S Yegnasubramanian

Associate Professor

19992019
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Research Output 1999 2019

2008

CpG Island hypermethylation profile in the serum of men with clinically localized and hormone refractory metastatic prostate cancer

Bastian, P. J., Palapattu, G. S., Yegnasubramanian, S., Rogers, C. G., Lin, X., Mangold, L. A., Trock, B., Eisenberger, M., Partin, A. W. & Nelson, W. G., Feb 2008, In : Journal of Urology. 179, 2, p. 529-534 6 p.

Research output: Contribution to journalArticle

CpG Islands
Prostatic Neoplasms
Hormones
Serum
Genes

DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity

Yegnasubramanian, S., Haffner, M. C., Zhang, Y., Gurel, B., Cornish, T. C., Wu, Z., Irizarry, R. A., Morgan, J., Hicks, J., DeWeese, T., Isaacs, W. B., Bova, G. S., Demarzo, A. M. & Nelson, W. G., Nov 1 2008, In : Cancer Research. 68, 21, p. 8954-8967 14 p.

Research output: Contribution to journalArticle

CpG Islands
Prostatic Neoplasms
DNA
Neoplasms
Prostate

Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors

Netto, G. J., Nakai, Y., Nakayama, M., Jadallah, S., Toubaji, A., Nonomura, N., Albadine, R., Hicks, J. L., Epstein, J. I., Yegnasubramanian, S., Nelson, W. G. & Demarzo, A. M., Nov 2008, In : Modern Pathology. 21, 11, p. 1337-1344 8 p.

Research output: Contribution to journalArticle

Seminoma
Germ Cells
DNA
Methylation
Neoplasms

Molecular alterations in prostate cancer as diagnostic, prognostic, and therapeutic targets

Gurel, B., Iwata, T., Koh, C. M., Yegnasubramanian, S., Nelson, W. G. & Demarzo, A. M., Nov 2008, In : Advances in Anatomic Pathology. 15, 6, p. 319-331 13 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Therapeutics
Molecular Pathology
Cause of Death
Adenocarcinoma

Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fibroblasts.

Suzuki, T., Farrar, J. E., Yegnasubramanian, S., Zahed, M., Suzuki, N. & Arceci, R. J., Sep 2008, In : Epigenetics. 3, 5, p. 281-291 11 p.

Research output: Contribution to journalArticle

Cell Aging
Fibroblasts
DNA
Small Interfering RNA
5-Methylcytosine
2007

Abnormal DNA methylation, epigenetics, and prostate cancer

Nelson, W. G., Yegnasubramanian, S., Agoston, A. T., Bastian, P. J., Lee, B. H., Nakayama, M. & Demarzo, A. M., May 1 2007, In : Frontiers in bioscience : a journal and virtual library. 12, 11, p. 4254-4266 13 p.

Research output: Contribution to journalArticle

Oncology
DNA sequences
Methyltransferases
Biomarkers
DNA Methylation

Prognostic value of preoperative serum cell-free circulating DNA in men with prostate cancer undergoing radical prostatectomy

Bastian, P. J., Palapattu, G. S., Yegnasubramanian, S., Lin, X., Rogers, C. G., Mangold, L. A., Trock, B., Eisenberger, M., Partin, A. W. & Nelson, W. G., Sep 15 2007, In : Clinical Cancer Research. 13, 18, p. 5361-5367 7 p.

Research output: Contribution to journalArticle

Prostatectomy
Prostate-Specific Antigen
Prostatic Neoplasms
DNA
Serum
2006
DNA Methylation
CpG Islands
Prostate
Enzymes
DNA
2005

Erratum: Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer (Journal of Biological Chemistry (2005) 280 (18302-18310))

Agoston, A. T., Argani, P., Yegnasubramanian, S., Demarzo, A. M., Ansari-Lari, M. A., Hicks, J. L., Davidson, N. E. & Nelson, W. G., Aug 5 2005, In : Journal of Biological Chemistry. 280, 31, p. 28828 1 p.

