Ryan Riddle

Associate Professor

20052019
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Research Output 2005 2019

  • 40 Article
  • 3 Chapter
  • 2 Review article
  • 1 Conference contribution
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Article
2019

Asporin restricts mesenchymal stromal cell differentiation, alters the tumor microenvironment, and drives metastatic progression

Hughes, R. M., Simons, B. W., Khan, H., Miller, R., Kugler, V., Torquato, S., Theodros, D., Haffner, M. C., Lotan, T., Huang, J., Davicioni, E., An, S. S., Riddle, R. C., Thorek, D. L. J., Garraway, I. P., Fertig, E. J., Isaacs, J. T., Nathaniel Brennen, W., Park, B. H. & Hurley, P. J., Jan 1 2019, In : Cancer Research. 79, 14, p. 3636-3650 15 p.

Research output: Contribution to journalArticle

Open Access
Tumor Microenvironment
Mesenchymal Stromal Cells
Cell Differentiation
Neoplasms
Neoplasm Metastasis

Heparin-Conjugated Decellularized Bone Particles Promote Enhanced Osteogenic Signaling of PDGF-BB to Adipose-Derived Stem Cells in Tissue Engineered Bone Grafts

Rindone, A. N., Kachniarz, B., Achebe, C. C., Riddle, R., O'Sullivan, A. N., Dorafshar, A. H. & Grayson, W. L., Jan 1 2019, In : Advanced Healthcare Materials. 1801565.

Research output: Contribution to journalArticle

Bone Matrix
Platelets
Stem cells
Grafts
Heparin

Lrp4 expression by adipocytes and osteoblasts differentially impacts sclerostin's endocrine effects on body composition and glucose metabolism

Kim, S. P., Da, H., Li, Z., Kushwaha, P., Beil, C., Mei, L., Xiong, W. C., Wolfgang, M. J., Clemens, T. & Riddle, R., Jan 1 2019, In : Journal of Biological Chemistry. 294, 17, p. 6899-6911 13 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Osteoblasts
Body Composition
Adipocytes
Metabolism

The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage

Zhang, Q., Riddle, R., Yang, Q., Rosen, C. R., Guttridge, D. C., Dirckx, N., Faugere, M. C., Farber, C. R. & Clemens, T., Sep 3 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17980-17989 10 p.

Research output: Contribution to journalArticle

Open Access
Osteoblasts
Maintenance
RNA
Bone and Bones
DNA Damage
2018

b-Catenin directs long-Chain fatty acid catabolism in the osteoblasts of male mice

Frey, J. L., Kim, S. P., Li, Z., Wolfgang, M. J. & Riddle, R., Jan 1 2018, In : Endocrinology. 159, 1, p. 272-284 13 p.

Research output: Contribution to journalArticle

Catenins
Osteoblasts
Fatty Acids
Frizzled Receptors
White Adipose Tissue
2017

Bone cell bioenergetics and skeletal energy homeostasis

Riddle, R. & Clemens, T., Apr 1 2017, In : Physiological Reviews. 97, 2, p. 667-698 32 p.

Research output: Contribution to journalArticle

Energy Metabolism
Homeostasis
Bone and Bones
Metabolic Diseases
Skeleton

Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase

Ziegler, S. G., Ferreira, C. R., MacFarlane, E., Riddle, R., Tomlinson, R. E., Chew, E. Y., Martin, L., Ma, C. T., Sergienko, E., Pinkerton, A. B., Millán, J. L., Gahl, W. A. & Dietz, H. C., Jun 7 2017, In : Science Translational Medicine. 9, 393, eaal1669.

