Robert F Siliciano

Professor

1976 …2019
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Research Output 1976 2019

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Article
2019

Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size

Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group, Apr 1 2019, In : PLoS computational biology. 15, 4, p. e1006849

Research output: Contribution to journalArticle

Open Access
Repeatability
human immunodeficiency virus
Human immunodeficiency virus 1
repeatability
HIV-1

Incentives for Viral Suppression in People Living with HIV: A Randomized Clinical Trial

Silverman, K., Holtyn, A. F., Rodewald, A. M., Siliciano, R. F., Jarvis, B. P., Subramaniam, S., Leoutsakos, J. M., Getty, C. A., Ruhs, S., Marzinke, M. A. & Fingerhood, M., Jan 1 2019, In : AIDS and behavior.

Research output: Contribution to journalArticle

Viral Load
Motivation
Randomized Controlled Trials
HIV
Acquired Immunodeficiency Syndrome

The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections

Bender, A. M., Simonetti, F. R., Kumar, M. R., Fray, E. J., Bruner, K. M., Timmons, A. E., Tai, K. Y., Jenike, K. M., Antar, A., Liu, P. T., Ho, Y. C., Raugi, D. N., Seydi, M., Gottlieb, G. S., Okoye, A. A., Del Prete, G. Q., Picker, L. J., Mankowski, J. L., Lifson, J. D., Siliciano, J. M. & 4 others, Laird, G., Barouch, D. H., Clements, J. E. & Siliciano, R. F., Jul 10 2019, In : Cell Host and Microbe. 26, 1, p. 73-85.e4

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
HIV-2
Viral Genome
HIV Infections
Genome
2018

CMPK2 and BCL-G are associated with type 1 interferon–induced HIV restriction in humans

El-Diwany, R., Soliman, M., Sugawara, S., Breitwieser, F., Skaist, A., Coggiano, C., Sangal, N., Chattergoon, M. A., Bailey, J., Siliciano, R. F., Blankson, J. N., Ray, S. C., Wheelan, S., Thomas, D. L. & Balagopal, A., Aug 1 2018, In : Science advances. 4, 8, eaat0843.

Research output: Contribution to journalArticle

HIV-1
HIV
Interferons
RNA
Genes

Cross-reactive microbial peptides can modulate HIV-specific CD8+ T cell responses

Pohlmeyer, C. W., Laskey, S. B., Beck, S., Xu, D. C., Capoferri, A. A., Garliss, C. C., May, M. E., Livingston, A., Lichmira, W., Moore, R. D., Sue Leffell, M., Butler, N. J., Thorne, J., Flynn, J. A., Siliciano, R. F. & Blankson, J. N., Feb 1 2018, In : PLoS One. 13, 2, e0192098.

Research output: Contribution to journalArticle

T-cells
Human immunodeficiency virus 1
HIV-1
T-lymphocytes
HIV

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane

Wang, Z., Gurule, E. E., Brennan, T. P., Gerold, J. M., Kwon, K. J., Hosmane, N. N., Kumar, M. R., Beg, S. A., Capoferri, A. A., Ray, S. C., Ho, Y. C., Hill, A. L., Siliciano, J. M. & Siliciano, R. F., Jan 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 11, p. E2575-E2584

Research output: Contribution to journalArticle

Waxes
HIV-1
Clone Cells
Proviruses
Cell Proliferation

HIV-1 latent reservoir size and diversity are stable following brief treatment interruption

Salantes, D. B., Zheng, Y., Mampe, F., Srivastava, T., Beg, S., Lai, J., Li, J. Z., Tressler, R. L., Koup, R. A., Hoxie, J., Abdel-Mohsen, M., Sherrill-Mix, S., McCormick, K., Overton, E. T., Bushman, F. D., Learn, G. H., Siliciano, R. F., Siliciano, J. M., Tebas, P. & Bar, K. J., Jul 2 2018, In : Journal of Clinical Investigation. 128, 7, p. 3102-3115 14 p.

Research output: Contribution to journalArticle

HIV-1
Viremia
Viruses
DNA Viruses
DNA

Insight into treatment of HIV infection from viral dynamics models

Hill, A. L., Rosenbloom, D. I. S., Nowak, M. A. & Siliciano, R. F., Sep 1 2018, In : Immunological Reviews. 285, 1, p. 9-25 17 p.

