S Yegnasubramanian

Associate Professor

19992019
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Research Output 1999 2019

1999

An equilibrium model of endothelial cell adhesion via integrin-dependent and integrin-independent ligands

Chan, B. P., Bhat, V. D., Yegnasubramanian, S., Reichert, W. M. & Truskey, G. A., Dec 1999, In : Biomaterials. 20, 23-24, p. 2395-2403 9 p.

Research output: Contribution to journalArticle

Avidin
Cell adhesion
Endothelial cells
Cell Adhesion
Integrins
2004

GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer

Nakayama, M., Gonzalgo, M. L., Yegnasubramanian, S., Lin, X., Demarzo, A. M. & Nelson, W. G., 2004, In : Journal of Cellular Biochemistry. 91, 3, p. 540-552 13 p.

Research output: Contribution to journalArticle

CpG Islands
Biomarkers
Prostatic Neoplasms
DNA
Polymerase Chain Reaction

Hypermethylation of CpG Islands in Primary and Metastatic Human Prostate Cancer

Yegnasubramanian, S., Kowalski, J., Gonzalgo, M. L., Zahurak, M., Piantadosi, S., Walsh, P., Bova, G. S., Demarzo, A. M., Isaacs, W. B. & Nelson, W. G., Mar 15 2004, In : Cancer Research. 64, 6, p. 1975-1986 12 p.

Research output: Contribution to journalArticle

CpG Islands
Prostatic Neoplasms
Prostate
Cyclooxygenase 2
Cell Line

MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: Changes in chromatin structure induced by treatment with 5-aza-cytidine

David, G. L., Yegnasubramanian, S., Kumar, A., Marchi, V. L., Demarzo, A. M., Lin, X. & Nelson, W. G., Jun 2004, In : Cancer Biology and Therapy. 3, 6, p. 540-548 9 p.

Research output: Contribution to journalArticle

Cytidine
MCF-7 Cells
Chromatin
Breast Neoplasms
Methylation

Molecular biomarker in prostate cancer: The role of CpG island hypermethylation

Bastian, P. J., Yegnasubramanian, S., Palapattu, G. S., Rogers, C. G., Lin, X., Demarzo, A. M. & Nelson, W. G., Dec 2004, In : European Urology. 46, 6, p. 698-708 11 p.

Research output: Contribution to journalArticle

CpG Islands
Prostatic Neoplasms
Biomarkers
Neoplasms
Neoplasm Grading

Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysis

Gonzalgo, M. L., Yegnasubramanian, S., Yan, G., Rogers, C. G., Nicol, T. L., Nelson, W. G. & Pavlovich, C., Nov 1 2004, In : Clinical Cancer Research. 10, 21, p. 7276-7283 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Methylation
Cluster Analysis
Technology
Kidney
2005

Erratum: Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer (Journal of Biological Chemistry (2005) 280 (18302-18310))

Agoston, A. T., Argani, P., Yegnasubramanian, S., Demarzo, A. M., Ansari-Lari, M. A., Hicks, J. L., Davidson, N. E. & Nelson, W. G., Aug 5 2005, In : Journal of Biological Chemistry. 280, 31, p. 28828 1 p.

Research output: Contribution to journalArticle

Protein Stability
Methyltransferases
Breast Neoplasms
DNA
Proteins

Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer

Agoston, A. T., Argani, P., Yegnasubramanian, S., Demarzo, A. M., Ansari-Lari, M. A., Hicks, J. L., Davidson, N. E. & Nelson, W. G., May 6 2005, In : Journal of Biological Chemistry. 280, 18, p. 18302-18310 9 p.

Research output: Contribution to journalArticle

Protein Stability
Methyltransferases
Breast Neoplasms
DNA
Proteins

Preoperative serum DNA GSTP1 CpG island hypermethylation and the risk of early prostate-specific antigen recurrence following radical prostatectomy

Bastian, P. J., Palapattu, G. S., Lin, X., Yegnasubramanian, S., Mangold, L. A., Trock, B., Eisenberger, M., Partin, A. W. & Nelson, W. G., Jun 1 2005, In : Clinical Cancer Research. 11, 11, p. 4037-4043 7 p.

Research output: Contribution to journalArticle

CpG Islands
Prostate-Specific Antigen
Prostatectomy
Recurrence
DNA

Procainamide is a specific inhibitor of DNA methyltransferase 1

Lee, B. H., Yegnasubramanian, S., Lin, X. & Nelson, W. G., Dec 9 2005, In : Journal of Biological Chemistry. 280, 49, p. 40749-40756 8 p.

