Robin McKenzie

Associate Professor

1985 …2019

Research output per year

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Research Output

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Article
2019

Hyperimmune Bovine Colostral Anti-CS17 Antibodies Protect Against Enterotoxigenic Escherichia coli Diarrhea in a Randomized, Doubled-Blind, Placebo-Controlled Human Infection Model

Savarino, S. J., McKenzie, R., Tribble, D. R., Porter, C. K., O'Dowd, A., Sincock, S. A., Poole, S. T., Denearing, B., Woods, C. M., Kim, H., Grahek, S. L., Brinkley, C., Crabb, J. H. & Bourgeois, L., Jul 2 2019, In : Journal of Infectious Diseases. 220, 3, p. 505-513 9 p., jiz135.

Research output: Contribution to journalArticle

Open Access
2018

An evaluation of provider-chosen antibiotic indications as a targeted antimicrobial stewardship intervention

Timmons, V., Townsend, J., McKenzie, R., Burdalski, C. & Adams-Sommer, V., Jan 1 2018, (Accepted/In press) In : American Journal of Infection Control.

Research output: Contribution to journalArticle

Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score

Porter, C. K., Lynen, A., Riddle, M. S., Talaat, K., Sack, D., Gutiérrez, R. L., McKenzie, R., DeNearing, B., Feijoo, B., Kaminski, R. W., Taylor, D. N., Kirkpatrick, B. D. & Bourgeois, A. L., Mar 1 2018, In : PloS one. 13, 3, e0194325.

Research output: Contribution to journalArticle

Open Access

Procalcitonin-guided antibiotic therapy reduces antibiotic use for lower respiratory tract infections in a United States medical center: Results of a clinical trial

Townsend, J., Adams, V., Galiatsatos, P., Pearse, D., Pantle, H., Masterson, M., Kisuule, F., Jacob, E., Kiruthi, C., Ortiz, P., Agbanlog, A., Jurao, R., Stern, S., Nayak, S., Melgar, M., Sama, J., Irwin, J., Mazidi, C., Psoter, K. & McKenzie, R., 2018, In : Open Forum Infectious Diseases. 5, 12

Research output: Contribution to journalArticle

Open Access
2017

Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial

Savarino, S. J., McKenzie, R., Tribble, D. R., Porter, C. K., O'Dowd, A., Cantrell, J. A., Sincock, S. A., Poole, S. T., Denearing, B., Woods, C. M., Kim, H., Grahek, S. L., Brinkley, C., Crabb, J. H. & Bourgeois, L., Jul 1 2017, In : Journal of Infectious Diseases. 216, 1, p. 7-13 7 p.

Research output: Contribution to journalArticle

Safety, tolerability, systemic exposure, and metabolism of CRS3123, a methionyl-tRNA synthetase inhibitor developed for treatment of Clostridium difficile, in a Phase 1 Study

Nayak, S. U., Griffiss, J. M. L., Blumer, J., O’Riordan, M. A., Gray, W., McKenzie, R., Jurao, R. A., An, A. T., Le, M., Bell, S. J., Ochsner, U. A., Jarvis, T. C., Janjic, N. & Zenilman, J. M., Aug 2017, In : Antimicrobial agents and chemotherapy. 61, 8, e02760-16.

Research output: Contribution to journalArticle

2016

An evidenced-based scale of disease severity following human challenge with enteroxigenic Escherichia coli

Porter, C. K., Riddle, M. S., Alcala, A. N., Sack, D. A., Harro, C., Chakraborty, S., Gutierrez, R. L., Savarino, S. J., Darsley, M., McKenzie, R., DeNearing, B., Steinsland, H., Tribble, D. R. & Bourgeois, A. L., Mar 2016, In : PloS one. 11, 3, e0149358.

