Robert B Scharpf

Associate Professor

19972018
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  • 2 Similar Profiles
Single Nucleotide Polymorphism Medicine & Life Sciences
DNA Copy Number Variations Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Genome Medicine & Life Sciences
Genes Chemical Compounds
Blood Platelets Medicine & Life Sciences
Microarrays Chemical Compounds
Genome-Wide Association Study Medicine & Life Sciences

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Research Output 1997 2018

Neoadjuvant PD-1 blockade in resectable lung cancer

Forde, P. M. , Chaft, J. E. , Smith, K. N. , Anagnostou, V. , Cottrell, T. R. , Hellmann, M. D. , Zahurak, M. , Broderick, S. , Yang, S. C. , Jones, D. R. , Battafarano, R. J. , Velez, M. J. , Rekhtman, N. , Olah, Z. , Verde, F. , Naidoo, J. , Marrone, K. A. , Guo, H. , Sidhom, J. W. , Zhang, J. & 15 others Caushi, J. X., Chan, H. Y., Scharpf, R. B., White, J., Gabrielson, E., Wang, H., Rosner, G. L., Rusch, V., Wolchok, J. D., Merghoub, T., Taube, J. M., Velculescu, V. E., Topalian, S. L., Brahmer, J. R. & Pardoll, D. M. May 24 2018 In : New England Journal of Medicine. 378, 21, p. 1976-1986 11 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Clone Cells
Neoplasms
Non-Small Cell Lung Carcinoma
T-Lymphocytes

Direct detection of early-stage cancers using circulating tumor DNA

Phallen, J. , Sausen, M. , Adleff, V. , Leal, A. , Hruban, C. , White, J. , Anagnostou, V. , Fiksel, J. , Cristiano, S. , Papp, E. , Speir, S. , Reinert, T. , Orntoft, M. B. W. , Woodward, B. D. , Murphy, D. , Parpart-Li, S. , Riley, D. , Nesselbush, M. , Sengamalay, N. , Georgiadis, A. & 17 others Li, Q. K., Madsen, M. R., Mortensen, F. V., Huiskens, J., Punt, C., Van Grieken, N., Fijneman, R., Meijer, G., Husain, H., Scharpf, R. B., Diaz, L. A., Jones, S., Angiuoli, S., Ørntoft, T., Nielsen, H. J., Andersen, C. L. & Velculescu, V. E. Aug 16 2017 In : Science translational medicine. 9, 403, eaan2415

Research output: Contribution to journalArticle

Early Detection of Cancer
DNA
Neoplasms
High-Throughput Nucleotide Sequencing
Mutation

Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer

Anagnostou, V. , Smith, K. N. , Forde, P. M. , Niknafs, N. , Bhattacharya, R. , White, J. , Zhang, T. , Adleff, V. , Phallen, J. , Wali, N. , Hruban, C. , Guthrie, V. B. , Rodgers, K. , Naidoo, J. , Kang, H. , Sharfman, W. , Georgiades, C. , Verde, F. , Illei, P. , Li, Q. K. & 9 others Gabrielson, E., Brock, M. V., Zahnow, C. A., Baylin, S. B., Scharpf, R. B., Brahmer, J. R., Karchin, R., Pardoll, D. M. & Velculescu, V. E. Mar 1 2017 In : Cancer Discovery. 7, 3, p. 264-276 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasms
T-Lymphocytes
Mutation
T-Cell Antigen Receptor

GATA3 frameshift mutation promotes tumor growth in human luminal breast cancer cells and induces transcriptional changes seen in primary GATA3 mutant breast cancers

Gustin, J. P., Miller, J., Farag, M., Marc Rosen, D., Thomas, M., Scharpf, R. B. & Lauring, J. Jan 1 2017 In : Oncotarget. 8, 61, p. 103415-103427 13 p.

Research output: Contribution to journalArticle

Frameshift Mutation
Breast Neoplasms
Mutation
Growth
Neoplasms

Genome-wide association of copy number polymorphisms and kidney function

Li, M., Carey, J., Cristiano, S., Susztak, K., Coresh, J., Boerwinkle, E., Kao, W. H. L., Beaty, T. H., Köttgen, A. & Scharpf, R. B. Jan 1 2017 In : PLoS ONE. 12, 1, e0170815

Research output: Contribution to journalArticle

DNA Copy Number Variations
glomerular filtration rate
renal function
Polymorphism
Glomerular Filtration Rate