S Yegnasubramanian

Associate Professor

19992019

Research output per year

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Research Output

2014

The diet as a cause of human prostate cancer

Nelson, W. G., Demarzo, A. M. & Yegnasubramanian, S., Jan 1 2014, In : Cancer treatment and research. 159, p. 51-68 18 p.

Research output: Contribution to journalArticle

2013

Aiming for the outliers: Cancer precision medicine through targeting kinases with extreme expression

Yegnasubramanian, S. & Maitra, A., Mar 2013, In : Cancer Discovery. 3, 3, p. 252-254 3 p.

Research output: Contribution to journalArticle

A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes

Shinohara, D. B., Vaghasia, A. M., Yu, S. H., Mak, T. N., Brüggemann, H., Nelson, W. G., De Marzo, A. M., Yegnasubramanian, S. & Sfanos, K. S., Jun 1 2013, In : Prostate. 73, 9, p. 1007-1015 9 p.

Research output: Contribution to journalArticle

Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli

Canene-Adams, K., Sfanos, K., Liang, C. T., Yegnasubramanian, S., Nelson, W. G., Brayton, C. & Demarzo, A. M., Nov 27 2013, In : PLoS One. 8, 11, e79842.

Research output: Contribution to journalArticle

DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases

Aryee, M. J., Liu, W., Engelmann, J. C., Nuhn, P., Gurel, M., Haffner, M. C., Esopi, D., Irizarry, R. A., Getzenberg, R. H., Nelson, W. G., Luo, J., Xu, J., Isaacs, W. B., Bova, G. S. & Yegnasubramanian, S., Jan 23 2013, In : Science Translational Medicine. 5, 169, 169ra10.

Research output: Contribution to journalArticle

Epigenetic changes in prostate cancer

Nelson, W. G., Haffner, M. C., Demarzo, A. M. & Yegnasubramanian, S., Jul 1 2013, Prostate Cancer: A Comprehensive Perspective. Springer-Verlag London Ltd, p. 169-179 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Explanatory chapter: Next generation sequencing

Yegnasubramanian, S., 2013, Methods in Enzymology. Vol. 529. p. 201-208 8 p. (Methods in Enzymology; vol. 529).

Research output: Chapter in Book/Report/Conference proceedingChapter

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations

Gerber, J. M., Gucwa, J., Esopi, D., Gurel, M., Haffner, M. C., Vala, M., Nelson, W. G., Jones, R. J. & Yegnasubramanian, S., May 2013, In : Oncotarget. 4, 5, p. 715-728 14 p.

Research output: Contribution to journalArticle

Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer

Weier, C., Haffner, M. C., Mosbruger, T., Esopi, D. M., Hicks, J., Zheng, Q., Fedor, H., Isaacs, W. B., De Marzo, A. M., Nelson, W. G. & Yegnasubramanian, S., Jun 1 2013, In : Journal of Pathology. 230, 2, p. 174-183 10 p.

Research output: Contribution to journalArticle

Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer

Schweizer, M. T., Lin, J., Blackford, A., Bardia, A., King, S., Armstrong, A. J., Rudek-Renaut, M., Yegnasubramanian, S. & Carducci, M. A., Dec 2013, In : Prostate Cancer and Prostatic Diseases. 16, 4, p. 357-361 5 p.

Research output: Contribution to journalArticle

Preparation of fragment libraries for next-generation sequencing on the applied biosystems SOLiD platform

Yegnasubramanian, S., 2013, Methods in Enzymology. Vol. 529. p. 185-200 16 p. (Methods in Enzymology; vol. 529).

Research output: Chapter in Book/Report/Conference proceedingChapter

Prostate in flammation and prostate cancer

Nelson, W. G., Sfanos, K., Demarzo, A. M. & Yegnasubramanian, S., Jan 1 2013, Management of Prostate Cancer: Third Edition. Humana Press Inc., p. 103-115 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Resistance emerges to second-generation antiandrogens in prostate cancer

Nelson, W. G. & Yegnasubramanian, S., Sep 1 2013, In : Cancer discovery. 3, 9, p. 971-974 4 p.

Research output: Contribution to journalArticle

Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene

Alder, J., Parry, E. M., Yegnasubramanian, S., Wagner, C. L., Lieblich, L. M., Auerbach, R., Auerbach, A. D., Wheelan, S. & Armanios, M., Nov 2013, In : Human Mutation. 34, 11, p. 1481-1485 5 p.

