S Yegnasubramanian

Associate Professor

19992020

Research output per year

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Research Output

2020

A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target

Freeman, Z. T., Nirschl, T. R., Hovelson, D. H., Johnston, R. J., Engelhardt, J. J., Selby, M. J., Kochel, C. M., Lan, R. Y., Zhai, J., Ghasemzadeh, A., Gupta, A., Skaist, A. M., Wheelan, S. J., Jiang, H., Pearson, A. T., Snyder, L. A., Korman, A. J., Tomlins, S. A., Yegnasubramanian, S. & Drake, C. G., Mar 2 2020, In : Journal of Clinical Investigation. 130, 3, p. 1405-1416 12 p.

Research output: Contribution to journalArticle

Open Access

An in Situ Atlas of Mitochondrial DNA in Mammalian Tissues Reveals High Content in Stem and Proliferative Compartments

Chen, J., Zheng, Q., Peiffer, L. B., Hicks, J. L., Haffner, M. C., Rosenberg, A. Z., Levi, M., Wang, X. X., Ozbek, B., Baena-Del Valle, J., Yegnasubramanian, S. & De Marzo, A. M., Jul 2020, In : American Journal of Pathology. 190, 7, p. 1565-1579 15 p.

Research output: Contribution to journalArticle

Open Access

Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines

Kagohara, L. T., Zamuner, F., Davis-Marcisak, E. F., Sharma, G., Considine, M., Allen, J., Yegnasubramanian, S., Gaykalova, D. A. & Fertig, E. J., Jul 7 2020, In : British journal of cancer. 123, 1, p. 101-113 13 p.

Research output: Contribution to journalArticle

Open Access

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

Esopi, D., Graham, M. K., Brosnan-Cashman, J. A., Meyers, J., Vaghasia, A., Gupta, A., Kumar, B., Haffner, M., Heaphy, C. M., De Marzo, A. M., Meeker, A. K., Nelson, W. G., Wheelan, S. & Yegnasubramanian, S., Jan 1 2020, (Accepted/In press) In : Cellular Oncology.

Research output: Contribution to journalArticle

Open Access
2019

A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs

Giovinazzo, H., Walker, D., Wyhs, N., Liu, J., Esopi, D. M., Vaghasia, A. M., Jain, Y., Bhamidipati, A., Zhou, J., Nelson, W. G. & Yegnasubramanian, S., Apr 30 2019, In : Oncotarget. 10, 32, p. 3040-3050 11 p.

Research output: Contribution to journalArticle

Open Access

Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

Ando, M., Saito, Y., Xu, G., Bui, N. Q., Medetgul-Ernar, K., Pu, M., Fisch, K., Ren, S., Sakai, A., Fukusumi, T., Liu, C., Haft, S., Pang, J., Mark, A., Gaykalova, D. A., Guo, T., Favorov, A. V., Yegnasubramanian, S., Fertig, E. J., Ha, P. & 5 others, Tamayo, P., Yamasoba, T., Ideker, T., Messer, K. & Califano, J. A., Dec 1 2019, In : Nature communications. 10, 1, 2188.

Research output: Contribution to journalArticle

Open Access

Consequences of interleukin 1β-triggered chronic inflammation in the mouse prostate gland: Altered architecture associated with prolonged CD4+ infiltration mimics human proliferative inflammatory atrophy

Ashok, A., Keener, R., Rubenstein, M., Stookey, S., Bajpai, S., Hicks, J., Alme, A. K., Drake, C. G., Zheng, Q., Trabzonlu, L., Yegnasubramanian, S., De Marzo, A. M. & Bieberich, C. J., May 2019, In : Prostate. 79, 7, p. 732-745 14 p.