Research output: Contribution to journalArticle

HIV Infections
Investigational Therapies
Viremia
Therapeutics
Infection

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ t cells

Huang, S. H., Ren, Y., Thomas, A. S., Chan, D., Mueller, S., Ward, A. R., Patel, S., Bollard, C. M., Cruz, C. R., Karandish, S., Truong, R., Macedo, A. B., Bosque, A., Kovacs, C., Benko, E., Piechocka-Trocha, A., Wong, H., Jeng, E., Nixon, D. F., Ho, Y. C. & 3 others, Siliciano, R. F., Walker, B. D. & Brad Jones, R., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 876-889 14 p.

Research output: Contribution to journalArticle

HIV
T-Lymphocytes
Proviruses
Cytotoxic T-Lymphocytes
Virus Replication

The role of CD32 during HIV-1 infection

Bertagnolli, L. N., White, J. A., Simonetti, F. R., Beg, S. A., Lai, J., Tomescu, C., Murray, A. J., Antar, A., Zhang, H., Margolick, J. B., Hoh, R., Deeks, S. G., Tebas, P., Montaner, L. J., Siliciano, R. F., Laird, G. & Siliciano, J. M., Sep 20 2018, In : Nature. 561, 7723, p. E17-E19

Research output: Contribution to journalArticle

human immunodeficiency virus
infection
2017

Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape

Pollack, R. A., Jones, R. B., Pertea, M., Bruner, K. M., Martin, A. R., Thomas, A. S., Capoferri, A. A., Beg, S. A., Huang, S. H., Karandish, S., Hao, H., Halper-Stromberg, E., Yong, P. C., Kovacs, C., Benko, E., Siliciano, R. F. & Ho, Y. C., Apr 12 2017, In : Cell Host and Microbe. 21, 4, p. 494-506.e4

Research output: Contribution to journalArticle

Proviruses
Cytotoxic T-Lymphocytes
HIV-1
T-Lymphocyte Epitopes
Tissue Donors

HIV-1 persistence following extre277277mely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study

Henrich, T. J., Hatano, H., Bacon, O., Hogan, L. E., Rutishauser, R., Hill, A., Kearney, M. F., Anderson, E. M., Buchbinder, S. P., Cohen, S. E., Abdel-Mohsen, M., Pohlmeyer, C. W., Fromentin, R., Hoh, R., Liu, A. Y., McCune, J. M., Spindler, J., Pate, K., Hobbs, K. S., Thanh, C. & 12 others, Gibson, E. A., Kuritzkes, D. R., Siliciano, R. F., Price, R. W., Richman, D. D., Chomont, N., Siliciano, J. M., Mellors, J. W., Yukl, S. A., Blankson, J. N., Liegler, T. & Deeks, S. G., Nov 1 2017, In : PLoS Medicine. 14, 11, e1002417.

Research output: Contribution to journalArticle

HIV Infections
Observational Studies
HIV-1
HIV
RNA

Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

Hosmane, N. N., Kwon, K. J., Bruner, K. M., Capoferri, A. A., Beg, S., Rosenbloom, D. I. S., Keele, B. F., Ho, Y. C., Siliciano, J. M. & Siliciano, R. F., Apr 1 2017, In : Journal of Experimental Medicine. 214, 4, p. 959-972 14 p.

Research output: Contribution to journalArticle

HIV-1
Cell Proliferation
T-Lymphocytes
Virus Release
Virus Replication

Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity

Martin, A. R., Pollack, R. A., Capoferri, A., Ambinder, R. F., Durand, C. & Siliciano, R. F., Feb 1 2017, In : Journal of Clinical Investigation. 127, 2, p. 651-656 6 p.

Research output: Contribution to journalArticle

Sirolimus
HIV-1
Cytokines
T-Lymphocytes
Immunosuppressive Agents

Reduced frequency of cells latently infected with replication-competent human immunodeficiency virus-1 in virally suppressed individuals living in Rakai, Uganda

Prodger, J., Lai, J., Reynolds, S. J., Keruly, J. C., Moore, R. D., Kasule, J., Kityamuweesi, T., Buule, P., Serwadda, D., Nason, M., Capoferri, A. A., Porcella, S. F., Siliciano, R. F., Redd, A., Siliciano, J. M. & Quinn, T. C., Oct 1 2017, In : Clinical Infectious Diseases. 65, 8, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

Uganda
HIV-1
T-Lymphocytes
Baltimore
Virus Diseases

Re-evaluating evolution in the HIV reservoir

Rosenbloom, D. I. S., Hill, A. L., Laskey, S. B. & Siliciano, R. F., Nov 22 2017, In : Nature. 551, 7681, p. E6-E8

