Robert Wojciechowski

Assistant Professor

19952018
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Research Output 1995 2018

2018

Detailed genetic characteristics of an international large cohort of patients with Stargardt disease: ProgStar study report 8

Fujinami, K., Strauss, R. W., Chiang, J., Audo, I. S., Bernstein, P. S., Birch, D. G., Bomotti, S. M., Cideciyan, A. V., Ervin, A. M., Marino, M. J., Sahel, J. A., Mohand-Said, S., Sunness, J. S., Traboulsi, E. I., West, S. K., Wojciechowski, R., Zrenner, E., Michaelides, M. & Scholl, H. P. N., Jun 19 2018, (Accepted/In press) In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

Gene Frequency
Computer Simulation
France
Germany
Virulence

Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma

UK Biobank Eye and Vision Consortium & NEIGHBORHOOD Consortium, May 21 2018, (Accepted/In press) In : Nature Genetics. p. 1-5 5 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Glaucoma
Genome
Angiopoietins
Genetic Models

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

CREAM, 23andMe Research Team & UK Biobank Eye and Vision Consortium, Jun 1 2018, In : Nature Genetics. 50, 6, p. 834-848 15 p.

Research output: Contribution to journalArticle

Refractive Errors
Genome-Wide Association Study
Meta-Analysis
Light
Retina

Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

International Glaucoma Genetics Consortium & NEIGHBORHOOD Consortium, Jan 1 2018, In : PLoS Genetics. 14, 1, e1007145.

Research output: Contribution to journalArticle

glaucoma
Glaucoma
genomics
risk factor
Quantitative Trait Loci

Longitudinal Changes of Fixation Location and Stability Within 12 Months in Stargardt Disease: ProgStar Report No. 12

ProgStar Study Group, Sep 1 2018, In : American Journal of Ophthalmology. 193, p. 54-61 8 p.

Research output: Contribution to journalArticle

Disease Progression
Natural History
Confidence Intervals
Counseling
Cohort Studies

Visual acuity change over 24 months and its association with foveal phenotype and genotype in individuals with stargardt disease progstar study report no. 10

Kong, X., Fujinami, K., Strauss, R. W., Munoz, B., West, S. K., Cideciyan, A. V., Michaelides, M., Ahmed, M., Ervin, A. M., Schönbach, E., Cheetham, J. K., Scholl, H. P. N., Scholl, H. P. N., Strauss, R. W., Wolfson, Y., Bittencourt, M., Shah, S. M., Ahmed, M., Schönbach, E., Fujinami, K. & 185 others, Traboulsi, E., Ehlers, J., Marino, M., Crowe, S., Briggs, R., Borer, A., Pinter, A., Fecko, T., Burgnoni, N., Sunness, J. S., Applegate, C., Russell, L., Michaelides, M., Esposti, S. D., Moore, A., Webster, A., Connor, S., Barnfield, J., Salchi, Z., Alfageme, C., McCudden, V., Pefkianaki, M., Aboshiha, J., Liew, G., Holder, G., Robson, A., King, A., Narvaez, D. I. C., Barnard, K., Grigg, C., Dunbar, H., Obadeyi, Y., Girard-Claudon, K., Swann, H., Rughani, A., Amoah, C., Carrington, D., Bibi, K., Ting Co, E., Illiyas, M. N., Begum, H., Carter, A., Georgiou, A., Lewis, S., Shaheen, S., Shinmar, H., Burton, L., Bernstein, P., Wegner, K., Sawyer, B. L., Carlstrom, B., Farnsworth, K., Fry, C., Chandler, M., Jenkins, G., Creel, D., Birch, D., Wang, Y. Z., Rodriguez, L., Locke, K., Klein, M., Mejia, P., Cideciyan, A. V., Jacobson, S. G., Schwartz, S. B., Matsui, R., Gruzensky, M., Charng, J., Roman, A. J., Zrenner, E., Nasser, F., Hahn, G. A., Wilhelm, B., Peters, T., Beier, B., Koenig, T., Kramer, S., Sahel, J. A., Mohand-Said, S., Audo, I., Laurent-Coriat, C., Sliesoraityte, I., Zeitz, C., Boyard, F., Tran, M. H., Chapon, M., Chaumette, C., Amaudruz, J., Ganem, V., Sancho, S., Girmens, A., Scholl, H. P. N., Strauss, R. W., Wolfson, Y., Shah, S. M., Ahmed, M., Schönbach, E., Wojciechowski, R., Khan, S., Emmert, D. G., Cain, D., Herring, M., Bassinger, J., Liberto, L., West, S. K., Ervin, A. M., Munoz, B., Kong, K., Dreger, K., Jones, J., Burke, R., Sadda, S., Ip, M. S., Jha, A., Ho, A., Kramer, B., Lam, N., Tawdros, R., Zhou, Y. D., Carmona, J., Uji, A., Hariri, A., Lock, A., Elshafei, A., Ganegoda, A., Petrossian, C., Jenkins, D., Strnad, E., Baghdasaryan, E., Ito, E., Samson, F., Blanquel, G., Akil, H., Melendez, J., Lei, J., Huang, J., Chau, J., Falavarjani, K. G., Espino, K., Li, M., Mendoza, M., Nittala, M. G., Roded, N., Saleh, N., Huang, P., Pitetta, S., Balasubramanian, S., Leahy, S., Srinivas, S. J., Velaga, S. B., Margaryan, T., Tepelus, T., Brown, T., Fan, W., Murillo, Y., Shi, Y., Aguilar, K., Chan, C., Santos, L., Seo, B., Sison, C., Perez, S., Chao, S., Miyasato, K., Higgins, J., Luna, Z., Menchaca, A., Gonzalez, N., Robledo, V., Carig, K., Baker, K., Ellenbogen, D., Bluemel, D., Sanford, T., Linares, D., Tran, M., Nava, L., Oberoi, M., Romero, M., Chiguil, V., Bynum-Bain, G., Kim, M., Mendiguren, C., Huang, X. & Smith, M., Aug 1 2018, In : JAMA Ophthalmology. 136, 8, p. 920-928 9 p.

