Robert John Adams

Associate Provost

1974 …2018
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Research Output 1974 2018

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Article
2018
Simian Immunodeficiency Virus
Macaca
Encephalitis
Meningitis
Central Nervous System
2017
Simian Immunodeficiency Virus
Macaca
HIV
Virus Diseases
Neurocognitive Disorders

Evolution of T Cell Responses during Measles Virus Infection and RNA Clearance

Nelson, A. N., Putnam, N., Hauer, D., Baxter, V. K., Adams, R. J. & Griffin, D. E. Dec 1 2017 In : Scientific Reports. 7, 1, 11474

Research output: Contribution to journalArticle

Measles virus
Virus Diseases
Interleukin-17
RNA
T-Lymphocytes

Genetic characterization of a captive colony of pigtailed Macaques (Macaca nemestrina)

Zhang, X., Kanthaswamy, S., Trask, J. S., Ng, J., Oldt, R. F., Mankowski, J. L., Adams, R. J. & Smith, D. G. Jul 1 2017 In : Journal of the American Association for Laboratory Animal Science. 56, 4, p. 390-395 6 p.

Research output: Contribution to journalArticle

Macaca nemestrina
biomedical research
inbreeding
single nucleotide polymorphism
heterozygosity

Immune activation of platelets in response to serial phlebotomy in pigtailed macaques (Macaca nemestrina)

Vermillion, M. S., Lyons, C. E., Najarro, K. M., Adams, R. J. & Metcalf Pate, K. A. Jul 1 2017 In : Comparative Medicine. 67, 4, p. 360-367 8 p.

Research output: Contribution to journalArticle

Macaca nemestrina
platelet activation
Phlebotomy
blood platelet count
Platelet Activation
2016

Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control

Beck, S. E., Queen, S. E., Viscidi, R., Johnson, D., Kent, S. J., Adams, R. J., Tarwater, P. M. & Mankowski, J. L. Jan 4 2016 (Accepted/In press) In : Journal of NeuroVirology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Major Histocompatibility Complex
Central Nervous System
Macaca
Central Nervous System Diseases

Discovery of 6-Diazo-5-oxo- l -norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

Rais, R., Jančařík, A., Tenora, L., Nedelcovych, M., Alt, J., Englert, J., Rojas, C., Le, A., Elgogary, A., Tan, J., Monincová, L., Pate, K., Adams, R., Ferraris, D., Powell, J., Majer, P. & Slusher, B. S. Sep 22 2016 In : Journal of Medicinal Chemistry. 59, 18, p. 8621-8633 13 p.

Research output: Contribution to journalArticle

Diazooxonorleucine
Prodrugs
Glioblastoma
Haplorhini
Glutamine
Macaca nemestrina
Vitamin B Complex
vitamin B complex
Macaca
vitamin B12
2015

A murine viral outgrowth assay to detect residual HIV type 1 in patients with undetectable viral loads

Metcalf Pate, K. A. , Pohlmeyer, C. W. , Walker-Sperling, V. E. , Foote, J. B. , Najarro, K. M. , Cryer, C. G. , Salgado, M. , Gama, L. , Engle, E. L. , Shirk, E. N. , Queen, S. E. , Chioma, S. , Vermillion, M. S. , Bullock, B. , Li, M. , Lyons, C. E. , Adams, R. J. , Zink, M. C. , Clements, J. E. , Mankowski, J. L. & 1 others Blankson, J. N. Nov 1 2015 In : Journal of Infectious Diseases. 212, 9, p. 1387-1396 10 p.

Research output: Contribution to journalArticle

Viral Load
HIV-1
HIV
Simian Immunodeficiency Virus
T-Lymphocytes

A replicating adenovirus capsid display recombinant elicits antibodies against Plasmodium falciparum sporozoites in Aotus nancymaae monkeys

Karen, K. A., Deal, C., Adams, R. J., Nielsen, C., Ward, C., Espinosa, D. A., Xie, J., Zavala, F. & Ketner, G. 2015 In : Infection and Immunity. 83, 1, p. 268-275 8 p.