Research output: Contribution to journalArticle

2015

Animal-associated exposure to rabies virus among travelers, 1997–2012

Gautret, P., Harvey, K., Pandey, P., Lim, P. L., Leder, K., Piyaphanee, W., Shaw, M., McDonald, S. C., Schwartz, E., Esposito, D. H., Parola, P., Delmont, J., Torresi, J., Brown, G., Yoshimura, Y., Tachikawa, N., Kurai, H., Sagara, H., Von Sonnenburg, F., Kanagawa, S. & 90 others, Kato, Y., Mizunno, Y., Hern, A., Chappuis, F., Loutan, L., Keystone, J. S., Kain, K., Grobusch, M., De Vries, P., Gadroen, K., Using, J., Fröberg, G., Libman, M. D., Ward, B., Dick Maclean, J., Rapp, C., Aoun, O., Valdez, L. M., Siu, H., Cramer, J., Burchard, G. D., Phu, P. T. H., Anderson, N., Batchelor, T., Meisch, D., Jensenius, M., Lalloo, D. G., Beeching, N. J., Stauffer, W., Walker, P., Kass, R., Jean Haulman, N., Roesel, D., Jong, E. C., Wang, A., Eason, J., Kendall, B., Hale, D. C., Anand, R., Gelman, S. S., Chen, L. H., Wilson, M. E., Silachamroon, U., Borwein, S., Van Genderen, P. J., Vincelette, J., Gurtman, A., Kozarsky, P. E., Wu, H., Fairley, J., Franco-Paredes, C., Schlagenhauf, P., Weber, R., Steffen, R., Yates, J., Ansdell, V., Mendelson, M., Vincent, P., Mockenhaupt, F., Harms, G., Perret, C., Valdivieso, F., Doyle, P., Ghesquiere, W., Cahill, J. D., McKinley, G., McCarthy, A., Caumes, E., Pérignon, A., Anderson, S., Hynes, N. A., Bradley Sack, R., McKenzie, R., Field, V., Connor, B. A., Muller, R., Freedman, D. O., Hagmann, S., Miller, A. O., Gkrania-Klotsas, E., Tenenboim, S., Jenks, N. P., Kerr, C., Licitra, C., Crespo, A., Castelli, F., Carosi, G., Holtom, P., Goad, J. & Anglim, A., 2015, In : Emerging infectious diseases. 21, 4, p. 569-577 9 p.

Research output: Contribution to journalArticle

2014

Safety and pharmacokinetics of XOMA 3AB, A novel mixture of three monoclonal antibodies against botulinum toxin A

Nayak, S. U., Griffiss, J. M., McKenzie, R., Fuchs, E. J., Jurao, R. A., An, A. T., Ahene, A., Tomic, M., Hendrix, C. W. & Zenilman, J. M., Sep 2014, In : Antimicrobial agents and chemotherapy. 58, 9, p. 5047-5053 7 p.

Research output: Contribution to journalArticle

Travel-associated disease among US residents visiting US GeoSentinel clinics after return from international travel

GeoSentinel Surveillance Network, Dec 1 2014, In : Family Practice. 31, 6, p. 678-687 10 p.

Research output: Contribution to journalArticle

2012

Characteristics and spectrum of disease among ill returned travelers from pre- and post-earthquake Haiti: The geosentinel experience

Esposito, D. H., Han, P. V., Kozarsky, P. E., Walker, P. F., Gkrania-Klotsas, E., Barnett, E. D., Libman, M., McCarthy, A. E., Field, V., Connor, B. A., Schwartz, E., MacDonald, S., Sotir, M. J., Ward, B., Maclean, J. D., Loutan, L., Chappuis, F., Stauffer, W. M., Cahill, J. D., McKinley, G. & 33 others, Licitra, C., Crespo, A., Fairley, J., Franco-Paredes, C., Caumes, E., Pérignon, A., Keystone, J. S., Kain, K. C., Hynes, N., Sack, R. B., McKenzie, R., Von Sonnenburg, F., Coyle, C. M., Wittner, M., Freedman, D. O., Burchard, G. D., Rapp, C., Aoun, O., Haulman, N. J., Roesel, D., Jong, E. C., De Vries, P., Gadroen, K., Chen, L. H., Perret, C., Mendelson, M., Vincent, P., Lynch, M. W., Kanagawa, S., Kato, Y., Hale, D. V. C., Anand, R. & Gelman, S. S., Jan 1 2012, In : American Journal of Tropical Medicine and Hygiene. 86, 1, p. 23-28 6 p.

Research output: Contribution to journalArticle

2011

Comparative evaluation of the antibody in lymphocyte supernatant (ALS) and enzyme-linked immunospot (ELISPOT) assays for measuring mucosal immune responses to Shigella antigens

Feller, A. J., McKenzie, R., Taylor, D. N., Woods, C. C., Grahek, S. L., Islam, D., Venkatesan, M. M., Hale, T. L. & Bourgeois, A. L., Nov 3 2011, In : Vaccine. 29, 47, p. 8487-8489 3 p.

