Robert George Weiss

Professor

1989 …2019
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Research Output 1989 2019

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2019

High-resolution creatine mapping of mouse brain at 11.7 T using non-steady-state chemical exchange saturation transfer

Chen, L., Wei, Z., Cai, S., Li, Y., Liu, G., Lu, H., Weiss, R. G., Van Zijl, P. C. & Xu, J., Jan 1 2019, (Accepted/In press) In : NMR in biomedicine. e4168.

Research output: Contribution to journalArticle

Brain Mapping
Creatine
Magnetization
Brain
Bovine Serum Albumin

Intravascular Stem Cell Bioreactor for Prevention of Adverse Remodeling After Myocardial Infarction

Johnston, P. V., Hwang, C-W., Bogdan, V., Mills, K. J., Eggan, E. R., Leszczynska, A., Wu, K. C-C., Herzka, D., Brinker, J. A., Schulman, S. P., Banerjee, M., Florea, V., Natsumeda, M., Tompkins, B., Balkan, W., Hare, J. M., Tomaselli, G. F., Weiss, R. G. & Gerstenblith, G., Aug 6 2019, In : Journal of the American Heart Association. 8, 15, p. e012351

Research output: Contribution to journalArticle

Open Access
Bioreactors
Stem Cells
Myocardial Infarction
Placebos
Stroke Volume
Open Access
Creatine Kinase
Energy Metabolism
Heart Diseases
Magnetic Resonance Spectroscopy
Heart Failure
2018
Creatine Kinase
Magnetic Resonance Spectroscopy
Heart Failure
Adenosine Triphosphate
Healthy Volunteers
Phosphocreatine
Creatine
Skeletal Muscle
Guanidine
Calibration

Precision and accuracy of cross-sectional area measurements used to measure coronary endothelial function with spiral MRI

Schar, M., Soleimanifard, S., Bonanno, G., Yerly, J., Hays, A. & Weiss, R. G., Jan 1 2018, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Blood Vessels
Coronary Vessels
Exercise
Health
caN protocol

Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine: The ROPA-DOP Trial

Osler Medical Housestaff, Oct 1 2018, In : JACC: Heart Failure. 6, 10, p. 859-870 12 p.

Research output: Contribution to journalArticle

Dopamine
Heart Failure
Diuretics
Furosemide
Confidence Intervals

Regional coronary endothelial dysfunction is related to the degree of local epicardial fat in people with HIV

Iantorno, M., Soleimanifard, S., Schar, M., Brown, T. T., Bonanno, G., Barditch-Crovo, P., Mathews, L., Lai, S., Gerstenblith, G., Weiss, R. G. & Hays, A., Nov 1 2018, In : Atherosclerosis. 278, p. 7-14 8 p.

Research output: Contribution to journalArticle

Coronary Artery Disease
Fats
HIV
Adipose Tissue
Exercise
Cross-Over Studies
Xanthine Oxidase
Coronary Artery Disease
Coronary Vessels
Placebos
2017

Coronary artery endothelial dysfunction is present in HIV positive individuals without significant coronary artery disease

Iantorno, M., Schar, M., Soleimanifard, S., Brown, T. T., Moore, R. D., Barditch-crovo, P., Stuber, M., Lai, S., Gerstenblith, G., Weiss, R. G. & Hays, A., Mar 28 2017, (Accepted/In press) In : AIDS.

Research output: Contribution to journalArticle

Coronary Artery Disease
Coronary Vessels
HIV
Interleukin-6
Inflammation

Coronary endothelial function is better in healthy premenopausal women than in healthy older postmenopausal women and men

Mathews, L., Iantorno, M., Schar, M., Bonanno, G., Gerstenblith, G., Weiss, R. G. & Hays, A., Oct 1 2017, In : PLoS One. 12, 10, e0186448.

Research output: Contribution to journalArticle

exercise
Exercise
gender differences
Sex Characteristics
cardiovascular diseases

Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure

Weiss, K., Schar, M., Panjrath, G. S., Zhang, Y., Sharma, K., Bottomley, P. A., Golozar, A., Steinberg, A., Gerstenblith, G., Russell, S. D. & Weiss, R. G., Jul 1 2017, In : Circulation: Heart Failure. 10, 7, e004129.

Research output: Contribution to journalArticle

Skeletal Muscle
Heart Failure
Exercise
Phosphates
Fatigue

Impaired left atrial function predicts inappropriate shocks in primary prevention implantable cardioverter-defibrillator candidates

Tao, S., Ashikaga, H., Ciuffo, L. A., Yoneyama, K., Lima, J., Frank, T. F., Weiss, R. G., Tomaselli, G. F. & Wu, K. C-C., Jul 1 2017, In : Journal of Cardiovascular Electrophysiology. 28, 7, p. 796-805 10 p.

