Robert John Adams

Associate Professor

1974 …2020

Research output per year

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Research Output

2020

A durable protective immune response to wild-type measles virus infection of macaques is due to viral replication and spread in lymphoid tissues

Lin, W. H. W., Moran, E., Adams, R. J., Sievers, R. E., Hauer, D., Godin, S. & Griffin, D. E., Apr 1 2020, In : Science translational medicine. 12, 537, eaax7799.

Research output: Contribution to journalArticle

Association of persistent wild-type measles virus RNA with long-term humoral immunity in rhesus macaques

Nelson, A. N., Lin, W. H. W., Shivakoti, R., Putnam, N. E., Mangus, L., Adams, R. J., Hauer, D., Baxter, V. K. & Griffin, D. E., Feb 13 2020, In : JCI Insight. 5, 3, e134992.

Research output: Contribution to journalArticle

Open Access
2019

SIV-Induced Immune Activation and Metabolic Alterations in the Dorsal Root Ganglia During Acute Infection

Mangus, L., Weinberg, R. L., Knight, A. C., Queen, S. E., Adams, R. J. & Mankowski, J. L., Jan 1 2019, In : Journal of Neuropathology and Experimental Neurology. 78, 1, p. 78-87 10 p.

Research output: Contribution to journalArticle

2018

Lymphocyte-Dominant Encephalitis and Meningitis in Simian Immunodeficiency Virus–Infected Macaques Receiving Antiretroviral Therapy

Mangus, L., Beck, S., Queen, S. E., Brill, S. A., Shirk, E. N., Pate, K., Muth, D. C., Adams, R. J., Gama, L., Clements, J. E. & Mankowski, J. L., Jan 1 2018, In : American Journal of Pathology. 188, 1, p. 125-134 10 p.

Research output: Contribution to journalArticle

2017

An SIV/macaque model targeted to study HIV-associated neurocognitive disorders

Beck, S., Queen, S. E., Pate, K., Mangus, L., Abreu, C. M., Gama, L., Witwer, K. W., Adams, R. J., Zink, M. C., Clements, J. E. & Mankowski, J. L., Oct 3 2017, (Accepted/In press) In : Journal of NeuroVirology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Evolution of T Cell Responses during Measles Virus Infection and RNA Clearance

Nelson, A. N., Putnam, N., Hauer, D., Baxter, V. K., Adams, R. J. & Griffin, D. E., Dec 1 2017, In : Scientific reports. 7, 1, 11474.

Research output: Contribution to journalArticle

Genetic characterization of a captive colony of pigtailed Macaques (Macaca nemestrina)

Zhang, X., Kanthaswamy, S., Trask, J. S., Ng, J., Oldt, R. F., Mankowski, J. L., Adams, R. J. & Smith, D. G., Jul 1 2017, In : Journal of the American Association for Laboratory Animal Science. 56, 4, p. 390-395 6 p.

Research output: Contribution to journalArticle

Immune activation of platelets in response to serial phlebotomy in pigtailed macaques (Macaca nemestrina)

Vermillion, M. S., Lyons, C. E., Najarro, K. M., Adams, R. J. & Pate, K., Jul 1 2017, In : Comparative Medicine. 67, 4, p. 360-367 8 p.

Research output: Contribution to journalArticle

2016

Discovery of 6-Diazo-5-oxo- l -norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

Rais, R., Jančařík, A., Tenora, L., Nedelcovych, M., Alt, J., Englert, J., Rojas, C., Le, A., Elgogary, A., Tan, J., Monincová, L., Pate, K., Adams, R., Ferraris, D., Powell, J., Majer, P. & Slusher, B. S., Sep 22 2016, In : Journal of medicinal chemistry. 59, 18, p. 8621-8633 13 p.

Research output: Contribution to journalArticle

2015

A murine viral outgrowth assay to detect residual HIV type 1 in patients with undetectable viral loads

Metcalf Pate, K. A., Pohlmeyer, C. W., Walker-Sperling, V. E., Foote, J. B., Najarro, K. M., Cryer, C. G., Salgado, M., Gama, L., Engle, E. L., Shirk, E. N., Queen, S. E., Chioma, S., Vermillion, M. S., Bullock, B., Li, M., Lyons, C. E., Adams, R. J., Zink, M. C., Clements, J. E., Mankowski, J. L. & 1 others, Blankson, J. N., Nov 1 2015, In : Journal of Infectious Diseases. 212, 9, p. 1387-1396 10 p.

