Robert A Brodsky

Professor

1990 …2020

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2020

A complementary new drug for PNH

Brodsky, R. A., Mar 19 2020, In : Blood. 135, 12, p. 884-885 2 p.

Research output: Contribution to journalArticle

Open Access

Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS

Chaturvedi, S., Braunstein, E. M., Yuan, X., Yu, J., Alexander, A., Chen, H., Gavriilaki, E., Alluri, R., Streiff, M. B., Petri, M., Crowther, M. A., McCrae, K. R. & Brodsky, R. A., Jan 23 2020, In : Blood. 135, 4, p. 239-251 13 p.

Research output: Contribution to journalArticle

Haploidentical BMT for severe aplastic anemia with intensive GVHD prophylaxis including posttransplant cyclophosphamide

DeZern, A. E., Zahurak, M. L., Symons, H. J., Cooke, K. R., Rosner, G. L., Gladstone, D. E., Huff, C. A., Swinnen, L. J., Imus, P., Borrello, I., Wagner-Johnston, N., Ambinder, R. F., Luznik, L., Bolaños-Meade, J., Fuchs, E. J., Jones, R. J. & Brodsky, R. A., Apr 28 2020, In : Blood Advances. 4, 8, p. 1770-1779 10 p.

Research output: Contribution to journalArticle

Open Access

Pretransplant Genetic Susceptibility: Clinical Relevance in Transplant-Associated Thrombotic Microangiopathy

Gavriilaki, E., Touloumenidou, T., Sakellari, I., Batsis, I., Mallouri, D., Psomopoulos, F., Tsagiopoulou, M., Koutra, M., Yannaki, E., Papalexandri, A., Taylor, P., Nikolousis, E., Stamouli, M., Holbro, A., Baltadakis, I., Liga, M., Spyridonidis, A., Tsirigotis, P., Charchalakis, N., Tsakiris, D. A. & 4 others, Brodsky, R. A., Passweg, J., Stamatopoulos, K. & Anagnostopoulos, A., Apr 1 2020, In : Thrombosis and Haemostasis. 120, 4, p. 638-646 9 p.

Research output: Contribution to journalArticle

2019

Defining early hematopoietic-fated primitive streak specification of human pluripotent stem cells by the orchestrated balance of Wnt, activin, and BMP signaling

Shen, J., Lyu, C., Zhu, Y., Feng, Z., Zhang, S., Hoyle, D. L., Ji, G., Brodsky, R. A., Cheng, T. & Wang, Z. Z., Sep 2019, In : Journal of Cellular Physiology. 234, 9, p. 16136-16147 12 p.

Research output: Contribution to journalArticle

Haploidentical Bone Marrow Transplantation with Post-Transplantation Cyclophosphamide Plus Thiotepa Improves Donor Engraftment in Patients with Sickle Cell Anemia: Results of an International Learning Collaborative

de la Fuente, J., Dhedin, N., Koyama, T., Bernaudin, F., Kuentz, M., Karnik, L., Socié, G., Culos, K. A., Brodsky, R. A., DeBaun, M. R. & Kassim, A. A., Jun 2019, In : Biology of Blood and Marrow Transplantation. 25, 6, p. 1197-1209 13 p.

Research output: Contribution to journalArticle

Linking complement activation, coagulation, and neutrophils in transplant-associated thrombotic microangiopathy

Gavriilaki, E., Chrysanthopoulou, A., Sakellari, I., Batsis, I., Mallouri, D., Touloumenidou, T., Papalexandri, A., Mitsios, A., Arampatzioglou, A., Ritis, K., Brodsky, R. A., Mitroulis, I. & Anagnostopoulos, A., Jan 1 2019, In : Thrombosis and Haemostasis. 119, 9, p. 1433-1440 8 p.

Research output: Contribution to journalArticle

Rare Germline Mutations in Complement Regulatory Genes Make the Antiphospholipid Syndrome Catastrophic

Chaturvedi, S., Braunstein, E. M., Yuan, X., Chen, H., Alluri, R. K., Streiff, M. B., Petri, M., Crowther, M., McCrae, K. R. & Brodsky, R. A., Nov 13 2019, In : Blood. 134, 1, 1 p.

