Robert A Brodsky

Professor

1990 …2020
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Research Output 1990 2020

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Article
2019
Odds Ratio
Hemolysis
Isoantibodies
Hyperbilirubinemia
Complement Activation

Defining early hematopoietic-fated primitive streak specification of human pluripotent stem cells by the orchestrated balance of Wnt, activin, and BMP signaling

Shen, J., Lyu, C., Zhu, Y., Feng, Z., Zhang, S., Hoyle, D. L., Ji, G., Brodsky, R. A., Cheng, T. & Wang, Z. Z., Jan 1 2019, In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Primitive Streak
Activins
Pluripotent Stem Cells
Bone Morphogenetic Proteins
Stem cells

Haploidentical Bone Marrow Transplantation with Post-Transplantation Cyclophosphamide Plus Thiotepa Improves Donor Engraftment in Patients with Sickle Cell Anemia: Results of an International Learning Collaborative

de la Fuente, J., Dhedin, N., Koyama, T., Bernaudin, F., Kuentz, M., Karnik, L., Socié, G., Culos, K. A., Brodsky, R. A., DeBaun, M. R. & Kassim, A. A., Jan 1 2019, (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalArticle

Thiotepa
Sickle Cell Anemia
Bone Marrow Transplantation
Cyclophosphamide
Transplantation

Linking complement activation, coagulation, and neutrophils in transplant-associated thrombotic microangiopathy

Gavriilaki, E., Chrysanthopoulou, A., Sakellari, I., Batsis, I., Mallouri, D., Touloumenidou, T., Papalexandri, A., Mitsios, A., Arampatzioglou, A., Ritis, K., Brodsky, R. A., Mitroulis, I. & Anagnostopoulos, A., Jan 1 2019, In : Thrombosis and Haemostasis. 119, 9, p. 1433-1440 8 p.

Research output: Contribution to journalArticle

Thrombotic Microangiopathies
Complement Activation
Graft vs Host Disease
Neutrophils
Transplants

Rare Germline Mutations in Complement Regulatory Genes Make the Antiphospholipid Syndrome Catastrophic

Chaturvedi, S., Braunstein, E. M., Yuan, X., Chen, H., Alluri, R. K., Streiff, M. B., Petri, M., Crowther, M., McCrae, K. R. & Brodsky, R. A., Nov 13 2019, In : Blood. 134, 1, 1 p.

Research output: Contribution to journalArticle

Antiphospholipid Syndrome
Germ-Line Mutation
Regulator Genes
Genes
Advisory Committees

Reduced ADAMTS13 activity during TTP remission is associated with stroke in TTP survivors

Upreti, H., Kasmani, J., Dane, K., Braunstein, E., Streiff, M. B., Shanbhag, S. P., Moliterno, A. R., Sperati, C. J., Gottesman, R. F., Brodsky, R. A., Kickler, T. S. & Chaturvedi, S., Sep 26 2019, In : Blood. 134, 13, p. 1037-1045 9 p.

Research output: Contribution to journalArticle

Thrombotic Thrombocytopenic Purpura
Survivors
Stroke
Recovery
Patient treatment

Warm autoimmune hemolytic anemia

Brodsky, R. A., Aug 15 2019, In : New England Journal of Medicine. 381, 7, p. 647-654 8 p.

Research output: Contribution to journalArticle

Coombs Test
Autoimmune Hemolytic Anemia
Erythrocyte Indices
Reticulocytes
Splenomegaly
2018
Hemophagocytic Lymphohistiocytosis
Quality Improvement
Hemorrhage
Odds Ratio
Biopsy

Diagnostic utility of telomere length testing in a hospital-based setting

Alder, J., Hanumanthu, V. S., Strong, M. A., Dezern, A., Stanley, S. E., Takemoto, C. M., Danilova, L. V., Applegate, C. D., Bolton, S. G., Mohr, D. W., Brodsky, R. A., Casella, J. F., Greider, C. W., Brooks Jackson, J. & Armanios, M., Mar 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 10, p. E2358-E2365

Research output: Contribution to journalArticle

Telomere
Mutation
Bone Marrow
Telomerase
Flow Cytometry
Bone Marrow Transplantation
Fever
Transplants
Unrelated Donors
Cyclophosphamide
Paroxysmal Hemoglobinuria
Bone Marrow
Transplants
Aplastic Anemia
Hemolysis