Research output: Contribution to journalArticle

Pseudoxanthoma Elasticum
Alkaline Phosphatase
Adenosine Triphosphate
Gene Targeting
Liver Failure

Fatty acid metabolism by the osteoblast

Kushwaha, P., Wolfgang, M. J. & Riddle, R., 2017, (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

Osteoblasts
Fatty Acids
Bone Development
Lipid Metabolism
Skeleton

Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner

Kim, S. P., Li, Z., Zoch, M. L., Frey, J. L., Bowman, C. E., Kushwaha, P., Ryan, K. A., Goh, B. C., Scafidi, S., Pickett, J. E., Faugere, M. C., Kershaw, E. E., Thorek, D. L. J., Clemens, T., Wolfgang, M. J. & Riddle, R., Aug 17 2017, In : JCI insight. 2, 16

Research output: Contribution to journalArticle

Open Access
Osteoblasts
Fatty Acids
Diet
Bone and Bones
Skeleton

Lack of Lrp5 signaling in osteoblasts sensitizes male mice to diet-induced disturbances in glucose metabolism

Kim, S. P., Frey, J. L., Li, Z., Goh, B. C. & Riddle, R., Nov 1 2017, In : Endocrinology. 158, 11, p. 3805-3816 12 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Osteoblasts
Diet
Glucose
High Fat Diet

Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance

Lee, J., Choi, J., Selen Alpergin, E. S., Zhao, L., Hartung, T., Scafidi, S., Riddle, R. & Wolfgang, M. J., Jul 18 2017, In : Cell Reports. 20, 3, p. 655-667 13 p.

Research output: Contribution to journalArticle

Glucose Intolerance
Oxidation resistance
Nutrition
Fatty Acids
Obesity
Nerve Growth Factor
Osteogenesis
Osteocytes
Catenins
Forelimb

Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

Kim, S. P., Frey, J. L., Li, Z., Kushwaha, P., Zoch, M. L., Tomlinson, R. E., Da, H., Aja, S. M., Noh, H. L., Kim, J. K., Hussain, M., Thorek, D. L. J., Wolfgang, M. J. & Riddle, R., Dec 26 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11238-E11247

Research output: Contribution to journalArticle

Body Composition
Adipocytes
Adipose Tissue
Bone and Bones
Catenins
2016

Glucose transporter-4 facilitates insulin-stimulated glucose uptake in osteoblasts

Li, Z., Frey, J. L., Wong, G. W., Faugere, M. C., Wolfgang, M. J., Kim, J. K., Riddle, R. & Clemens, T., Nov 1 2016, In : Endocrinology. 157, 11, p. 4094-4103 10 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Osteoblasts
Insulin
Glucose
Osteocytes

In vivo radiometric analysis of glucose uptake and distribution in mouse bone

Zoch, M. L., Abou, D., Clemens, T., Thorek, D. L. J. & Riddle, R., Apr 5 2016, In : Bone Research. 4, 16004.

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18
Bone and Bones
Glucose
Osteoblasts
Osteogenesis

New insights into the biology of osteocalcin

Zoch, M. L., Clemens, T. & Riddle, R., Jan 1 2016, In : Bone. 82, p. 42-49 8 p.

Research output: Contribution to journalArticle

Osteocalcin
Bone and Bones
Testis
Skeletal Muscle
Insulin

Whole-Body and Microenvironmental Localization of Radium-223 in Naïve and Mouse Models of Prostate Cancer Metastasis

Abou, D., Ulmert, D., Doucet, M., Hobbs, R., Riddle, R. & Thorek, D. L. J., May 1 2016, In : Journal of the National Cancer Institute. 108, 5, djv380.

Research output: Contribution to journalArticle

Radium
Prostatic Neoplasms
Neoplasm Metastasis
Bone and Bones
Castration
2015

Bone and the regulation of global energy balance

Zhang, Q., Riddle, R. & Clemens, T., Jun 1 2015, In : Journal of Internal Medicine. 277, 6, p. 681-689 9 p.

Research output: Contribution to journalArticle

Osteoblasts
Bone and Bones
Skeleton
Mutant Strains Mice
Insulin

Osteoblast menin regulates bone mass in vivo

Kanazawa, I., Canaff, L., Rafeh, J. A., Angrula, A., Li, J., Riddle, R., Boraschi-Diaz, I., Komarova, S. V., Clemens, T., Murshed, M. & Hendy, G. N., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 3910-3924 15 p.

Research output: Contribution to journalArticle

Osteoblasts
Bone
Bone and Bones
Knockout Mice
Pregnancy

Parathyroid Hormone Reprograms Osteoblast Metabolism

Riddle, R., Nov 1 2015, In : Journal of Bone and Mineral Research. 30, 11, p. 1956-1958 3 p.