Research output: Contribution to journalArticle

Reduced ADAMTS13 activity during TTP remission is associated with stroke in TTP survivors

Upreti, H., Kasmani, J., Dane, K., Braunstein, E., Streiff, M. B., Shanbhag, S. P., Moliterno, A. R., Sperati, C. J., Gottesman, R. F., Brodsky, R. A., Kickler, T. S. & Chaturvedi, S., Sep 26 2019, In : Blood. 134, 13, p. 1037-1045 9 p.

Research output: Contribution to journalArticle

Warm autoimmune hemolytic anemia

Brodsky, R. A., Aug 15 2019, In : New England Journal of Medicine. 381, 7, p. 647-654 8 p.

Research output: Contribution to journalArticle

Diagnostic utility of telomere length testing in a hospital-based setting

Alder, J., Hanumanthu, V. S., Strong, M. A., Dezern, A., Stanley, S. E., Takemoto, C. M., Danilova, L. V., Applegate, C. D., Bolton, S. G., Mohr, D. W., Brodsky, R. A., Casella, J. F., Greider, C. W., Brooks Jackson, J. & Armanios, M., Mar 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 10, p. E2358-E2365

Research output: Contribution to journalArticle

Effectiveness of eculizumab in patients with paroxysmal nocturnal hemoglobinuria (PNH) with or without aplastic anemia in the International PNH Registry

Lee, J. W., Peffault de Latour, R., Brodsky, R. A., Jang, J. H., Hill, A., Röth, A., Schrezenmeier, H., Wilson, A., Marantz, J. L. & Maciejewski, J. P., Jan 1 2018, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

Germline mutations in the alternative pathway of complement predispose to HELLP syndrome

Vaught, A., Braunstein, E., Jasem, J., Yuan, X., Makhlin, I., Eloundou, S., Baines, A. C., Merrill, S., Chaturvedi, S., Blakemore, K., Sperati, C. J. & Brodsky, R. A., Mar 22 2018, In : JCI insight. 3, 6

Research output: Contribution to journalArticle

Open Access
2017

A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model

Yuan, X., Li, Z., Baines, A. C., Gavriilaki, E., Ye, Z., Wen, Z., Braunstein, E., Biesecker, L. G., Cheng, L., Dong, X. & Brodsky, R. A., Apr 1 2017, In : PLoS One. 12, 4, e0174074.

Research output: Contribution to journalArticle

Complementopathies

Baines, A. C. & Brodsky, R. A., 2017, (Accepted/In press) In : Blood Reviews.

Research output: Contribution to journalArticle

Hypotonia and intellectual disability without dysmorphic features in a patient with PIGN-related disease

Thiffault, I., Zuccarelli, B., Welsh, H., Yuan, X., Farrow, E., Zellmer, L., Miller, N., Soden, S., Abdelmoity, A., Brodsky, R. A. & Saunders, C., Nov 2 2017, In : BMC Medical Genetics. 18, 1, 124.

Research output: Contribution to journalArticle

In vitro evidence of complement activation in transplantation-associated thrombotic microangiopathy

Rotz, S. J., Luebbering, N., Dixon, B. P., Gavriilaki, E., Brodsky, R. A., Dandoy, C. E., Jodele, S. & Davies, S. M., Sep 12 2017, In : Blood Advances. 1, 20, p. 1632-1634 3 p.

Research output: Contribution to journalArticle

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

Kanakry, C. G., Bolanos Meade, F. J., Kasamon, Y. L., Zahurak, M., Durakovic, N., Furlong, T., Mielcarek, M., Medeot, M., Gojo, I., Smith, B. D., Kanakry, J. A., Borrello, I. M., Brodsky, R. A., Gladstone, D., Huff, C. A., Matsui, W. H., Swinnen, L., Cooke, K. R., Ambinder, R. F., Fuchs, E. J. & 6 others, De Lima, M. J., Andersson, B. S., Varadhan, R., O'Donnell, P. V., Jones, R. J. & Luznik, L., Mar 9 2017, In : Blood. 129, 10, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features

Teye, E. K., Sido, A., Xin, P., Finnberg, N. K., Gokare, P., Kawasawa, Y. I., Salzberg, A. C., Shimko, S., Bayerl, M., Ehmann, W. C., Claxton, D. F., Rybka, W. B., Drabick, J. J., Wang, H. G., Abraham, T., El-Deiry, W. S., Brodsky, R. A., J.Hohl, R. & Pu, J. J., Jan 1 2017, In : Oncotarget. 8, 18, p. 29887-29905 19 p.