Research output: Contribution to journalArticle

In vitro antimicrobial susceptibility of bacterial enteropathogens isolated from international travelers to Mexico, Guatemala, and India from 2006 to 2008

Ouyang-Latimer, J., Jafri, S., VanTassel, A., Jiang, Z. D., Gurleen, K., Rodriguez, S., Nandy, R. K., Ramamurthy, T., Chatterjee, S., McKenzie, R., Steffen, R. & DuPont, H. L., Feb 1 2011, In : Antimicrobial agents and chemotherapy. 55, 2, p. 874-878 5 p.

Research output: Contribution to journalArticle

Lactoferrin for the prevention of post-antibiotic diarrhoea

Laffan, A. M., McKenzie, R., Forti, J., Conklin, D., Marcinko, R., Shrestha, R., Bellantoni, M. & Greenough, W. B., Dec 1 2011, In : Journal of Health, Population and Nutrition. 29, 6, p. 547-551 5 p.

Research output: Contribution to journalArticle

Volunteer challenge with enterotoxigenic Escherichia coli that express intestinal colonization factor fimbriae CS17 and CS19

McKenzie, R., Porter, C. K., Cantrell, J. A., DeNearing, B., O'Dowd, A., Grahek, S. L., Sincock, S. A., Woods, C., Sebeny, P., Sack, D. A., Tribble, D. R., Bourgeois, A. L. & Savarino, S. J., Jul 1 2011, In : Journal of Infectious Diseases. 204, 1, p. 60-64 5 p.

Research output: Contribution to journalArticle

2010

Microbial Etiology of Travelers' Diarrhea in Mexico, Guatemala, and India: Importance of Enterotoxigenic Bacteroides fragilis and Arcobacter Species

Jiang, Z. D., Dupont, H. L., Brown, E. L., Nandy, R. K., Ramamurthy, T., Sinha, A., Ghosh, S., Guin, S., Gurleen, K., Rodrigues, S., Chen, J. J., McKenzie, R. & Steffen, R., Apr 1 2010, In : Journal of clinical microbiology. 48, 4, p. 1417-1419 3 p.

Research output: Contribution to journalArticle

2008

A double-blind, placebo-controlled trial to evaluate the efficacy of PTL-003, an attenuated enterotoxigenic E. coli (ETEC) vaccine strain, in protecting against challenge with virulent ETEC

McKenzie, R., Darsley, M., Thomas, N., Randall, R., Carpenter, C., Forbes, E., Finucane, M., Sack, R. B., Hall, E. & Bourgeois, A. L., Aug 26 2008, In : Vaccine. 26, 36, p. 4731-4739 9 p.

Research output: Contribution to journalArticle

Safety and immunogenicity of WRSd1, a live attenuated Shigella dysenteriae type 1 vaccine candidate

McKenzie, R., Venkatesan, M. M., Wolf, M. K., Islam, D., Grahek, S., Jones, A. M., Bloom, A., Taylor, D. N., Hale, T. L. & Bourgeois, A. L., Jun 19 2008, In : Vaccine. 26, 26, p. 3291-3296 6 p.

Research output: Contribution to journalArticle

Systemic pharmacokinetics of rifaximin in volunteers with shigellosis

Taylor, D. N., McKenzie, R., Durbin, A., Carpenter, C., Haake, R. & Bourgeois, A. L., Mar 2008, In : Antimicrobial agents and chemotherapy. 52, 3, p. 1179-1181 3 p.

Research output: Contribution to journalArticle

Use of a patch containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase II, randomised, double-blind, placebo-controlled field trial

Frech, S. A., DuPont, H. L., Bourgeois, A. L., McKenzie, R., Belkind-Gerson, J., Figueroa, J. F., Okhuysen, P. C., Guerrero, N. H., Martinez-Sandoval, F. G., Meléndez-Romero, J. HM., Jiang, Z. D., Asturias, E. J., Halpern, J., Torres, O. R., Hoffman, A. S., Villar, C. P., Kassem, R. N., Flyer, D. C., Andersen, B. H., Kazempour, K. & 2 others, Breisch, S. A. & Glenn, G. M., 2008, In : The Lancet. 371, 9629, p. 2019-2025 7 p.

Research output: Contribution to journalArticle

2007

Safety and immunogenicity of an enterotoxigenic Escherichia coli vaccine patch containing heat-labile toxin: Use of skin pretreatment to disrupt the stratum corneum

Glenn, G. M., Villar, C. P., Flyer, D. C., Bourgeois, A. L., McKenzie, R., Lavker, R. M. & Frech, S. A., May 1 2007, In : Infection and immunity. 75, 5, p. 2163-2170 8 p.