Research output: Contribution to journalArticle

Visual Acuity
Genotype
Phenotype
Stargardt disease 1
Outcome Assessment (Health Care)
2017

Genetically low vitamin D concentrations and myopic refractive error: A Mendelian randomization study

Consortium for Refractive Error and Myopia (CREAM), Dec 1 2017, In : International Journal of Epidemiology. 46, 6, p. 1882-1890 9 p.

Research output: Contribution to journalArticle

Refractive Errors
Myopia
Random Allocation
Vitamin D
Genome-Wide Association Study

Incidence of atrophic lesions in Stargardt disease in the progression of atrophy secondary to Stargardt disease (ProgStar) study report No. 5

for the ProgStar Study Group & Shah, S. M., Jul 1 2017, In : JAMA Ophthalmology. 135, 7, p. 687-695 9 p.

Research output: Contribution to journalArticle

Atrophy
Disease Progression
Incidence
Outcome Assessment (Health Care)
Retinal Pigment Epithelium

INVOLVEMENT OF MULTIPLE MOLECULAR PATHWAYS IN THE GENETICS OF OCULAR REFRACTION AND MYOPIA

Wojciechowski, R. & Cheng, C. Y., Apr 11 2017, (Accepted/In press) In : Retina.

Research output: Contribution to journalArticle

Ocular Refraction
Refractive Errors
Myopia
Genes
Genetic Databases

Macular sensitivity measured with microperimetry in stargardt disease in the progression of atrophy secondary to stargardt disease (ProgStar) study report No. 7

for the ProgStar Study Group & Shah, S. M., Jul 1 2017, In : JAMA Ophthalmology. 135, 7, p. 696-703 8 p.

Research output: Contribution to journalArticle

Visual Field Tests
Atrophy
Disease Progression
Scotoma
Visual Acuity

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics

NEIGHBORHOOD Consortium, 2017, In : Human Molecular Genetics. 26, 2, p. 438-453 16 p.

Research output: Contribution to journalArticle

Optic Disk
Intraocular Pressure
Meta-Analysis
Primary Open Angle Glaucoma
Optic Nerve Diseases
2016

Assessing the Genetic Predisposition of Education on Myopia: A Mendelian Randomization Study

Cuellar-Partida, G., Lu, Y., Kho, P. F., Hewitt, A. W., Wichmann, H. E., Yazar, S., Stambolian, D., Bailey-Wilson, J. E., Wojciechowski, R., Wang, J. J., Mitchell, P., Mackey, D. A. & MacGregor, S., Jan 1 2016, In : Genetic Epidemiology. 40, 1, p. 66-72 7 p.

Research output: Contribution to journalArticle

Myopia
Genetic Predisposition to Disease
Random Allocation
Education
Observational Studies
Gene-Environment Interaction
Refractive Errors
Myopia
Far East
Genome-Wide Association Study

Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos

International Glaucoma Genetics Consortium, Nov 15 2016, In : Human Molecular Genetics. 25, 22, p. 5035-5045 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Hispanic Americans
Single Nucleotide Polymorphism
Cornea
Keratoconus

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Fan, Q., Verhoeven, V. J. M., Wojciechowski, R., Barathi, V. A., Hysi, P. G., Guggenheim, J. A., Hohn, R., Vitart, V., Khawaja, A. P., Yamashiro, K., Hosseini, S. M., Lehtimaki, T., Lu, Y., Haller, T., Xie, J., Delcourt, C., Pirastu, M., Wedenoja, J., Gharahkhani, P., Venturini, C. & 134 others, Miyake, M., Hewitt, A. W., Guo, X., Mazur, J., Huffman, J. E., Williams, K. M., Polasek, O., Campbell, H., Rudan, I., Vatavuk, Z., Wilson, J. F., Joshi, P. K., McMahon, G., St Pourcain, B., Evans, D. M., Simpson, C. L., Schwantes-An, T. H., Igo, R. P., Mirshahi, A., Cougnard-Gregoire, A., Bellenguez, C., Blettner, M., Raitakari, O., Kahonen, M., Seppala, I., Zeller, T., Meitinger, T., Ried, J. S., Gieger, C., Portas, L., Van Leeuwen, E. M., Amin, N., Uitterlinden, A. G., Rivadeneira, F., Hofman, A., Vingerling, J. R., Wang, Y. X., Wang, X., Tai-Hui Boh, E., Ikram, M. K., Sabanayagam, C., Gupta, P., Tan, V., Zhou, L., Ho, C. E. H., Lim, WE., Beuerman, R. W., Siantar, R., Tai, E. S., Vithana, E., Mihailov, E., Khor, C. C., Hayward, C., Luben, R. N., Foster, P. J., Klein, B. E. K., Klein, R., Wong, H. S., Mitchell, P., Metspalu, A., Aung, T., Young, T. L., He, M., Parssinen, O., Van Duijn, C. M., Jin Wang, J., Williams, C., Jonas, J. B., Teo, Y. Y., MacKey, D. A., Oexle, K., Yoshimura, N., Paterson, A. D., Pfeiffer, N., Wong, T. Y., Baird, P. N., Stambolian, D., Wilson, J. E. B., Cheng, C. Y., Hammond, C. J., Klaver, C. C. W., Saw, S. M., Rahi, J. S., Korobelnik, J. F., Kemp, J. P., Timpson, N. J., Smith, G. D., Craig, J. E., Burdon, K. P., Fogarty, R. D., Iyengar, S. K., Chew, E., Janmahasatian, S., Martin, N. G., MacGregor, S., Xu, L., Schache, M., Nangia, V., Panda-Jonas, S., Wright, A. F., Fondran, J. R., Lass, J. H., Feng, S., Zhao, J. H., Khaw, K. T., Wareham, N. J., Rantanen, T., Kaprio, J., Pang, C. P., Chen, L. J., Tam, P. O., Jhanji, V., Young, A. L., Doring, A., Raffel, L. J., Cotch, M. F., Li, X., Yip, S. P., Yap, M. K. H., Biino, G., Vaccargiu, S., Fossarello, M., Fleck, B., Yazar, S., Tideman, J. W. L., Tedja, M., Deangelis, M. M., Morrison, M., Farrer, L., Zhou, X., Chen, W., Mizuki, N., Meguro, A. & Makela, K. M., Mar 29 2016, In : Nature Communications. 7, 11008.