Research output: Contribution to journalArticle

cells and cell components
viral disease
immune system
human immunodeficiency virus
subpopulation

Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 Infection

Shan, L., Deng, K., Gao, H., Xing, S., Capoferri, A. A., Durand, C., Rabi, S. A., Laird, G., Kim, M., Hosmane, N. N., Yang, H. C., Zhang, H., Margolick, J. B., Li, L., Cai, W., Ke, R., Flavell, R. A., Siliciano, J. M. & Siliciano, R. F., Oct 17 2017, In : Immunity. 47, 4, p. 766-775.e3

Research output: Contribution to journalArticle

HIV Infections
HIV-1
T-Lymphocytes
Infection
Viral Gene Expression Regulation
2016

Defective proviruses rapidly accumulate during acute HIV-1 infection

Bruner, K. M., Murray, A. J., Pollack, R. A., Soliman, M. G., Laskey, S. B., Capoferri, A. A., Lai, J., Strain, M. C., Lada, S. M., Hoh, R., Ho, Y. C., Richman, D. D., Deeks, S. G., Siliciano, J. M. & Siliciano, R. F., Aug 8 2016, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

Proviruses
Virus Diseases
Viruses
HIV-1
Infection

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

Hansen, E. C., Ransom, M., Hesselberth, J. R., Hosmane, N. N., Capoferri, A. A., Bruner, K. M., Pollack, R. A., Zhang, H., Drummond, M. B., Siliciano, J. M., Siliciano, R. F. & Stivers, J., Sep 20 2016, In : eLife. 5, September, e18447.

Research output: Contribution to journalArticle

Uracil
Myeloid Cells
HIV-1
DNA
Viral DNA

Evaluating Clonal Expansion of HIV-Infected Cells: Optimization of PCR Strategies to Predict Clonality

Laskey, S. B., Pohlmeyer, C. W., Bruner, K. M. & Siliciano, R. F., Aug 1 2016, In : PLoS Pathogens. 12, 8, e1005689.

Research output: Contribution to journalArticle

Viral Genome
HIV
HIV-1
Polymerase Chain Reaction
Sequence Analysis

Genome editing for clinical HIV isolates

Kim, M. & Siliciano, R. F., Apr 7 2016, In : Nature Biotechnology. 34, 4, p. 388-389 2 p.

Research output: Contribution to journalArticle

Genes

HIV integration site analysis of cellular models of HIV latency with a probe-enriched next-generation sequencing assay

Sunshine, S., Kirchner, R., Amr, S. S., Mansur, L., Shakhbatyan, R., Kim, M., Bosque, A., Siliciano, R. F., Planelles, V., Hofmann, O., Sui, S. H. & Li, J. Z., May 1 2016, In : Journal of Virology. 90, 9, p. 4511-4519 9 p.

Research output: Contribution to journalArticle

HIV
assays
genes
Genes
cells

Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions

Hill, A. L., Rosenbloom, D. I. S., Siliciano, J. M. & Siliciano, R. F., Aug 1 2016, In : PLoS Pathogens. 12, 8, e1005679.

Research output: Contribution to journalArticle

HIV

Progress toward HIV eradication: Case reports, current efforts, and the challenges associated with cure

Martin, A. R. & Siliciano, R. F., Jan 14 2016, In : Annual Review of Medicine. 67, p. 215-228 14 p.

Research output: Contribution to journalArticle

Curing
Assays
HIV
HIV Infections
Research

Quantitative evaluation of the antiretroviral efficacy of dolutegravir

Laskey, S. B. & Siliciano, R. F., Nov 17 2016, In : JCI insight. 1, 19, p. e90033

Research output: Contribution to journalArticle

HIV-1
Integrase Inhibitors
HIV Protease Inhibitors
Mutation
Reverse Transcriptase Inhibitors

Reactivation of SIV reservoirs in the brain of virally suppressed macaques

The LRA-SIV Study Group, Sep 20 2016, (Accepted/In press) In : AIDS.

Research output: Contribution to journalArticle

Macaca
Brain
Viral Load
In Situ Hybridization
Acquired Immunodeficiency Syndrome

Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV

Hill, A. L., Rosenbloom, D. I. S., Goldstein, E., Hanhauser, E., Kuritzkes, D. R., Siliciano, R. F. & Henrich, T. J., Apr 1 2016, In : PLoS Pathogens. 12, 4, e1005535.