Research output: Contribution to journalArticle

A replicating adenovirus capsid display recombinant elicits antibodies against Plasmodium falciparum sporozoites in Aotus nancymaae monkeys

Karen, K. A., Deal, C., Adams, R. J., Nielsen, C., Ward, C., Espinosa, D. A., Xie, J., Zavala, F. & Ketner, G., Jan 1 2015, In : Infection and immunity. 83, 1, p. 268-275 8 p.

Research output: Contribution to journalArticle

Limited in vivo production of type i or type III interferon after infection of macaques with vaccine or wild-type strains of measles virus

Shivakoti, R., Hauer, D., Adams, R. J., Lin, W. H. W., Duprex, W. P., De Swart, R. L. & Griffin, D. E., Apr 1 2015, In : Journal of Interferon and Cytokine Research. 35, 4, p. 292-301 10 p.

Research output: Contribution to journalArticle

Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior

Freeman, Z. T., Rice, K. A., Soto, P. L., Pate, K. A. M., Weed, M. R., Ator, N. A., DeLeon, I. G., Wong, D. F., Zhou, Y., Mankowski, J. L., Zink, M. C., Adams, R. J. & Hutchinson, E. K., May 26 2015, In : Translational Psychiatry. 5, 5, e567.

Research output: Contribution to journalArticle

Neuroinflammation and virus replication in the spinal cord of simian immunodeficiency virus-infected macaques

Mangus, L. M., Dorsey, J. L., Laast, V. A., Hauer, P., Queen, S. E., Adams, R. J., McArthur, J. C. & Mankowski, J. L., Jan 3 2015, In : Journal of neuropathology and experimental neurology. 74, 1, p. 38-47 10 p.

Research output: Contribution to journalArticle

Persistent peripheral nervous system damage in simian immunodeficiency virus-infected macaques receiving antiretroviral therapy

Dorsey, J. L., Mangus, L. M., Hauer, P., Ebenezer, G. J., Queen, S. E., Laast, V. A., Adams, R. J. & Mankowski, J. L., Jan 1 2015, In : Journal of neuropathology and experimental neurology. 74, 11, p. 1053-1060 8 p.

Research output: Contribution to journalArticle

Open Access

Pharmacokinetics and immunogenicity of a recombinant human butyrylcholinesterase bioscavenger in macaques following intravenous and pulmonary delivery

Rosenberg, Y. J., Adams, R. J., Hernandez-Abanto, S., Jiang, X., Sun, W., Mao, L. & Lee, K. D., Dec 5 2015, In : Chemico-Biological Interactions. 242, p. 219-226 8 p.

Research output: Contribution to journalArticle

Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis

Muth, D. C., McAlexander, M. A., Ostrenga, L. J., Pate, N. M., Izzi, J. M., Adams, R. J., Pate, K. A. M., Beck, S. E., Karim, B. & Witwer, K. W., Aug 8 2015, In : BMC veterinary research. 11, 1, 187.

Research output: Contribution to journalArticle

2014

CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.

Kelly, K. M., Tocchetti, C. G., Lyashkov, A., Tarwater, P. M., Bedja, D., Graham, D. R., Beck, S. E., Metcalf Pate, K. A., Queen, S. E., Adams, R. J., Paolocci, N. & Mankowski, J. L., 2014, In : Journal of the American Heart Association. 3, 2, p. e000874

Research output: Contribution to journalArticle

Corrigendum to "vaccination with hpv16 l2e6e7 fusion protein in gpi-0100 adjuvant elicits protective humoral and cell-mediated immunity" [vaccine 27 (2009) 1040-1049]

Karanam, B., Gambhira, R., Peng, S., Jagu, S., Kim, D. J., Ketner, G. W., Stern, P. L., Adams, R. J. & Roden, R. B. S., Jan 3 2014, In : Vaccine. 32, 2, 1 p.