Research output: Contribution to journalArticle

myopia
Refractive Errors
Myopia
loci
Polymorphism

Visual Acuity Loss and Associated Risk Factors in the Retrospective Progression of Stargardt Disease Study (ProgStar Report No. 2)

Kong, X., Strauss, R. W., Muñoz, B., West, S., Scholl, H. P. N., Kong, X., Strauss, R. W., Michaelides, M., Strauss, R. W., Cideciyan, A. V., Sahel, J. A., Scholl, H. P. N., Strauss, R. W., Wolfson, Y., Bittencourt, M., Shah, S. M., Ahmed, M., Schonbach, E., Fujinami, K., Ehlers, J. & 137 others, Marino, M., Crowe, S., Briggs, R., Borer, A., Pinter, A., Fecko, T., Brugnoni, N., Sunness, J. S., Applegate, C., Russell, L., Michaelides, M., Moore, A., Webster, A., Connor, S., McCudden, V., Pefkianaki, M., Aboshiha, J., Liew, G., Holder, G., Robson, A., King, A., Cajas Narvaez, D. I., Barnard, K., Grigg, C., Dunbar, H., Obadeyi, Y., Girard-Claudon, K., Swann, H., Rughani, A., Amoah, C., Carrington, D., Bibi, K., Co, E. T., Carter, A., Georgiou, A., Lewis, S., Shaheen, S., Shinmar, H., Burton, L., Bernstein, P., Wegner, K., Sawyer, B. L., Carlstrom, B., Farnsworth, K., Fry, C., Chandler, M., Jenkins, G., Creel, D., Birch, D., Wang, Y. Z., Rodriguez, L., Locke, K., Klein, M., Mejia, P., Cideciyan, A. V., Jacobson, S. G., Schwartz, S. B., Matsui, R., Gruzensky, M., Roman, A. J., Zrenner, E., Nasser, F., Hahn, G. A., Wilhelm, B., Peters, T., Beier, B., Koenig, T., Kramer, S., Sahel, J. A., Mohand-Said, S., Audo, I., Laurent-Coriat, C., Sliesoraityte, I., Zeitz, C., Boyard, F., Tran, M. H., Chapon, M., Chaumette, C., Amaudruz, J., Ganem, V., Sancho, S., Girmens, A., Scholl, H. P. N., Strauss, R. W., Wolfson, Y., Shah, S. M., Ahmed, M., Schonbach, E., Wojciechowski, R., Khan, S., Emmert, D. G., Cain, D., Herring, M., Bassinger, J., Liberto, L., West, S., Ervin, A. M., Munoz, B., Kong, X., Dreger, K., Jones, J., Jha, A., Ho, A., Kramer, B., Hariri, A., Blanquel, G. R., Lam, N., Pitetta, S., Shi, Y., Tawdros, R., Petrossian, C., Jenkins, D., Gupta, M., Zhou, Y. D., Aguilar, K., Chan, C., Santos, L., Seo, B., Sison, C., Perez, S., Chao, S., Miyasato, K., Higgins, J., Luna, Z., Menchaca, A., Gonzalez, N., Robledo, V., Carig, K., Baker, K., Ellenbogen, D., Russell, J., Bluemel, D., Moreno, A., Pham, R., Sanford, T., Linares, D. & Tran, M., Sep 1 2016, In : Ophthalmology. 123, 9, p. 1887-1897 11 p.

Research output: Contribution to journalArticle

Visual Acuity
Outcome Assessment (Health Care)
Age of Onset
Stargardt disease 1
Vision Disorders
2015

APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans

Tkatchenko, A. V., Tkatchenko, T. V., Guggenheim, J. A., Verhoeven, V. J. M., Hysi, P. G., Wojciechowski, R., Singh, P. K., Kumar, A., Thinakaran, G. & Williams, C., Aug 1 2015, In : PLoS Genetics. 11, 8, e1005432.

