Robert A Brodsky

Professor

1990 …2020
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Research Output 1990 2020

2020

Are genetic approaches still needed to cure sickle cell disease?

Brodsky, R. A. & DeBaun, M. R., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 7-9 3 p.

Research output: Contribution to journalReview article

Open Access
Sickle Cell Anemia
Unemployment
Globins
Valine
Amino Acid Substitution

Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS

Chaturvedi, S., Braunstein, E. M., Yuan, X., Yu, J., Alexander, A., Chen, H., Gavriilaki, E., Alluri, R., Streiff, M. B., Petri, M., Crowther, M. A., McCrae, K. R. & Brodsky, R. A., Jan 23 2020, In : Blood. 135, 4, p. 239-251 13 p.

Research output: Contribution to journalArticle

Antiphospholipid Syndrome
Regulator Genes
Complement Membrane Attack Complex
Glycoproteins
Thrombosis

Sequential cellular niches control the generation of enucleated erythrocytes from human pluripotent stem cells

Shen, J., Zhu, Y., Lyu, C., Feng, Z., Lyu, S., Zhao, Y., Hoyle, D. L., Ji, G., Miao, W., Zhang, X., Cheng, L., Brodsky, R. A., Cheng, T. & Wang, Z. Z., Jan 31 2020, In : Haematologica. 105, 2, p. E48-E51

Research output: Contribution to journalLetter

Open Access
2019
Odds Ratio
Hemolysis
Isoantibodies
Hyperbilirubinemia
Complement Activation

Complement in the Pathophysiology of the Antiphospholipid Syndrome

Chaturvedi, S., Brodsky, R. A. & McCrae, K. R., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalReview article

Open Access
Antiphospholipid Antibodies
Antiphospholipid Syndrome
Complement Activation
Complement Inactivating Agents
Thrombosis

Defining early hematopoietic-fated primitive streak specification of human pluripotent stem cells by the orchestrated balance of Wnt, activin, and BMP signaling

Shen, J., Lyu, C., Zhu, Y., Feng, Z., Zhang, S., Hoyle, D. L., Ji, G., Brodsky, R. A., Cheng, T. & Wang, Z. Z., Jan 1 2019, In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Primitive Streak
Activins
Pluripotent Stem Cells
Bone Morphogenetic Proteins
Stem cells

Haploidentical Bone Marrow Transplantation with Post-Transplantation Cyclophosphamide Plus Thiotepa Improves Donor Engraftment in Patients with Sickle Cell Anemia: Results of an International Learning Collaborative

de la Fuente, J., Dhedin, N., Koyama, T., Bernaudin, F., Kuentz, M., Karnik, L., Socié, G., Culos, K. A., Brodsky, R. A., DeBaun, M. R. & Kassim, A. A., Jan 1 2019, (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalArticle

Thiotepa
Sickle Cell Anemia
Bone Marrow Transplantation
Cyclophosphamide
Transplantation

Linking complement activation, coagulation, and neutrophils in transplant-associated thrombotic microangiopathy

Gavriilaki, E., Chrysanthopoulou, A., Sakellari, I., Batsis, I., Mallouri, D., Touloumenidou, T., Papalexandri, A., Mitsios, A., Arampatzioglou, A., Ritis, K., Brodsky, R. A., Mitroulis, I. & Anagnostopoulos, A., Jan 1 2019, In : Thrombosis and Haemostasis. 119, 9, p. 1433-1440 8 p.

Research output: Contribution to journalArticle

Thrombotic Microangiopathies
Complement Activation
Graft vs Host Disease
Neutrophils
Transplants

Paroxysmal nocturnal hemoglobinuria without GPI-anchor deficiency

Brodsky, R. A., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5074-5076 3 p.

Research output: Contribution to journalReview article

Paroxysmal Hemoglobinuria
Complement Inactivating Agents
Aseptic Meningitis
Glycosylphosphatidylinositols
Germ-Line Mutation

Rare Germline Mutations in Complement Regulatory Genes Make the Antiphospholipid Syndrome Catastrophic

Chaturvedi, S., Braunstein, E. M., Yuan, X., Chen, H., Alluri, R. K., Streiff, M. B., Petri, M., Crowther, M., McCrae, K. R. & Brodsky, R. A., Nov 13 2019, In : Blood. 134, 1, 1 p.

Research output: Contribution to journalArticle

Antiphospholipid Syndrome
Germ-Line Mutation
Regulator Genes
Genes
Advisory Committees

Reduced ADAMTS13 activity during TTP remission is associated with stroke in TTP survivors

Upreti, H., Kasmani, J., Dane, K., Braunstein, E., Streiff, M. B., Shanbhag, S. P., Moliterno, A. R., Sperati, C. J., Gottesman, R. F., Brodsky, R. A., Kickler, T. S. & Chaturvedi, S., Sep 26 2019, In : Blood. 134, 13, p. 1037-1045 9 p.

