Robert A Casero

Professor

1980 …2020

Research output per year

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Research Output

2020

(R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder-Robinson syndrome

Stewart, T. M., Khomutov, M., Foley, J. R., Guo, X., Holbert, C. E., Dunston, T. T., Schwartz, C. E., Gabrielson, K., Khomutov, A. & Casero, R. A., Mar 6 2020, In : Journal of Biological Chemistry. 295, 10, p. 3247-3256 10 p.

Research output: Contribution to journalArticle

A phase I dose-escalation study of the polyamine analog PG-11047 in patients with advanced solid tumors

Murray Stewart, T., Desai, A. A., Fitzgerald, M. L., Marton, L. J. & Casero, R. A., Jun 1 2020, In : Cancer Chemotherapy and Pharmacology. 85, 6, p. 1089-1096 8 p.

Research output: Contribution to journalArticle

Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum

Holbert, C. E., Dunworth, M., Foley, J. R., Dunston, T. T., Stewart, T. M. & Casero, R. A., Jul 3 2020, In : The Journal of biological chemistry. 295, 27, p. 9061-9068 8 p.

Research output: Contribution to journalArticle

Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease

Holshouser, S., Cafiero, R., Robinson, M., Kirkpatrick, J., Casero, R. A., Hyacinth, H. I. & Woster, P. M., Jun 23 2020, In : ACS Omega. 5, 24, p. 14750-14758 9 p.

Research output: Contribution to journalArticle

Open Access

Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy

Geck, R. C., Foley, J. R., Stewart, T. M., Asara, J. M., Casero, R. A. & Toker, A., May 8 2020, In : Journal of Biological Chemistry. 295, 19, p. 6263-6277 15 p.

Research output: Contribution to journalReview article

Open Access

Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex

Kapfhamer, D., McKenna, J., Yoon, C. J., Murray-Stewart, T., Casero, R. A. & Gambello, M. J., Aug 11 2020, In : Human molecular genetics. 29, 14, p. 2395-2407 13 p.

Research output: Contribution to journalArticle

Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy

Affronti, H. C., Rowsam, A. M., Pellerite, A. J., Rosario, S. R., Long, M. D., Jacobi, J. J., Bianchi-Smiraglia, A., Boerlin, C. S., Gillard, B. M., Karasik, E., Foster, B. A., Moser, M., Wilton, J. H., Attwood, K., Nikiforov, M. A., Azabdaftari, G., Pili, R., Phillips, J. G., Casero, R. A. & Smiraglia, D. J., Dec 1 2020, In : Nature communications. 11, 1, 52.

Research output: Contribution to journalArticle

Open Access

Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling

Sierra, J. C., Piazuelo, M. B., Luis, P. B., Barry, D. P., Allaman, M. M., Asim, M., Sebrell, T. A., Finley, J. L., Rose, K. L., Hill, S., Holshouser, S. L., Casero, R. A., Cleveland, J. L., Woster, P. M., Schey, K. L., Bimczok, D., Schneider, C., Gobert, A. P. & Wilson, K. T., May 28 2020, In : Oncogene. 39, 22, p. 4465-4474 10 p.

Research output: Contribution to journalArticle

2019

DFMO and 5-azacytidine increase M1 macrophages in the tumor microenvironment of murine ovarian cancer

Travers, M., Brown, S. M., Dunworth, M., Holbert, C. E., Wiehagen, K. R., Bachman, K. E., Foley, J. R., Stone, M. L., Baylin, S. B., Casero, R. A. & Zahnow, C. A., 2019, In : Cancer Research. 79, 13, p. 3445-3454 10 p.

Research output: Contribution to journalArticle

Dual inhibitors of LSD1 and spermine oxidase

Holshouser, S., Dunworth, M., Murray-Stewart, T., Peterson, Y. K., Burger, P., Kirkpatrick, J., Chen, H. H., Casero, R. A. & Woster, P. M., 2019, In : MedChemComm. 10, 5, p. 778-790 13 p.

Research output: Contribution to journalArticle

Elevation of cellular Mg2+ levels by the Mg2+ transporter, Alr1, supports growth of polyamine-deficient Saccharomyces cerevisiae cells

Hanner, A. S., Dunworth, M., Casero, R. A., MacDiarmid, C. W. & Park, M. H., Nov 8 2019, In : Journal of Biological Chemistry. 294, 45, p. 17131-17142 12 p.