Research output: Contribution to journalArticle

Sporozoites
Capsid
Plasmodium falciparum
Adenoviridae
Haplorhini

Limited in vivo production of type i or type III interferon after infection of macaques with vaccine or wild-type strains of measles virus

Shivakoti, R., Hauer, D., Adams, R. J., Lin, W. H. W., Duprex, W. P., De Swart, R. L. & Griffin, D. E. Apr 1 2015 In : Journal of Interferon and Cytokine Research. 35, 4, p. 292-301 10 p.

Research output: Contribution to journalArticle

Measles virus
Macaca
Interferons
Vaccines
Infection
Simian Immunodeficiency Virus
Central Nervous System Diseases
Macaca
Macaca mulatta
Incidence
Guanfacine
Self-Injurious Behavior
Macaca mulatta
Pharmacology
Macaca

Neuroinflammation and virus replication in the spinal cord of simian immunodeficiency virus-infected macaques

Mangus, L. M., Dorsey, J. L., Laast, V. A., Hauer, P., Queen, S. E., Adams, R. J., McArthur, J. C. & Mankowski, J. L. Jan 3 2015 In : Journal of Neuropathology and Experimental Neurology. 74, 1, p. 38-47 10 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Macaca
Virus Replication
Spinal Cord
Peripheral Nervous System
Central Nervous System Diseases
Macaca
HIV
Biomarkers
MHC Class I Genes
Simian Immunodeficiency Virus
Peripheral Nervous System
Macaca
HIV
Nerve Fibers

Pharmacokinetics and immunogenicity of a recombinant human butyrylcholinesterase bioscavenger in macaques following intravenous and pulmonary delivery

Rosenberg, Y. J., Adams, R. J., Hernandez-Abanto, S., Jiang, X., Sun, W., Mao, L. & Lee, K. D. Dec 5 2015 In : Chemico-Biological Interactions. 242, p. 219-226 8 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Pharmacokinetics
Macaca
Animals
Lung

Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis

Muth, D. C., McAlexander, M. A., Ostrenga, L. J., Pate, N. M., Izzi, J. M., Adams, R. J., Pate, K. A. M., Beck, S. E., Karim, B. O. & Witwer, K. W. Aug 8 2015 In : BMC Veterinary Research. 11, 1, 187

Research output: Contribution to journalArticle

exosomes
Exosomes
Endometriosis
Macaca
Primate Diseases
Macaca mulatta
animal injuries
incidence
animal well-being
abnormal behavior
2014

CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.

Kelly, K. M., Tocchetti, C. G., Lyashkov, A., Tarwater, P. M., Bedja, D., Graham, D. R., Beck, S. E., Metcalf Pate, K. A., Queen, S. E., Adams, R. J., Paolocci, N. & Mankowski, J. L. 2014 In : Journal of the American Heart Association. 3, 2

Research output: Contribution to journalArticle

Macaca
HIV
Cardiac Myocytes
Viral Load
Chemokines

Corrigendum to "vaccination with hpv16 l2e6e7 fusion protein in gpi-0100 adjuvant elicits protective humoral and cell-mediated immunity" [vaccine 27 (2009) 1040-1049]

Karanam, B., Gambhira, R., Peng, S., Jagu, S., Kim, D. J., Ketner, G. W., Stern, P. L., Adams, R. J. & Roden, R. B. S. Jan 3 2014 In : Vaccine. 32, 2, p. 309 1 p.

Research output: Contribution to journalArticle

Cellular Immunity
cell-mediated immunity
adjuvants
Vaccination
Vaccines

Immune Responses in Macaques to a Prototype Recombinant Adenovirus Live Oral Human Papillomavirus 16 Vaccine

Berg, M. G., Adams, R. J., Gambhira, R., Siracusa, M. C., Scott, A. L., Roden, R. B. S. & Ketner, G. 2014 In : Clinical and Vaccine Immunology. 21, 9, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

Papillomavirus Vaccines
Human papillomavirus 16
Immunization
Macaca
Viruses

Loss of corneal sensory nerve fibers in SIV-infected macaques: An alternate approach to investigate HIV-induced PNS damage

Dorsey, J. L., Mangus, L. M., Oakley, J. D., Beck, S. E., Kelly, K. M., Queen, S. E., Metcalf Pate, K. A., Adams, R. J., Marfurt, C. F. & Mankowski, J. L. 2014 In : American Journal of Pathology. 184, 6, p. 1652-1659 8 p.

