Research Output 1976 2017

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2017

Corrigendum: Nuclear landscape of HIV-1 infection and integration

Lusic, M. & Siliciano, R. F. Feb 27 2017 (Accepted/In press) In : Nature Reviews Microbiology.

Research output: Research - peer-reviewArticle

Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape

Pollack, R. A., Jones, R. B., Pertea, M., Bruner, K. M., Martin, A. R., Thomas, A. S., Capoferri, A. A., Beg, S. A., Huang, S. H., Karandish, S., Hao, H., Halper-Stromberg, E., Yong, P. C., Kovacs, C., Benko, E., Siliciano, R. F. & Ho, Y. C. Apr 12 2017 In : Cell Host and Microbe. 21, 4, p. 494-506.e4

Research output: Research - peer-reviewArticle

Proviruses
Cytotoxic T-Lymphocytes
HIV-1
T-Lymphocyte Epitopes
Tissue Donors

Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

Hosmane, N. N., Kwon, K. J., Bruner, K. M., Capoferri, A. A., Beg, S., Rosenbloom, D. I. S., Keele, B. F., Ho, Y. C., Siliciano, J. D. & Siliciano, R. F. Apr 1 2017 In : Journal of Experimental Medicine. 214, 4, p. 959-972 14 p.

Research output: Research - peer-reviewArticle

HIV-1
Cell Proliferation
T-Lymphocytes
Infection
Virus Release

Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity

Martin, A. R., Pollack, R. A., Capoferri, A., Ambinder, R. F., Durand, C. M. & Siliciano, R. F. Feb 1 2017 In : Journal of Clinical Investigation. 127, 2, p. 651-656 6 p.

Research output: Research - peer-reviewArticle

Sirolimus
HIV-1
Cytokines
T-Lymphocytes
Immunosuppressive Agents
2016

Defective proviruses rapidly accumulate during acute HIV-1 infection

Bruner, K. M., Murray, A. J., Pollack, R. A., Soliman, M. G., Laskey, S. B., Capoferri, A. A., Lai, J., Strain, M. C., Lada, S. M., Hoh, R., Ho, Y. C., Richman, D. D., Deeks, S. G., Siliciano, J. D. & Siliciano, R. F. Aug 8 2016 (Accepted/In press) In : Nature Medicine.

Research output: Research - peer-reviewArticle

Proviruses
Virus Diseases
HIV-1
Viruses
Infection

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

Hansen, E. C., Ransom, M., Hesselberth, J. R., Hosmane, N. N., Capoferri, A. A., Bruner, K. M., Pollack, R. A., Zhang, H., Drummond, M. B., Siliciano, J. M., Siliciano, R. & Stivers, J. T. Sep 20 2016 In : eLife. 5, September, e18447

Research output: Research - peer-reviewArticle

Uracil
Myeloid Cells
HIV-1
DNA
Infection

Evaluating Clonal Expansion of HIV-Infected Cells: Optimization of PCR Strategies to Predict Clonality

Laskey, S. B., Pohlmeyer, C. W., Bruner, K. M. & Siliciano, R. F. Aug 1 2016 In : PLoS Pathogens. 12, 8, e1005689

Research output: Research - peer-reviewArticle

Viral Genome
HIV
Polymerase Chain Reaction
HIV-1
Sequence Analysis

Genome editing for clinical HIV isolates

Kim, M. & Siliciano, R. F. Apr 7 2016 In : Nature Biotechnology. 34, 4, p. 388-389 2 p.

Research output: Research - peer-reviewArticle

HIV integration site analysis of cellular models of HIV latency with a probe-enriched next-generation sequencing assay

Sunshine, S., Kirchner, R., Amr, S. S., Mansur, L., Shakhbatyan, R., Kim, M., Bosque, A., Siliciano, R. F., Planelles, V., Hofmann, O., Sui, S. H. & Li, J. Z. May 1 2016 In : Journal of Virology. 90, 9, p. 4511-4519 9 p.

Research output: Research - peer-reviewArticle

assays
HIV
genes
cells
Genes

Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions

Hill, A. L., Rosenbloom, D. I. S., Siliciano, J. D. & Siliciano, R. F. Aug 1 2016 In : PLoS Pathogens. 12, 8, e1005679

Research output: Research - peer-reviewArticle

Progress toward HIV eradication: Case reports, current efforts, and the challenges associated with cure

Martin, A. R. & Siliciano, R. F. Jan 14 2016 In : Annual Review of Medicine. 67, p. 215-228 14 p.