Research output: Contribution to journalArticle

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

Kong, X., Chen, J., Xie, W., Brown, S. M., Cai, Y., Wu, K., Fan, D., Nie, Y., Yegnasubramanian, S., Tiedemann, R. L., Tao, Y., Chiu Yen, R. W., Topper, M. J., Zahnow, C. A., Easwaran, H., Rothbart, S. B., Xia, L. & Baylin, S. B., Apr 15 2019, In : Cancer cell. 35, 4, p. 633-648.e7

Research output: Contribution to journalArticle

If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease

Sfanos, K. S., Yegnasubramanian, S., Nelson, W. G., Lotan, T. L., Kulac, I., Hicks, J. L., Zheng, Q., Bieberich, C. J., Haffner, M. C. & De Marzo, A. M., Jan 2019, In : Asian Journal of Urology. 6, 1, p. 10-25 16 p.

Research output: Contribution to journalReview article

Open Access

Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition

Mao, W., Ghasemzadeh, A., Freeman, Z. T., Obradovic, A., Chaimowitz, M. G., Nirschl, T. R., McKiernan, E., Yegnasubramanian, S. & Drake, C. G., Oct 25 2019, In : Journal for immunotherapy of cancer. 7, 1, 277.

Research output: Contribution to journalArticle

Open Access

Lactoferrin CpG Island Hypermethylation and Decoupling of mRNA and Protein Expression in the Early Stages of Prostate Carcinogenesis

Porter, C. M., Haffner, M., Kulac, I., Maynard, J. P., Baena-Del Valle, J. A., Isaacs, W. B., Yegnasubramanian, S., De Marzo, A. M. & Sfanos, K. S., Nov 2019, In : American Journal of Pathology. 189, 11, p. 2311-2322 12 p.

Research output: Contribution to journalArticle

Molecular pathology of high-grade prostatic intraepithelial neoplasia: Challenges and opportunities

Trabzonlu, L., Kulac, I., Zheng, Q., Hicks, J. L., Haffner, M. C., Nelson, W. G., Sfanos, K. S., Ertunc, O., Lotan, T. L., Heaphy, C. M., Meeker, A. K., Yegnasubramanian, S. & De Marzo, A. M., Apr 2019, In : Cold Spring Harbor Perspectives in Medicine. 9, 4, a030403.

Research output: Contribution to journalArticle

Publisher Correction: Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers (Nature Communications, (2019), 10, 1, (2188), 10.1038/s41467-019-09937-w)

Ando, M., Saito, Y., Xu, G., Bui, N. Q., Medetgul-Ernar, K., Pu, M., Fisch, K., Ren, S., Sakai, A., Fukusumi, T., Liu, C., Haft, S., Pang, J., Mark, A., Gaykalova, D. A., Guo, T., Favorov, A. V., Yegnasubramanian, S., Fertig, E. J., Ha, P. & 5 others, Tamayo, P., Yamasoba, T., Ideker, T., Messer, K. & Califano, J. A., Dec 1 2019, In : Nature communications. 10, 1, 2415.

Research output: Contribution to journalComment/debate

Open Access
2018

Characterization of novel cell lines derived from a MYC-driven murine model of lethal metastatic adenocarcinoma of the prostate

Markowski, M., Hubbard, G. K., Hicks, J. L., Zheng, Q., King, A., Esopi, D., Rege, A., Yegnasubramanian, S., Bieberich, C. J. & Demarzo, A. M., Jan 1 2018, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer

Haffner, M. C., Guner, G., Taheri, D., Netto, G. J., Palsgrove, D. N., Zheng, Q., Guedes, L. B., Kim, K., Tsai, H., Esopi, D. M., Lotan, T. L., Sharma, R., Meeker, A. K., Chinnaiyan, A. M., Nelson, W. G., Yegnasubramanian, S., Luo, J., Mehra, R., Antonarakis, E. S., Drake, C. G. & 1 others, De Marzo, A. M., Jun 2018, In : American Journal of Pathology. 188, 6, p. 1478-1485 8 p.

Research output: Contribution to journalArticle

ETS2 is a prostate basal cell marker and is highly expressed in prostate cancers aberrantly expressing p63

Torres, A., Alshalalfa, M., Davicioni, E., Gupta, A., Yegnasubramanian, S., Wheelan, S. J., Epstein, J. I., De Marzo, A. M. & Lotan, T. L., Sep 1 2018, In : Prostate. 78, 12, p. 896-904 9 p.