Research output: Contribution to journalArticle

Refractive Errors
Myopia
gene
Vision Disorders
mice

Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium

Li, Q., Wojciechowski, R., Simpson, C. L., Hysi, P. G., Verhoeven, V. J. M., Ikram, M. K., Höhn, R., Vitart, V., Hewitt, A. W., Oexle, K., Mäkelä, K. M., MacGregor, S., Pirastu, M., Fan, Q., Cheng, C. Y., St Pourcain, B., McMahon, G., Kemp, J. P., Northstone, K., Rahi, J. S. & 69 others, Cumberland, P. M., Martin, N. G., Sanfilippo, P. G., Lu, Y., Wang, Y. X., Hayward, C., Polašek, O., Campbell, H., Bencic, G., Wright, A. F., Wedenoja, J., Zeller, T., Schillert, A., Mirshahi, A., Lackner, K., Yip, S. P., Yap, M. K. H., Ried, J. S., Gieger, C., Murgia, F., Wilson, J. F., Fleck, B., Yazar, S., Vingerling, J. R., Hofman, A., Uitterlinden, A., Rivadeneira, F., Amin, N., Karssen, L., Oostra, B. A., Zhou, X., Teo, Y. Y., Tai, E. S., Vithana, E., Barathi, V., Zheng, Y., Siantar, R. G., Neelam, K., Shin, Y., Lam, J., Yonova-Doing, E., Venturini, C., Hosseini, S. M., Wong, H. S., Lehtimäki, T., Kähönen, M., Raitakari, O., Timpson, N. J., Evans, D. M., Khor, C. C., Aung, T., Young, T. L., Mitchell, P., Klein, B., van Duijn, C. M., Meitinger, T., Jonas, J. B., Baird, P. N., Mackey, D. A., Wong, T. Y., Saw, S. M., Pärssinen, O., Stambolian, D., Hammond, C. J., Klaver, C. C. W., Williams, C., Paterson, A. D., Bailey-Wilson, J. E. & Guggenheim, J. A., 2015, In : Human Genetics. 134, 2, p. 131-146 16 p.

Research output: Contribution to journalArticle

Refractive Errors
Astigmatism
Genome-Wide Association Study
Meta-Analysis
Population
X-Linked Genes
Retinitis Pigmentosa
Mutation
DNA
2014

Common mechanisms underlying refractive error identified in functional analysis of gene lists from genome-wide association study results in 2 European British cohorts

Hysi, P. G., Mahroo, O. A., Cumberland, P., Wojciechowski, R., Williams, K. M., Young, T. L., Mackey, D. A., Rahi, J. S., Hammond, C. J. & Wiggs, J. L., Jan 2014, In : JAMA Ophthalmology. 132, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Refractive Errors
Genome-Wide Association Study
Genes
Population
Genetic Association Studies

Education influences the association between genetic variants and refractive error: A meta-analysis of five Singapore studies

Fan, Q., Wojciechowski, R., Ikram, M. K., Cheng, C. Y., Chen, P., Zhou, X., Pan, C. W., Khor, C. C., Tai, E. S., Aung, T., Wong, T. Y., Teo, Y. Y. & Saw, S. M., 2014, In : Human Molecular Genetics. 23, 2, p. 546-554 9 p.

Research output: Contribution to journalArticle

Refractive Errors
Singapore
Meta-Analysis
Myopia
Education

Family history is a strong risk factor for prevalent angle closure in a south Indian population

Kavitha, S., Zebardast, N., Palaniswamy, K., Wojciechowski, R., Chan, E. S., Friedman, D. S., Venkatesh, R. & Ramulu, P., Nov 1 2014, In : Ophthalmology. 121, 11, p. 2091-2097 7 p.

Research output: Contribution to journalArticle

Siblings
Angle Closure Glaucoma
Population
Gonioscopy
Manometry

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

Hysi, P. G., Cheng, C. Y., Springelkamp, H., Macgregor, S., Bailey, J. N. C., Wojciechowski, R., Vitart, V., Nag, A., Hewitt, A. W., Höhn, R., Venturini, C., Mirshahi, A., Ramdas, W. D., Thorleifsson, G., Vithana, E., Khor, C. C., Stefansson, A. B., Liao, J., Haines, J. L., Amin, N. & 71 others, Wang, Y. X., Wild, P. S., Ozel, A. B., Li, J. Z., Fleck, B. W., Zeller, T., Staffieri, S. E., Teo, Y. Y., Cuellar-Partida, G., Luo, X., Allingham, R. R., Richards, J. E., Senft, A., Karssen, L. C., Zheng, Y., Bellenguez, C., Xu, L., Iglesias, A. I., Wilson, J. F., Kang, J. H., Van Leeuwen, E. M., Jonsson, V., Thorsteinsdottir, U., Despriet, D. D. G., Ennis, S., Moroi, S. E., Martin, N. G., Jansonius, N. M., Yazar, S., Tai, E. S., Amouyel, P., Kirwan, J., Van Koolwijk, L. M. E., Hauser, M. A., Jonasson, F., Leo, P., Loomis, S. J., Fogarty, R., Rivadeneira, F., Kearns, L., Lackner, K. J., De Jong, P. T. V. M., Simpson, C. L., Pennell, C. E., Oostra, B. A., Uitterlinden, A. G., Saw, S. M., Lotery, A. J., Bailey-Wilson, J. E., Hofman, A., Vingerling, J. R., Maubaret, C., Pfeiffer, N., Wolfs, R. C. W., Lemij, H. G., Young, T. L., Pasquale, L. R., Delcourt, C., Spector, T. D., Klaver, C. C. W., Small, K. S., Burdon, K. P., Stefansson, K., Wong, T. Y., Viswanathan, A., Mackey, D. A., Craig, J. E., Wiggs, J. L., Van Duijn, C. M., Hammond, C. J. & Zack, D. J., Sep 26 2014, In : Nature Genetics. 46, 10, p. 1126-1130 5 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Glaucoma
Genome
Meta-Analysis
Chromosomes