Research output: Contribution to journalArticle

Tight correlation of 5-hydroxymethylcytosine and Polycomb marks in health and disease

Haffner, M. C., Pellakuru, L. G., Ghosh, S., Lotan, T., Nelson, W. G., Demarzo, A. M. & Yegnasubramanian, S., Jun 15 2013, In : Cell cycle (Georgetown, Tex.). 12, 12, p. 1835-1841 7 p.

Research output: Contribution to journalArticle

Tracking the clonal origin of lethal prostate cancer

Haffner, M. C., Mosbruger, T., Esopi, D. M., Fedor, H., Heaphy, C. M., Walker, D. A., Adejola, N., Gürel, M., Hicks, J., Meeker, A. K., Halushka, M. K., Simons, J. W., Isaacs, W. B., De Marzo, A. M., Nelson, W. G. & Yegnasubramanian, S., Nov 1 2013, In : Journal of Clinical Investigation. 123, 11, p. 4918-4922 5 p.

Research output: Contribution to journalArticle

2012

A DNA hypermethylation module for the stem/progenitor cell signature of cancer

Easwaran, H., Johnstone, S. E., Van Neste, L., Ohm, J., Mosbruger, T., Wang, Q., Aryee, M. J., Joyce, P., Ahuja, N., Weisenberger, D., Collisson, E., Zhu, J., Yegnasubramanian, S., Matsui, W. & Baylin, S. B., May 2012, In : Genome Research. 22, 5, p. 837-849 13 p.

Research output: Contribution to journalArticle

A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts

Ribas, J., Ni, X., Castanares, M., Liu, M. M., Esopi, D., Yegnasubramanian, S., Rodriguez, R., Mendell, J. T. & Lupold, S., Aug 2012, In : Nucleic Acids Research. 40, 14, p. 6821-6833 13 p.

Research output: Contribution to journalArticle

Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer

Hu, R., Lu, C., Mostaghel, E. A., Yegnasubramanian, S., Gurel, M., Tannahill, C., Edwards, J., Isaacs, W. B., Nelson, P. S., Bluemn, E., Plymate, S. R. & Luo, J., Jul 15 2012, In : Cancer Research. 72, 14, p. 3457-3462 6 p.

Research output: Contribution to journalArticle

Global levels of H3K27me3 track with differentiation in Vivo and are deregulated by MYC in prostate cancer

Pellakuru, L. G., Iwata, T., Gurel, B., Schultz, D., Hicks, J., Bethel, C., Yegnasubramanian, S. & Demarzo, A. M., Aug 2012, In : American Journal of Pathology. 181, 2, p. 560-569 10 p.

Research output: Contribution to journalArticle

Overexpression of ribosomal RNA in prostate cancer is common but not linked to rDNA promoter hypomethylation

Uemura, M., Zheng, Q., Koh, C. M., Nelson, W. G., Yegnasubramanian, S. & Demarzo, A. M., Mar 8 2012, In : Oncogene. 31, 10, p. 1254-1263 10 p.

Research output: Contribution to journalArticle

Prospective study of genomic hypomethylation of leukocyte DNA and colorectal cancer risk

Huang, W. Y., Su, L. J., Hayes, R. B., Moore, L. E., Katki, H. A., Berndt, S. I., Weissfeld, J. L., Yegnasubramanian, S. & Purdue, M. P., Nov 2012, In : Cancer Epidemiology Biomarkers and Prevention. 21, 11, p. 2014-2021 8 p.

Research output: Contribution to journalArticle

USP2a Activation of MYC in Prostate Cancer

Nelson, W. G., Demarzo, A. M. & Yegnasubramanian, S., Mar 2012, In : Cancer Discovery. 2, 3, p. 206-207 2 p.

Research output: Contribution to journalArticle

2011

Accurate genome-scale percentage DNA methylation estimates from microarray data

Aryee, M. J., Wu, Z., Ladd-Acosta, C. M., Herb, B., Feinberg, A. P., Yegnasubramanian, S. & Irizarry, R. A., Apr 2011, In : Biostatistics. 12, 2, p. 197-210 14 p.