Research output: Research - peer-reviewArticle

Curing
Assays
HIV
HIV Infections
Research

Reactivation of SIV reservoirs in the brain of virally suppressed macaques

Gama, L., Abreu, C. M., Shirk, E. N., Price, S. L., Li, M., Laird, G. M., Pate, K. A. M., Wietgrefe, S. W., O’connor, S. L., Pianowski, L., Haase, A. T., van Lint, C., Siliciano, R. F., Clements, J. E., Authors, D. & The LRA-SIV Study Group Sep 20 2016 (Accepted/In press) In : AIDS.

Research output: Research - peer-reviewArticle

Macaca
Brain
Therapeutics
Viral Load
In Situ Hybridization

Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV

Hill, A. L., Rosenbloom, D. I. S., Goldstein, E., Hanhauser, E., Kuritzkes, D. R., Siliciano, R. F. & Henrich, T. J. Apr 1 2016 In : PLoS Pathogens. 12, 4, e1005535

Research output: Research - peer-reviewArticle

HIV
Therapeutics
Viral Load
Infection
Withholding Treatment

Recent developments in the effort to cure HIV infection: Going beyond N = 1

Siliciano, J. D. & Siliciano, R. F. Feb 1 2016 In : Journal of Clinical Investigation. 126, 2, p. 409-414 6 p.

Research output: Research - peer-reviewArticle

HIV Infections
HIV
Therapeutics
T-Lymphocytes
Virus Latency

The mTOR Complex Controls HIV Latency

Besnard, E., Hakre, S., Kampmann, M., Lim, H. W., Hosmane, N. N., Martin, A., Bassik, M. C., Verschueren, E., Battivelli, E., Chan, J., Svensson, J. P., Gramatica, A., Conrad, R. J., Ott, M., Greene, W. C., Krogan, N. J., Siliciano, R. F., Weissman, J. S. & Verdin, E. Dec 14 2016 In : Cell Host and Microbe. 20, 6, p. 785-797 13 p.

Research output: Research - peer-reviewArticle

HIV
Genome
Therapeutics
Trans-Activators
Small Interfering RNA
2015

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Deng, K. , Pertea, M. , Rongvaux, A. , Wang, L. , Durand, C. M. , Ghiaur, G. , Lai, J. , McHugh, H. L. , Hao, H. , Zhang, H. , Margolick, J. B. , Gurer, C. , Murphy, A. J. , Valenzuela, D. M. , Yancopoulos, G. D. , Deeks, S. G. , Strowig, T. , Kumar, P. , Siliciano, J. D. , Salzberg, S. L. & 3 others Flavell, R. A., Shan, L. & Siliciano, R. F. Jan 15 2015 In : Nature. 517, 7534, p. 381-385 5 p.

Research output: Research - peer-reviewArticle

Cytotoxic T-Lymphocytes
Viruses
Mutation
Epitopes
Therapeutics

Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations

Laird, G. M., Bullen, C. K., Rosenbloom, D. I. S., Martin, A. R., Hill, A. L., Durand, C. M., Siliciano, J. D. & Siliciano, R. F. May 1 2015 In : Journal of Clinical Investigation. 125, 5, p. 1901-1912 12 p.

Research output: Research - peer-reviewArticle

Drug Combinations
HIV-1
Viruses
T-Lymphocytes
Histone Deacetylase Inhibitors

HIV-1 integration landscape during latent and active infection

Cohn, L. B., Silva, I. T., Oliveira, T. Y., Rosales, R. A., Parrish, E. H., Learn, G. H., Hahn, B. H., Czartoski, J. L., McElrath, M. J., Lehmann, C., Klein, F., Caskey, M., Walker, B. D., Siliciano, J. D., Siliciano, R. F., Jankovic, M. & Nussenzweig, M. C. Jan 29 2015 In : Cell. 160, 3, p. 420-432 13 p.

Research output: Research - peer-reviewArticle

HIV-1
T-Lymphocytes
Infection
T-cells
Proviruses

HIV reservoirs: What, where and how to target them

Churchill, M. J., Deeks, S. G., Margolis, D. M., Siliciano, R. F. & Swanstrom, R. Dec 16 2015 In : Nature Reviews Microbiology. 14, 1, p. 55-60 6 p.

Research output: Research - peer-reviewArticle

HIV
Viruses
Infection
Proviruses
Viremia

Medroxyprogesterone acetate increases HIV-1 infection of unstimulated peripheral blood mononuclear cells in vitro

Sampah, M. E. S., Laird, G. M., Blankson, J. N., Siliciano, R. F. & Coleman, J. S. Jun 19 2015 In : AIDS. 29, 10, p. 1137-1146 10 p.