Genome-wide association studies of refractive error and myopia, lessons learned, and implications for the future

Hysi, P. G., Wojciechowski, R., Rahi, J. S. & Hammond, C. J., May 29 2014, In : Investigative Ophthalmology and Visual Science. 55, 5, p. 3344-3351 8 p.

Research output: Contribution to journalArticle

Refractive Errors
Genome-Wide Association Study
Myopia
Ethnic Groups

Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci

Simpson, C. L., Wojciechowski, R., Oexle, K., Murgia, F., Portas, L., Li, X., Virginie, J. M. V., Vitart, V., Schache, M., Mohsen Hosseini, S., Hysi, P. G., Raffel, L. J., Cotch, M. F., Chew, E., Klein, B. E. K., Klein, R., Wong, T. Y., Van Duijn, C. M., Mitchell, P., Saw, S. M. & 33 others, Fossarello, M., Wang, J. J., Polašek, O., Campbell, H., Rudan, I., Oostra, B. A., Uitterlinden, A. G., Hofman, A., Rivadeneira, F., Amin, N., Karssen, L. C., Vingerling, J. R., Döring, A., Bettecken, T., Bencic, G., Gieger, C., Wichmann, H. E., Wilson, J. F., Venturini, C., Fleck, B., Cumberland, P. M., Rahi, J. S., Hammond, C. J., Hayward, C., Wright, A. F., Paterson, A. D., Baird, P. N., Klaver, C. C. W., Rotter, J. I., Pirastu, M., Meitinger, T., Bailey-Wilson, J. E. & Stambolian, D., Sep 18 2014, In : PLoS One. 9, 9, e107110.

Research output: Contribution to journalArticle

Hyperopia
Myopia
meta-analysis
Meta-Analysis
Genes
2013

Association study in a South Indian population supports rs1015213 as a risk factor for primary angle closure

Duvesh, R., Verma, A., Venkatesh, R., Kavitha, S., Ramulu, P., Wojciechowski, R. & Sundaresan, P., 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5624-5628 5 p.

Research output: Contribution to journalArticle

Angle Closure Glaucoma
Single Nucleotide Polymorphism
Population
Intergenic DNA
Glaucoma

Erratum: Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia (Nature Genetics (2013) 45 (314-318))

Verhoeven, V. J. M., Hysi, P. G., Wojciechowski, R., Fan, Q., Guggenheim, J. A., Höhn, R., MacGregor, S., Hewitt, A. W., Nag, A., Cheng, C. Y., Yonova-Doing, E., Zhou, X., Ikram, M. K., Buitendijk, G. H. S., McMahon, G., Kemp, J. P., St Pourcain, B., Simpson, C. L., Mäkelä, K. M., Lehtimäki, T. & 88 others, Kähönen, M., Paterson, A. D., Hosseini, S. M., Wong, H. S., Xu, L., Jonas, J. B., Pärssinen, O., Wedenoja, J., Yip, S. P., Ho, D. W. H., Pang, C. P., Chen, L. J., Burdon, K. P., Craig, J. E., Klein, B. E. K., Klein, R., Haller, T., Metspalu, A., Khor, C. C., Tai, E. S., Aung, T., Vithana, E., Tay, W. T., Barathi, V. A., Chen, P., Li, R., Liao, J., Zheng, Y., Ong, R. T., Döring, A., Evans, D. M., Timpson, N. J., Verkerk, A. J. M. H., Meitinger, T., Raitakari, O., Hawthorne, F., Spector, T. D., Karssen, L. C., Pirastu, M., Murgia, F., Ang, W., Mishra, A., Montgomery, G. W., Pennell, C. E., Cumberland, P. M., Cotlarciuc, I., Mitchell, P., Wang, J. J., Schache, M., Janmahasathian, S., Igo, R. P., Lass, J. H., Chew, E., Iyengar, S. K., Gorgels, T. G. M. F., Rudan, I., Hayward, C., Wright, A. F., Polasek, O., Vatavuk, Z., Wilson, J. F., Fleck, B., Zeller, T., Mirshahi, A., Müller, C., Uitterlinden, A. G., Rivadeneira, F., Vingerling, J. R., Hofman, A., Oostra, B. A., Amin, N., Bergen, A. A. B., Teo, Y. Y., Rahi, J. S., Vitart, V., Williams, C., Baird, P. N., Wong, T. Y., Oexle, K., Pfeiffer, N., Mackey, D. A., Young, T. L., Van Duijn, C. M., Saw, S. M., Bailey-Wilson, J. E., Stambolian, D., Klaver, C. C. & Hammond, C. J., Jun 2013, In : Nature Genetics. 45, 6, p. 712 1 p.