Research output: Contribution to journalArticle

Procainamide
Methyltransferases
DNA
5-methyldeoxycytidine
HCT116 Cells
2006
DNA Methylation
CpG Islands
Prostate
Enzymes
DNA
2007

Abnormal DNA methylation, epigenetics, and prostate cancer

Nelson, W. G., Yegnasubramanian, S., Agoston, A. T., Bastian, P. J., Lee, B. H., Nakayama, M. & Demarzo, A. M., May 1 2007, In : Frontiers in bioscience : a journal and virtual library. 12, 11, p. 4254-4266 13 p.

Research output: Contribution to journalArticle

Oncology
DNA sequences
Methyltransferases
Biomarkers
DNA Methylation

Prognostic value of preoperative serum cell-free circulating DNA in men with prostate cancer undergoing radical prostatectomy

Bastian, P. J., Palapattu, G. S., Yegnasubramanian, S., Lin, X., Rogers, C. G., Mangold, L. A., Trock, B., Eisenberger, M., Partin, A. W. & Nelson, W. G., Sep 15 2007, In : Clinical Cancer Research. 13, 18, p. 5361-5367 7 p.

Research output: Contribution to journalArticle

Prostatectomy
Prostate-Specific Antigen
Prostatic Neoplasms
DNA
Serum
2008

CpG-insel-hypermethylierung der DNA: Perspektiven eines molekularen biomarkers für das prostatakarzinom

Translated title of the contribution: CpG island hypermethylation of the DNA: Perspectives of a molecular biomarker for prostate cancerBastian, P. J., Ellinger, J., Von Rücker, A., Müller, S. C., Yegnasubramanian, S., Nelson, W. G. & Stief, C. G., Sep 2008, In : Urologe - Ausgabe A. 47, 9, p. 1205-1207 3 p.

Research output: Contribution to journalArticle

CpG Islands
Prostatic Neoplasms
Biomarkers
DNA
Prostatectomy

CpG Island hypermethylation profile in the serum of men with clinically localized and hormone refractory metastatic prostate cancer

Bastian, P. J., Palapattu, G. S., Yegnasubramanian, S., Rogers, C. G., Lin, X., Mangold, L. A., Trock, B., Eisenberger, M., Partin, A. W. & Nelson, W. G., Feb 2008, In : Journal of Urology. 179, 2, p. 529-534 6 p.

Research output: Contribution to journalArticle

CpG Islands
Prostatic Neoplasms
Hormones
Serum
Genes

DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity

Yegnasubramanian, S., Haffner, M. C., Zhang, Y., Gurel, B., Cornish, T. C., Wu, Z., Irizarry, R. A., Morgan, J., Hicks, J., DeWeese, T., Isaacs, W. B., Bova, G. S., Demarzo, A. M. & Nelson, W. G., Nov 1 2008, In : Cancer Research. 68, 21, p. 8954-8967 14 p.

Research output: Contribution to journalArticle

CpG Islands
Prostatic Neoplasms
DNA
Neoplasms
Prostate

Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors

Netto, G. J., Nakai, Y., Nakayama, M., Jadallah, S., Toubaji, A., Nonomura, N., Albadine, R., Hicks, J. L., Epstein, J. I., Yegnasubramanian, S., Nelson, W. G. & Demarzo, A. M., Nov 2008, In : Modern Pathology. 21, 11, p. 1337-1344 8 p.

Research output: Contribution to journalArticle

Seminoma
Germ Cells
DNA
Methylation
Neoplasms

Molecular alterations in prostate cancer as diagnostic, prognostic, and therapeutic targets

Gurel, B., Iwata, T., Koh, C. M., Yegnasubramanian, S., Nelson, W. G. & Demarzo, A. M., Nov 2008, In : Advances in Anatomic Pathology. 15, 6, p. 319-331 13 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Therapeutics
Molecular Pathology
Cause of Death
Adenocarcinoma

Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fibroblasts.

Suzuki, T., Farrar, J. E., Yegnasubramanian, S., Zahed, M., Suzuki, N. & Arceci, R. J., Sep 2008, In : Epigenetics. 3, 5, p. 281-291 11 p.