Research output: Contribution to journalArticle

Macaca
Nerve Fibers
HIV
Peripheral Nervous System Diseases
Trigeminal Ganglion

TGFβ-mediated downregulation of thrombopoietin is associated with platelet decline in asymptomatic SIV infection

Pate, K. A. M., Lyons, C. E., Dorsey, J. L., Queen, S. E., Adams, R. J., Morrell, C. N. & Mankowski, J. L. Apr 15 2014 In : Journal of Acquired Immune Deficiency Syndromes. 65, 5, p. 510-516 7 p.

Research output: Contribution to journalArticle

Thrombopoietin
Simian Immunodeficiency Virus
Virus Diseases
Blood Platelets
Down-Regulation

Vaccine-induced measles virus-specific T cells do not prevent infection or disease but facilitate subsequent clearance of viral RNA

Lin, W. H. W., Pan, C. H., Adams, R. J., Laube, B. L. & Griffin, D. E. Apr 15 2014 In : mBio. 5, 2, e01047-14

Research output: Contribution to journalArticle

Measles virus
Viral RNA
Vaccines
T-Lymphocytes
Infection
2013
Macaca nemestrina
Enterocolitis
enterocolitis
amyloidosis
Biopsy

Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: Reduced replicating and latent SIV in the brain

Kelly, K. M., Beck, S. E., Pate, K. A. M., Queen, S. E., Dorsey, J. L., Adams, R. J., Avery, L. B., Hubbard, W., Tarwater, P. M. & Mankowski, J. L. Nov 28 2013 In : AIDS. 27, 18

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Macaca
Central Nervous System
Brain
Central Nervous System Diseases

Platelet activation and platelet-monocyte aggregate formation contribute to decreased platelet count during acute simian immunodeficiency virus infection in pig-tailed macaques

Metcalf Pate, K. A., Lyons, C. E., Dorsey, J. L., Shirk, E. N., Queen, S. E., Adams, R. J., Gama, L., Morrell, C. N. & Mankowski, J. L. Sep 15 2013 In : Journal of Infectious Diseases. 208, 6, p. 874-883 10 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Platelet Activation
Macaca
Virus Diseases
Platelet Count

Poor immune responses of newborn rhesus macaques to measles virus DNA vaccines expressing the hemagglutinin and fusion glycoproteins

Polack, F. P., Lydy, S. L., Lee, S. H., Rota, P. A., Bellini, W. J., Adams, R. J., Robinson, H. L. & Griffin, D. E. Feb 2013 In : Clinical and Vaccine Immunology. 20, 2, p. 205-210 6 p.

Research output: Contribution to journalArticle

Measles virus
DNA Vaccines
Hemagglutinins
Macaca mulatta
Viruses

Pulmonary delivery of an aerosolized recombinant human butyrylcholinesterase pretreatment protects against aerosolized paraoxon in macaques

Rosenberg, Y. J., Laube, B., Mao, L., Jiang, X., Hernandez-Abanto, S., Lee, K. D. & Adams, R. Mar 25 2013 In : Chemico-Biological Interactions. 203, 1, p. 167-171 5 p.

Research output: Contribution to journalArticle

Paraoxon
Butyrylcholinesterase
Organophosphates
Macaca
Aerosols
MicroRNAs
Real-Time Polymerase Chain Reaction
Polymerase Chain Reaction
Macaca
Genes

Serum albumin and body weight as biomarkers for the antemortem identification of bone and gastrointestinal disease in the common marmoset

Baxter, V. K., Shaw, G. C., Sotuyo, N. P., Carlson, C. S., Olson, E. J., Christine Zink, M., Mankowski, J. L., Adams, R. J., Hutchinson, E. K. & Metcalf Pate, K. A. Dec 6 2013 In : PLoS One. 8, 12, e82747

Research output: Contribution to journalArticle

bone diseases
Callithrix
Callithrix jacchus
Gastrointestinal Diseases
Callitrichidae

Vaxfectin adjuvant improves antibody responses of juvenile rhesus macaques to a DNA vaccine encoding the measles virus hemagglutinin and fusion proteins

Lin, W. H. W., Vilalta, A., Adams, R. J., Rolland, A., Sullivan, S. M. & Griffin, D. E. Jun 2013 In : Journal of Virology. 87, 12, p. 6560-6568 9 p.