Effectiveness of eculizumab in patients with paroxysmal nocturnal hemoglobinuria (PNH) with or without aplastic anemia in the International PNH Registry

Lee, J. W., Peffault de Latour, R., Brodsky, R. A., Jang, J. H., Hill, A., Röth, A., Schrezenmeier, H., Wilson, A., Marantz, J. L. & Maciejewski, J. P., Jan 1 2018, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

Paroxysmal Hemoglobinuria
Aplastic Anemia
Registries
eculizumab

Germline mutations in the alternative pathway of complement predispose to HELLP syndrome

Vaught, A., Braunstein, E., Jasem, J., Yuan, X., Makhlin, I., Eloundou, S., Baines, A. C., Merrill, S., Chaturvedi, S., Blakemore, K., Sperati, C. J. & Brodsky, R. A., Mar 22 2018, In : JCI insight. 3, 6

Research output: Contribution to journalArticle

Open Access
Alternative Complement Pathway
Germ-Line Mutation
Hemolysis
Blood Platelets
Liver
Bone Marrow Transplantation
Cyclophosphamide
Tissue Donors
Confidence Intervals
Transplants
Aplastic Anemia
Bone Marrow Transplantation
Tissue Donors
Graft vs Host Disease
HLA Antigens
Tacrolimus
Graft vs Host Disease
Bone Marrow Transplantation
Transplantation
Arm
2017

A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model

Yuan, X., Li, Z., Baines, A. C., Gavriilaki, E., Ye, Z., Wen, Z., Braunstein, E., Biesecker, L. G., Cheng, L., Dong, X. & Brodsky, R. A., Apr 1 2017, In : PLoS One. 12, 4, e0174074.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Neurons
Toxicity
complement
neurodevelopment
Aplastic Anemia
Cyclophosphamide
Transplantation
Tissue Donors
Graft vs Host Disease
Graft vs Host Disease
Cyclophosphamide
Transplantation
Recurrence
Bone Marrow

Complementopathies

Baines, A. C. & Brodsky, R. A., 2017, (Accepted/In press) In : Blood Reviews.

Research output: Contribution to journalArticle

Paroxysmal Hemoglobinuria
Autoimmune Hemolytic Anemia
Complement Activation
Immune System
Infection
Graft vs Host Disease
Cyclophosphamide
Disease-Free Survival
Confidence Intervals
Transplants
Muscular Diseases
Cyclophosphamide
Stem Cells
Signal Recognition Particle
Therapeutics

Hypotonia and intellectual disability without dysmorphic features in a patient with PIGN-related disease

Thiffault, I., Zuccarelli, B., Welsh, H., Yuan, X., Farrow, E., Zellmer, L., Miller, N., Soden, S., Abdelmoity, A., Brodsky, R. A. & Saunders, C., Nov 2 2017, In : BMC Medical Genetics. 18, 1, 124.

Research output: Contribution to journalArticle

Muscle Hypotonia
Intellectual Disability
Glycosylphosphatidylinositols
Exome
Phenotype

In vitro evidence of complement activation in transplantation-associated thrombotic microangiopathy

Rotz, S. J., Luebbering, N., Dixon, B. P., Gavriilaki, E., Brodsky, R. A., Dandoy, C. E., Jodele, S. & Davies, S. M., Sep 12 2017, In : Blood Advances. 1, 20, p. 1632-1634 3 p.

Research output: Contribution to journalArticle

Thrombotic Microangiopathies
Complement Activation
Transplantation
In Vitro Techniques
Homologous Transplantation
Bone Marrow Transplantation
Systemic Lupus Erythematosus
Cyclophosphamide
Transplantation

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

Kanakry, C. G., Bolanos Meade, F. J., Kasamon, Y. L., Zahurak, M., Durakovic, N., Furlong, T., Mielcarek, M., Medeot, M., Gojo, I., Smith, B. D., Kanakry, J. A., Borrello, I. M., Brodsky, R. A., Gladstone, D., Huff, C. A., Matsui, W. H., Swinnen, L., Cooke, K. R., Ambinder, R. F., Fuchs, E. J. & 6 others, De Lima, M. J., Andersson, B. S., Varadhan, R., O'Donnell, P. V., Jones, R. J. & Luznik, L., Mar 9 2017, In : Blood. 129, 10, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