Research output: Contribution to journalArticle

Protein Stability
Methyltransferases
Breast Neoplasms
DNA
Proteins

Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer

Agoston, A. T., Argani, P., Yegnasubramanian, S., Demarzo, A. M., Ansari-Lari, M. A., Hicks, J. L., Davidson, N. E. & Nelson, W. G., May 6 2005, In : Journal of Biological Chemistry. 280, 18, p. 18302-18310 9 p.

Research output: Contribution to journalArticle

Protein Stability
Methyltransferases
Breast Neoplasms
DNA
Proteins

Preoperative serum DNA GSTP1 CpG island hypermethylation and the risk of early prostate-specific antigen recurrence following radical prostatectomy

Bastian, P. J., Palapattu, G. S., Lin, X., Yegnasubramanian, S., Mangold, L. A., Trock, B., Eisenberger, M., Partin, A. W. & Nelson, W. G., Jun 1 2005, In : Clinical Cancer Research. 11, 11, p. 4037-4043 7 p.

Research output: Contribution to journalArticle

CpG Islands
Prostate-Specific Antigen
Prostatectomy
Recurrence
DNA

Procainamide is a specific inhibitor of DNA methyltransferase 1

Lee, B. H., Yegnasubramanian, S., Lin, X. & Nelson, W. G., Dec 9 2005, In : Journal of Biological Chemistry. 280, 49, p. 40749-40756 8 p.

Research output: Contribution to journalArticle

Procainamide
Methyltransferases
DNA
5-methyldeoxycytidine
HCT116 Cells
2004

GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer

Nakayama, M., Gonzalgo, M. L., Yegnasubramanian, S., Lin, X., Demarzo, A. M. & Nelson, W. G., 2004, In : Journal of Cellular Biochemistry. 91, 3, p. 540-552 13 p.

Research output: Contribution to journalArticle

CpG Islands
Biomarkers
Prostatic Neoplasms
DNA
Polymerase Chain Reaction

Hypermethylation of CpG Islands in Primary and Metastatic Human Prostate Cancer

Yegnasubramanian, S., Kowalski, J., Gonzalgo, M. L., Zahurak, M., Piantadosi, S., Walsh, P., Bova, G. S., Demarzo, A. M., Isaacs, W. B. & Nelson, W. G., Mar 15 2004, In : Cancer Research. 64, 6, p. 1975-1986 12 p.

Research output: Contribution to journalArticle

CpG Islands
Prostatic Neoplasms
Prostate
Cyclooxygenase 2
Cell Line

MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: Changes in chromatin structure induced by treatment with 5-aza-cytidine

David, G. L., Yegnasubramanian, S., Kumar, A., Marchi, V. L., Demarzo, A. M., Lin, X. & Nelson, W. G., Jun 2004, In : Cancer Biology and Therapy. 3, 6, p. 540-548 9 p.

Research output: Contribution to journalArticle

Cytidine
MCF-7 Cells
Chromatin
Breast Neoplasms
Methylation

Molecular biomarker in prostate cancer: The role of CpG island hypermethylation

Bastian, P. J., Yegnasubramanian, S., Palapattu, G. S., Rogers, C. G., Lin, X., Demarzo, A. M. & Nelson, W. G., Dec 2004, In : European Urology. 46, 6, p. 698-708 11 p.

Research output: Contribution to journalArticle

CpG Islands
Prostatic Neoplasms
Biomarkers
Neoplasms
Neoplasm Grading

Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysis

Gonzalgo, M. L., Yegnasubramanian, S., Yan, G., Rogers, C. G., Nicol, T. L., Nelson, W. G. & Pavlovich, C., Nov 1 2004, In : Clinical Cancer Research. 10, 21, p. 7276-7283 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Methylation
Cluster Analysis
Technology
Kidney
1999

An equilibrium model of endothelial cell adhesion via integrin-dependent and integrin-independent ligands

Chan, B. P., Bhat, V. D., Yegnasubramanian, S., Reichert, W. M. & Truskey, G. A., Dec 1999, In : Biomaterials. 20, 23-24, p. 2395-2403 9 p.

Research output: Contribution to journalArticle

Avidin
Cell adhesion
Endothelial cells
Cell Adhesion
Integrins