Research output: Contribution to journalArticle

Viral Fusion Proteins
Measles virus
DNA Vaccines
Hemagglutinins
recombinant vaccines
2012

Diastolic dysfunction is associated with myocardial viral load in simian immunodeficiency virus-infected macaques

Kelly, K. M., Tarwater, P. M., Karper, J. M., Bedja, D., Queen, S. E., Tunin, R. S., Adams, R. J., Kass, D. A. & Mankowski, J. L. Apr 24 2012 In : AIDS. 26, 7, p. 815-823 9 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Macaca
Viral Load
Myocardium
Virus Replication

Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics

Lin, W. H. W., Kouyos, R. D., Adams, R. J., Grenfell, B. T. & Griffin, D. E. Sep 11 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 37, p. 14989-14994 6 p.

Research output: Contribution to journalArticle

Measles virus
RNA
Infection
Viral RNA
Immunity
Macaca
Virus Replication
Cocaine
HIV Infections
Inflammation

SIV-induced impairment of neurovascular repair: A potential role for VEGF

Ebenezer, G. J., McArthur, J. C., Polydefkis, M., Dorsey, J. L., O'Donnell, R., Hauer, P., Adams, R. J. & Mankowski, J. L. Jun 2012 In : Journal of NeuroVirology. 18, 3, p. 222-230 9 p.

Research output: Contribution to journalArticle

Macaca
Vascular Endothelial Growth Factor A
Nerve Fibers
Blood Vessels
Axotomy
2011

Macrophage-mediated dorsal root ganglion damage precedes altered nerve conduction in SIV-infected macaques

Laast, V. A., Shim, B., Johanek, L. M., Dorsey, J. L., Hauer, P. E., Tarwater, P. M., Adams, R. J., Pardo, C. A., McArthur, J. C., Ringkamp, M. & Mankowski, J. L. Nov 2011 In : American Journal of Pathology. 179, 5, p. 2337-2345 9 p.

Research output: Contribution to journalArticle

Neural Conduction
Spinal Ganglia
Macaca
Macrophages
Unmyelinated Nerve Fibers

Osteopontin enhances HIV replication and is increased in the brain and cerebrospinal fluid of HIV-infected individuals

Brown, A., Islam, T., Adams, R., Nerle, S., Kamara, M., Eger, C., Marder, K., Cohen, B., Schifitto, G., McArthur, J. C., Sacktor, N. & Pardo, C. A. Aug 2011 In : Journal of NeuroVirology. 17, 4, p. 382-392 11 p.

Research output: Contribution to journalArticle

Osteopontin
Cerebrospinal Fluid
HIV
Brain
Macrophages

Replication-competent simian immunodeficiency virus (SIV) gag escape mutations archived in latent reservoirs during antiretroviral treatment of SIV-infected macaques

Queen, S. E., Mears, B. M., Kelly, K. M., Dorsey, J. L., Liao, Z., Dinoso, J. B., Gama, L., Adams, R. J., Zink, M. C., Clements, J. E., Kent, S. J. & Mankowski, J. L. Sep 2011 In : Journal of Virology. 85, 17, p. 9167-9175 9 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Highly Active Antiretroviral Therapy
Macaca
mutation

Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques

Lin, W. H., Griffin, D. E., Rota, P. A., Papania, M., Cape, S. P., Bennett, D., Quinn, B., Sievers, R. E., Shermer, C., Powell, K., Adams, R. J., Godin, S. & Winston, S. Feb 15 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 2987-2992 6 p.

Research output: Contribution to journalArticle

Measles Vaccine
Attenuated Vaccines
Measles virus
Measles
Macaca mulatta
2010

A chimeric alphavirus replicon particle vaccine expressing the hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques from measles

Pan, C. H., Greer, C. E., Hauer, D., Legg, H. S., Lee, E. Y., Bergen, M. J., Lau, B., Adams, R. J., Polo, J. M. & Griffin, D. E. Apr 2010 In : Journal of Virology. 84, 8, p. 3798-3807 10 p.