Busulfan
Immunosuppressive Agents
Cyclophosphamide
Immunosuppression
Grafts
Histocompatibility
Homologous Transplantation
Bone Marrow Transplantation
Tissue Donors
Allografts

PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features

Teye, E. K., Sido, A., Xin, P., Finnberg, N. K., Gokare, P., Kawasawa, Y. I., Salzberg, A. C., Shimko, S., Bayerl, M., Ehmann, W. C., Claxton, D. F., Rybka, W. B., Drabick, J. J., Wang, H. G., Abraham, T., El-Deiry, W. S., Brodsky, R. A., J.Hohl, R. & Pu, J. J., 2017, In : Oncotarget. 8, 18, p. 29887-29905 19 p.

Research output: Contribution to journalArticle

Genomic Instability
Acute Myeloid Leukemia
Gene Expression
Protein Deficiency
M Phase Cell Cycle Checkpoints
Open Access
Cyclophosphamide
Graft vs Host Disease
Unrelated Donors
Transplantation
Bone Marrow

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

Yuan, X., Gavriilaki, E., Thanassi, J. A., Yang, G., Baines, A. C., Podos, S. D., Huang, Y., Huang, M. & Brodsky, R. A., Feb 28 2017, In : Haematologica. 102, 3, p. 466-475 10 p.

Research output: Contribution to journalArticle

Complement Factor D
Alternative Complement Pathway
Paroxysmal Hemoglobinuria
Hemolysis
Complement C5

Transplant-associated thrombotic microangiopathy: opening Pandora’s box

Gavriilaki, E., Sakellari, I., Anagnostopoulos, A. & Brodsky, R. A., Mar 13 2017, (Accepted/In press) In : Bone Marrow Transplantation.

Research output: Contribution to journalArticle

Thrombotic Microangiopathies
Transplants
Complement Activation
Cell Transplantation
Alternative Complement Pathway
2016

A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia

Braunstein, E., Li, R., Sobreira, N., Marosy, B., Hetrick, K., Doheny, K., Gocke, C., Valle, D., Brodsky, R. A. & Cheng, L., Jul 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Changing prognosis in paroxysmal nocturnal haemoglobinuria disease subcategories: an analysis of the International PNH Registry

on behalf of the PNH Registry, Sep 1 2016, In : Internal Medicine Journal. 46, 9, p. 1044-1053 10 p.

Research output: Contribution to journalArticle

Paroxysmal Hemoglobinuria
Registries
Aplastic Anemia
Hemolytic Anemia
Survival

Definitive Hematopoietic Multipotent Progenitor Cells Are Transiently Generated From Hemogenic Endothelial Cells in Human Pluripotent Stem Cells

Bai, H., Liu, Y., Xie, Y., Hoyle, D. L., Brodsky, R. A., Cheng, L., Cheng, T. & Wang, Z. Z., May 1 2016, In : Journal of Cellular Physiology. 231, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Hemangioblasts
Pluripotent Stem Cells
Endothelial cells
Hematopoietic Stem Cells
Stem cells

Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndrome

Vaught, A., Gavriilaki, E., Hueppchen, N. A., Blakemore, K., Yuan, X., Seifert, S. M., York, S. & Brodsky, R. A., May 1 2016, In : Experimental Hematology. 44, 5, p. 390-398 9 p.

Research output: Contribution to journalArticle

HELLP Syndrome
Complement Activation
Serum
Complement Inactivating Agents
Pre-Eclampsia

High-dose Cyclophosphamide is Effective Therapy for Pediatric Severe Aplastic Anemia

Gamper, C. J., Takemoto, C. M., Chen, A. R., Symons, H. J., Loeb, D. M., Casella, J. F., Dezern, A. E., King, K. E., McGonigle, A. M., Jones, R. J. & Brodsky, R. A., Jul 27 2016, (Accepted/In press) In : Journal of Pediatric Hematology/Oncology.

