., Hubbard, G. K., Moncaliano, M. C., Hruszkewycz, A., Vaghasia, A., Yegnasubramanian, S., Wheelan, S., Meeker, A. K., Heaphy, C. M., Graham, M. K. & Demarzo, A. M., Jan 1 2018, In : Journal of Pathology. 244, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer

Shrestha, E., White, J. R., Yu, S. H., Kulac, I., Ertunc, O., Demarzo, A. M., Yegnasubramanian, S., Mangold, L. A., Partin, A. W. & Sfanos, K., Jan 1 2018, In : Journal of Urology. 199, 1, p. 161-171 11 p.

Research output: Contribution to journalArticle

Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy

Xu, X., Wu, J., Liu, S., Saw, P. E., Tao, W., Li, Y., Krygsman, L., Yegnasubramanian, S., Demarzo, A. M., Shi, J., Bieberich, C. J. & Farokhzad, O. C., Jan 1 2018, (Accepted/In press) In : Small.

Research output: Contribution to journalArticle

Transcriptional profiling identifies novel regulators of macrophage polarization

Gerrick, K. Y., Gerrick, E. R., Gupta, A., Wheelan, S., Yegnasubramanian, S. & Jaffee, E., Dec 1 2018, In : PLoS One. 13, 12, e0208602.

Research output: Contribution to journalArticle

Update on Systemic Prostate Cancer Therapies: Management of Metastatic Castration-resistant Prostate Cancer in the Era of Precision Oncology

Nuhn, P., De Bono, J. S., Fizazi, K., Freedland, S. J., Grilli, M., Kantoff, P. W., Sonpavde, G., Sternberg, C. N., Yegnasubramanian, S. & Antonarakis, E., Jan 1 2018, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

2017

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination

Haffner, M. C., Esopi, D. M., Chaux, A., Gürel, M., Ghosh, S., Vaghasia, A. M., Tsai, H., Kim, K., Castagna, N., Lam, H., Hicks, J., Wyhs, N., Biswal Shinohara, D., Hurley, P., Simons, B. W., Schaeffer, E. M., Lotan, T., Isaacs, W. B., Netto, G. J., Demarzo, A. M. & 3 others, Nelson, W. G., An, S. & Yegnasubramanian, S., Dec 1 2017, In : Nature Communications. 8, 1, 142.

Research output: Contribution to journalArticle

Androgen Receptor Splice Variants Are Not Substrates of Nonsense-Mediated Decay

Ajiboye, A. S., Esopi, D., Yegnasubramanian, S. & Denmeade, S. R., Jun 1 2017, In : Prostate. 77, 8, p. 829-837 9 p.

Research output: Contribution to journalArticle

A novel functional splice variant of AKT3 defined by analysis of alternative splice expression in HPV-positive oropharyngeal cancers

Guo, T., Sakai, A., Afsari, B., Considine, M., Danilova, L. V., Favorov, A., Yegnasubramanian, S., Kelley, D. Z., Flam, E., Ha, P. K., Khan, Z., Wheelan, S., Gutkind, J. S., Fertig, E., Gaykalova, D. & Califano, J., Oct 1 2017, In : Cancer Research. 77, 19, p. 5248-5258 11 p.

Research output: Contribution to journalArticle

c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks

Barfeld, S. J., Urbanucci, A., Itkonen, H. M., Fazli, L., Hicks, J. L., Thiede, B., Rennie, P. S., Yegnasubramanian, S., Demarzo, A. M. & Mills, I. G., Apr 1 2017, In : EBioMedicine. 18, p. 83-93 11 p.

Research output: Contribution to journalArticle

2016

Androgen deprivation followed by acute androgen stimulation selectively sensitizes AR-positive prostate cancer cells to ionizing radiation

Hedayati, M., Haffner, M. C., Coulter, J. B., Raval, R. R., Zhang, Y., Zhou, H., Mian, O., Knight, E. J., Razavi, N., Dalrymple, S., Isaacs, J. T., Santos, A., Hales, R., Nelson, W. G., Yegnasubramanian, S. & DeWeese, T., Jul 1 2016, In : Clinical Cancer Research. 22, 13, p. 3310-3319 10 p.

Research output: Contribution to journalArticle

Combined MYC activation and Pten loss are sufficient to create genomic instability and lethal metastatic prostate cancer

Hubbard, G. K., Mutton, L. N., Khalili, M., McMullin, R. P., Hicks, J. L., Bianchi-Frias, D., Horn, L. A., Kulac, I., Moubarek, M. S., Nelson, P. S., Yegnasubramanian, S., Demarzo, A. M. & Bieberich, C. J., Jan 15 2016, In : Cancer Research. 76, 2, p. 283-292 10 p.