Research output: Contribution to journalArticle

Hypomethylation, endogenous retrovirus expression, and interferon signaling in testicular germ cell tumors

Haffner, M. C., Taheri, D., Luidy-Imada, E., Palsgrove, D. N., Eich, M. L., Netto, G. J., Matoso, A., Nirschl, T. R., Zheng, Q., Hicks, J. L., Nelson, W. G., De Marzo, A. M., Marchionni, L., Drake, C. G. & Yegnasubramanian, S., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8580-E8582

Research output: Contribution to journalLetter

MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer

Baena-Del Valle, J. A., Zheng, Q., Esopi, D. M., Rubenstein, M., Hubbard, G. K., Moncaliano, M. C., Hruszkewycz, A., Vaghasia, A., Yegnasubramanian, S., Wheelan, S. J., Meeker, A. K., Heaphy, C. M., Graham, M. K. & De Marzo, A. M., Jan 2018, In : Journal of Pathology. 244, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer

Shrestha, E., White, J. R., Yu, S. H., Kulac, I., Ertunc, O., De Marzo, A. M., Yegnasubramanian, S., Mangold, L. A., Partin, A. W. & Sfanos, K. S., Jan 2018, In : Journal of Urology. 199, 1, p. 161-171 11 p.

Research output: Contribution to journalArticle

Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy

Xu, X., Wu, J., Liu, S., Saw, P. E., Tao, W., Li, Y., Krygsman, L., Yegnasubramanian, S., De Marzo, A. M., Shi, J., Bieberich, C. J. & Farokhzad, O. C., Oct 11 2018, In : Small. 14, 41, 1802565.

Research output: Contribution to journalArticle

The inflammatory microenvironment and microbiome in prostate cancer development

Sfanos, K., Yegnasubramanian, S., Nelson, W. G. & Demarzo, A. M., Jan 1 2018, In : Nature Reviews Urology. 15, 1, p. 11-24 14 p.

Research output: Contribution to journalReview article

Transcriptional profiling identifies novel regulators of macrophage polarization

Gerrick, K. Y., Gerrick, E. R., Gupta, A., Wheelan, S. J., Yegnasubramanian, S. & Jaffee, E. M., Dec 2018, In : PloS one. 13, 12, e0208602.

Research output: Contribution to journalArticle

Update on Systemic Prostate Cancer Therapies: Management of Metastatic Castration-resistant Prostate Cancer in the Era of Precision Oncology

Nuhn, P., De Bono, J. S., Fizazi, K., Freedland, S. J., Grilli, M., Kantoff, P. W., Sonpavde, G., Sternberg, C. N., Yegnasubramanian, S. & Antonarakis, E., Jan 1 2018, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

2017

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination

Haffner, M. C., Esopi, D. M., Chaux, A., Gürel, M., Ghosh, S., Vaghasia, A. M., Tsai, H., Kim, K., Castagna, N., Lam, H., Hicks, J., Wyhs, N., Biswal Shinohara, D., Hurley, P. J., Simons, B. W., Schaeffer, E. M., Lotan, T. L., Isaacs, W. B., Netto, G. J., De Marzo, A. M. & 3 others, Nelson, W. G., An, S. S. & Yegnasubramanian, S., Dec 1 2017, In : Nature communications. 8, 1, 142.

Research output: Contribution to journalArticle

Androgen Receptor Splice Variants Are Not Substrates of Nonsense-Mediated Decay

Ajiboye, A. S., Esopi, D., Yegnasubramanian, S. & Denmeade, S. R., Jun 1 2017, In : Prostate. 77, 8, p. 829-837 9 p.

Research output: Contribution to journalArticle

A novel functional splice variant of AKT3 defined by analysis of alternative splice expression in HPV-positive oropharyngeal cancers

Guo, T., Sakai, A., Afsari, B., Considine, M., Danilova, L., Favorov, A. V., Yegnasubramanian, S., Kelley, D. Z., Flam, E., Ha, P. K., Khan, Z., Wheelan, S. J., Gutkind, J. S., Fertig, E. J., Gaykalova, D. A. & Califano, J., Oct 1 2017, In : Cancer Research. 77, 19, p. 5248-5258 11 p.