Research output: Contribution to journalArticle

HIV
Therapeutics
Viral Load
Withholding Treatment
Hematopoietic Stem Cells

Recent developments in the effort to cure HIV infection: Going beyond N = 1

Siliciano, J. M. & Siliciano, R. F., Feb 1 2016, In : Journal of Clinical Investigation. 126, 2, p. 409-414 6 p.

Research output: Contribution to journalArticle

HIV Infections
HIV
T-Lymphocytes
Virus Latency
Therapeutics
CD4-Positive T-Lymphocytes
Virus Replication
HIV Infections
HIV-1
T-Lymphocytes

The mTOR Complex Controls HIV Latency

Besnard, E., Hakre, S., Kampmann, M., Lim, H. W., Hosmane, N. N., Martin, A., Bassik, M. C., Verschueren, E., Battivelli, E., Chan, J., Svensson, J. P., Gramatica, A., Conrad, R. J., Ott, M., Greene, W. C., Krogan, N. J., Siliciano, R. F., Weissman, J. S. & Verdin, E., Dec 14 2016, In : Cell Host and Microbe. 20, 6, p. 785-797 13 p.

Research output: Contribution to journalArticle

HIV
Genome
Trans-Activators
Small Interfering RNA
HIV-1
2015

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Deng, K., Pertea, M., Rongvaux, A., Wang, L., Durand, C., Ghiaur, G., Lai, J., McHugh, H. L., Hao, H., Zhang, H., Margolick, J. B., Gurer, C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Deeks, S. G., Strowig, T., Kumar, P., Siliciano, J. M., Salzberg, S. L. & 3 others, Flavell, R. A., Shan, L. & Siliciano, R. F., Jan 15 2015, In : Nature. 517, 7534, p. 381-385 5 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Viruses
Mutation
Epitopes
Virus Diseases

Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations

Laird, G., Bullen, C. K., Rosenbloom, D. I. S., Martin, A. R., Hill, A. L., Durand, C., Siliciano, J. M. & Siliciano, R. F., May 1 2015, In : Journal of Clinical Investigation. 125, 5, p. 1901-1912 12 p.

Research output: Contribution to journalArticle

Drug Combinations
HIV-1
Viruses
T-Lymphocytes
Histone Deacetylase Inhibitors

HIV-1 integration landscape during latent and active infection

Cohn, L. B., Silva, I. T., Oliveira, T. Y., Rosales, R. A., Parrish, E. H., Learn, G. H., Hahn, B. H., Czartoski, J. L., McElrath, M. J., Lehmann, C., Klein, F., Caskey, M., Walker, B. D., Siliciano, J. M., Siliciano, R. F., Jankovic, M. & Nussenzweig, M. C., Jan 29 2015, In : Cell. 160, 3, p. 420-432 13 p.

Research output: Contribution to journalArticle

T-cells
HIV-1
T-Lymphocytes
Proviruses
Infection

HIV reservoirs: What, where and how to target them

Churchill, M. J., Deeks, S. G., Margolis, D. M., Siliciano, R. F. & Swanstrom, R., Dec 16 2015, In : Nature Reviews Microbiology. 14, 1, p. 55-60 6 p.

Research output: Contribution to journalArticle

HIV
Viruses
Proviruses
Viremia
Constitution and Bylaws

Medroxyprogesterone acetate increases HIV-1 infection of unstimulated peripheral blood mononuclear cells in vitro

Sampah, M. E. S., Laird, G., Blankson, J. N., Siliciano, R. F. & Coleman Fennell, J. S., Jun 19 2015, In : AIDS. 29, 10, p. 1137-1146 10 p.

Research output: Contribution to journalArticle

Medroxyprogesterone Acetate
HIV Infections
HIV-1
Blood Cells
Infection

Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance

Gray, W. T., Frey, K. M., Laskey, S. B., Mislak, A. C., Spasov, K. A., Lee, W. G., Bollini, M., Siliciano, R. F., Jorgensen, W. L. & Anderson, K. S., Oct 8 2015, In : ACS Medicinal Chemistry Letters. 6, 10, p. 1075-1079 5 p.

Research output: Contribution to journalArticle

Rilpivirine
efavirenz
HIV Reverse Transcriptase
RNA-Directed DNA Polymerase
Mutation

Reply

Siliciano, J. M. & Siliciano, R. F., 2015, In : The Journal of Allergy and Clinical Immunology. 136, 1, p. 214 1 p.