Research output: Contribution to journalArticle

Cell Aging
Fibroblasts
DNA
Small Interfering RNA
5-Methylcytosine
2009

Anti-inflammatory drugs, antioxidants, and prostate cancer prevention

Bardia, A., Platz, E. A., Yegnasubramanian, S., Demarzo, A. M. & Nelson, W. G., Aug 2009, In : Current Opinion in Pharmacology. 9, 4, p. 419-426 8 p.

Research output: Contribution to journalArticle

Chemoprevention
Prostatic Neoplasms
Anti-Inflammatory Agents
Antioxidants
Prostate

Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

Liu, W., Laitinen, S., Khan, S., Vihinen, M., Kowalski, J., Yu, G., Chen, L., Ewing, C. M., Eisenberger, M., Carducci, M. A., Nelson, W. G., Yegnasubramanian, S., Luo, J., Wang, Y., Xu, J., Isaacs, W. B., Visakorpi, T. & Bova, G. S., May 2009, In : Nature Medicine. 15, 5, p. 559-565 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Clone cells
Cells
Polymorphism
Neoplasms

Erratum: Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer (Nature Medicine (2009) 15 (559-565))

Liu, W., Laitinen, S., Khan, S., Vihinen, M., Kowalski, J., Yu, G., Chen, L., Ewing, C. M., Eisenberger, M., Carducci, M. A., Nelson, W. G., Yegnasubramanian, S., Luo, J., Wang, Y., Xu, J., Isaacs, W. B., Visakorpi, T. & Bova, G. S., Jul 2009, In : Nature Medicine. 15, 7, p. 819 1 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Medicine

Genetic and epigenetic inactivation of LPL gene in human prostate cancer

Kim, J. W., Cheng, Y., Liu, W., Li, T., Yegnasubramanian, S., Zheng, S. L., Xu, J., Isaacs, W. B. & Chang, B. L., Feb 1 2009, In : International Journal of Cancer. 124, 3, p. 734-738 5 p.

Research output: Contribution to journalArticle

Lipoprotein Lipase
Epigenomics
Prostatic Neoplasms
Genes
CpG Islands

Minireview: Epigenetic alterations in human prostate cancers

Nelson, W. G., Demarzo, A. M. & Yegnasubramanian, S., Sep 2009, In : Endocrinology. 150, 9, p. 3991-4002 12 p.

Research output: Contribution to journalArticle

Epigenomics
Prostatic Neoplasms
Androgens
Genome
Phenotype

miR-21: An androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth

Ribas, J., Ni, X., Haffner, M., Wentzel, E. A., Salmasi, A. H., Chowdhury, W. H., Kudrolli, T. A., Yegnasubramanian, S., Luo, J., Rodriguez, R., Mendell, J. T. & Lupold, S., 2009, In : Cancer Research. 69, 18, p. 7165-7169 5 p.

Research output: Contribution to journalArticle

Androgen Receptors
MicroRNAs
Androgens
Prostatic Neoplasms
Hormones
2010

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

Haffner, M. C., Aryee, M. J., Toubaji, A., Esopi, D. M., Albadine, R., Gurel, B., Isaacs, W. B., Bova, G. S., Liu, W., Xu, J., Meeker, A. K., Netto, G., Demarzo, A. M., Nelson, W. G. & Yegnasubramanian, S., Aug 2010, In : Nature Genetics. 42, 8, p. 668-675 8 p.

Research output: Contribution to journalArticle

Gene Rearrangement
Neoplasm Genes
Androgens
Prostatic Neoplasms
Androgen Receptors

Loss of kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth

Zhang, P., Singh, A., Yegnasubramanian, S., Esopi, D., Kombairaju, P., Bodas, M., Wu, H., Bova, S. G. & Biswal, S., Feb 2010, In : Molecular Cancer Therapeutics. 9, 2, p. 336-346 11 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Growth
Neoplasms
Pharmaceutical Preparations
Glutathione

MYC and prostate cancer

Koh, C. M., Bieberich, C. J., Dang, C. V., Nelson, W. G., Yegnasubramanian, S. & Demarzo, A. M., 2010, In : Genes and Cancer. 1, 6, p. 617-628 12 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Disease Progression
Neoplasms
Adenocarcinoma
Prostatic Intraepithelial Neoplasia

MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells

Iwata, T., Schultz, D., Hicks, J., Hubbard, G. K., Mutton, L. N., Lotan, T., Bethel, C., Lotz, M. T., Yegnasubramanian, S., Nelson, W. G., Dang, C. V., Xu, M., Anele, U., Koh, C. M., Bieberich, C. J. & Demarzo, A. M., Feb 25 2010, In : PLoS One. 5, 2, e9427.