Research output: Contribution to journalArticle

Transcutaneous immunization with the heat-labile toxin (LT) of enterotoxigenic Escherichia coli (ETEC): Protective efficacy in a double-blind, placebo-controlled challenge study

McKenzie, R., Bourgeois, A. L., Frech, S. A., Flyer, D. C., Bloom, A., Kazempour, K. & Glenn, G. M., May 4 2007, In : Vaccine. 25, 18, p. 3684-3691 8 p.

Research output: Contribution to journalArticle

2006

Comparative safety and immunogenicity of two attenuated enterotoxigenic Escherichia coli vaccine strains in healthy adults

McKenzie, R., Bourgeois, A. L., Engstrom, F., Hall, E., Chang, H. S., Gomes, J. G., Kyle, J. L., Cassels, F., Turner, A. K., Randall, R., Darsley, M., Lee, C., Bedford, P., Shimko, J. & Sack, D. A., Feb 1 2006, In : Infection and immunity. 74, 2, p. 994-1000 7 p.

Research output: Contribution to journalArticle

Comparison of the antibody in lymphocyte supernatant (ALS) and ELISPOT assays for detection of mucosal immune responses to antigens of enterotoxigenic Escherichia coli in challenged and vaccinated volunteers

Carpenter, C. M., Hall, E. R., Randall, R., McKenzie, R., Cassels, F., Diaz, N., Thomas, N., Bedford, P., Darsley, M., Gewert, C., Howard, C., Sack, R. B., Sack, D. A., Chang, H. S., Gomes, G. & Bourgeois, A. L., May 1 2006, In : Vaccine. 24, 18, p. 3709-3718 10 p.

Research output: Contribution to journalArticle

Evaluation of Salmonella enterica serovar Typhi (Ty2 aroC-ssaV-) M01ZH09, with a defined mutation in the Salmonella pathogenicity island 2, as a live, oral typhoid vaccine in human volunteers

Kirkpatrick, B. D., McKenzie, R., O'Neill, J. P., Larsson, C. J., Bourgeois, A. L., Shimko, J., Bentley, M., Makin, J., Chatfield, S., Hindle, Z., Fidler, C., Robinson, B. E., Ventrone, C. H., Bansal, N., Carpenter, C. M., Kutzko, D., Hamlet, S., Lapointe, C. & Taylor, D. N., Jan 12 2006, In : Vaccine. 24, 2, p. 116-123 8 p.

Research output: Contribution to journalArticle

Rifaximin, a nonabsorbed oral antibiotic, prevents shigellosis after experimental challenge

Taylor, D. N., McKenzie, R., Durbin, A., Carpenter, C., Atzinger, C. B., Haake, R. & Bourgeois, A. L., May 1 2006, In : Clinical Infectious Diseases. 42, 9, p. 1283-1288 6 p.

Research output: Contribution to journalArticle

Safety and immunogenicity of an oral, inactivated, whole-cell vaccine for Shigella sonnei: preclinical studies and a Phase I trial

McKenzie, R., Walker, R. I., Nabors, G. S., Verg, L. L. V. D., Carpenter, C., Gomes, G., Forbes, E., Tian, J. H., Yang, H. H., Pace, J. L., Jackson, W. J. & Bourgeois, A. L., May 1 2006, In : Vaccine. 24, 18, p. 3735-3745 11 p.

Research output: Contribution to journalArticle

2001

Fludrocortisone acetate to treat neurally mediated hypotension in chronic fatigue syndrome: A randomized controlled trial

Rowe, P. C., Calkins, H., DeDusk, K., McKenzie, R., Anand, R., Sharma, G., Cuccherini, B. A., Soto, N., Hohman, P., Snader, S., Lucas, K. E., Wolff, M. & Straus, S. E., Jan 3 2001, In : Journal of the American Medical Association. 285, 1, p. 52-59 8 p.

Research output: Contribution to journalArticle

Open Access
2000

Decreased bone mineral density during low dose glucocorticoid administration in a randomized, placebo controlled trial

McKenzie, R., Reynolds, J. C., O'Fallon, A., Dale, J., Deloria, M., Blackwelder, W. & Straus, S. E., Sep 28 2000, In : Journal of Rheumatology. 27, 9, p. 2222-2226 5 p.