Research output: Contribution to journalComment/debate

Immune Responses in Macaques to a Prototype Recombinant Adenovirus Live Oral Human Papillomavirus 16 Vaccine

Berg, M. G., Adams, R. J., Gambhira, R., Siracusa, M. C., Scott, A. L., Roden, R. B. S. & Ketner, G., Sep 2014, In : Clinical and Vaccine Immunology. 21, 9, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

Loss of corneal sensory nerve fibers in SIV-infected macaques: An alternate approach to investigate HIV-induced PNS damage

Dorsey, J. L., Mangus, L. M., Oakley, J. D., Beck, S. E., Kelly, K. M., Queen, S. E., Metcalf Pate, K. A., Adams, R. J., Marfurt, C. F. & Mankowski, J. L., Jun 2014, In : American Journal of Pathology. 184, 6, p. 1652-1659 8 p.

Research output: Contribution to journalArticle

TGFβ-mediated downregulation of thrombopoietin is associated with platelet decline in asymptomatic SIV infection

Pate, K. A. M., Lyons, C. E., Dorsey, J. L., Queen, S. E., Adams, R. J., Morrell, C. N. & Mankowski, J. L., Apr 15 2014, In : Journal of acquired immune deficiency syndromes. 65, 5, p. 510-516 7 p.

Research output: Contribution to journalArticle

Vaccine-induced measles virus-specific T cells do not prevent infection or disease but facilitate subsequent clearance of viral RNA

Lin, W. H. W., Pan, C. H., Adams, R. J., Laube, B. L. & Griffin, D. E., Apr 15 2014, In : mBio. 5, 2, e01047-14.

Research output: Contribution to journalArticle

2013

Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: Reduced replicating and latent SIV in the brain

Kelly, K. M., Beck, S. E., Pate, K. A. M., Queen, S. E., Dorsey, J. L., Adams, R. J., Avery, L. B., Hubbard, W., Tarwater, P. M. & Mankowski, J. L., Nov 28 2013, In : AIDS. 27, 18, p. F21-F28

Research output: Contribution to journalArticle

Platelet activation and platelet-monocyte aggregate formation contribute to decreased platelet count during acute simian immunodeficiency virus infection in pig-tailed macaques

Metcalf Pate, K. A., Lyons, C. E., Dorsey, J. L., Shirk, E. N., Queen, S. E., Adams, R. J., Gama, L., Morrell, C. N. & Mankowski, J. L., Sep 15 2013, In : Journal of Infectious Diseases. 208, 6, p. 874-883 10 p.

Research output: Contribution to journalArticle

Poor immune responses of newborn rhesus macaques to measles virus DNA vaccines expressing the hemagglutinin and fusion glycoproteins

Polack, F. P., Lydy, S. L., Lee, S. H., Rota, P. A., Bellini, W. J., Adams, R. J., Robinson, H. L. & Griffin, D. E., Feb 1 2013, In : Clinical and Vaccine Immunology. 20, 2, p. 205-210 6 p.

Research output: Contribution to journalArticle

Pulmonary delivery of an aerosolized recombinant human butyrylcholinesterase pretreatment protects against aerosolized paraoxon in macaques

Rosenberg, Y. J., Laube, B., Mao, L., Jiang, X., Hernandez-Abanto, S., Lee, K. D. & Adams, R., Mar 25 2013, In : Chemico-Biological Interactions. 203, 1, p. 167-171 5 p.

Research output: Contribution to journalArticle

Serum albumin and body weight as biomarkers for the antemortem identification of bone and gastrointestinal disease in the common marmoset

Baxter, V. K., Shaw, G. C., Sotuyo, N. P., Carlson, C. S., Olson, E. J., Christine Zink, M., Mankowski, J. L., Adams, R. J., Hutchinson, E. K. & Metcalf Pate, K. A., Dec 6 2013, In : PloS one. 8, 12, e82747.

Research output: Contribution to journalArticle

Vaxfectin adjuvant improves antibody responses of juvenile rhesus macaques to a DNA vaccine encoding the measles virus hemagglutinin and fusion proteins

Lin, W. H. W., Vilalta, A., Adams, R. J., Rolland, A., Sullivan, S. M. & Griffin, D. E., Jun 1 2013, In : Journal of virology. 87, 12, p. 6560-6568 9 p.

Research output: Contribution to journalArticle

2012

Diastolic dysfunction is associated with myocardial viral load in simian immunodeficiency virus-infected macaques

Kelly, K. M., Tarwater, P. M., Karper, J. M., Bedja, D., Queen, S. E., Tunin, R. S., Adams, R. J., Kass, D. A. & Mankowski, J. L., Apr 24 2012, In : AIDS. 26, 7, p. 815-823 9 p.

