Research Output 1976 2017

2017

Corrigendum: Nuclear landscape of HIV-1 infection and integration

Lusic, M. & Siliciano, R. F. Feb 27 2017 In : Nature Reviews Microbiology.

Research output: Contribution to journalArticle

Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape

Pollack, R. A., Jones, R. B., Pertea, M., Bruner, K. M., Martin, A. R., Thomas, A. S., Capoferri, A. A., Beg, S. A., Huang, S. H., Karandish, S., Hao, H., Halper-Stromberg, E., Yong, P. C., Kovacs, C., Benko, E., Siliciano, R. F. & Ho, Y. C. Apr 12 2017 In : Cell Host and Microbe. 21, 4, p. 494-506.e4

Research output: Contribution to journalArticle

Proviruses
Cytotoxic T-Lymphocytes
HIV-1
T-Lymphocyte Epitopes
RNA

HIV persistence: Clonal expansion of cells in the latent reservoir

Kwon, K. J. & Siliciano, R. F. Jun 30 2017 In : Journal of Clinical Investigation. 127, 7, p. 2536-2538 3 p.

Research output: Contribution to journalReview article

Proviruses
HIV-1
HIV
Viruses
Th1 Cells

Nuclear landscape of HIV-1 infection and integration

Lusic, M. & Siliciano, R. F. Feb 1 2017 In : Nature Reviews Microbiology. 15, 2, p. 69-82 14 p.

Research output: Contribution to journalReview article

HIV Infections
HIV-1
Viral Genome
DNA
Life Cycle Stages

Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

Hosmane, N. N., Kwon, K. J., Bruner, K. M., Capoferri, A. A., Beg, S., Rosenbloom, D. I. S., Keele, B. F., Ho, Y. C., Siliciano, J. D. & Siliciano, R. F. Apr 1 2017 In : Journal of Experimental Medicine. 214, 4, p. 959-972 14 p.

Research output: Contribution to journalArticle

HIV-1
Cell Proliferation
T-Lymphocytes
Infection
Virus Release

Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity

Martin, A. R., Pollack, R. A., Capoferri, A., Ambinder, R. F., Durand, C. M. & Siliciano, R. F. Feb 1 2017 In : Journal of Clinical Investigation. 127, 2, p. 651-656 6 p.

Research output: Contribution to journalArticle

Sirolimus
HIV-1
Cytokines
T-Lymphocytes
Immunosuppressive Agents
2016

Defective proviruses rapidly accumulate during acute HIV-1 infection

Bruner, K. M., Murray, A. J., Pollack, R. A., Soliman, M. G., Laskey, S. B., Capoferri, A. A., Lai, J., Strain, M. C., Lada, S. M., Hoh, R., Ho, Y. C., Richman, D. D., Deeks, S. G., Siliciano, J. D. & Siliciano, R. F. Aug 8 2016 In : Nature Medicine.

Research output: Contribution to journalArticle

Proviruses
HIV-1
Infection
Bulimia
Secondary Prevention

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

Hansen, E. C., Ransom, M., Hesselberth, J. R., Hosmane, N. N., Capoferri, A. A., Bruner, K. M., Pollack, R. A., Zhang, H., Drummond, M. B., Siliciano, J. M., Siliciano, R. & Stivers, J. T. Sep 20 2016 In : eLife. 5, September, e18447

Research output: Contribution to journalArticle

Uracil
Myeloid Cells
HIV-1
DNA
Infection

Evaluating Clonal Expansion of HIV-Infected Cells: Optimization of PCR Strategies to Predict Clonality

Laskey, S. B., Pohlmeyer, C. W., Bruner, K. M. & Siliciano, R. F. Aug 1 2016 In : PLoS Pathogens. 12, 8, e1005689

Research output: Contribution to journalArticle

Viral Genome
HIV
Polymerase Chain Reaction
HIV-1
Sequence Analysis

Genome editing for clinical HIV isolates

Kim, M. & Siliciano, R. F. Apr 7 2016 In : Nature Biotechnology. 34, 4, p. 388-389 2 p.

Research output: Contribution to journalArticle

Genes

HIV integration site analysis of cellular models of HIV latency with a probe-enriched next-generation sequencing assay

Sunshine, S., Kirchner, R., Amr, S. S., Mansur, L., Shakhbatyan, R., Kim, M., Bosque, A., Siliciano, R. F., Planelles, V., Hofmann, O., Sui, S. H. & Li, J. Z. May 1 2016 In : Journal of Virology. 90, 9, p. 4511-4519 9 p.