Research output: Contribution to journalArticle

Refractive Errors
Myopia
Meta-Analysis
Genome

Focusing In on the Complex Genetics of Myopia

Wojciechowski, R. & Hysi, P. G., Apr 2013, In : PLoS Genetics. 9, 4, e1003442.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Myopia
Genetic Predisposition to Disease
genome-wide association study
myopia

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

Verhoeven, V. J. M., Hysi, P. G., Wojciechowski, R., Fan, Q., Guggenheim, J. A., Höhn, R., Macgregor, S., Hewitt, A. W., Nag, A., Cheng, C. Y., Yonova-Doing, E., Zhou, X., Ikram, M. K., Buitendijk, G. H. S., Mcmahon, G., Kemp, J. P., Pourcain, B. S., Simpson, C. L., Mäkelä, K. M., Lehtimäki, T. & 88 others, Kähönen, M., Paterson, A. D., Hosseini, S. M., Wong, H. S., Xu, L., Jonas, J. B., Pärssinen, O., Wedenoja, J., Yip, S. P., Ho, D. W. H., Pang, C. P., Chen, L. J., Burdon, K. P., Craig, J. E., Klein, B. E. K., Klein, R., Haller, T., Metspalu, A., Khor, C. C., Tai, E. S., Aung, T., Vithana, E., Tay, W. T., Barathi, V. A., Chen, P., Li, R., Liao, J., Zheng, Y., Ong, R. T., Döring, A., Evans, D. M., Timpson, N. J., Verkerk, A. J. M. H., Meitinger, T., Raitakari, O., Hawthorne, F., Spector, T. D., Karssen, L. C., Pirastu, M., Murgia, F., Ang, W., Mishra, A., Montgomery, G. W., Pennell, C. E., Cumberland, P. M., Cotlarciuc, I., Mitchell, P., Wang, J. J., Schache, M., Janmahasathian, S., Igo, R. P., Lass, J. H., Chew, E., Iyengar, S. K., Gorgels, T. G. M. F., Rudan, I., Hayward, C., Wright, A. F., Polasek, O., Vatavuk, Z., Wilson, J. F., Fleck, B., Zeller, T., Mirshahi, A., Müller, C., Uitterlinden, A. G., Rivadeneira, F., Vingerling, J. R., Hofman, A., Oostra, B. A., Amin, N., Bergen, A. A. B., Teo, Y. Y., Rahi, J. S., Vitart, V., Williams, C., Baird, P. N., Wong, T. Y., Oexle, K., Pfeiffer, N., Mackey, D. A., Young, T. L., Van Duijn, C. M., Saw, S. M., Bailey-Wilson, J. E., Stambolian, D., Klaver, C. C. & Hammond, C. J., Mar 2013, In : Nature Genetics. 45, 3, p. 314-318 5 p.

Research output: Contribution to journalArticle

Refractive Errors
Myopia
Meta-Analysis
Genome
Genetic Load

Matrix metalloproteinases and educational attainment in refractive error: Evidence of gene-environment interactions in the age-related eye disease study

Wojciechowski, R., Yee, S. S., Simpson, C. L., Bailey-Wilson, J. E. & Stambolian, D., Feb 2013, In : Ophthalmology. 120, 2, p. 298-305 8 p.

Research output: Contribution to journalArticle

Gene-Environment Interaction
Refractive Errors
Eye Diseases
Matrix Metalloproteinases
Single Nucleotide Polymorphism

Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error

Stambolian, D., Wojciechowski, R., Oexle, K., Pirastu, M., Li, X., Raffe, L. J., Cotch, M. F., Chew, E. Y., Klein, B., Klein, R., Wong, T. Y., Simpson, C. L., Klaver, C. C. W., van Duijn, C. M., Verhoeven, V. J. M., Baird, P. N., Vitart, V., Paterson, A. D., Mitchell, P., Saw, S. M. & 41 others, Fossarello, M., Kazmierkiewicz, K., Murgia, F., Portas, L., Schache, M., Richardson, A., Xie, J., Wang, J. J., Rochtchina, E., Viswanathan, A. C., Hayward, C., Wright, A. F., Polašek, O., Campbell, H., Rudan, I., Oostra, B. A., Uitterlinden, A. G., Hofman, A., Rivadeneira, F., Amin, N., Karssen, L. C., Vingerling, J. R., Hosseini, S. M., Döring, A., Bettecken, T., Vatavuk, Z., Gieger, C., Wichmann, H. E., Wilson, J. F., Fleck, B., Foster, P. J., Topouzis, F., McGuffin, P., Sim, X., Inouye, M., Holliday, E. G., Attia, J., Scott, R. J., Rotter, J. I., Meitinger, T. & Bailey-Wilson, J. E., Jul 2013, In : Human Molecular Genetics. 22, 13, p. 2754-2764 11 p.