Research output: Contribution to journalArticle

Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation

Gondek, L., Zheng, G., Ghiaur, G., Dezern, A., Matsui, W., Yegnasubramanian, S., Lin, M-T., Levis, M. J., Eshleman, J., Varadhan, R., Tucker, N., Jones, R. J. & Gocke, C., Mar 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies

Munari, E., Chaux, A., Vaghasia, A. M., Taheri, D., Karram, S., Bezerra, S. M., Roibon, N. G., Nelson, W. G., Yegnasubramanian, S., Netto, G. J. & Haffner, M. C., Jan 1 2016, In : PLoS One. 11, 1, e0146302.

Research output: Contribution to journalArticle

GSTP1 Loss results in accumulation of oxidative DNA base damage and promotes prostate cancer cell survival following exposure to protracted oxidative stress

Mian, O. Y., Khattab, M. H., Hedayati, M., Coulter, J., Abubaker- Sharif, B., Schwaninger, J. M., Veeraswamy, R. K., Brooks, J. D., Hopkins, L., Shinohara, D. B., Cornblatt, B., Nelson, W. G., Yegnasubramanian, S. & DeWeese, T., Feb 1 2016, In : Prostate. 76, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia (PIN) and intraductal carcinoma through retrograde glandular colonization

Haffner, M. C., Weier, C., Xu, M. M., Vaghasia, A., Gürel, B., Gümüşkaya, B., Esopi, D. M., Fedor, H., Tan, H. L., Kulac, I., Hicks, J., Isaacs, W. B., Lotan, T., Nelson, W. G., Yegnasubramanian, S. & Demarzo, A. M., Jan 1 2016, In : Journal of Pathology. 238, 1, p. 31-41 11 p.

Research output: Contribution to journalArticle

2015

Androgen-regulated SPARCL1 in the tumor microenvironment inhibits metastatic progression

Hurley, P., Hughes, R. M., Simons, B. W., Huang, J., Miller, R. M., Shinder, B., Haffner, M. C., Esopi, D., Kimura, Y., Jabbari, J., Ross, A. E., Erho, N., Vergara, I. A., Faraj, S. F., Davicioni, E., Netto, G. J., Yegnasubramanian, S., An, S. & Schaeffer, E. M., Oct 15 2015, In : Cancer Research. 75, 20, p. 4322-4334 13 p.

Research output: Contribution to journalArticle

Diagnostic challenges of clonal heterogeneity in prostate cancer

Haffner, M. C., Demarzo, A. M., Yegnasubramanian, S., Epstein, J. I. & Carter, H. B., Mar 1 2015, In : Journal of Clinical Oncology. 33, 7, p. e38-e40

Research output: Contribution to journalArticle

Global DNA methylation changes and differential gene expression in Anaplasma phagocytophilum-infected human neutrophils

Sinclair, S. H. G., Yegnasubramanian, S. & Dumler, J. S., Jul 29 2015, In : Clinical Epigenetics. 7, 1, 77.

Research output: Contribution to journalArticle

Prostate adenocarcinomas aberrantly expressing p63 are molecularly distinct from usual-type prostatic adenocarcinomas

Tan, H. L., Haffner, M. C., Esopi, D. M., Vaghasia, A. M., Giannico, G. A., Ross, H. M., Ghosh, S., Hicks, J. L., Zheng, Q., Sangoi, A. R., Yegnasubramanian, S., Osunkoya, A. O., Demarzo, A. M., Epstein, J. I. & Lotan, T., Mar 1 2015, In : Modern Pathology. 28, 3, p. 446-456 11 p.

Research output: Contribution to journalArticle

Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation

Singer, B. D., Mock, J. R., Aggarwal, N. R., Garibaldi, B. T., Sidhaye, V., Florez, M. A., Chau, E., Gibbs, K. W., Mandke, P., Tripathi, A., Yegnasubramanian, S., King, L. S. & D'Alessio, F., May 1 2015, In : American Journal of Respiratory Cell and Molecular Biology. 52, 5, p. 641-652 12 p.

Research output: Contribution to journalArticle

Should Gleason 6 be labeled as cancer?

Kulac, I., Haffner, M. C., Yegnasubramanian, S., Epstein, J. I. & Demarzo, A. M., May 27 2015, In : Current Opinion in Urology. 25, 3, p. 238-245 8 p.

Research output: Contribution to journalArticle

2014

Biobanking of derivatives from radical retropubic and robot-assisted laparoscopic prostatectomy tissues as part of the prostate cancer biorepository network

Darshan, M., Zheng, Q., Fedor, H. L., Wyhs, N., Yegnasubramanian, S., Lee, P., Melamed, J., Netto, G. J., Trock, B., Demarzo, A. M. & Sfanos, K., Jan 2014, In : Prostate. 74, 1, p. 61-69 9 p.