Research output: Contribution to journalArticle

c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks

Barfeld, S. J., Urbanucci, A., Itkonen, H. M., Fazli, L., Hicks, J. L., Thiede, B., Rennie, P. S., Yegnasubramanian, S., DeMarzo, A. M. & Mills, I. G., Apr 2017, In : EBioMedicine. 18, p. 83-93 11 p.

Research output: Contribution to journalArticle

2016

Androgen deprivation followed by acute androgen stimulation selectively sensitizes AR-positive prostate cancer cells to ionizing radiation

Hedayati, M., Haffner, M. C., Coulter, J. B., Raval, R. R., Zhang, Y., Zhou, H., Mian, O., Knight, E. J., Razavi, N., Dalrymple, S., Isaacs, J. T., Santos, A., Hales, R., Nelson, W. G., Yegnasubramanian, S. & DeWeese, T., Jul 1 2016, In : Clinical Cancer Research. 22, 13, p. 3310-3319 10 p.

Research output: Contribution to journalArticle

Combined MYC activation and Pten loss are sufficient to create genomic instability and lethal metastatic prostate cancer

Hubbard, G. K., Mutton, L. N., Khalili, M., McMullin, R. P., Hicks, J. L., Bianchi-Frias, D., Horn, L. A., Kulac, I., Moubarek, M. S., Nelson, P. S., Yegnasubramanian, S., De Marzo, A. M. & Bieberich, C. J., Jan 15 2016, In : Cancer Research. 76, 2, p. 283-292 10 p.

Research output: Contribution to journalArticle

Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation

Gondek, L., Zheng, G., Ghiaur, G., Dezern, A., Matsui, W., Yegnasubramanian, S., Lin, M-T., Levis, M. J., Eshleman, J., Varadhan, R., Tucker, N., Jones, R. J. & Gocke, C., Mar 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies

Munari, E., Chaux, A., Vaghasia, A. M., Taheri, D., Karram, S., Bezerra, S. M., Roibon, N. G., Nelson, W. G., Yegnasubramanian, S., Netto, G. J. & Haffner, M. C., Jan 1 2016, In : PloS one. 11, 1, e0146302.

Research output: Contribution to journalArticle

GSTP1 Loss results in accumulation of oxidative DNA base damage and promotes prostate cancer cell survival following exposure to protracted oxidative stress

Mian, O. Y., Khattab, M. H., Hedayati, M., Coulter, J., Abubaker- Sharif, B., Schwaninger, J. M., Veeraswamy, R. K., Brooks, J. D., Hopkins, L., Shinohara, D. B., Cornblatt, B., Nelson, W. G., Yegnasubramanian, S. & DeWeese, T. L., Feb 1 2016, In : Prostate. 76, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

Inflammation, Microbiota, and Prostate Cancer

Puhr, M., Demarzo, A. M., Isaacs, W. B., Lucia, M. S., Sfanos, K., Yegnasubramanian, S. & Culig, Z., Oct 1 2016, In : European Urology Focus. 2, 4, p. 374-382 9 p.

Research output: Contribution to journalReview article

Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia (PIN) and intraductal carcinoma through retrograde glandular colonization

Haffner, M. C., Weier, C., Xu, M. M., Vaghasia, A., Gürel, B., Gümüşkaya, B., Esopi, D. M., Fedor, H., Tan, H. L., Kulac, I., Hicks, J., Isaacs, W. B., Lotan, T. L., Nelson, W. G., Yegnasubramanian, S. & De Marzo, A. M., Jan 1 2016, In : Journal of Pathology. 238, 1, p. 31-41 11 p.

Research output: Contribution to journalArticle

Premalignancy in prostate cancer: Rethinking what we know

Demarzo, A. M., Haffner, M. C., Lotan, T., Yegnasubramanian, S. & Nelson, W. G., Aug 1 2016, In : Cancer Prevention Research. 9, 8, p. 648-656 9 p.