Research output: Contribution to journalArticle

Parathyroid Hormone Receptors
Parathyroid Hormone-Related Protein
Parathyroid Hormone
Osteoblasts

Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast

Frey, J. L., Li, Z., Ellis, J. M., Zhang, Q., Farber, C. R., Aja, S. M., Wolfgang, M. J., Clemens, T. & Riddle, R., 2015, In : Molecular and Cellular Biology. 35, 11, p. 1979-1991 13 p.

Research output: Contribution to journalArticle

Osteoblasts
Fatty Acids
Bone and Bones
Osteocytes
Catenins
2014

Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone

Frey, J. L., Stonko, D. P., Faugere, M. C. & Riddle, R., May 13 2014, In : Bone Research. 2, 14005.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Parathyroid Hormone
Osteoblasts
Bone and Bones
Osteogenesis

Insulin, osteoblasts, and energy metabolism: Why bone counts calories

Riddle, R. & Clemens, T., Apr 1 2014, In : Journal of Clinical Investigation. 124, 4, p. 1465-1467 3 p.

Research output: Contribution to journalArticle

Osteoblasts
Energy Metabolism
Insulin
Bone and Bones
Osteocalcin

Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis

Riddle, R., Frey, J. L., Tomlinson, R. E., Ferron, M., Li, Y., DiGirolamo, D., Faugere, M. C., Hussain, M., Karsenty, G. & Clemens, T., 2014, In : Molecular and Cellular Biology. 34, 10, p. 1850-1862 13 p.

Research output: Contribution to journalArticle

Osteoblasts
Homeostasis
Osteocalcin
Glucose
Insulin
2013

A mouse model for human osteogenesis imperfecta type VI

Bogan, R., Riddle, R., Li, Z., Kumar, S., Nandal, A., Faugere, M. C., Boskey, A., Crawford, S. E. & Clemens, T., Jul 2013, In : Journal of Bone and Mineral Research. 28, 7, p. 1531-1536 6 p.

Research output: Contribution to journalArticle

Bone and Bones
Minerals
Fourier Analysis
Osteoblasts
Microscopy

BRMS1 sensitizes breast cancer cells to ATP-induced growth suppression

Zhang, Y., Chin-Quee, K., Riddle, R., Li, Z., Zhou, Z. & Donahue, H. J., Apr 1 2013, In : BioResearch Open Access. 2, 2, p. 77-83 7 p.

Research output: Contribution to journalArticle

Adenosine Triphosphate
Cells
Breast Neoplasms
Growth
Apoptosis

Lrp5 and Lrp6 Exert Overlapping Functions in Osteoblasts during Postnatal Bone Acquisition

Riddle, R., Diegel, C. R., Leslie, J. M., van Koevering, K. K., Faugere, M. C., Clemens, T. & Williams, B. O., May 10 2013, In : PLoS One. 8, 5, e63323.

Research output: Contribution to journalArticle

osteoblasts
Osteoblasts
Bone
bones
Bone and Bones
2011

Hypoxia-inducible factor-1α protein negatively regulates load-induced bone formation

Riddle, R., Leslie, J. M., Gross, T. S. & Clemens, T., Dec 30 2011, In : Journal of Biological Chemistry. 286, 52, p. 44449-44456 8 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Osteogenesis
Osteoblasts
Bone
Osteocytes
2010

Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice

Mavalli, M. D., DiGirolamo, D., Fan, Y., Riddle, R., Campbell, K. S., Van Groen, T., Frank, S. J., Sperling, M. A., Esser, K. A., Bamman, M. M. & Clemens, T., Nov 1 2010, In : Journal of Clinical Investigation. 120, 11, p. 4007-4020 14 p.