Research output: Research - peer-reviewArticle

Medroxyprogesterone Acetate
HIV Infections
HIV-1
Blood Cells
In Vitro Techniques

Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance

Gray, W. T., Frey, K. M., Laskey, S. B., Mislak, A. C., Spasov, K. A., Lee, W. G., Bollini, M., Siliciano, R. F., Jorgensen, W. L. & Anderson, K. S. Oct 8 2015 In : ACS Medicinal Chemistry Letters. 6, 10, p. 1075-1079 5 p.

Research output: Research - peer-reviewArticle

Rilpivirine
efavirenz
HIV Reverse Transcriptase
Mutation
RNA-Directed DNA Polymerase

Reply

Siliciano, J. D. & Siliciano, R. F. 2015 In : The Journal of Allergy and Clinical Immunology. 136, 1, p. 214 1 p.

Research output: Research - peer-reviewArticle

Stoichiometric parameters of HIV-1 entry

Zarr, M. & Siliciano, R. Jan 1 2015 In : Virology. 474, p. 1-9 9 p.

Research output: Research - peer-reviewArticle

HIV-1
CD4 Antigens
Theoretical Models
Viruses

Towards an HIV-1 cure: Measuring the latent reservoir

Bruner, K. M., Hosmane, N. N. & Siliciano, R. F. Apr 1 2015 In : Trends in Microbiology. 23, 4, p. 192-203 12 p.

Research output: Research - peer-reviewArticle

HIV-1
HIV Infections
Clinical Trials
T-Lymphocytes
Polymerase Chain Reaction
2014

A mechanistic theory to explain the efficacy of antiretroviral therapy

Laskey, S. B. & Siliciano, R. F. Jan 1 2014 In : Nature Reviews Microbiology. 12, 11, p. 772-780 9 p.

Research output: Research - peer-reviewArticle

Therapeutics
Infection
Acquired Immunodeficiency Syndrome
Pharmaceutical Preparations

A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides

Laird, G. M., Eisele, E. E., Rabi, S. A., Nikolaeva, D. & Siliciano, R. F. 2014 In : The Journal of antimicrobial chemotherapy. 69, 4, p. 988-994 7 p., dkt471

Research output: Research - peer-reviewArticle

Cardiac Glycosides
HIV-1
Gene Expression
Therapeutics
Highly Active Antiretroviral Therapy

A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy

Spivak, A. M., Andrade, A., Eisele, E., Hoh, R., Bacchetti, P., Bumpus, N. N., Emad, F., Buckheit, R., Ccance-Katz, E. F., Lai, J., Kennedy, M., Chander, G., Siliciano, R. F., Siliciano, J. D. & Deeks, S. G. 2014 In : Clinical Infectious Diseases. 58, 6, p. 883-890 8 p.

Research output: Research - peer-reviewArticle

Disulfiram
HIV-1
Safety
Therapeutics
Viremia

A primary CD4+ T cell model of HIV-1 latency established after activation through the T cell receptor and subsequent return to quiescence

Kim, M., Hosmane, N. N., Bullen, C. K., Capoferri, A., Yang, H. C., Siliciano, J. D. & Siliciano, R. F. Nov 20 2014 In : Nature Protocols. 9, 12, p. 2755-2770 16 p.

Research output: Research - peer-reviewArticle

T-cells
T-Cell Antigen Receptor
Chemical activation
HIV-1
T-Lymphocytes

CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells

Cockerham, L. R., Siliciano, J. D., Sinclair, E., O'Doherty, U., Palmer, S., Yukl, S. A., Strain, M. C., Chomont, N., Hecht, F. M., Siliciano, R. F., Richman, D. D. & Deeks, S. G. Oct 23 2014 In : PLoS One. 9, 10, e110731

Research output: Research - peer-reviewArticle

T-cells
Chemical activation
Association reactions
DNA
HIV

Dual zinc-Finger nucleases block HIV infection

Durand, C. M. & Siliciano, R. F. Jan 2 2014 In : Blood. 123, 1, p. 2-3 2 p.

Research output: Research - peer-reviewArticle

CCR5 Receptors
CXCR4 Receptors
Zinc Fingers
Genetic Therapy
HIV Infections

HIV: Not-so-innocent bystanders

Cox, A. L. & Siliciano, R. F. 2014 In : Nature. 505, 7484, p. 492-493 2 p.

Research output: Research - peer-reviewArticle

HIV: Early treatment may not be early enough

Deng, K. & Siliciano, R. F. 2014 In : Nature. 512, 1, p. 35-36 2 p.