Research output: Contribution to journalArticle

Left Atrial Function
Implantable Defibrillators
Primary Prevention
Atrial Fibrillation
Shock

Investigation of the contribution of total creatine to the CEST Z-spectrum of brain using a knockout mouse model

Chen, L., Zeng, H., Xu, X., Yadav, N. N., Cai, S., Puts, N., Barker, P. B., Li, T., Weiss, R. G., Van Zijl, P. C. & Xu, J., Dec 1 2017, In : NMR in Biomedicine. 30, 12, e3834.

Research output: Contribution to journalArticle

Creatine
Knockout Mice
Brain
Phosphocreatine
Guanidine
Coronary Artery Disease
Exercise
Healthy Volunteers
Blood Vessels
Coronary Vessels

Self-gated golden angle spiral cine MRI for coronary endothelial function assessment

Bonanno, G., Hays, A., Weiss, R. G. & Schar, M., Jan 1 2017, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Cine Magnetic Resonance Imaging
Electrocardiography
Sexually Transmitted Diseases
Exercise
Coronary Vessels
2016
Defibrillators
Primary Prevention
Stroke Volume
Cicatrix
Magnetic Resonance Spectroscopy

MRS in the failing heart: From mice to humans

Weiss, R. G., Gupta, A. & Bottomley, P. A., 2016, In : eMagRes. 5, 2, p. 1271-1282 12 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Creatine Kinase
Magnetic Resonance Spectroscopy
Heart Failure
Adenosine Triphosphate

Simultaneous Noninvasive Assessment of Systemic and Coronary Endothelial Function

Iantorno, M., Hays, A., Schar, M., Krishnaswamy, R., Soleimanifard, S., Steinberg, A., Stuber, M., Gerstenblith, G. & Weiss, R. G., Mar 1 2016, In : Circulation: Cardiovascular Imaging. 9, 3, e003954.

Research output: Contribution to journalArticle

Mammary Arteries
Exercise
Magnetic Resonance Imaging
Healthy Volunteers
Coronary Vessels
2015
Nitric Oxide
omega-N-Methylarginine
Exercise
Coronary Artery Disease
Vasodilation
Creatine Kinase
Reaction kinetics
Phosphates
Adenosine Triphosphate
Fluxes

Outcomes and Worsening Renal Function in Patients Hospitalized with Heart Failure with Preserved Ejection Fraction

Sharma, K., Hill, T., Grams, M., Daya, N. R., Hays, A., Fine, D. M., Thiemann, D. R., Weiss, R. G., Tedford, R. J., Kass, D. A., Schulman, S. P. & Russell, S. D., Nov 15 2015, In : The American Journal of Cardiology. 116, 10, p. 1534-1540 7 p.

Research output: Contribution to journalArticle

Heart Failure
Kidney
Morbidity
Urban Population
Hypertension

Stem cell impregnated nanofiber stent sleeve for on-stent production and intravascular delivery of paracrine factors

Hwang, C-W., Johnston, P. V., Gerstenblith, G., Weiss, R. G., Tomaselli, G. F., Bogdan, V. E., Panigrahi, A., Leszczynska, A. & Xia, Z., 2015, In : Biomaterials. 52, 1, p. 318-326 9 p.

Research output: Contribution to journalArticle

Nanofibers
Stents
Stem cells
Stem Cells
Mesenchymal Stromal Cells

The MRI evaluation of nitric-oxide mediated systemic endothelial function and coronary endothelial function in healthy subjects and patients with coronary artery disease

Iantorno, M., Soleimanifard, S., Steinberg, A. M., Schär, M., Stuber, M., Gerstenblith, G., Weiss, R. & Hays, A., Feb 3 2015, (Accepted/In press) In : Journal of Cardiovascular Magnetic Resonance. p. 1-2 2 p.

Research output: Contribution to journalArticle

Coronary Artery Disease
Healthy Volunteers
Nitric Oxide
Creatine Kinase
Phosphocreatine
Adenosine Triphosphate
Heart Failure
Healthy Volunteers
2014

Comparison of the relation between left ventricular anatomy and QRS duration in patients with cardiomyopathy with versus without left bundle branch block

Chan, D. D., Wu, K. C-C., Loring, Z., Galeotti, L., Gerstenblith, G., Tomaselli, G., Weiss, R. G., Wagner, G. S. & Strauss, D. G., May 15 2014, In : The American Journal of Cardiology. 113, 10, p. 1717-1722 6 p.