Research output: Contribution to journalArticle

2018

Corrigendum to “Structure–activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures” [Bioorg. Med. Chem. 23 (2015) 1601–1612]

Nowotarski, S. L., Pachaiyappan, B., Holshouser, S. L., Kutz, C. J., Li, Y., Huang, Y., Sharma, S. K., Casero, R. A. & Woster, P. M., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes

Lane, D. J. R., Bae, D. H., Siafakas, A. R., Suryo Rahmanto, Y., Al-Akra, L., Jansson, P. J., Casero, R. A. & Richardson, D. R., Sep 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 9, p. 2793-2813 21 p.

Research output: Contribution to journalArticle

Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies

Murray-Stewart, T., Dunworth, M., Lui, Y., Giardiello, F. M., Woster, P. M. & Casero, R. A., Aug 2018, In : PloS one. 13, 8, e0202677.

Research output: Contribution to journalArticle

Distinct immunomodulatory effects of spermine oxidase in colitis induced by epithelial injury or infection

Gobert, A. P., Al-Greene, N. T., Singh, K., Coburn, L. A., Sierra, J. C., Verriere, T. G., Luis, P. B., Schneider, C., Asim, M., Allaman, M. M., Barry, D. P., Cleveland, J. L., Shields, C. E. D., Casero, R. A., Washington, M. K., Piazuelo, M. B. & Wilson, K. T., Jun 5 2018, In : Frontiers in immunology. 9, JUN, 1242.

Research output: Contribution to journalArticle

Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis

Cruz-Correa, M., Hylind, L. M., Marrero, J. H., Zahurak, M. L., Murray-Stewart, T., Casero, R. A., Montgomery, E. A., Iacobuzio-Donahue, C., Brosens, L. A., Offerhaus, G. J., Umar, A., Rodriguez, L. M. & Giardiello, F. M., Sep 2018, In : Gastroenterology. 155, 3, p. 668-673 6 p.

Research output: Contribution to journalArticle

Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex

McKenna, J., Kapfhamer, D., Kinchen, J. M., Wasek, B., Dunworth, M., Murray-Stewart, T., Bottiglieri, T., Casero, R. A. & Gambello, M. J., Jun 15 2018, In : Human molecular genetics. 27, 12, p. 2113-2124 12 p.

Research output: Contribution to journalArticle

N1-Nonyl-1,4-diaminobutane ameliorates brain infarction size in photochemically induced thrombosis model mice

Masuko, T., Takao, K., Samejima, K., Shirahata, A., Igarashi, K., Casero, R. A., Kizawa, Y. & Sugita, Y., Apr 13 2018, In : Neuroscience Letters. 672, p. 118-122 5 p.

Research output: Contribution to journalArticle

Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia

Gong, S., Sovio, U., Aye, I. L., Gaccioli, F., Dopierala, J., Johnson, M. D., Wood, A. M., Cook, E., Jenkins, B. J., Koulman, A., Casero, R. A., Constância, M., Charnock-Jones, D. S. & Smith, G. C., Jul 12 2018, In : JCI Insight. 3, 13

Research output: Contribution to journalArticle

Open Access

Polyamine catabolism and oxidative damage

Stewart, T. M., Dunston, T. T., Woster, P. M. & Casero, R. A., Nov 30 2018, In : Journal of Biological Chemistry. 293, 48, p. 18736-18745 10 p.

Research output: Contribution to journalReview article

Polyamine metabolism and cancer: treatments, challenges and opportunities

Casero, R. A., Murray Stewart, T. & Pegg, A. E., Nov 1 2018, In : Nature Reviews Cancer. 18, 11, p. 681-695 15 p.

Research output: Contribution to journalReview article

Polymeric Prodrugs Targeting Polyamine Metabolism Inhibit Zika Virus Replication

Routhu, N. K., Xie, Y., Dunworth, M., Casero, R. A., Oupicky, D. & Byrareddy, S. N., Sep 4 2018, In : Molecular Pharmaceutics. 15, 9, p. 4284-4295 12 p.

Research output: Contribution to journalArticle

Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features

Jain, V., Raina, S., Gheware, A. P., Singh, R., Rehman, R., Negi, V., Murray Stewart, T., Mabalirajan, U., Mishra, A. K., Casero, R. A., Agrawal, A. & Ghosh, B., Oct 2018, In : Allergy: European Journal of Allergy and Clinical Immunology. 73, 10, p. 2033-2045 13 p.

Research output: Contribution to journalArticle

Targeting the aryl hydrocarbon receptor/polyamine biosynthesis axis of evil for cancer therapy

Casero, R. A., Oct 1 2018, In : Journal of Clinical Investigation. 128, 10, p. 4254-4256 3 p.