Research output: Contribution to journalArticle

1998

Low-dose hydrocortisone for treatment of chronic fatigue syndrome: A randomized controlled trial

McKenzie, R., O'Fallon, A., Dale, J., Demitrack, M., Sharma, G., Deloria, M., Garcia-Borreguero, D., Blackwelder, W. & Straus, S. E., Sep 23 1998, In : Journal of the American Medical Association. 280, 12, p. 1061-1066 6 p.

Research output: Contribution to journalArticle

1997

Histopathologic changes associated with fialuridine hepatotoxicity

Kleiner, D. E., Gaffey, M. J., Sallie, R., Tsokos, M., Nichols, L., McKenzie, R., Straus, S. E. & Hoofnagle, J. H., Mar 1 1997, In : Modern Pathology. 10, 3, p. 192-199 8 p.

Research output: Contribution to journalArticle

Immunotherapy of recurrent genital herpes with recombinant herpes simplex virus type 2 glycoproteins D and B: Results of a placebo-controlled vaccine trial

Straus, S. E., Wald, A., Kost, R. G., McKenzie, R., Langenberg, A. G. M., Hohman, P., Lekstrom, J., Cox, E., Nakamura, M., Sekulovich, R., Izu, A., Dekker, C. & Corey, L., Jan 1 1997, In : Journal of Infectious Diseases. 176, 5, p. 1129-1134 6 p.

Research output: Contribution to journalArticle

Open Access
1996

Therapeutic immunization for recurrent herpes simplex virus infections

McKenzie, R. & Straus, S. E., 1996, In : Advances in experimental medicine and biology. 394, p. 67-83 17 p.

Research output: Contribution to journalArticle

Vaccine therapy for herpes simplex virus infections: An historical perspective

McKenzie, R. & Straus, S. E., Jan 1 1996, In : Reviews in Medical Virology. 6, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

1995

Hepatic failure and lactic acidosis due to fialuridine (fiau), an investigational nucleoside analogue for chronic hepatitis b

Mckenzie, R., Fried, M. W., Sallie, R., Conjeevaram, H., di Bisceglie, A. M., Park, Y., Savarese, B., Kleiner, D., Tsokos, M., Luciano, C., Pruett, T., Stotka, J. L., Straus, S. E. & Hoofnagle, J. H., Oct 26 1995, In : New England Journal of Medicine. 333, 17, p. 1099-1105 7 p.

Research output: Contribution to journalArticle

1992

Regulation of complement activity by vaccinia virus complement-control protein

McKenzie, R., Kotwal, G. J., Moss, B., Hammer, C. H. & Frank, M. M., Dec 1992, In : Journal of Infectious Diseases. 166, 6, p. 1245-1250 6 p.

Research output: Contribution to journalArticle

1991

The causes of death in patients with human immunodeficiency virus infection: A clinical and pathologic study with emphasis on the role of pulmonary diseases

McKenzie, R., Travis, W. D., Dolan, S. A., Pittaluga, S., Feuerstein, I. M., Shelhamer, J., Yarchoan, R. & Masur, H., Sep 1991, In : Medicine (United States). 70, 5, p. 326-343 18 p.

Research output: Contribution to journalArticle

1990

Inhibition of the complement cascade by the major secretory protein of vaccinia virus

Kotwal, G. J., Isaacs, S. N., Mckenzie, R., Frank, M. M. & Moss, B., Jan 1 1990, In : Science. 250, 4982, p. 827-830 4 p.

Research output: Contribution to journalArticle

1988

Ludwig’s Angina: Report of a Case and Review of the Literature

Moreland, L. W., Corey, J. & Mckenzie, R., Feb 1988, In : Archives of internal medicine. 148, 2, p. 461-466 6 p.

Research output: Contribution to journalArticle

1987

Effect of antimicrobials on blood cultures in endocarditis

McKenzie, R. & Reimer, L. G., Nov 1987, In : Diagnostic Microbiology and Infectious Disease. 8, 3, p. 165-172 8 p.

Research output: Contribution to journalArticle

1986

Temporal arteritis presenting with diplopia.

Moreland, L. W., Brick, J. E. & McKenzie, R., Dec 1986, In : The West Virginia medical journal. 82, 12, p. 481-482 2 p.

Research output: Contribution to journalArticle

1985

Blastomycosis of the Esophagus Presenting With Gastrointestinal Bleeding

McKenzie, R. & Khakoo, R., Jan 1 1985, In : Gastroenterology. 88, 5, p. 1271-1273 3 p.

Research output: Contribution to journalArticle