Research output: Contribution to journalArticle

HIV
genes
cells
Genes
assays

Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions

Hill, A. L., Rosenbloom, D. I. S., Siliciano, J. D. & Siliciano, R. F. Aug 1 2016 In : PLoS Pathogens. 12, 8, e1005679

Research output: Contribution to journalArticle

HIV

Measuring the frequency of latent HIV-1 in resting CD4+ T cells using a limiting dilution coculture assay

Laird, G. M., Rosenbloom, D. I. S., Lai, J., Siliciano, R. F. & Siliciano, J. D. 2016 Methods in Molecular Biology. Humana Press Inc., Vol. 1354, p. 239-253 15 p. (Methods in Molecular Biology; vol. 1354)

Research output: Chapter in Book/Report/Conference proceedingChapter

Coculture Techniques
HIV-1
T-Lymphocytes
HIV Infections
Viruses

Progress toward HIV eradication: Case reports, current efforts, and the challenges associated with cure

Martin, A. R. & Siliciano, R. F. Jan 14 2016 In : Annual Review of Medicine. 67, p. 215-228 14 p.

Research output: Contribution to journalArticle

Caprylates
Aldrin
Beryllium
HIV
HIV Infections

Reactivation of SIV reservoirs in the brain of virally suppressed macaques

Gama, L., Abreu, C. M., Shirk, E. N., Price, S. L., Li, M., Laird, G. M., Pate, K. A. M., Wietgrefe, S. W., O’connor, S. L., Pianowski, L., Haase, A. T., van Lint, C., Siliciano, R. F., Clements, J. E., Authors, D. & The LRA-SIV Study Group Sep 20 2016 In : AIDS.

Research output: Contribution to journalArticle

Macaca
Brain
Viral Load
In Situ Hybridization
Polymerase Chain Reaction

Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV

Hill, A. L., Rosenbloom, D. I. S., Goldstein, E., Hanhauser, E., Kuritzkes, D. R., Siliciano, R. F. & Henrich, T. J. Apr 1 2016 In : PLoS Pathogens. 12, 4, e1005535

Research output: Contribution to journalArticle

HIV
Viral Load
Infection
Withholding Treatment
Hematopoietic Stem Cells

Recent developments in the effort to cure HIV infection: Going beyond N = 1

Siliciano, J. D. & Siliciano, R. F. Feb 1 2016 In : Journal of Clinical Investigation. 126, 2, p. 409-414 6 p.

Research output: Contribution to journalArticle

HIV Infections
HIV
T-Lymphocytes
Virus Latency
Neutralizing Antibodies
HIV Infections
T-Lymphocytes

The latent reservoir for HIV-1: How immunologic memory and clonal expansion contribute to HIV-1 persistence

Murray, A. J., Kwon, K. J., Farber, D. L. & Siliciano, R. F. Jul 15 2016 In : Journal of Immunology. 197, 2, p. 407-417 11 p.

Research output: Contribution to journalReview article

Immunologic Memory
HIV-1
HIV Infections
Viremia
Limit of Detection

The mTOR Complex Controls HIV Latency

Besnard, E., Hakre, S., Kampmann, M., Lim, H. W., Hosmane, N. N., Martin, A., Bassik, M. C., Verschueren, E., Battivelli, E., Chan, J., Svensson, J. P., Gramatica, A., Conrad, R. J., Ott, M., Greene, W. C., Krogan, N. J., Siliciano, R. F., Weissman, J. S. & Verdin, E. Dec 14 2016 In : Cell Host and Microbe. 20, 6, p. 785-797 13 p.

Research output: Contribution to journalArticle

HIV
Genome
Trans-Activators
Small Interfering RNA
HIV-1
2015

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Deng, K. , Pertea, M. , Rongvaux, A. , Wang, L. , Durand, C. M. , Ghiaur, G. , Lai, J. , McHugh, H. L. , Hao, H. , Zhang, H. , Margolick, J. B. , Gurer, C. , Murphy, A. J. , Valenzuela, D. M. , Yancopoulos, G. D. , Deeks, S. G. , Strowig, T. , Kumar, P. , Siliciano, J. D. , Salzberg, S. L. & 3 others Flavell, R. A., Shan, L. & Siliciano, R. F. Jan 15 2015 In : Nature. 517, 7534, p. 381-385 5 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Viruses
Mutation
Epitopes
Pharmacology