Research output: Contribution to journalArticle

Prostatic Intraepithelial Neoplasia
epithelial cells
Epithelial Cells
neoplasms
mice

Prostate cancer: New answers prompt new questions regarding cell of origin

Demarzo, A. M., Nelson, W. G., Bieberich, C. J. & Yegnasubramanian, S., Dec 2010, In : Nature Reviews Urology. 7, 12, p. 650-652 3 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
2011

Accurate genome-scale percentage DNA methylation estimates from microarray data

Aryee, M. J., Wu, Z., Ladd-Acosta, C. M., Herb, B., Feinberg, A. P., Yegnasubramanian, S. & Irizarry, R. A., Apr 2011, In : Biostatistics. 12, 2, p. 197-210 14 p.

Research output: Contribution to journalArticle

DNA Methylation
Microarray Data
Methylation
Percentage
Genome

Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene

Koh, C. M., Gurel, B., Sutcliffe, S., Aryee, M. J., Schultz, D., Iwata, T., Uemura, M., Zeller, K. I., Anele, U., Zheng, Q., Hicks, J. L., Nelson, W. G., Dang, C. V., Yegnasubramanian, S. & Demarzo, A. M., Apr 2011, In : American Journal of Pathology. 178, 4, p. 1824-1834 11 p.

Research output: Contribution to journalArticle

Oncogenes
Prostate
Gene Expression
Prostatic Neoplasms
Neoplasms

A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment

Platz, E. A., Yegnasubramanian, S., Liu, J., Chong, C. R., Shim, J. S., Kenfield, S. A., Stampfer, M. J., Willett, W. C., Giovannucci, E. & Nelson, W. G., Jun 2011, In : Cancer Discovery. 1, 1, p. 68-77 10 p.

Research output: Contribution to journalArticle

Digoxin
Prostatic Neoplasms
Pharmaceutical Preparations
Therapeutics
Drug Repositioning

Beefing up Prostate Cancer Therapy with Performance-Enhancing (Anti-) Steroids

Nelson, W. G., Haffner, M. C. & Yegnasubramanian, S., Jul 12 2011, In : Cancer Cell. 20, 1, p. 7-9 3 p.

Research output: Contribution to journalArticle

Androgens
Prostatic Neoplasms
Steroids
New England
Medicine

Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences

Yegnasubramanian, S., Wu, Z., Haffner, M. C., Esopi, D., Aryee, M. J., Badrinath, R., He, T. L., Morgan, J. D., Carvalho, B., Zheng, Q., Demarzo, A. M., Irizarry, R. A. & Nelson, W. G., Jun 13 2011, In : BMC Genomics. 12, 313.

Research output: Contribution to journalArticle

Intergenic DNA
Conserved Sequence
Chromosome Mapping
DNA Methylation
Methylation

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

Lin, J., Haffner, M. C., Zhang, Y., Lee, B. H., Brennen, W., Britton, J., Kachhap, S., Shim, J. S., Liu, J., Nelson, W. G., Yegnasubramanian, S. & Carducci, M. A., Mar 1 2011, In : Prostate. 71, 4, p. 333-343 11 p.

Research output: Contribution to journalArticle

Disulfiram
Prostatic Neoplasms
Cytosine
DNA
Methyltransferases

Etiology of prostate cancer: Role of inflammation

Nelson, W. G., Isaacs, W. B. & Yegnasubramanian, S., Jan 1 2011, Recent Advances in Prostate Cancer: Basic Science Discoveries and Clinical Advances. World Scientific Publishing Co., p. 97-132 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Prostatic Neoplasms
Inflammation

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers

Haffner, M. C., Chaux, A., Meeker, A. K., Esopi, D. M., Gerber, J., Pellakuru, L. G., Toubaji, A., Argani, P., Iacobuzio-Donahue, C., Nelson, W. G., Netto, G. J., Demarzo, A. M. & Yegnasubramanian, S., Aug 2011, In : Oncotarget. 2, 8, p. 627-637 11 p.

Research output: Contribution to journalArticle

Stem Cells
Neoplasms
5-hydroxymethylcytosine
Cytosine
DNA Methylation

Humanizing π-class glutathione s-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., Demarzo, A. M., Speed, T., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G., Oct 11 2011, In : PLoS One. 6, 10, e25707.