Research output: Contribution to journalArticle

Refractive Errors
Genome-Wide Association Study
Meta-Analysis
HapMap Project
Chromosomes, Human, Pair 16

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error

Cheng, C. Y., Schache, M., Ikram, M. K., Young, T. L., Guggenheim, J. A., Vitart, V., MacGregor, S., Verhoeven, V. J. M., Barathi, V. A., Liao, J., Hysi, P. G., Bailey-Wilson, J. E., St. Pourcain, B., Kemp, J. P., McMahon, G., Timpson, N. J., Evans, D. M., Montgomery, G. W., Mishra, A., Wang, Y. X. & 88 others, Wang, J. J., Rochtchina, E., Polasek, O., Wright, A. F., Amin, N., Van Leeuwen, E. M., Wilson, J. F., Pennell, C. E., Van Duijn, C. M., De Jong, P. T. V. M., Vingerling, J. R., Zhou, X., Chen, P., Li, R., Tay, W. T., Zheng, Y., Chew, M., Burdon, K. P., Craig, J. E., Iyengar, S. K., Igo, R. P., Lass, J. H., Chew, E. Y., Haller, T., Mihailov, E., Metspalu, A., Wedenoja, J., Simpson, C. L., Wojciechowski, R., Höhn, R., Mirshahi, A., Zeller, T., Pfeiffer, N., Lackner, K. J., Bettecken, T., Meitinger, T., Oexle, K., Pirastu, M., Portas, L., Nag, A., Williams, K. M., Yonova-Doing, E., Klein, R., Klein, B. E., Hosseini, S. M., Paterson, A. D., Makela, K. M., Lehtimaki, T., Kahonen, M., Raitakari, O., Yoshimura, N., Matsuda, F., Chen, L. J., Pang, C. P., Yip, S. P., Yap, M. K. H., Meguro, A., Mizuki, N., Inoko, H., Foster, P. J., Zhao, J. H., Vithana, E., Tai, E. S., Fan, Q., Xu, L., Campbell, H., Fleck, B., Rudan, I., Aung, T., Hofman, A., Uitterlinden, A. G., Bencic, G., Khor, C. C., Forward, H., Pärssinen, O., Mitchell, P., Rivadeneira, F., Hewitt, A. W., Williams, C., Oostra, B. A., Teo, Y. Y., Hammond, C. J., Stambolian, D., MacKey, D. A., Klaver, C. C. W., Wong, T. Y., Saw, S. M. & Baird, P. N., Aug 8 2013, In : American Journal of Human Genetics. 93, 2, p. 264-277 14 p.

Research output: Contribution to journalArticle

Eye Axial Length
Refractive Errors
Genome-Wide Association Study
Myopia
Hyperopia

Regional replication of association with refractive error on 15q14 and 15q25 in the age-related eye disease study cohort

Simpson, C. L., Wojciechowski, R., Yee, S. S., Soni, P., Bailey-Wilson, J. E. & Stambolian, D., Nov 2 2013, In : Molecular Vision. 19, p. 2173-2186 14 p.

Research output: Contribution to journalArticle

Refractive Errors
Eye Diseases
Single Nucleotide Polymorphism
Cohort Studies
Chromosomes, Human, Pair 15
2012

Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium

Verhoeven, V. J. M., Hysi, P. G., Saw, S. M., Vitart, V., Mirshahi, A., Guggenheim, J. A., Cotch, M. F., Yamashiro, K., Baird, P. N., Mackey, D. A., Wojciechowski, R., Kamran Ikram, M., Hewitt, A. W., Duggal, P., Janmahasatian, S., Khor, C. C., Fan, Q., Zhou, X., Young, T. L., Tai, E. S. & 75 others, Goh, L. K., Li, Y. J., Aung, T., Vithana, E., Teo, Y. Y., Tay, W., Sim, X., Rudan, I., Hayward, C., Wright, A. F., Polasek, O., Campbell, H., Wilson, J. F., Fleck, B. W., Nakata, I., Yoshimura, N., Yamada, R., Matsuda, F., Ohno-Matsui, K., Nag, A., McMahon, G., St. Pourcain, B., Lu, Y., Rahi, J. S., Cumberland, P. M., Bhattacharya, S., Simpson, C. L., Atwood, L. D., Li, X., Raffel, L. J., Murgia, F., Portas, L., Despriet, D. D. G., Van Koolwijk, L. M. E., Wolfram, C., Lackner, K. J., Tönjes, A., Mägi, R., Lehtimäki, T., Kähönen, M., Esko, T., Metspalu, A., Rantanen, T., Pärssinen, O., Klein, B. E., Meitinger, T., Spector, T. D., Oostra, B. A., Smith, A. V., De Jong, P. T. V. M., Hofman, A., Amin, N., Karssen, L. C., Rivadeneira, F., Vingerling, J. R., Eiríksdóttir, G., Gudnason, V., Döring, A., Bettecken, T., Uitterlinden, A. G., Williams, C., Zeller, T., Castagné, R., Oexle, K., Van Duijn, C. M., Iyengar, S. K., Mitchell, P., Wang, J. J., Höhn, R., Pfeiffer, N., Bailey-Wilson, J. E., Stambolian, D., Wong, T. Y., Hammond, C. J. & Klaver, C. C. W., Sep 2012, In : Human Genetics. 131, 9, p. 1467-1480 14 p.

Research output: Contribution to journalArticle

Refractive Errors
Myopia
Single Nucleotide Polymorphism
Meta-Analysis
Hyperopia
2011

Dissecting the genetic heterogeneity of myopia susceptibility in an Ashkenazi Jewish population using ordered subset analysis

Simpson, C. L., Wojciechowski, R., Ibay, G., Stambolian, D. & Bailey-Wilson, J. E., 2011, In : Molecular Vision. 17, p. 16411651 1 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Myopia
Chromosomes, Human, Pair 22
Population
Chromosomes

Dissecting the genetic heterogeneity of myopia susceptibility in an Ashkenazi Jewish population using ordered subset analysis.