Research output: Contribution to journalArticle

Clinical validation of KRAS, BRAF, and EGFR mutation detection using next-generation sequencing

Lin, M-T., Mosier, S. L., Thiess, M., Beierl, K. F., Debeljak, M., Tseng, L. H., Chen, G., Yegnasubramanian, S., Ho, H., Cope, L., Wheelan, S., Gocke, C. & Eshleman, J., 2014, In : American Journal of Clinical Pathology. 141, 6, p. 856-866 11 p.

Research output: Contribution to journalArticle

Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer

Khor, T. O. O., Fuentes, F., Shu, L., Paredes-Gonzalez, X., Yang, A. Y. U., Liu, Y., Smiraglia, D. J., Yegnasubramanian, S., Nelson, W. G. & Kong, A. N. T. O., Dec 1 2014, In : Cancer Prevention Research. 7, 12, p. 1186-1197 12 p.

Research output: Contribution to journalArticle

Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer

Guerrero-Preston, R., Michailidi, C., Marchionni, L., Pickering, C. R., Frederick, M. J., Myers, J. N., Yegnasubramanian, S., Hadar, T., Noordhuis, M. G., Zizkova, V., Fertig, E., Agrawal, N., Westra, W., Koch, W. M., Califano, J., Velculescu, V. E. & Sidransky, D., Jan 5 2014, In : Epigenetics. 9, 7, p. 1031-1046 16 p.

Research output: Contribution to journalArticle

Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer

Sharad, S., Ravindranath, L., Haffner, M. C., Li, H., Yan, W., Sesterhenn, I. A., Chen, Y., Ali, A., Srinivasan, A., McLeod, D. G., Yegnasubramanian, S., Srivastava, S., Dobi, A. & Petrovics, G., Feb 4 2014, In : Epigenetics. 9, 6, p. 918-927 10 p.

Research output: Contribution to journalArticle

RNA-seq of the nucleolus reveals abundant SNORD44-derived small RNAs

Bai, B., Yegnasubramanian, S., Wheelan, S. & Laiho, M., Sep 1 2014, In : PLoS One. 9, 9, e107519.

Research output: Contribution to journalArticle

The diet as a cause of human prostate cancer

Nelson, W. G., Demarzo, A. M. & Yegnasubramanian, S., 2014, In : Cancer Treatment and Research. 159, p. 51-68 18 p.

Research output: Contribution to journalArticle

2013

Aiming for the outliers: Cancer precision medicine through targeting kinases with extreme expression

Yegnasubramanian, S. & Maitra, A., Mar 2013, In : Cancer Discovery. 3, 3, p. 252-254 3 p.

Research output: Contribution to journalArticle

A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes

Shinohara, D. B., Vaghasia, A. M., Yu, S. H., Mak, T. N., Brüggemann, H., Nelson, W. G., Demarzo, A. M., Yegnasubramanian, S. & Sfanos, K., Jun 2013, In : Prostate. 73, 9, p. 1007-1015 9 p.

Research output: Contribution to journalArticle

Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli

Canene-Adams, K., Sfanos, K., Liang, C. T., Yegnasubramanian, S., Nelson, W. G., Brayton, C. & Demarzo, A. M., Nov 27 2013, In : PLoS One. 8, 11, e79842.

Research output: Contribution to journalArticle

DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases

Aryee, M. J., Liu, W., Engelmann, J. C., Nuhn, P., Gurel, M., Haffner, M. C., Esopi, D., Irizarry, R. A., Getzenberg, R. H., Nelson, W. G., Luo, J., Xu, J., Isaacs, W. B., Bova, G. S. & Yegnasubramanian, S., Jan 23 2013, In : Science Translational Medicine. 5, 169, 169ra10.

Research output: Contribution to journalArticle

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations

Gerber, J. M., Gucwa, J., Esopi, D., Gurel, M., Haffner, M. C., Vala, M., Nelson, W. G., Jones, R. J. & Yegnasubramanian, S., May 2013, In : Oncotarget. 4, 5, p. 715-728 14 p.

Research output: Contribution to journalArticle

Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer

Weier, C., Haffner, M. C., Mosbruger, T., Esopi, D. M., Hicks, J., Zheng, Q., Fedor, H., Isaacs, W. B., Demarzo, A. M., Nelson, W. G. & Yegnasubramanian, S., Jun 2013, In : Journal of Pathology. 230, 2, p. 174-183 10 p.

Research output: Contribution to journalArticle

Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer

Schweizer, M. T., Lin, J., Blackford, A., Bardia, A., King, S., Armstrong, A. J., Rudek-Renaut, M., Yegnasubramanian, S. & Carducci, M. A., Dec 2013, In : Prostate Cancer and Prostatic Diseases. 16, 4, p. 357-361 5 p.

Research output: Contribution to journalArticle