Research output: Contribution to journalReview article

2017

Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury

Zahedi, K., Barone, S., Destefano-Shields, C., Brooks, M., Murray-Stewart, T., Dunworth, M., Li, W., Doherty, J. R., Hall, M. A., Smith, R. D., Cleveland, J. L., Casero, R. A. & Soleimani, M., Sep 2017, In : PloS one. 12, 9, e0184570.

Research output: Contribution to journalArticle

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano 11047

Murray Stewart, T., Ferrari, E., Xie, Y., Yu, F., Marton, L. J., Oupicky, D. & Casero, R. A., Apr 1 2017, In : PLoS One. 12, 4, e0175917.

Research output: Contribution to journalArticle

Correction: Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047 (PLoS ONE (2017) 12:4 (e0175917) DOI: 10.1371/journal.pone.0175917)

Murray-Stewart, T., Ferrari, E., Xie, Y., Yu, F., Marton, L. J., Oupicky, D. & Casero, R. A., May 2017, In : PloS one. 12, 5, e0178102.

Research output: Contribution to journalComment/debate

Elucidating the Structure of N1-Acetylisoputreanine: A Novel Polyamine Catabolite in Human Urine

Fitzgerald, B. L., Mahapatra, S., Farmer, D. K., McNeil, M. R., Casero, R. A. & Belisle, J. T., Jul 31 2017, In : ACS Omega. 2, 7, p. 3921-3930 10 p.

Research output: Contribution to journalArticle

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy

Xie, Y., Murray-Stewart, T., Wang, Y., Yu, F., Li, J., Marton, L. J., Casero, R. A. & Oupický, D., Jan 28 2017, In : Journal of Controlled Release. 246, p. 110-119 10 p.

Research output: Contribution to journalArticle

Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth

Liu, Y., Murray-Stewart, T., Casero, R. A., Kagiampakis, I., Jin, L., Jiawen, Z., Huihui, W., Che, Q., Huan, T., Ke, J., Feizhou, J., Fangyuan, W. & Wan, X., Jun 2017, In : International journal of oncology. 50, 6, p. 2011-2023 13 p.

Research output: Contribution to journalArticle

2016

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection

Hardbower, D. M., Asim, M., Murray-Stewart, T., Casero, R. A., Verriere, T., Lewis, N. D., Chaturvedi, R., Piazuelo, M. B. & Wilson, K. T., Oct 1 2016, In : Amino Acids. 48, 10, p. 2375-2388 14 p.

Research output: Contribution to journalArticle

Decrease in acrolein toxicity based on the decline of polyamine oxidases

Uemura, T., Nakamura, M., Sakamoto, A., Suzuki, T., Dohmae, N., Terui, Y., Tomitori, H., Casero, R. A., Kashiwagi, K. & Igarashi, K., Oct 1 2016, In : International Journal of Biochemistry and Cell Biology. 79, p. 151-157 7 p.

Research output: Contribution to journalArticle

Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer

Murray Stewart, T., Sierra, J. C., Piazuelo, M. B., Mera, R. M., Chaturvedi, R., Bravo, L. E., Correa, P., Schneider, B. G., Wilson, K. T. & Casero, R. A., Apr 4 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation. A Perfect Combination for Cancer Therapy.

Zahnow, C. A., Topper, M., Stone, M., Murray-Stewart, T., Li, H., Baylin, S. B. & Casero, R. A., Jan 1 2016, Advances in Cancer Research, 2016. Fisher, P. B. & Tew, K. D. (eds.). Academic Press Inc., p. 55-111 57 p. (Advances in Cancer Research; vol. 130).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue

Almaliti, J., Al-Hamashi, A. A., Negmeldin, A. T., Hanigan, C. L., Perera, L., Pflum, M. K. H., Casero, R. A. & Tillekeratne, L. M. V., Dec 8 2016, In : Journal of medicinal chemistry. 59, 23, p. 10642-10660 19 p.

Research output: Contribution to journalArticle

MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition

Luo, H., Shenoy, A. K., Li, X., Jin, Y., Jin, L., Cai, Q., Tang, M., Liu, Y., Chen, H., Reisman, D., Wu, L., Seto, E., Qiu, Y., Dou, Y., Casero, R. A. & Lu, J., Jun 21 2016, In : Cell Reports. 15, 12, p. 2665-2678 14 p.

Research output: Contribution to journalArticle

Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment

Destefano Shields, C. E., Van Meerbeke, S. W., Housseau, F., Wang, H., Huso, D. L., Casero, R. A., O'Hagan, H. M. & Sears, C. L., Jul 1 2016, In : Journal of Infectious Diseases. 214, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

Targeting polyamine metabolism for cancer therapy and prevention

Tracy, R. M. S., Woster, P. M. & Casero, R. A., 2016, In : Biochemical Journal. 473, 19, p. 2937-2953 17 p.