Research output: Contribution to journalArticle

Bundle-Branch Block
Cardiomyopathies
Anatomy
Papillary Muscles
Cardiac Resynchronization Therapy
Magnetic Resonance Angiography
Coronary Angiography
Coronary Vessels
Magnetic Fields
Radio

Skeletal muscle ATP kinetics are impaired in frail mice

Akki, A., Yang, H., Gupta, A., Chacko, V. P., Yano, T., Leppo, M. K., Steenbergen, C. J., Walston, J. D. & Weiss, R. G., 2014, In : Age. 36, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Skeletal Muscle
Adenosine Triphosphate
Muscle Weakness
Phosphates
Geriatrics
Coronary Artery Disease
Cause of Death
Atherosclerosis
Coronary Vessels
Cardiovascular Diseases
2013

Cardiac MRI scar patterns differ by sex in an implantable cardioverter-defibrillator and cardiac resynchronization therapy cohort

Loring, Z., Strauss, D. G., Gerstenblith, G., Tomaselli, G. F., Weiss, R. G. & Wu, K. C-C., May 2013, In : Heart Rhythm. 10, 5, p. 659-665 7 p.

Research output: Contribution to journalArticle

Cardiac Resynchronization Therapy
Implantable Defibrillators
Cicatrix
Equipment and Supplies
Primary Prevention

Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathy

Abraham, M. R., Bottomley, P. A., Dimaano, V. L., Pinheiro, A., Steinberg, A., Traill, T. A., Abraham, T. P. & Weiss, R. G., Sep 15 2013, In : The American Journal of Cardiology. 112, 6, p. 861-866 6 p.

Research output: Contribution to journalArticle

Phosphocreatine
Hypertrophic Cardiomyopathy
Creatine Kinase
Adenosine Triphosphate
Mutation

Creatine Kinase-Overexpression Improves Myocardial Energetics, Contractile Dysfunction and Survival in Murine Doxorubicin Cardiotoxicity

Gupta, A., Rohlfsen, C., Leppo, M. K., Chacko, V. P., Wang, Y., Steenbergen, C. J. & Weiss, R. G., Oct 1 2013, In : PLoS One. 8, 10, e74675.

Research output: Contribution to journalArticle

doxorubicin
creatine kinase
Creatine Kinase
Doxorubicin
MM Form Creatine Kinase

Dynamic analysis of cardiac rhythms for discriminating atrial fibrillation from lethal ventricular arrhythmias

DeMazumder, D., Lake, D. E., Cheng, A., Moss, T. J., Guallar, E., Weiss, R. G., Jones, S., Tomaselli, G. F. & Moorman, J. R., Jun 2013, In : Circulation: Arrhythmia and Electrophysiology. 6, 3, p. 555-561 7 p.

Research output: Contribution to journalArticle

Implantable Defibrillators
Atrial Fibrillation
Cardiac Arrhythmias
Shock
Ventricular Fibrillation

Exercise-induced decrease in myocardial high-energy phosphate metabolites in patients with Chagas heart disease.

Betim Paes Leme, A. M., Salemi, V. M. C., Weiss, R. G., Parga, J. R., Ianni, B. M., Mady, C. & Kalil-Filho, R., Jul 2013, In : Journal of Cardiac Failure. 19, 7, p. 454-460 7 p.

Research output: Contribution to journalArticle

Chagas Disease
Heart Diseases
Phosphates
Exercise
Adenosine Triphosphate
chemical equilibrium
Spectrum Analysis
coding
Magnetic Resonance Imaging
Spectroscopy

Left ventricular mechanical dyssynchrony by cardiac magnetic resonance is greater in patients with strict vs nonstrict electrocardiogram criteria for left bundle-branch block

Andersson, L. G., Wu, K. C-C., Wieslander, B., Loring, Z., Frank, T. F., Maynard, C., Gerstenblith, G., Tomaselli, G. F., Weiss, R. G., Wagner, G. S., Ugander, M. & Strauss, D. G., Jun 2013, In : American Heart Journal. 165, 6, p. 956-963 8 p.

Research output: Contribution to journalArticle

Bundle-Branch Block
Electrocardiography
Magnetic Resonance Spectroscopy
Cardiac Resynchronization Therapy
Implantable Defibrillators

Localization of myocardial scar in patients with cardiomyopathy and left bundle branch block using electrocardiographic Selvester QRS scoring

Wieslander, B., Wu, K. C-C., Loring, Z., Andersson, L. G., Frank, T. F., Gerstenblith, G., Tomaselli, G. F., Weiss, R. G., Wagner, G. S., Ugander, M. & Strauss, D. G., May 2013, In : Journal of Electrocardiology. 46, 3, p. 249-255 7 p.