Designing and interpreting limiting dilution assays: General principles and applications to the latent reservoir for human immunodeficiency virus-1

Rosenbloom, D. I. S., Elliott, O., Hill, A. L., Henrich, T. J., Siliciano, J. M. & Siliciano, R. F. 2015 In : Open Forum Infectious Diseases. 2, 4, ofv123

Research output: Contribution to journalReview article

HIV-1
Infection
HIV
Virus Latency
Communicable Diseases

Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations

Laird, G. M., Bullen, C. K., Rosenbloom, D. I. S., Martin, A. R., Hill, A. L., Durand, C. M., Siliciano, J. D. & Siliciano, R. F. May 1 2015 In : Journal of Clinical Investigation. 125, 5, p. 1901-1912 12 p.

Research output: Contribution to journalArticle

Drug Combinations
HIV-1
Viruses
T-Lymphocytes
Histone Deacetylase Inhibitors

HIV-1 integration landscape during latent and active infection

Cohn, L. B., Silva, I. T., Oliveira, T. Y., Rosales, R. A., Parrish, E. H., Learn, G. H., Hahn, B. H., Czartoski, J. L., McElrath, M. J., Lehmann, C., Klein, F., Caskey, M., Walker, B. D., Siliciano, J. D., Siliciano, R. F., Jankovic, M. & Nussenzweig, M. C. Jan 29 2015 In : Cell. 160, 3, p. 420-432 13 p.

Research output: Contribution to journalArticle

HIV-1
T-Lymphocytes
Infection
Lutheran Blood-Group System
T-cells

HIV reservoirs: What, where and how to target them

Churchill, M. J., Deeks, S. G., Margolis, D. M., Siliciano, R. F. & Swanstrom, R. Dec 16 2015 In : Nature Reviews Microbiology. 14, 1, p. 55-60 6 p.

Research output: Contribution to journalArticle

HIV
Viruses
Infection
Proviruses
Viremia

Medroxyprogesterone acetate increases HIV-1 infection of unstimulated peripheral blood mononuclear cells in vitro

Sampah, M. E. S., Laird, G. M., Blankson, J. N., Siliciano, R. F. & Coleman, J. S. Jun 19 2015 In : AIDS. 29, 10, p. 1137-1146 10 p.

Research output: Contribution to journalArticle

Medroxyprogesterone Acetate
HIV Infections
HIV-1
Blood Cells
In Vitro Techniques

Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance

Gray, W. T., Frey, K. M., Laskey, S. B., Mislak, A. C., Spasov, K. A., Lee, W. G., Bollini, M., Siliciano, R. F., Jorgensen, W. L. & Anderson, K. S. Oct 8 2015 In : ACS Medicinal Chemistry Letters. 6, 10, p. 1075-1079 5 p.

Research output: Contribution to journalArticle

HIV Reverse Transcriptase
RNA-Directed DNA Polymerase
Antiviral Agents
Mutation
Cytochrome c Group

Reply

Siliciano, J. D. & Siliciano, R. F. 2015 In : The Journal of Allergy and Clinical Immunology. 136, 1, p. 214 1 p.

Research output: Contribution to journalArticle

Stoichiometric parameters of HIV-1 entry

Zarr, M. & Siliciano, R. Jan 1 2015 In : Virology. 474, p. 1-9 9 p.

Research output: Contribution to journalArticle

HIV-1
CD4 Antigens
Viruses
HIV-1
T-Lymphocytes

Towards an HIV-1 cure: Measuring the latent reservoir

Bruner, K. M., Hosmane, N. N. & Siliciano, R. F. Apr 1 2015 In : Trends in Microbiology. 23, 4, p. 192-203 12 p.

Research output: Contribution to journalArticle

HIV-1
HIV Infections
Clinical Trials
T-Lymphocytes
Polymerase Chain Reaction
2014

A mechanistic theory to explain the efficacy of antiretroviral therapy

Laskey, S. B. & Siliciano, R. F. Jan 1 2014 In : Nature Reviews Microbiology. 12, 11, p. 772-780 9 p.