Research output: Contribution to journalArticle

Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene

Koh, C. M., Gurel, B., Sutcliffe, S., Aryee, M. J., Schultz, D., Iwata, T., Uemura, M., Zeller, K. I., Anele, U., Zheng, Q., Hicks, J. L., Nelson, W. G., Dang, C. V., Yegnasubramanian, S. & De Marzo, A. M., Apr 2011, In : American Journal of Pathology. 178, 4, p. 1824-1834 11 p.

Research output: Contribution to journalArticle

A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment

Platz, E. A., Yegnasubramanian, S., Liu, J., Chong, C. R., Shim, J. S., Kenfield, S. A., Stampfer, M. J., Willett, W. C., Giovannucci, E. & Nelson, W. G., Jun 2011, In : Cancer Discovery. 1, 1, p. 68-77 10 p.

Research output: Contribution to journalArticle

Beefing up Prostate Cancer Therapy with Performance-Enhancing (Anti-) Steroids

Nelson, W. G., Haffner, M. C. & Yegnasubramanian, S., Jul 12 2011, In : Cancer Cell. 20, 1, p. 7-9 3 p.

Research output: Contribution to journalArticle

Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences

Yegnasubramanian, S., Wu, Z., Haffner, M. C., Esopi, D., Aryee, M. J., Badrinath, R., He, T. L., Morgan, J. D., Carvalho, B., Zheng, Q., Demarzo, A. M., Irizarry, R. A. & Nelson, W. G., Jun 13 2011, In : BMC Genomics. 12, 313.

Research output: Contribution to journalArticle

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

Lin, J., Haffner, M. C., Zhang, Y., Lee, B. H., Brennen, W., Britton, J., Kachhap, S., Shim, J. S., Liu, J., Nelson, W. G., Yegnasubramanian, S. & Carducci, M. A., Mar 1 2011, In : Prostate. 71, 4, p. 333-343 11 p.

Research output: Contribution to journalArticle

Etiology of prostate cancer: Role of inflammation

Nelson, W. G., Isaacs, W. B. & Yegnasubramanian, S., Jan 1 2011, Recent Advances in Prostate Cancer: Basic Science Discoveries and Clinical Advances. World Scientific Publishing Co., p. 97-132 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers

Haffner, M. C., Chaux, A., Meeker, A. K., Esopi, D. M., Gerber, J., Pellakuru, L. G., Toubaji, A., Argani, P., Iacobuzio-Donahue, C., Nelson, W. G., Netto, G. J., Demarzo, A. M. & Yegnasubramanian, S., Aug 2011, In : Oncotarget. 2, 8, p. 627-637 11 p.

Research output: Contribution to journalArticle

Humanizing π-class glutathione s-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., Demarzo, A. M., Speed, T., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G., Oct 11 2011, In : PLoS One. 6, 10, e25707.

Research output: Contribution to journalArticle

Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines

Sfanos, K., Aloia, A. L., Hicks, J. L., Esopi, D. M., Steranka, J. P., Shao, W., Sanchez-Martinez, S., Yegnasubramanian, S., Burns, K., Rein, A. & Demarzo, A. M., 2011, In : PLoS One. 6, 6, e20874.

Research output: Contribution to journalArticle

Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms

Koh, C. M., Iwata, T., Zheng, Q., Bethel, C., Yegnasubramanian, S. & De Marzo, A. M., Sep 2011, In : Oncotarget. 2, 9, p. 669-683 15 p.

Research output: Contribution to journalArticle

Open Access

Transcription-induced DNA double strand breaks: Both oncogenic force and potential therapeutic target?

Haffner, M. C., De Marzo, A. M., Meeker, A. K., Nelson, W. G. & Yegnasubramanian, S., Jun 15 2011, In : Clinical Cancer Research. 17, 12, p. 3858-3864 7 p.

Research output: Contribution to journalReview article

2010

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

Haffner, M. C., Aryee, M. J., Toubaji, A., Esopi, D. M., Albadine, R., Gurel, B., Isaacs, W. B., Bova, G. S., Liu, W., Xu, J., Meeker, A. K., Netto, G., Demarzo, A. M., Nelson, W. G. & Yegnasubramanian, S., Aug 2010, In : Nature Genetics. 42, 8, p. 668-675 8 p.