Research output: Contribution to journalArticle

Bundle-Branch Block
Cardiomyopathies
Cicatrix
Cardiac Resynchronization Therapy
Gadolinium
Cardiovascular System
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Transgenic Mice
Blood Vessels

Metabolic rates of ATP transfer through creatine kinase (CK flux) predict clinical heart failure events and death

Bottomley, P. A., Panjrath, G. S., Lai, S., Hirsch, G. A., Wu, K. C-C., Najjar, S. S., Steinberg, A., Gerstenblith, G. & Weiss, R. G., Dec 11 2013, In : Science Translational Medicine. 5, 215, 215re3.

Research output: Contribution to journalArticle

Creatine Kinase
Heart Failure
Adenosine Triphosphate
Stroke Volume
MB Form Creatine Kinase

Non-Invasive Detection of Coronary Endothelial Response to Sequential Handgrip Exercise in Coronary Artery Disease Patients and Healthy Adults

Hays, A., Stuber, M., Hirsch, G. A., Yu, J., Schar, M., Weiss, R. G., Gerstenblith, G. & Kelle, S., Mar 11 2013, In : PLoS One. 8, 3, e58047.

Research output: Contribution to journalArticle

Coronary Artery Disease
exercise
blood flow
Exercise
Healthy Volunteers

Quantification of human high-energy phosphate metabolite concentrations at 3T with partial volume and sensitivity corrections

El-Sharkawy, A. M. M., Gabr, R. E., Schar, M., Weiss, R. G. & Bottomley, P. A., Nov 2013, In : NMR in Biomedicine. 26, 11, p. 1363-1371 9 p.

Research output: Contribution to journalArticle

Phosphocreatine
Metabolites
Adenosine Triphosphate
Phosphates
Tissue

Right, but not left, bundle branch block is associated with large anteroseptal scar

Strauss, D. G., Loring, Z., Selvester, R. H., Gerstenblith, G., Tomaselli, G., Weiss, R. G., Wagner, G. S. & Wu, K. C-C., Sep 10 2013, In : Journal of the American College of Cardiology. 62, 11, p. 959-967 9 p.

Research output: Contribution to journalArticle

Bundle-Branch Block
Cicatrix
Bundle of His
Implantable Defibrillators
Patient Rights
Magnetic Resonance Angiography
Coronary Vessels
Signal-To-Noise Ratio
Blood Volume
Coronary Angiography
2012
Allopurinol
Adenosine
Creatine Kinase
Adenosine Triphosphate
Xanthine Oxidase
Defibrillators
C-Reactive Protein
Cicatrix
Magnetic Resonance Imaging
Primary Prevention

Correspondence

Wu, K. C-C., Gerstenblith, G., Marine, J., Dalal, D., Cheng, A., Lima, J., Tomaselli, G. F., Weiss, R. G., Guallar, E. & Marban, E., 2012, In : Circulation: Cardiovascular Imaging. 5, 4

Research output: Contribution to journalArticle

Creatine kinase - Mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved

Gupta, A., Akki, A., Wang, Y., Leppo, M. K., Chacko, V. P., Foster, D. B., Caceres, V., Shi, S., Kirk, J. A., Su, J., Lai, S., Paolocci, N., Steenbergen, C. J., Gerstenblith, G. & Weiss, R. G., Jan 3 2012, In : Journal of Clinical Investigation. 122, 1, p. 291-302 12 p.

Research output: Contribution to journalArticle

Creatine Kinase
MM Form Creatine Kinase
Heart Failure
Adenosine Triphosphate
Constriction

Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium

Akki, A., Su, J., Yano, T., Gupta, A., Wang, Y., Leppo, M. K., Chacko, V. P., Steenbergen, C. J. & Weiss, R. G., Oct 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 7

Research output: Contribution to journalArticle

Creatine Kinase
Myocardium
Adenosine Triphosphate
Phosphocreatine
Pressure

Delayed Contrast-Enhanced MRI of the Coronary Artery Wall in Takayasu Arteritis

Schneeweis, C., Schnackenburg, B., Stuber, M., Berger, A., Schneider, U., Yu, J., Gebker, R., Weiss, R. G., Fleck, E., Kelle, S. & Lipinski, M., Dec 7 2012, In : PLoS One. 7, 12, e50655.

Research output: Contribution to journalArticle

arteritis
Takayasu Arteritis
gadolinium
Gadolinium
coronary vessels