Research output: Contribution to journalArticle

Virus Latency
CD4-Positive T-Lymphocytes
Anti-HIV Agents
Acute Myeloid Leukemia
HIV Infections

Stoichiometric parameters of HIV-1 entry

Zarr, M. & Siliciano, R. F., Jan 1 2015, In : Virology. 474, p. 1-9 9 p.

Research output: Contribution to journalArticle

HIV-1
CD4 Antigens
Theoretical Models
Viruses
Virus Latency
HIV-1
T-Lymphocytes

Towards an HIV-1 cure: Measuring the latent reservoir

Bruner, K. M., Hosmane, N. N. & Siliciano, R. F., Apr 1 2015, In : Trends in Microbiology. 23, 4, p. 192-203 12 p.

Research output: Contribution to journalArticle

HIV-1
HIV Infections
Clinical Trials
T-Lymphocytes
Polymerase Chain Reaction
2014

A mechanistic theory to explain the efficacy of antiretroviral therapy

Laskey, S. B. & Siliciano, R. F., Jan 1 2014, In : Nature Reviews Microbiology. 12, 11, p. 772-780 9 p.

Research output: Contribution to journalArticle

Infection
Acquired Immunodeficiency Syndrome
Therapeutics
Pharmaceutical Preparations

A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides

Laird, G., Eisele, E. E., Rabi, S. A., Nikolaeva, D. & Siliciano, R. F., 2014, In : The Journal of antimicrobial chemotherapy. 69, 4, p. 988-994 7 p., dkt471.

Research output: Contribution to journalArticle

Cardiac Glycosides
HIV-1
Gene Expression
Highly Active Antiretroviral Therapy
Life Cycle Stages

A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy

Spivak, A. M., Andrade, A., Eisele, E., Hoh, R., Bacchetti, P., Bumpus, N. N., Emad, F., Buckheit, R., Ccance-Katz, E. F., Lai, J., Kennedy, M., Chander, G., Siliciano, R. F., Siliciano, J. M. & Deeks, S. G., 2014, In : Clinical Infectious Diseases. 58, 6, p. 883-890 8 p.

Research output: Contribution to journalArticle

Disulfiram
HIV-1
Viremia
Safety
Confidence Intervals

A primary CD4+ T cell model of HIV-1 latency established after activation through the T cell receptor and subsequent return to quiescence

Kim, M., Hosmane, N. N., Bullen, C. K., Capoferri, A., Yang, H. C., Siliciano, J. M. & Siliciano, R. F., Nov 20 2014, In : Nature Protocols. 9, 12, p. 2755-2770 16 p.

Research output: Contribution to journalArticle

T-cells
T-Cell Antigen Receptor
HIV-1
Chemical activation
T-Lymphocytes

CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells

Cockerham, L. R., Siliciano, J. M., Sinclair, E., O'Doherty, U., Palmer, S., Yukl, S. A., Strain, M. C., Chomont, N., Hecht, F. M., Siliciano, R. F., Richman, D. D. & Deeks, S. G., Oct 23 2014, In : PLoS One. 9, 10, e110731.

Research output: Contribution to journalArticle

T-cells
T-lymphocytes
Chemical activation
Association reactions
HIV

Dual zinc-Finger nucleases block HIV infection

Durand, C. & Siliciano, R. F., Jan 2 2014, In : Blood. 123, 1, p. 2-3 2 p.

Research output: Contribution to journalArticle

CCR5 Receptors
CXCR4 Receptors
Gene therapy
Zinc Fingers
Genetic Therapy

Finding a Cure for Human Immunodeficiency Virus-1 Infection

Blankson, J. N., Siliciano, J. M. & Siliciano, R. F., Dec 1 2014, In : Infectious Disease Clinics of North America. 28, 4, p. 633-650 18 p.

Research output: Contribution to journalArticle

Virus Latency
Anti-HIV Agents
Highly Active Antiretroviral Therapy
Virus Diseases
HIV Infections

HIV: Not-so-innocent bystanders

Cox, A. & Siliciano, R. F., 2014, In : Nature. 505, 7484, p. 492-493 2 p.

Research output: Contribution to journalArticle

CD4-Positive T-Lymphocytes
cytology
Caspase 1
infectivity
acquired immune deficiency syndrome

HIV: Early treatment may not be early enough

Deng, K. & Siliciano, R. F., 2014, In : Nature. 512, 1, p. 35-36 2 p.

Research output: Contribution to journalArticle

Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
Viremia
Macaca mulatta
Viral Load