Research output: Contribution to journalArticle

Somatotropin Receptors
Muscle Development
Insulin Resistance
Skeletal Muscle
IGF Type 1 Receptor

Hypoxia-inducible factors 1α and 2α exert both distinct and overlapping functions in long bone development

Shomento, S. H., Wan, C., Cao, X., Faugere, M. C., Bouxsein, M. L., Clemens, T. & Riddle, R., Jan 1 2010, In : Journal of Cellular Biochemistry. 109, 1, p. 196-204 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Bone Development
Osteoblasts
Bone
Osteogenesis

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

Fulzele, K., Riddle, R., DiGirolamo, D., Cao, X., Wan, C., Chen, D., Faugere, M. C., Aja, S. M., Hussain, M., Brüning, J. C. & Clemens, T., Jul 2010, In : Cell. 142, 2, p. 309-319 11 p.

Research output: Contribution to journalArticle

Osteoblasts
Insulin Receptor
Body Composition
Osteocalcin
Bone

Rôles des facteurs de croissance vasculaires dans le développement et la réparation des os

Translated title of the contribution: Roles of vascular growth factors in bone development and repairRiddle, R., Lakhanpal, A. & Clemens, T., Nov 2010, In : Revue du Rhumatisme (Edition Francaise). 77, SUPPL. 3

Research output: Contribution to journalArticle

Bone Development
Intercellular Signaling Peptides and Proteins
vascular factor

Roles of vessel growth factors in bone development and repair

Riddle, R., Lakhanpal, A. & Clemens, T., Dec 2010, In : Joint Bone Spine. 77, 6, p. 517-518 2 p.

Research output: Contribution to journalArticle

Physiologic Neovascularization
Vascular Endothelial Growth Factors
Animal Disease Models
Hypoxia-Inducible Factor 1
Physiologic Calcification
2009

From streaming potentials to shear stress: 25 Years of bone cell mechanotransduction

Riddle, R. & Donahue, H. J., Feb 2009, In : Journal of Orthopaedic Research. 27, 2, p. 143-149 7 p.

Research output: Contribution to journalArticle

Bone and Bones
Extracellular Fluid
Tissue Engineering
Osteogenesis

Role of hypoxia-inducible factor-1α in angiogenic-osteogenic coupling

Riddle, R., Khatri, R., Schipani, E. & Clemens, T., Jun 2009, In : Journal of Molecular Medicine. 87, 6, p. 583-590 8 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Osteogenesis
Vascular Endothelial Growth Factor A
Bone and Bones
Peptide Initiation Factors
2008

Chemotransport contributes to the effect of oscillatory fluid flow on human bone marrow stromal cell proliferation

Riddle, R., Hippe, K. R. & Donahue, H. J., Jul 2008, In : Journal of Orthopaedic Research. 26, 7, p. 918-924 7 p.

Research output: Contribution to journalArticle

Stromal Cells
Mesenchymal Stromal Cells
Extracellular Fluid
Bone Marrow
Cell Proliferation

Fluid flow assays.

Riddle, R. C., Taylor, A. F. & Donahue, H. J., 2008, In : Methods in molecular biology (Clifton, N.J.). 455, p. 335-345 11 p.

Research output: Contribution to journalArticle

Bone and Bones
Extracellular Fluid
Osteogenesis
Glass
Cues
2007

ATP release mediates fluid flow-induced proliferation of human bone marrow stromal cells

Riddle, R., Taylor, A. F., Rogers, J. R. & Donahue, H. J., Apr 2007, In : Journal of Bone and Mineral Research. 22, 4, p. 589-600 12 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Adenosine Triphosphate
Calcineurin
Nucleotides
NFATC Transcription Factors
2006

MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation

Riddle, R., Taylor, A. F., Genetos, D. C. & Donahue, H. J., Mar 2006, In : American Journal of Physiology - Cell Physiology. 290, 3

Research output: Contribution to journalArticle

Calcium Signaling
Cell proliferation
Stem cells
Mesenchymal Stromal Cells
Flow of fluids
2005

ptena and ptenb genes play distinct roles in zebrafish embryogenesis

Croushore, J. A., Blasiole, B., Riddle, R., Thisse, C., Thisse, B., Canfield, V. A., Robertson, G. P., Cheng, K. C. & Levenson, R., Dec 2005, In : Developmental Dynamics. 234, 4, p. 911-921 11 p.

Research output: Contribution to journalArticle

Zebrafish
Embryonic Development
Branchial Region
Embryonic Structures
Central Nervous System