Research output: Contribution to journalArticle

Infection

A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides

Laird, G. M., Eisele, E. E., Rabi, S. A., Nikolaeva, D. & Siliciano, R. F. 2014 In : The Journal of antimicrobial chemotherapy. 69, 4, p. 988-994 7 p., dkt471

Research output: Contribution to journalArticle

Cardiac Glycosides
HIV-1
Gene Expression
Highly Active Antiretroviral Therapy
Life Cycle Stages

A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy

Spivak, A. M., Andrade, A., Eisele, E., Hoh, R., Bacchetti, P., Bumpus, N. N., Emad, F., Buckheit, R., Ccance-Katz, E. F., Lai, J., Kennedy, M., Chander, G., Siliciano, R. F., Siliciano, J. D. & Deeks, S. G. 2014 In : Clinical Infectious Diseases. 58, 6, p. 883-890 8 p.

Research output: Contribution to journalArticle

Disulfiram
HIV-1
Safety
Viremia
Confidence Intervals

A primary CD4+ T cell model of HIV-1 latency established after activation through the T cell receptor and subsequent return to quiescence

Kim, M., Hosmane, N. N., Bullen, C. K., Capoferri, A., Yang, H. C., Siliciano, J. D. & Siliciano, R. F. Nov 20 2014 In : Nature Protocols. 9, 12, p. 2755-2770 16 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
HIV-1
T-Lymphocytes
Anthralin
T-cells

CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells

Cockerham, L. R., Siliciano, J. D., Sinclair, E., O'Doherty, U., Palmer, S., Yukl, S. A., Strain, M. C., Chomont, N., Hecht, F. M., Siliciano, R. F., Richman, D. D. & Deeks, S. G. Oct 23 2014 In : PLoS One. 9, 10, e110731

Research output: Contribution to journalArticle

HIV
T-Lymphocytes
DNA
T-cells
T-lymphocytes

Dual zinc-Finger nucleases block HIV infection

Durand, C. M. & Siliciano, R. F. Jan 2 2014 In : Blood. 123, 1, p. 2-3 2 p.

Research output: Contribution to journalArticle

CCR5 Receptors
CXCR4 Receptors
Zinc Fingers
Genetic Therapy
HIV Infections
HIV-1
Infection

HIV: Early treatment may not be early enough

Deng, K. & Siliciano, R. F. 2014 In : Nature. 512, 1, p. 35-36 2 p.

Research output: Contribution to journalArticle

HIV

HIV: Not-so-innocent bystanders

Cox, A. L. & Siliciano, R. F. 2014 In : Nature. 505, 7484, p. 492-493 2 p.

Research output: Contribution to journalArticle

HIV

HIV prevention and treatment fields join forces

Deeksa, S. G. & Siliciano, R. 2014 In : EBioMedicine. 1, 1, p. 4-5 2 p.

Research output: Contribution to journalArticle

HIV

HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice

Salgado, M., Swanson, M. D., Pohlmeyer, C. W., Buckheit, R. W., Wu, J., Archin, N. M., Williams, T. M., Margolis, D. M., Siliciano, R. F., Garcia, J. V. & Blankson, J. N. 2014 In : Journal of Virology. 88, 6, p. 3340-3352 13 p.

Research output: Contribution to journalArticle

viruses
HIV long-term survivors
HLA-B Antigens
HIV-1
T-Lymphocytes
Inborn Errors Amino Acid Metabolism
HIV-1
T-cells
T-Lymphocytes
Anthralin

Opening Fronts in HIV Vaccine Development: Targeting reservoirs to clear and cure.

Siliciano, R. F. 2014 In : Nature Medicine. 20, 5, p. 480-481 2 p.

Research output: Contribution to journalArticle

AIDS Vaccines

Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1

Hill, A. L., Rosenbloom, D. I. S., Fu, F., Nowak, M. A. & Siliciano, R. F. Sep 16 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. 13475-13480 6 p.

Research output: Contribution to journalArticle

HIV-1
Viremia
HIV Infections
Bone Marrow
Clinical Trials
HIV Infections
HIV-1
Viruses
T-Lymphocytes
Infection

Rekindled HIV infection: What does the "Mississippi baby" tell us about curing HIV-1 infection?

Siliciano, J. D. & Siliciano, R. F. Aug 29 2014 In : Science. 345, 6200, p. 1005-1006 2 p.

Research output: Contribution to journalArticle

HIV Infections

Screening for noise in gene expression identifies drug synergies

Dar, R. D., Hosmane, N. N., Arkin, M. R., Siliciano, R. F. & Weinberger, L. S. 2014 In : Science. 344, 6190, p. 1392-1396 5 p.

Research output: Contribution to journalArticle

Cells
Fluctuations
Gene expression
Drugs
Fate
Histone Deacetylase Inhibitors
HIV-1
T-Lymphocytes
Infection
Transformed Cell Line