Research output: Contribution to journalArticle

Loss of kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth

Zhang, P., Singh, A., Yegnasubramanian, S., Esopi, D., Kombairaju, P., Bodas, M., Wu, H., Bova, S. G. & Biswal, S., Feb 1 2010, In : Molecular cancer therapeutics. 9, 2, p. 336-346 11 p.

Research output: Contribution to journalArticle

MYC and prostate cancer

Koh, C. M., Bieberich, C. J., Dang, C. V., Nelson, W. G., Yegnasubramanian, S. & Demarzo, A. M., 2010, In : Genes and Cancer. 1, 6, p. 617-628 12 p.

Research output: Contribution to journalArticle

MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells

Iwata, T., Schultz, D., Hicks, J., Hubbard, G. K., Mutton, L. N., Lotan, T., Bethel, C., Lotz, M. T., Yegnasubramanian, S., Nelson, W. G., Dang, C. V., Xu, M., Anele, U., Koh, C. M., Bieberich, C. J. & Demarzo, A. M., Feb 25 2010, In : PLoS One. 5, 2, e9427.

Research output: Contribution to journalArticle

Prostate cancer: New answers prompt new questions regarding cell of origin

De Marzo, A. M., Nelson, W. G., Bieberich, C. J. & Yegnasubramanian, S., Dec 1 2010, In : Nature Reviews Urology. 7, 12, p. 650-652 3 p.

Research output: Contribution to journalArticle

2009

Anti-inflammatory drugs, antioxidants, and prostate cancer prevention

Bardia, A., Platz, E. A., Yegnasubramanian, S., Demarzo, A. M. & Nelson, W. G., Aug 2009, In : Current Opinion in Pharmacology. 9, 4, p. 419-426 8 p.

Research output: Contribution to journalArticle

Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

Liu, W., Laitinen, S., Khan, S., Vihinen, M., Kowalski, J., Yu, G., Chen, L., Ewing, C. M., Eisenberger, M., Carducci, M. A., Nelson, W. G., Yegnasubramanian, S., Luo, J., Wang, Y., Xu, J., Isaacs, W. B., Visakorpi, T. & Bova, G. S., May 2009, In : Nature Medicine. 15, 5, p. 559-565 7 p.

Research output: Contribution to journalArticle

Erratum: Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer (Nature Medicine (2009) 15 (559-565))

Liu, W., Laitinen, S., Khan, S., Vihinen, M., Kowalski, J., Yu, G., Chen, L., Ewing, C. M., Eisenberger, M., Carducci, M. A., Nelson, W. G., Yegnasubramanian, S., Luo, J., Wang, Y., Xu, J., Isaacs, W. B., Visakorpi, T. & Bova, G. S., Jul 2009, In : Nature Medicine. 15, 7, p. 819 1 p.

Research output: Contribution to journalArticle

Genetic and epigenetic inactivation of LPL gene in human prostate cancer

Kim, J. W., Cheng, Y., Liu, W., Li, T., Yegnasubramanian, S., Zheng, S. L., Xu, J., Isaacs, W. B. & Chang, B. L., Feb 1 2009, In : International Journal of Cancer. 124, 3, p. 734-738 5 p.

Research output: Contribution to journalArticle

Minireview: Epigenetic alterations in human prostate cancers

Nelson, W. G., De Marzo, A. M. & Yegnasubramanian, S., Sep 1 2009, In : Endocrinology. 150, 9, p. 3991-4002 12 p.

Research output: Contribution to journalShort survey

miR-21: An androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth

Ribas, J., Ni, X., Haffner, M., Wentzel, E. A., Salmasi, A. H., Chowdhury, W. H., Kudrolli, T. A., Yegnasubramanian, S., Luo, J., Rodriguez, R., Mendell, J. T. & Lupold, S., 2009, In : Cancer Research. 69, 18, p. 7165-7169 5 p.

Research output: Contribution to journalArticle

2008

CpG-insel-hypermethylierung der DNA: Perspektiven eines molekularen biomarkers für das prostatakarzinom

Translated title of the contribution: CpG island hypermethylation of the DNA: Perspectives of a molecular biomarker for prostate cancerBastian, P. J., Ellinger, J., Von Rücker, A., Müller, S. C., Yegnasubramanian, S., Nelson, W. G. & Stief, C. G., Sep 1 2008, In : Urologe - Ausgabe A. 47, 9, p. 1205-1207 3 p.

Research output: Contribution to journalArticle