Research output: Contribution to journalArticle

Aplastic Anemia
Cyclophosphamide
Pediatrics
Antilymphocyte Serum
Cyclosporine

Therapeutic drug monitoring for either oral or intravenous busulfan when combined with pre-and post-transplantation cyclophosphamide

Lombardi, L. R., Kanakry, C. G., Zahurak, M., Durakovic, N., Bolanos Meade, F. J., Kasamon, Y. L., Gladstone, D., Matsui, W., Borrello, I. M., Huff, C. A., Swinnen, L., Brodsky, R. A., Ambinder, R. F., Fuchs, E. J., Rosner, G., Jones, R. J. & Luznik, L., Mar 3 2016, In : Leukemia and Lymphoma. 57, 3, p. 666-675 10 p.

Research output: Contribution to journalArticle

Busulfan
Drug Monitoring
Cyclophosphamide
Transplantation
Pharmacokinetics
2015

Complement in Health and Disease

Brodsky, R. A., Jun 1 2015, In : Hematology/Oncology Clinics of North America. 29, 3, p. xi

Research output: Contribution to journalArticle

Complement Activation
Hemolytic Anemia
Adaptive Immunity
Innate Immunity
Autoimmune Diseases

Complement in hemolytic anemia

Brodsky, R. A., Dec 5 2015, In : Hematology. 2015, 1, p. 385-391 7 p.

Research output: Contribution to journalArticle

Hemolytic Anemia
Paroxysmal Hemoglobinuria
Autoimmune Hemolytic Anemia
Hemolysis
Thrombotic Microangiopathies

Complement in hemolytic anemia

Brodsky, R. A., Nov 26 2015, In : Blood. 126, 22, p. 2459-2465 7 p.

Research output: Contribution to journalArticle

Hemolytic Anemia
Autoimmune Hemolytic Anemia
Hemolysis
Thrombotic Microangiopathies
Alternative Complement Pathway

Idiopathic inflammatory myopathy treated with high-dose immunoablative cyclophosphamide-A long-term follow-up study

Lahouti, A. H., Brodsky, R. A. & Christopher-Stine, L., Oct 1 2015, In : JAMA Neurology. 72, 10, p. 1205-1206 2 p.

Research output: Contribution to journalArticle

Myositis
Immunosuppressive Agents
Cyclophosphamide

Modified Ham test for atypical hemolytic uremic syndrome

Gavriilaki, E., Yuan, X., Ye, Z., Ambinder, A. J., Shanbhag, S. P., Streiff, M. B., Kickler, T. S., Moliterno, A. R., Sperati, C. J. & Brodsky, R. A., Jun 4 2015, In : Blood. 125, 23, p. 3637-3646 10 p.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Assays
Cells
Phosphoinositide Phospholipase C
Complement Membrane Attack Complex
Cyclophosphamide
Transplantation
Bone Marrow
Graft vs Host Disease
Disease-Free Survival

Paroxysmal Nocturnal Hemoglobinuria. A Complement-Mediated Hemolytic Anemia

Dezern, A. & Brodsky, R. A., Jun 1 2015, In : Hematology/Oncology Clinics of North America. 29, 3, p. 479-494 16 p.

Research output: Contribution to journalArticle

Alternative Complement Pathway
Paroxysmal Hemoglobinuria
Complement Activation
Hemolytic Anemia
Hemolysis

Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide

McCurdy, S. R., Kanakry, J. A., Showel, M., Tsai, H. L., Bolanos Meade, F. J., Rosner, G., Kanakry, C. G., Perica, K., Symons, H., Brodsky, R. A., Gladstone, D., Huff, C. A., Pratz, K., Prince, G. T., Dezern, A., Gojo, I., Matsui, W. H., Borrello, I. M., McDevitt, M. A., Swinnen, L. & 7 others, Smith, B. D., Levis, M. J., Ambinder, R. F., Luznik, L., Jones, R. J., Fuchs, E. J. & Kasamon, Y. L., May 7 2015, In : Blood. 125, 19, p. 3024-3031 8 p.

Research output: Contribution to journalArticle

Cyclophosphamide
Blood
Transplantation
Bone Marrow
Disease-Free Survival
docetaxel
Castration
Therapeutic Uses
Anticoagulants
Prostatic Neoplasms