Robert Leone

Instructor

20132019
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Fingerprint Dive into the research topics where Robert Leone is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Immunotherapy Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Adenosine Medicine & Life Sciences
temozolomide Medicine & Life Sciences
Tumor Microenvironment Medicine & Life Sciences
Tumor Escape Medicine & Life Sciences
Autophagy Medicine & Life Sciences
Hydroxychloroquine Medicine & Life Sciences

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Research Output 2013 2019

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Leone, R. D., Zhao, L., Englert, J. M., Sun, I. M., Oh, M. H., Sun, I. H., Arwood, M. L., Bettencourt, I. A., Patel, C. H., Wen, J., Tam, A., Blosser, R. L., Prchalova, E., Alt, J., Rais, R., Slusher, B. S. & Powell, J. D., Nov 22 2019, In : Science. 366, 6468, p. 1013-1021 9 p.

Research output: Contribution to journalArticle

Tumor Escape
Glutamine
Neoplasms
Immunotherapy
T-Lymphocytes

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation

Brian Dalton, W., Helmenstine, E., Walsh, N., Gondek, L. P., Kelkar, D. S., Read, A., Natrajan, R., Christenson, E. S., Roman, B., Das, S., Zhao, L., Leone, R. D., Shinn, D., Groginski, T., Madugundu, A. K., Patil, A., Zabransky, D. J., Medford, A., Lee, J., Cole, A. J. & 12 others, Rosen, M., Thakar, M., Ambinder, A., Donaldson, J., DeZern, A. E., Cravero, K., Chu, D., Madero-Marroquin, R., Pandey, A., Hurley, P. J., Lauring, J. & Park, B. H., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4708-4723 16 p.

Research output: Contribution to journalArticle

Serine
Mutation
Down-Regulation
Spliceosomes
Mitochondrial Genes

Targeting metabolism to regulate immune responses in autoimmunity and cancer

Patel, C. H., Leone, R., Horton, M. & Powell, J., Jan 1 2019, In : Nature Reviews Drug Discovery.

Research output: Contribution to journalReview article

Autoimmunity
Neoplasms
Long-Term Memory
Graft Rejection
Cell Differentiation

Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models

Leone, R., Sun, I. M., Oh, M. H., Sun, I. H., Wen, J., Englert, J. & Powell, J., Jun 19 2018, (Accepted/In press) In : Cancer Immunology, Immunotherapy. p. 1-14 14 p.

Research output: Contribution to journalArticle

Purinergic P1 Receptors
T-Cell Antigen Receptor
Adenosine
Eragrostis
Regulatory T-Lymphocytes

Targeting adenosine for cancer immunotherapy

Leone, R. & Emens, L. A., Jan 1 2018, In : Journal for immunotherapy of cancer. 6, 1, 57.

Research output: Contribution to journalReview article

Open Access
Adenosine
Immunotherapy
Neoplasms
Immunity
Tumor Escape