Robert J Kurman

Professor Emeritus

1968 …2019
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Research Output 1968 2019

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Article
2019

Clinicopathologic and Molecular Features of Paired Cases of Metachronous Ovarian Serous Borderline Tumor and Subsequent Serous Carcinoma

Chui, M. H., Xing, D., Zeppernick, F., Wang, Z. Q., Hannibal, C. G., Frederiksen, K., Kjaer, S. K., Cope, L., Kurman, R. J., Shih, I. M., Wang, T-L. & Vang, R. S., Nov 1 2019, In : The American journal of surgical pathology. 43, 11, p. 1462-1472 11 p.

Research output: Contribution to journalArticle

Carcinoma
Neoplasms
Mutation
Genes
Codon

Comprehensive Surgical Staging in Stage 1 Clear Cell and Endometrioid Ovarian Carcinomas: Is it Necessary?

Padhy, R. R., Savage, J. & Kurman, R. J., May 1 2019, In : International Journal of Gynecological Pathology. 38, 3, p. 241-246 6 p.

Research output: Contribution to journalArticle

Endometrioid Carcinoma
Carcinoma
Pathology
Disease-Free Survival
Adjuvant Chemotherapy

Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions

Wu, R. C., Wang, P., Lin, S. F., Zhang, M., Song, Q., Chu, T., Wang, B. G., Kurman, R. J., Vang, R. S., Kinzler, K. W., Tomasetti, C., Jiao, Y., Shih, I. M. & Wang, T-L., Jan 1 2019, In : Journal of Pathology.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Carcinoma in Situ
Carcinoma
Mutation
History

Nine-valent HPV vaccine efficacy against related diseases and definitive therapy: comparison with historic placebo population

Giuliano, A. R., Joura, E. A., Garland, S. M., Huh, W. K., Iversen, O. E., Kjaer, S. K., Ferenczy, A., Kurman, R. J., Ronnett, B. M., Stoler, M. H., Bautista, O. M., Moeller, E., Ritter, M., Shields, C. & Luxembourg, A., Jan 1 2019, In : Gynecologic oncology.

Research output: Contribution to journalArticle

Papillomavirus Vaccines
Vaccines
Placebos
Population
Therapeutics

Two types of primary mucinous ovarian tumors can be distinguished based on their origin

Simons, M., Simmer, F., Bulten, J., Ligtenberg, M. J., Hollema, H., van Vliet, S., de Voer, R. M., Kamping, E. J., van Essen, D. F., Ylstra, B., Schwartz, L. E., Wang, Y., Massuger, L. F., Nagtegaal, I. D. & Kurman, R. J., Jan 1 2019, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Brenner Tumor
Teratoma
Neoplasms
Mutation
Cystadenoma
2018

Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

Wang, Y., Li, L., Douville, C., Cohen, J. D., Yen, T. T., Kinde, I., Sundfelt, K., Kjær, S. K., Hruban, R. H., Shih, I. M., Wang, T-L., Kurman, R. J., Springer, S., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tanner, E. J., Angarita, A. & 17 others, Lycke, M., Jochumsen, K., Afsari, B., Danilova, L. V., Levine, D. A., Jardon, K., Zeng, X., Arseneau, J., Fu, L., Diaz, L. A., Karchin, R., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Nickles Fader, A. N., Gilbert, L. & Papadopoulos, N., Mar 21 2018, In : Science Translational Medicine. 10, 433, 8793.

Research output: Contribution to journalArticle

Papanicolaou Test
Endometrial Neoplasms
Ovarian Neoplasms
Biopsy
Confidence Intervals

Fallopian tube lesions in women at high risk for ovarian cancer: A multicenter study

Visvanathan, K., Shaw, P., May, B. J., Bahadirli-Talbott, A., Kaushiva, A., Risch, H., Narod, S., Wang, T-L., Parkash, V., Vang, R. S., Levine, D. A., Soslow, R., Kurman, R. J. & Shih, I. M., Nov 1 2018, In : Cancer Prevention Research. 11, 11, p. 697-705 9 p.