Research output: Contribution to journalReview article

Prostate cancer epigenetics and its clinical implications

Yegnasubramanian, S., Jul 1 2016, In : Asian Journal of Andrology. 18, 4, p. 549-558 10 p.

Research output: Contribution to journalReview article

2015

Androgen-regulated SPARCL1 in the tumor microenvironment inhibits metastatic progression

Hurley, P. J., Hughes, R. M., Simons, B. W., Huang, J., Miller, R. M., Shinder, B., Haffner, M. C., Esopi, D., Kimura, Y., Jabbari, J., Ross, A. E., Erho, N., Vergara, I. A., Faraj, S. F., Davicioni, E., Netto, G. J., Yegnasubramanian, S., An, S. S. & Schaeffer, E. M., Oct 15 2015, In : Cancer Research. 75, 20, p. 4322-4334 13 p.

Research output: Contribution to journalArticle

Diagnostic challenges of clonal heterogeneity in prostate cancer

Haffner, M. C., De Marzo, A. M., Yegnasubramanian, S., Epstein, J. I. & Ballentine Carter, H., Mar 1 2015, In : Journal of Clinical Oncology. 33, 7, p. e38-e40

Research output: Contribution to journalArticle

Global DNA methylation changes and differential gene expression in Anaplasma phagocytophilum-infected human neutrophils

Sinclair, S. H. G., Yegnasubramanian, S. & Dumler, J. S., Jul 29 2015, In : Clinical Epigenetics. 7, 1, 77.

Research output: Contribution to journalArticle

Prostate adenocarcinomas aberrantly expressing p63 are molecularly distinct from usual-type prostatic adenocarcinomas

Tan, H. L., Haffner, M. C., Esopi, D. M., Vaghasia, A. M., Giannico, G. A., Ross, H. M., Ghosh, S., Hicks, J. L., Zheng, Q., Sangoi, A. R., Yegnasubramanian, S., Osunkoya, A. O., De Marzo, A. M., Epstein, J. I. & Lotan, T. L., Mar 1 2015, In : Modern Pathology. 28, 3, p. 446-456 11 p.

Research output: Contribution to journalArticle

Prostate Cancer

Nelson, W. G., Haffner, M. & Yegnasubramanian, S., Oct 30 2015, Targeted Therapy in Translational Cancer Research. Wiley-Blackwell, p. 273-286 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation

Singer, B. D., Mock, J. R., Aggarwal, N. R., Garibaldi, B. T., Sidhaye, V. K., Florez, M. A., Chau, E., Gibbs, K. W., Mandke, P., Tripathi, A., Yegnasubramanian, S., King, L. S. & D'Alessio, F. R., May 1 2015, In : American journal of respiratory cell and molecular biology. 52, 5, p. 641-652 12 p.

Research output: Contribution to journalArticle

Should Gleason 6 be labeled as cancer?

Kulac, I., Haffner, M. C., Yegnasubramanian, S., Epstein, J. I. & De Marzo, A. M., May 27 2015, In : Current opinion in urology. 25, 3, p. 238-245 8 p.

Research output: Contribution to journalReview article

2014

Biobanking of derivatives from radical retropubic and robot-assisted laparoscopic prostatectomy tissues as part of the prostate cancer biorepository network

Darshan, M., Zheng, Q., Fedor, H. L., Wyhs, N., Yegnasubramanian, S., Lee, P., Melamed, J., Netto, G. J., Trock, B. J., De Marzo, A. M. & Sfanos, K. S., Jan 1 2014, In : Prostate. 74, 1, p. 61-69 9 p.

Research output: Contribution to journalArticle

Clinical validation of KRAS, BRAF, and EGFR mutation detection using next-generation sequencing

Lin, M. T., Mosier, S. L., Thiess, M., Beierl, K. F., Debeljak, M., Tseng, L. H., Chen, G., Yegnasubramanian, S., Ho, H., Cope, L., Wheelan, S. J., Gocke, C. D. & Eshleman, J. R., Jun 2014, In : American journal of clinical pathology. 141, 6, p. 856-866 11 p.

Research output: Contribution to journalArticle