Research output: Contribution to journalArticle

Open Access

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

Yuan, X., Gavriilaki, E., Thanassi, J. A., Yang, G., Baines, A. C., Podos, S. D., Huang, Y., Huang, M. & Brodsky, R. A., Feb 28 2017, In : Haematologica. 102, 3, p. 466-475 10 p.

Research output: Contribution to journalArticle

Transplant-associated thrombotic microangiopathy: opening Pandora’s box

Gavriilaki, E., Sakellari, I., Anagnostopoulos, A. & Brodsky, R. A., Mar 13 2017, (Accepted/In press) In : Bone Marrow Transplantation.

Research output: Contribution to journalArticle

2016

A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia

Braunstein, E., Li, R., Sobreira, N., Marosy, B., Hetrick, K., Doheny, K., Gocke, C., Valle, D., Brodsky, R. A. & Cheng, L., Jul 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Changing prognosis in paroxysmal nocturnal haemoglobinuria disease subcategories: an analysis of the International PNH Registry

on behalf of the PNH Registry, Sep 1 2016, In : Internal Medicine Journal. 46, 9, p. 1044-1053 10 p.

Research output: Contribution to journalArticle

Definitive Hematopoietic Multipotent Progenitor Cells Are Transiently Generated From Hemogenic Endothelial Cells in Human Pluripotent Stem Cells

Bai, H., Liu, Y., Xie, Y., Hoyle, D. L., Brodsky, R. A., Cheng, L., Cheng, T. & Wang, Z. Z., May 1 2016, In : Journal of Cellular Physiology. 231, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndrome

Vaught, A., Gavriilaki, E., Hueppchen, N. A., Blakemore, K., Yuan, X., Seifert, S. M., York, S. & Brodsky, R. A., May 1 2016, In : Experimental Hematology. 44, 5, p. 390-398 9 p.

Research output: Contribution to journalArticle

High-dose Cyclophosphamide is Effective Therapy for Pediatric Severe Aplastic Anemia

Gamper, C. J., Takemoto, C. M., Chen, A. R., Symons, H. J., Loeb, D. M., Casella, J. F., Dezern, A. E., King, K. E., McGonigle, A. M., Jones, R. J. & Brodsky, R. A., Jul 27 2016, (Accepted/In press) In : Journal of Pediatric Hematology/Oncology.

Research output: Contribution to journalArticle

Therapeutic drug monitoring for either oral or intravenous busulfan when combined with pre-and post-transplantation cyclophosphamide

Lombardi, L. R., Kanakry, C. G., Zahurak, M., Durakovic, N., Bolaños-Meade, J., Kasamon, Y. L., Gladstone, D. E., Matsui, W., Borrello, I., Huff, C. A., Swinnen, L. J., Brodsky, R. A., Ambinder, R. F., Fuchs, E. J., Rosner, G. L., Jones, R. J. & Luznik, L., Mar 3 2016, In : Leukemia and Lymphoma. 57, 3, p. 666-675 10 p.

Research output: Contribution to journalArticle

2015

Complement in hemolytic anemia

Brodsky, R. A., Dec 5 2015, In : Hematology. 2015, 1, p. 385-391 7 p.

Research output: Contribution to journalArticle

Modified Ham test for atypical hemolytic uremic syndrome

Gavriilaki, E., Yuan, X., Ye, Z., Ambinder, A. J., Shanbhag, S. P., Streiff, M. B., Kickler, T. S., Moliterno, A. R., Sperati, C. J. & Brodsky, R. A., Jun 4 2015, In : Blood. 125, 23, p. 3637-3646 10 p.

Research output: Contribution to journalArticle

Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide

McCurdy, S. R., Kanakry, J. A., Showel, M. M., Tsai, H. L., Bolaños-Meade, J., Rosner, G. L., Kanakry, C. G., Perica, K., Symons, H. J., Brodsky, R. A., Gladstone, D. E., Huff, C. A., Pratz, K. W., Prince, G. T., Dezern, A. E., Gojo, I., Matsui, W. H., Borrello, I., McDevitt, M. A., Swinnen, L. J. & 7 others, Smith, B. D., Levis, M. J., Ambinder, R. F., Luznik, L., Jones, R. J., Fuchs, E. J. & Kasamon, Y. L., May 7 2015, In : Blood. 125, 19, p. 3024-3031 8 p.

Research output: Contribution to journalArticle