Research output: Contribution to journalArticle

Fallopian Tubes
Ovarian Neoplasms
Multicenter Studies
Carcinoma
Carcinoma in Situ

Human Papillomavirus Genotypes from Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age

Garland, S. M., Joura, E. A., Ault, K. A., Bosch, F. X., Brown, D. R., Castellsagué, X., Ferenczy, A., Ferris, D. G., Giuliano, A. R., Hernandez-Avila, M., Huh, W. K., Iversen, O. E., Kjaer, S. K., Kurman, R. J., Luna, J., Monsonego, J., Muñoz, N., Paavonen, J., Pitisuttihum, P., Ronnett, B. M. & 11 others, Steben, M., Stoler, M. H., Wheeler, C. M., Wiley, D. J., Perez, G., Saah, A. J., Luxembourg, A., Li, S., DiNubile, M. J., Wagner, M. & Velicer, C., Jan 1 2018, In : Obstetrics and Gynecology. 132, 2, p. 261-270 10 p.

Research output: Contribution to journalArticle

Genotype
Neoplasms
Warts
Uterine Cervical Neoplasms
Human papillomavirus 6
2017

A nationwide study of ovarian serous borderline tumors in Denmark 1978–2002. Risk of recurrence, and development of ovarian serous carcinoma

Hannibal, C. G., Vang, R. S., Junge, J., Frederiksen, K., Kurman, R. J. & Kjaer, S. K., Jan 1 2017, In : Gynecologic Oncology. 144, 1, p. 174-180 7 p.

Research output: Contribution to journalArticle

Denmark
Carcinoma
Recurrence
Neoplasms
Pathology

Atypical Proliferative (Borderline) Serous Tumor in the Brain: A Case Report

Xing, D., Jenson, E. G., Zwick, C. A., Rodriguez, F. J. & Kurman, R. J., Jul 11 2017, (Accepted/In press) In : International Journal of Gynecological Pathology.

Research output: Contribution to journalArticle

Brain Neoplasms
Cystadenofibroma
Neoplasms
Brain
Encephalomalacia

Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16–26 years: a randomised, double-blind trial

Huh, W. K., Joura, E. A., Giuliano, A. R., Iversen, O. E., de Andrade, R. P., Ault, K. A., Bartholomew, D., Cestero, R. M., Fedrizzi, E. N., Hirschberg, A. L., Mayrand, M. H., Ruiz-Sternberg, A. M., Stapleton, J. T., Wiley, D. J., Ferenczy, A., Kurman, R. J., Ronnett, B. M., Stoler, M. H., Cuzick, J., Garland, S. M. & 8 others, Kjaer, S. K., Bautista, O. M., Haupt, R., Moeller, E., Ritter, M., Roberts, C. C., Shields, C. & Luxembourg, A., Nov 11 2017, In : The Lancet. 390, 10108, p. 2143-2159 17 p.

Research output: Contribution to journalArticle

Papillomavirus Vaccines
Vaccines
Safety
Human papillomavirus 11
Human papillomavirus 6

High grade serous ovarian carcinomas originate in the fallopian tube

Labidi-Galy, S. I., Papp, E., Hallberg, D., Niknafs, N., Adleff, V., Noe, M., Bhattacharya, R., Novak, M., Jones, S., Phallen, J., Hruban, C. A., Hirsch, M. S., Lin, D. I., Schwartz, L., Maire, C. L., Tille, J. C., Bowden, M., Ayhan, A., Wood, L. D., Scharpf, R. B. & 6 others, Kurman, R. J., Wang, T-L., Shih, I. M., Karchin, R., Drapkin, R. & Velculescu, V. E., Dec 1 2017, In : Nature Communications. 8, 1, 1093.

Research output: Contribution to journalArticle

Fallopian Tubes
Carcinoma in Situ
Tumors
grade
cancer
Carcinoma
Population
Neoplasms
Confidence Intervals
Terminology

Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma

Ducie, J., Dao, F., Considine, M., Olvera, N., Shaw, P. A., Kurman, R. J., Shih, I. M., Soslow, R. A., Cope, L. & Levine, D. A., Dec 1 2017, In : Nature Communications. 8, 1, 1217.