Research output: Contribution to journalArticle

acetaminophen
overdose
hepatotoxicity
Acetaminophen
Transferases

Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines

Sfanos, K., Aloia, A. L., Hicks, J. L., Esopi, D. M., Steranka, J. P., Shao, W., Sanchez-Martinez, S., Yegnasubramanian, S., Burns, K., Rein, A. & Demarzo, A. M., 2011, In : PLoS One. 6, 6, e20874.

Research output: Contribution to journalArticle

Gammaretrovirus
prostatic neoplasms
Prostatic Neoplasms
Cells
cell lines

Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms

Koh, C. M., Iwata, T., Zheng, Q., Bethel, C., Yegnasubramanian, S. & Demarzo, A. M., Sep 2011, In : Oncotarget. 2, 9, p. 669-683 15 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasms
Up-Regulation
Prostate
pol Genes
Double-Stranded DNA Breaks
Prostatic Neoplasms
DNA-Activated Protein Kinase
Type II DNA Topoisomerase
DNA Repair
2012

A DNA hypermethylation module for the stem/progenitor cell signature of cancer

Easwaran, H., Johnstone, S. E., Van Neste, L., Ohm, J., Mosbruger, T., Wang, Q., Aryee, M. J., Joyce, P., Ahuja, N., Weisenberger, D., Collisson, E., Zhu, J., Yegnasubramanian, S., Matsui, W. & Baylin, S. B., May 2012, In : Genome Research. 22, 5, p. 837-849 13 p.

Research output: Contribution to journalArticle

Stem Cells
DNA
Chromatin
Embryonic Stem Cells
Neoplasms

A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts

Ribas, J., Ni, X., Castanares, M., Liu, M. M., Esopi, D., Yegnasubramanian, S., Rodriguez, R., Mendell, J. T. & Lupold, S., Aug 2012, In : Nucleic Acids Research. 40, 14, p. 6821-6833 13 p.

Research output: Contribution to journalArticle

Polyadenylation
Vacuoles
Membrane Proteins
Genes
MicroRNAs
Glioma
Brain
Phenotype
brain
phenotype

Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer

Hu, R., Lu, C., Mostaghel, E. A., Yegnasubramanian, S., Gurel, M., Tannahill, C., Edwards, J., Isaacs, W. B., Nelson, P. S., Bluemn, E., Plymate, S. R. & Luo, J., Jul 15 2012, In : Cancer Research. 72, 14, p. 3457-3462 6 p.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
Ligands
Therapeutics

Global levels of H3K27me3 track with differentiation in Vivo and are deregulated by MYC in prostate cancer

Pellakuru, L. G., Iwata, T., Gurel, B., Schultz, D., Hicks, J., Bethel, C., Yegnasubramanian, S. & Demarzo, A. M., Aug 2012, In : American Journal of Pathology. 181, 2, p. 560-569 10 p.

Research output: Contribution to journalArticle

Chromatin
Prostatic Neoplasms
Stem Cells
Prostatic Intraepithelial Neoplasia
Neoplasms

Overexpression of ribosomal RNA in prostate cancer is common but not linked to rDNA promoter hypomethylation

Uemura, M., Zheng, Q., Koh, C. M., Nelson, W. G., Yegnasubramanian, S. & Demarzo, A. M., Mar 8 2012, In : Oncogene. 31, 10, p. 1254-1263 10 p.

Research output: Contribution to journalArticle

Ribosomal DNA
Prostatic Neoplasms
Ribosomal RNA
5.8S Ribosomal RNA
18S Ribosomal RNA

Prospective study of genomic hypomethylation of leukocyte DNA and colorectal cancer risk

Huang, W. Y., Su, L. J., Hayes, R. B., Moore, L. E., Katki, H. A., Berndt, S. I., Weissfeld, J. L., Yegnasubramanian, S. & Purdue, M. P., Nov 2012, In : Cancer Epidemiology Biomarkers and Prevention. 21, 11, p. 2014-2021 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Leukocytes
Prospective Studies
Folic Acid
DNA

USP2a Activation of MYC in Prostate Cancer

Nelson, W. G., Demarzo, A. M. & Yegnasubramanian, S., Mar 2012, In : Cancer Discovery. 2, 3, p. 206-207 2 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
MicroRNAs
Prostatic Neoplasms
Messenger RNA
Deubiquitinating Enzymes