Research output: Contribution to journalArticle

Venezuelan Equine Encephalitis Viruses
Sindbis virus
Sindbis Virus
Alphavirus
replicon

HIV and SIV induce alterations in CNS CaMKII expression and activation: A potential mechanism for cognitive impairment

Gupta, R. G., Kelly, K. M., Helke, K. L., Queen, S. E., Karper, J. M., Dorsey, J. L., Brice, A. K., Adams, R. J., Tarwater, P. M., Kolson, D. L. & Mankowski, J. L. 2010 In : American Journal of Pathology. 176, 6, p. 2776-2784 9 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Calcium-Calmodulin-Dependent Protein Kinases
HIV
Hippocampus
Macaca

Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA

Zink, M. C., Brice, A. K., Kelly, K. M., Queen, S. E., Gama, L., Li, M., Adams, R. J., Bartizal, C., Varrone, J., Alireza Rabi, S., Graham, D. R., Tarwater, P. M., Mankowski, J. L. & Clements, J. E. Jul 1 2010 In : Journal of Infectious Diseases. 202, 1, p. 161-170 10 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Highly Active Antiretroviral Therapy
Viral DNA
Macaca
Central Nervous System
2009

Altered cutaneous nerve regeneration in a simian immunodeficiency virus/macaque intracutaneous axotomy model

Ebenezer, G. J., Laast, V. A., Dearman, B., Hauer, P., Tarwater, P. M., Adams, R. J., Zink, M. C., McArthur, J. C. & Mankowski, J. L. May 20 2009 In : Journal of Comparative Neurology. 514, 3, p. 272-283 12 p.

Research output: Contribution to journalArticle

Axotomy
Simian Immunodeficiency Virus
Nerve Regeneration
Schwann Cells
Macaca

Vaccination with HPV16 L2E6E7 fusion protein in GPI-0100 adjuvant elicits protective humoral and cell-mediated immunity

Karanam, B., Gambhira, R., Peng, S., Jagu, S., Kim, D. J., Ketner, G. W., Stern, P. L., Adams, R. J. & Roden, R. B. S. Feb 11 2009 In : Vaccine. 27, 7, p. 1040-1049 10 p.

Research output: Contribution to journalArticle

Human papillomavirus 16
Papillomaviridae
Cellular Immunity
cell-mediated immunity
adjuvants
2008

Dose-dependent protection against or exacerbation of disease by a polylactide glycolide microparticle-adsorbed, alphavirus-based measles virus DNA vaccine in rhesus macaques

Pan, C. H., Nair, N., Adams, R. J., Zink, M. C., Lee, E. Y., Polack, F. P., Singh, M., O'Hagan, D. T. & Griffin, D. E. Apr 2008 In : Clinical and Vaccine Immunology. 15, 4, p. 697-706 10 p.

Research output: Contribution to journalArticle

Alphavirus
Measles virus
DNA Vaccines
Macaca mulatta
Viruses

Natural host genetic resistance to lentiviral CNS sisease: A neuroprotective MHC class I allele in SIV-infected macaques

Mankowski, J. L., Queen, S. E., Fernandez, C. S., Tarwater, P. M., Karper, J. M., Adams, R. J. & Kent, S. J. Nov 3 2008 In : PLoS One. 3, 11, e3603

Research output: Contribution to journalArticle

genetic resistance
Macaca
Neurology
central nervous system
Central Nervous System

Use of vaxfectin adjuvant with DNA vaccine encoding the measles virus hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques against measles virus

Pan, C. H., Jimenez, G. S., Nair, N., Wei, Q., Adams, R. J., Polack, F. P., Rolland, A., Vilalta, A. & Griffin, D. E. Aug 2008 In : Clinical and Vaccine Immunology. 15, 8, p. 1214-1221 8 p.

Research output: Contribution to journalArticle

Viral Fusion Proteins
Measles virus
DNA Vaccines
Hemagglutinins
Macaca mulatta

VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease

Chen, M. K., Kuwabara, H., Zhou, Y., Adams, R. J., Brašić, J. R., McGlothan, J. L., Verina, T., Burton, N. C., Alexander, M., Kumar, A., Wong, D. F. & Guilarte, T. R. Apr 2008 In : Journal of Neurochemistry. 105, 1, p. 78-90 13 p.

Research output: Contribution to journalArticle

Vesicular Monoamine Transport Proteins
Dopaminergic Neurons
Primates
Neurons
Parkinson Disease