Research output: Contribution to journalArticle

MicroRNAs
Tumors
grade
cancer
RNA

Parity, infertility, oral contraceptives, and hormone replacement therapy and the risk of ovarian serous borderline tumors: A nationwide case-control study

Rasmussen, E. L. K., Hannibal, C. G., Dehlendorff, C., Baandrup, L., Junge, J., Vang, R. S., Kurman, R. J. & Kjaer, S. K., Mar 1 2017, In : Gynecologic Oncology. 144, 3, p. 571-576 6 p.

Research output: Contribution to journalArticle

Hormone Replacement Therapy
Oral Contraceptives
Parity
Infertility
Case-Control Studies

Steroid hormone synthesis by the ovarian stroma surrounding epithelial ovarian tumors: a potential mechanism in ovarian tumorigenesis

Blanco, L. Z., Kuhn, E., Morrison, J. C., Bahadirli-Talbott, A., Smith-Sehdev, A. & Kurman, R. J., Jan 6 2017, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Carcinogenesis
Steroids
Hormones
Neoplasms
Endometriosis
2016

CCNE1 amplification and centrosome number abnormality in serous tubal intraepithelial carcinoma: further evidence supporting its role as a precursor of ovarian high-grade serous carcinoma

Kuhn, E., Wang, T-L., Doberstein, K., Bahadirli-Talbott, A., Ayhan, A., Sehdev, A. S., Drapkin, R., Kurman, R. J. & Shih, I. M., Jul 22 2016, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Centrosome
Carcinoma in Situ
Cyclins
Carcinoma
Chromosomal Instability

Diagnostic potential of tumor DNA from ovarian cyst fluid

Wang, Y., Sundfeldt, K., Mateoiu, C., Shih, I. M., Kurman, R. J., Schaefer, J., Silliman, N., Kinde, I., Springer, S., Foote, M., Kristjansdottir, B., James, N., Kinzler, K. W., Papadopoulos, N., Diaz, L. A. & Vogelstein, B., Jul 15 2016, In : eLife. 5, 2016JULY, e15175.

Research output: Contribution to journalArticle

Cyst Fluid
Ovarian Cysts
Tumors
Fluids
DNA
Atlases
Genome
Carcinoma
Mutation
Neoplasms

PD-L1 Expression in Human Placentas and Gestational Trophoblastic Diseases

Veras, E., Kurman, R. J., Wang, T-L. & Shih, I. M., Jun 29 2016, (Accepted/In press) In : International Journal of Gynecological Pathology.

Research output: Contribution to journalArticle

Gestational Trophoblastic Disease
Trophoblastic Neoplasms
Placenta
Trophoblasts
Choriocarcinoma

Seromucinous tumors of the ovary. What's in a name?

Kurman, R. J. & Shih, I. M., Jan 1 2016, In : International Journal of Gynecological Pathology. 35, 1, p. 78-81 4 p.

Research output: Contribution to journalArticle

Names
Ovary
Neoplasms
Epithelium
Cystadenoma

The dualistic model of ovarian carcinogenesis revisited, revised, and expanded

Kurman, R. J. & Shih, I. M., Apr 1 2016, In : American Journal of Pathology. 186, 4, p. 733-747 15 p.

Research output: Contribution to journalArticle

Carcinogenesis
Carcinoma
Neoplasms
Ovary
Brenner Tumor
2015

Clonality analysis of combined Brenner and mucinous tumours of the ovary reveals their monoclonal origin

Wang, Y., Wu, R. C., Shwartz, L. E., Haley, L., Lin, M-T., Shih, I. M. & Kurman, R. J., Oct 1 2015, In : Journal of Pathology. 237, 2, p. 146-151 6 p.

Research output: Contribution to journalArticle

Brenner Tumor
Neoplasms
X Chromosome Inactivation
Fallopian Tubes
Teratoma

Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma

Chui, M. H., Wang, Y., Wu, R. C., Seidman, J., Kurman, R. J., Wang, T-L. & Shih, I. M., Mar 1 2015, In : Modern Pathology. 28, 3, p. 437-445 9 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Protein Isoforms
Epithelium
Carcinoma
Stem Cells

Molecular analysis of ovarian mucinous carcinoma reveals different cell of origins

Wang, Y., Shwartz, L. E., Anderson, D., Lin, M-T., Haley, L., Wu, R. C., Vang, R. S., Shih, I. M. & Kurman, R. J., 2015, In : Oncotarget. 6, 26, p. 22949-22958 10 p.