Research output: Research - peer-reviewArticle

HIV prevention and treatment fields join forces

Deeksa, S. G. & Siliciano, R. 2014 In : EBioMedicine. 1, 1, p. 4-5 2 p.

Research output: Research - peer-reviewArticle

HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice

Salgado, M., Swanson, M. D., Pohlmeyer, C. W., Buckheit, R. W., Wu, J., Archin, N. M., Williams, T. M., Margolis, D. M., Siliciano, R. F., Garcia, J. V. & Blankson, J. N. 2014 In : Journal of Virology. 88, 6, p. 3340-3352 13 p.

Research output: Research - peer-reviewArticle

Human immunodeficiency virus 1
T-lymphocytes
viruses
mice
HIV long-term survivors
HIV-1
T-cells
Transcription
Assays
Messenger RNA

Opening Fronts in HIV Vaccine Development: Targeting reservoirs to clear and cure.

Siliciano, R. F. 2014 In : Nature Medicine. 20, 5, p. 480-481 2 p.

Research output: Research - peer-reviewArticle

Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1

Hill, A. L., Rosenbloom, D. I. S., Fu, F., Nowak, M. A. & Siliciano, R. F. Sep 16 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. 13475-13480 6 p.

Research output: Research - peer-reviewArticle

HIV-1
Therapeutics
Benchmarking
Viremia
HIV Infections
HIV Infections
HIV-1
Therapeutics
Viruses
T-Lymphocytes

Rekindled HIV infection: What does the "Mississippi baby" tell us about curing HIV-1 infection?

Siliciano, J. D. & Siliciano, R. F. Aug 29 2014 In : Science. 345, 6200, p. 1005-1006 2 p.

Research output: Research - peer-reviewArticle

Screening for noise in gene expression identifies drug synergies

Dar, R. D., Hosmane, N. N., Arkin, M. R., Siliciano, R. F. & Weinberger, L. S. 2014 In : Science. 344, 6190, p. 1392-1396 5 p.

Research output: Research - peer-reviewArticle

Gene Expression
AIDS/HIV
Drugs
Cells
Synergy
Histone Deacetylase Inhibitors
HIV-1
T-Lymphocytes
Infection
Pharmaceutical Preparations

Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection

Shan, L. & Siliciano, R. F. Jun 2 2014 In : Journal of Clinical Investigation. 124, 6, p. 2368-2371 4 p.

Research output: Research - peer-reviewArticle

HIV Infections
HIV-1
Infection
Bacterial Translocation
Macaca
2013

Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins

Dobrowsky, T. M., Rabi, S. A., Nedellec, R., Daniels, B. R., Mullins, J. I., Mosier, D. E., Siliciano, R. F. & Wirtz, D. 2013 In : Scientific Reports. 3, 3014

Research output: Research - peer-reviewArticle

env Gene Products
HIV-1
Membrane Proteins
Cell Fusion
Tensile Strength

An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients.

Spina, C. A. , Anderson, J. , Archin, N. M. , Bosque, A. , Chan, J. , Famiglietti, M. , Greene, W. C. , Kashuba, A. , Lewin, S. R. , Margolis, D. M. , Mau, M. , Ruelas, D. , Saleh, S. , Shirakawa, K. , Siliciano, R. F. , Singhania, A. , Soto, P. C. , Terry, V. H. , Verdin, E. , Woelk, C. & 3 others Wooden, S., Xing, S. & Planelles, V. 2013 In : PLoS Pathogens. 9, 12

Research output: Research - peer-reviewArticle

HIV-1
T-Lymphocytes
HIV
Pharmaceutical Preparations
Therapeutics

A novel PCR assay for quantification of HIV-1 RNA

Shan, L., Rabi, S. A., Laird, G. M., Eisele, E. E., Zhang, H., Margolick, J. B. & Siliciano, R. F. Jun 2013 In : Journal of Virology. 87, 11, p. 6521-6525 5 p.

Research output: Research - peer-reviewArticle

HIV-1
RNA
Polymerase Chain Reaction
Human immunodeficiency virus 1
assays

Association of pol diversity with antiretroviral treatment outcomes among HIV-infected african children

Chen, I., Khaki, L., Lindsey, J. C., Fry, C., Cousins, M. M., Siliciano, R. F., Violari, A., Palumbo, P. & Eshleman, S. H. Nov 27 2013 In : PLoS One. 8, 11, e81213

Research output: Research - peer-reviewArticle

HIV
melting
Melting
Freezing
Therapeutics