Research output: Contribution to journalReview article

2015

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase

Chaturvedi, R., De Sablet, T., Asim, M., Piazuelo, M. B., Barry, D. P., Verriere, T. G., Sierra, J. C., Hardbower, D. M., Delgado, A. G., Schneider, B. G., Israel, D. A., Romero-Gallo, J., Nagy, T. A., Morgan, D. R., Murray-Stewart, T., Bravo, L. E., Peek, R. M., Fox, J. G., Woster, P. M., Casero, R. A. & 2 others, Correa, P. & Wilson, K. T., Jun 27 2015, In : Oncogene. 34, 26, p. 3429-3440 12 p.

Research output: Contribution to journalArticle

Mammalian polyamine catabolism

Murray Stewart, T. & Casero, R. A., Jan 1 2015, Polyamines: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer Japan, p. 61-76 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolism links bacterial biofilms and colon carcinogenesis

Johnson, C. H., Dejea, C. M., Edler, D., Hoang, L. T., Santidrian, A. F., Felding, B. H., Ivanisevic, J., Cho, K., Wick, E. C., Hechenbleikner, E. M., Uritboonthai, W., Goetz, L., Casero, R. A., Pardoll, D. M., White, J. R., Patti, G. J., Sears, C. L. & Siuzdak, G., Jun 2 2015, In : Cell Metabolism. 21, 6, p. 891-897 7 p.

Research output: Contribution to journalArticle

Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures

Nowotarski, S. L., Pachaiyappan, B., Holshouser, S. L., Kutz, C. J., Li, Y., Huang, Y., Sharma, S. K., Casero, R. A. & Woster, P. M., Apr 1 2015, In : Bioorganic and Medicinal Chemistry. 23, 7, p. 1601-1612 12 p.

Research output: Contribution to journalArticle

2014

Activation of EGFR and ERBB2 by helicobacter pylori results in survival of gastric epithelial cells with DNA damage

Chaturvedi, R., Asim, M., Piazuelo, M. B., Yan, F., Barry, D. P., Sierra, J. C., Delgado, A. G., Hill, S., Casero, R. A., Bravo, L. E., Dominguez, R. L., Correa, P., Polk, D. B., Washington, M. K., Rose, K. L., Schey, K. L., Morgan, D. R., Peek, R. M. & Wilson, K. T., Jun 2014, In : Gastroenterology. 146, 7, p. 1739-1751.e14

Research output: Contribution to journalArticle

A selective phenelzine analogue inhibitor of histone demethylase LSD1

Prusevich, P., Kalin, J. H., Ming, S. A., Basso, M., Givens, J., Li, X., Hu, J., Taylor, M. S., Cieniewicz, A. M., Hsiao, P. Y., Huang, R., Roberson, H., Adejola, N., Avery, L. B., Casero, R. A., Taverna, S. D., Qian, J., Tackett, A. J., Ratan, R. R., McDonald, O. G. & 2 others, Feinberg, A. P. & Cole, P. A., Jun 20 2014, In : ACS chemical biology. 9, 6, p. 1284-1293 10 p.

Research output: Contribution to journalArticle

Polyamine catabolism in carcinogenesis: Potential targets for chemotherapy and chemoprevention

Battaglia, V., DeStefano Shields, C., Murray-Stewart, T. & Casero, R. A., Mar 2014, In : Amino Acids. 46, 3, p. 511-519 9 p.

Research output: Contribution to journalShort survey

Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury

Zahedi, K., Barone, S., Wang, Y., Murray-Stewart, T., Roy-Chaudhury, P., Smith, R. D., Casero, R. A. & Soleimani, M., Nov 12 2014, In : PloS one. 9, 11, e110161.

Research output: Contribution to journalArticle

Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: Enhancement of antimicrobial nitric oxide generation by depletion of spermine

Chaturvedi, R., Asim, M., Barry, D. P., Frye, J. W., Casero, R. A. & Wilson, K. T., Mar 2014, In : Amino Acids. 46, 3, p. 531-542 12 p.

Research output: Contribution to journalArticle

Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups

Bhansali, P., Hanigan, C. L., Perera, L., Casero, R. A. & Tillekeratne, L. M. V., Oct 30 2014, In : European Journal of Medicinal Chemistry. 86, p. 528-541 14 p.

Research output: Contribution to journalArticle

2013

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism

Murray-Stewart, T., Hanigan, C. L., Woster, P. M., Marton, L. J. & Casero, R. A., Oct 2013, In : Molecular cancer therapeutics. 12, 10, p. 2088-2099 12 p.

Research output: Contribution to journalArticle