Research output: Contribution to journalArticle

Mucinous Adenocarcinoma
Teratoma
Neoplasms
Microsatellite Repeats
Mucinous Cystadenoma
Neoplasms, Cystic, Mucinous, and Serous
Ovarian Cysts
Ovarian Neoplasms
Cysts
Carcinogenesis
Cysts
Carcinogenesis
Epithelium
Calbindin 2
Carcinoma
2014

A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development

Sherman-Baust, C. A., Kuhn, E., Valle, B. L., Shih, I. M., Kurman, R. J., Wang, T-L., Amano, T., Ko, M. S., Miyoshi, I., Araki, Y., Lehrmann, E., Zhang, Y., Becker, K. G. & Morin, P. J., 2014, In : Journal of Pathology. 233, 3, p. 228-237 10 p.

Research output: Contribution to journalArticle

Fallopian Tubes
Ovarian Neoplasms
Carcinoma
Viral Tumor Antigens
Epithelium

A nationwide study of serous "borderline" ovarian tumors in Denmark 1978-2002: Centralized pathology review and overall survival compared with the general population

Hannibal, C. G., Vang, R. S., Junge, J., Frederiksen, K., Kjaerbye-Thygesen, A., Andersen, K. K., Tabor, A., Kurman, R. J. & Kjaer, S. K., 2014, In : Gynecologic Oncology. 134, 2, p. 267-273 7 p.

Research output: Contribution to journalArticle

Denmark
Pathology
Survival
Population
Neoplasms

BRAF mutation is associated with a specific cell type with features suggestive of senescence in ovarian serous borderline (atypical proliferative) tumors

Zeppernick, F., Ardighieri, L., Hannibal, C. G., Vang, R. S., Junge, J., Kjaer, S. K., Zhang, R., Kurman, R. J. & Shih, I. M., 2014, In : American Journal of Surgical Pathology. 38, 12, p. 1603-1611 9 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Molecular Biology
Cytoplasm
Carcinoma

Characterization of the immune cell repertoire in the normal fallopian tube

Ardighieri, L., Lonardi, S., Moratto, D., Facchetti, F., Shih, I. M., Vermi, W. & Kurman, R. J., 2014, In : International Journal of Gynecological Pathology. 33, 6, p. 581-591 11 p.

Research output: Contribution to journalArticle

Fallopian Tubes
T-Lymphocytes
Dendritic Cells
Immune System
Carcinogenesis
Trophoblasts
Trophoblastic Neoplasms
Placental Site Trophoblastic Tumor
Uterine Perforation
Chorion

Erratum: Trophoblastic disease (International Journal of Gynecology and Obstetrics (2012) 119 (S130-S136))

Ngan, H. Y. S., Kohorn, E. I., Cole, L. A., Kurman, R. J., Kim, S. J., Lurain, J. R., Seckl, M. J., Sasaki, S. & Soper, J. T., Apr 2014, In : International Journal of Gynecology and Obstetrics. 125, 1, p. 93 1 p.

Research output: Contribution to journalArticle

welan
Gynecology
Obstetrics
Lymph Nodes
Neoplasms
Cytoplasm
Carcinoma
Population
Endometrium
Hyperplasia
Differential Diagnosis
Endometrial Neoplasms
Mitotic Index

Mutational analysis of BRAF and KRAS in ovarian serous borderline (atypical proliferative) tumours and associated peritoneal implants

Ardighieri, L., Zeppernick, F., Hannibal, C. G., Vang, R. S., Cope, L., Junge, J., Kjaer, S. K., Kurman, R. J. & Shih, I. M., Jan 2014, In : Journal of Pathology. 232, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

Neoplasms
Mutation
Immunohistochemistry
Peritoneum
Denmark
carcinoma
ovarian neoplasms
pathogenesis
Carcinoma
neoplasms

Pathologic features associated with resolution of complex atypical hyperplasia and grade 1 endometrial adenocarcinoma after progestin therapy

Gunderson, C. C., Dutta, S., Nickles Fader, A. N., Maniar, K. P., Nasseri-Nik, N., Bristow, R. E., Diaz-Montes, T. P., Palermo, R. & Kurman, R. J., Jan 2014, In : Gynecologic Oncology. 132, 1, p. 33-37 5 p.