Simpson, C. L., Wojciechowski, R., Ibay, G., Stambolian, D. & Bailey-Wilson, J. E., 2011, In : Molecular Vision. 17, p. 1641-1651 11 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Myopia
Chromosomes, Human, Pair 22
Population
Chromosomes

Nature and nurture: The complex genetics of myopia and refractive error

Wojciechowski, R., Apr 2011, In : Clinical Genetics. 79, 4, p. 301-320 20 p.

Research output: Contribution to journalArticle

Refractive Errors
Myopia
Genes
Population
Hyperopia

Power vector analysis of refractive, corneal, and internal astigmatism in an elderly Chinese Population: The Shihpai Eye Study

Liu, Y. C., Chou, P., Wojciechowski, R., Lin, P. Y., Jui-Ling, C. L., Chen, S. J., Liu, J. H., Hsu, W. M. & Cheng, C. Y., Dec 2011, In : Investigative Ophthalmology and Visual Science. 52, 13, p. 9651-9657 7 p.

Research output: Contribution to journalArticle

Astigmatism
Population
Taiwan
Cataract
Lenses
2010

Association of matrix metalloproteinase gene polymorphisms with refractive error in amish and ashkenazi families

Wojciechowski, R., Bailey-Wilson, J. E. & Stambolian, D., Oct 2010, In : Investigative Ophthalmology and Visual Science. 51, 10, p. 4989-4995 7 p.

Research output: Contribution to journalArticle

Amish
Refractive Errors
Matrix Metalloproteinases
Single Nucleotide Polymorphism
Tissue Inhibitor of Metalloproteinases
Dry Eye Syndromes
Tears
Silicones
Eye Foreign Bodies
Randomized Controlled Trials

Structure-Function Correlations Using Scanning Laser Polarimetry in Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma

Lee, P. J., Liu, C. J. L., Wojciechowski, R., Bailey-Wilson, J. E. & Cheng, C. Y., May 2010, In : American Journal of Ophthalmology. 149, 5

Research output: Contribution to journalArticle

Scanning Laser Polarimetry
Angle Closure Glaucoma
Nerve Fibers
Visual Fields
Veterans Hospitals
2009

Fine-mapping of candidate region in Amish and Ashkenazi families confirms linkage of refractive error to a QTL on 1p34-p36

Wojciechowski, R., Bailey-Wilson, J. E. & Stambolian, D., Jul 17 2009, In : Molecular Vision. 15, p. 1398-1406 9 p.

Research output: Contribution to journalArticle

Amish
Refractive Errors
Quantitative Trait Loci
Ocular Refraction
Chromosome Mapping

Genomewide linkage scans for ocular refraction and meta-analysis of four populations in the Myopia Family Study

Wojciechowski, R., Stambolian, D., Ciner, E., Ibay, G., Holmes, T. N. & Bailey-Wilson, J. E., 2009, In : Investigative Ophthalmology and Visual Science. 50, 5, p. 2024-2032 9 p.

Research output: Contribution to journalArticle

Ocular Refraction
Myopia
Amish
Meta-Analysis
Population

Genome-wide Scan of African-American and White Families for Linkage to Myopia

Ciner, E., Ibay, G., Wojciechowski, R., Dana, D., Holmes, T. N., Bailey-Wilson, J. E. & Stambolian, D., Mar 2009, In : American Journal of Ophthalmology. 147, 3

Research output: Contribution to journalArticle

Myopia
African Americans
Genome
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 20
2008

Genomewide scan of ocular refraction in African-American families shows significant linkage to chromosome 7p15

Ciner, E., Wojciechowski, R., Ibay, G., Bailey-Wilson, J. E. & Stambolian, D., Jul 2008, In : Genetic Epidemiology. 32, 5, p. 454-463 10 p.

Research output: Contribution to journalArticle

Ocular Refraction
African Americans
Chromosomes
Quantitative Trait Loci
Myopia
2007

Correction of moderate myopia is associated with improvement in self-reported visual functioning among Mexican school-aged children

Esteso, P., Castanon, A., Toledo, S., Pereyra Rito, M. A., Ervin, A. M., Wojciechowski, R. & Congdon, N. G., Nov 2007, In : Investigative Ophthalmology and Visual Science. 48, 11, p. 4949-4954 6 p.

Research output: Contribution to journalArticle

Myopia
Mexico
Visual Acuity

Heritability and familial aggregation of refractive error in the Old Order Amish

Peet, J. A., Cotch, M. F., Wojciechowski, R., Bailey-Wilson, J. E. & Stambolian, D., Sep 2007, In : Investigative Ophthalmology and Visual Science. 48, 9, p. 4002-4006 5 p.

Research output: Contribution to journalArticle

Amish
Hyperopia
Refractive Errors
Myopia
Siblings

Punctal occlusion for dry eye syndrome

Ervin, A. M., Wojciechowski, R. & Schein, O., 2007, In : The Cochrane database of systematic reviews. 4, CD006775.

Research output: Contribution to journalArticle

Dry Eye Syndromes
2006

Genomewide scan in Ashkenazi Jewish families demonstrates evidence of linkage of ocular refraction to a QTL on chromosome 1p36

Wojciechowski, R., Moy, C., Ciner, E., Ibay, G., Reider, L., Bailey-Wilson, J. E. & Stambolian, D., May 2006, In : Human Genetics. 119, 4, p. 389-399 11 p.

Research output: Contribution to journalArticle

Ocular Refraction
Quantitative Trait Loci
Refractive Errors
Chromosomes
Neurofibromin 2
2005
Cataract
Population
Siblings
Steroids
Age Factors