Research output: Contribution to journalArticle

Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics

Lin, W. H. W., Kouyos, R. D., Adams, R. J., Grenfell, B. T. & Griffin, D. E., Sep 11 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 37, p. 14989-14994 6 p.

Research output: Contribution to journalArticle

SIV-induced impairment of neurovascular repair: A potential role for VEGF

Ebenezer, G. J., McArthur, J. C., Polydefkis, M., Dorsey, J. L., O'Donnell, R., Hauer, P., Adams, R. J. & Mankowski, J. L., Jun 1 2012, In : Journal of neurovirology. 18, 3, p. 222-230 9 p.

Research output: Contribution to journalArticle

2011

Macrophage-mediated dorsal root ganglion damage precedes altered nerve conduction in SIV-infected macaques

Laast, V. A., Shim, B., Johanek, L. M., Dorsey, J. L., Hauer, P. E., Tarwater, P. M., Adams, R. J., Pardo, C. A., McArthur, J. C., Ringkamp, M. & Mankowski, J. L., Nov 1 2011, In : American Journal of Pathology. 179, 5, p. 2337-2345 9 p.

Research output: Contribution to journalArticle

Osteopontin enhances HIV replication and is increased in the brain and cerebrospinal fluid of HIV-infected individuals

Brown, A., Islam, T., Adams, R., Nerle, S., Kamara, M., Eger, C., Marder, K., Cohen, B., Schifitto, G., McArthur, J. C., Sacktor, N. & Pardo, C. A., Aug 1 2011, In : Journal of neurovirology. 17, 4, p. 382-392 11 p.

Research output: Contribution to journalArticle

Replication-competent simian immunodeficiency virus (SIV) gag escape mutations archived in latent reservoirs during antiretroviral treatment of SIV-infected macaques

Queen, S. E., Mears, B. M., Kelly, K. M., Dorsey, J. L., Liao, Z., Dinoso, J. B., Gama, L., Adams, R. J., Zink, M. C., Clements, J. E., Kent, S. J. & Mankowski, J. L., Sep 1 2011, In : Journal of virology. 85, 17, p. 9167-9175 9 p.

Research output: Contribution to journalArticle

Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques

Lin, W. H., Griffin, D. E., Rota, P. A., Papania, M., Cape, S. P., Bennett, D., Quinn, B., Sievers, R. E., Shermer, C., Powell, K., Adams, R. J., Godin, S. & Winston, S., Feb 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 2987-2992 6 p.

Research output: Contribution to journalArticle

2010

A chimeric alphavirus replicon particle vaccine expressing the hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques from measles

Pan, C. H., Greer, C. E., Hauer, D., Legg, H. S., Lee, E. Y., Bergen, M. J., Lau, B., Adams, R. J., Polo, J. M. & Griffin, D. E., Apr 1 2010, In : Journal of virology. 84, 8, p. 3798-3807 10 p.

Research output: Contribution to journalArticle

HIV and SIV induce alterations in CNS CaMKII expression and activation: A potential mechanism for cognitive impairment

Gupta, R. G., Kelly, K. M., Helke, K. L., Queen, S. E., Karper, J. M., Dorsey, J. L., Brice, A. K., Adams, R. J., Tarwater, P. M., Kolson, D. L. & Mankowski, J. L., Jun 2010, In : American Journal of Pathology. 176, 6, p. 2776-2784 9 p.

Research output: Contribution to journalArticle

2009

Vaccination with HPV16 L2E6E7 fusion protein in GPI-0100 adjuvant elicits protective humoral and cell-mediated immunity

Karanam, B., Gambhira, R., Peng, S., Jagu, S., Kim, D. J., Ketner, G. W., Stern, P. L., Adams, R. J. & Roden, R. B. S., Feb 11 2009, In : Vaccine. 27, 7, p. 1040-1049 10 p.

Research output: Contribution to journalArticle

2008

Dose-dependent protection against or exacerbation of disease by a polylactide glycolide microparticle-adsorbed, alphavirus-based measles virus DNA vaccine in rhesus macaques

Pan, C. H., Nair, N., Adams, R. J., Zink, M. C., Lee, E. Y., Polack, F. P., Singh, M., O'Hagan, D. T. & Griffin, D. E., Apr 1 2008, In : Clinical and Vaccine Immunology. 15, 4, p. 697-706 10 p.

Research output: Contribution to journalArticle