Research output: Contribution to journalArticle

Progestins
Hyperplasia
Adenocarcinoma
Therapeutics
Progesterone Receptors

The pathogenesis of atypical proliferative Brenner tumor: An immunohistochemical and molecular genetic analysis

Kuhn, E., Ayhan, A., Shih, I. M., Seidman, J. D. & Kurman, R. J., Feb 2014, In : Modern Pathology. 27, 2, p. 231-237 7 p.

Research output: Contribution to journalArticle

Brenner Tumor
Molecular Biology
Neoplasms
Fluorescence In Situ Hybridization
Mutation
2013

Bokhman's dualistic model of endometrial carcinoma. Revisited

Kurman, R. J., Visvanathan, K. & Shih, I. M., May 2013, In : Gynecologic Oncology. 129, 2, p. 271-272 2 p.

Research output: Contribution to journalArticle

Carcinosarcoma
Endometrial Neoplasms
Adenocarcinoma

Evaluation of DNA from the papanicolaou test to detect ovarian and endometrial cancers

Kinde, I., Bettegowda, C., Wang, Y., Wu, J., Agrawal, N., Shih, I. M., Kurman, R. J., Dao, F., Levine, D. A., Giuntoli, R., Roden, R. S., Eshleman, J., Carvalho, J. P., Marie, S. K. N., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Diaz, L. A., Jan 9 2013, In : Science Translational Medicine. 5, 167, 167ra4.

Research output: Contribution to journalArticle

Papanicolaou Test
Endometrial Neoplasms
Ovarian Neoplasms
Mutation
DNA

Fallopian tube precursors of ovarian low- and high-grade serous neoplasms

Vang, R. S., Shih, I. M. & Kurman, R. J., Jan 2013, In : Histopathology. 62, 1, p. 44-58 15 p.

Research output: Contribution to journalArticle

Fallopian Tubes
Carcinoma
Neoplasms
Adenofibroma
Ovary

Origin and molecular pathogenesis of ovarian high-grade serous carcinoma

Kurman, R. J., Dec 2013, In : Annals of Oncology. 24, SUPPL.10, mdt463.

Research output: Contribution to journalArticle

Carcinoma
Neoplasms
Carcinoma in Situ
Ovary
Fallopian Tubes

Ovarian Brenner tumour: A morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium

Kuhn, E., Ayhan, A., Shih, I. M., Seidman, J. D. & Kurman, R. J., Dec 2013, In : European Journal of Cancer. 49, 18, p. 3839-3849 11 p.

Research output: Contribution to journalArticle

Brenner Tumor
Fallopian Tubes
Epithelium
Cilia
Metaplasia
2012

A binary histologic grading system for ovarian serous carcinoma is an independent prognostic factor: A population-based study of 4317 women diagnosed in Denmark 1978-2006

Hannibal, C. G., Vang, R. S., Junge, J., Kjaerbye-Thygesen, A., Kurman, R. J. & Kjaer, S. K., Jun 2012, In : Gynecologic Oncology. 125, 3, p. 655-660 6 p.

Research output: Contribution to journalArticle

Denmark
Carcinoma
Population
Pathology
Neoplasms
Hydatidiform Mole
Immunohistochemistry
Diploidy
Triploidy
Observer Variation
Hydatidiform Mole
Immunohistochemistry
Diploidy
Peptide PHI
Triploidy
Mutation
Neoplasms
Endometriosis
Papillary Cystadenoma
Staining and Labeling

Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses

Kuhn, E., Wu, R. C., Guan, B., Wu, G., Zhang, J., Wang, Y., Song, L., Yuan, X., Wei, L., Roden, R. S., Kuo, K. T., Nakayama, K., Clarke, B., Shaw, P., Olvera, N., Kurman, R. J., Levine, D. A., Wang, T-L. & Shih, I. M., Oct 3 2012, In : Journal of the National Cancer Institute. 104, 19, p. 1503-1513 11 p.

Research output: Contribution to journalArticle

Genome
Carcinoma
Carcinoma in Situ
Endometrial Neoplasms
Mutation