Research output: Contribution to journalArticle

Thrombotic Thrombocytopenic Purpura
Survivors
Stroke
Recovery
Patient treatment

Warm autoimmune hemolytic anemia

Brodsky, R. A., Aug 15 2019, In : New England Journal of Medicine. 381, 7, p. 647-654 8 p.

Research output: Contribution to journalArticle

Coombs Test
Autoimmune Hemolytic Anemia
Erythrocyte Indices
Reticulocytes
Splenomegaly

Warm Autoimmune Hemolytic Anemia. Reply

Brodsky, R. A., Nov 7 2019, In : The New England journal of medicine. 381, 19, p. 1881-1882 2 p.

Research output: Contribution to journalLetter

Autoimmune Hemolytic Anemia
2018

Acquired aplastic anemia

Dezern, A. & Brodsky, R. A., Nov 19 2018, Wintrobe's Clinical Hematology: Fourteenth Edition. Wolters Kluwer Health Pharma Solutions (Europe) Ltd, p. 2968-3003 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aplastic Anemia
Hemophagocytic Lymphohistiocytosis
Quality Improvement
Hemorrhage
Odds Ratio
Biopsy

Complement-driven anemia: more than just paroxysmal nocturnal hemoglobinuria

Merrill, S. & Brodsky, R. A., Nov 30 2018, In : Hematology. American Society of Hematology. Education Program. 2018, 1, p. 371-376 6 p.

Research output: Contribution to journalReview article

Alternative Complement Pathway
Paroxysmal Hemoglobinuria
Complement Inactivating Agents
Hemolysis
Anemia

Complement system

Brodsky, R. A. & Merrill, S., Nov 19 2018, Wintrobe's Clinical Hematology: Fourteenth Edition. Wolters Kluwer Health Pharma Solutions (Europe) Ltd, p. 1006-1055 50 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Diagnostic utility of telomere length testing in a hospital-based setting

Alder, J., Hanumanthu, V. S., Strong, M. A., Dezern, A., Stanley, S. E., Takemoto, C. M., Danilova, L. V., Applegate, C. D., Bolton, S. G., Mohr, D. W., Brodsky, R. A., Casella, J. F., Greider, C. W., Brooks Jackson, J. & Armanios, M., Mar 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 10, p. E2358-E2365

Research output: Contribution to journalArticle

Telomere
Mutation
Bone Marrow
Telomerase
Flow Cytometry
Bone Marrow Transplantation
Fever
Transplants
Unrelated Donors
Cyclophosphamide
Paroxysmal Hemoglobinuria
Bone Marrow
Transplants
Aplastic Anemia
Hemolysis

Effectiveness of eculizumab in patients with paroxysmal nocturnal hemoglobinuria (PNH) with or without aplastic anemia in the International PNH Registry

Lee, J. W., Peffault de Latour, R., Brodsky, R. A., Jang, J. H., Hill, A., Röth, A., Schrezenmeier, H., Wilson, A., Marantz, J. L. & Maciejewski, J. P., Jan 1 2018, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

Paroxysmal Hemoglobinuria
Aplastic Anemia
Registries
eculizumab

Germline mutations in the alternative pathway of complement predispose to HELLP syndrome

Vaught, A., Braunstein, E., Jasem, J., Yuan, X., Makhlin, I., Eloundou, S., Baines, A. C., Merrill, S., Chaturvedi, S., Blakemore, K., Sperati, C. J. & Brodsky, R. A., Mar 22 2018, In : JCI insight. 3, 6

Research output: Contribution to journalArticle

Open Access
Alternative Complement Pathway
Germ-Line Mutation
Hemolysis
Blood Platelets
Liver
Bone Marrow Transplantation
Cyclophosphamide
Tissue Donors
Confidence Intervals
Transplants
Aplastic Anemia
Bone Marrow Transplantation
Tissue Donors
Graft vs Host Disease
HLA Antigens
Tacrolimus
Graft vs Host Disease
Bone Marrow Transplantation
Transplantation
Arm

Single-board hematology fellowship track: A 10-year institutional experience

Naik, R. P., Marrone, K., Merrill, S., Donehower, R. C. & Brodsky, R. A., Jan 25 2018, In : Blood. 131, 4, p. 462-464 3 p.

Research output: Contribution to journalLetter

Graduate Medical Education
antineoplaston A10
Hematology
2017

A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model

Yuan, X., Li, Z., Baines, A. C., Gavriilaki, E., Ye, Z., Wen, Z., Braunstein, E., Biesecker, L. G., Cheng, L., Dong, X. & Brodsky, R. A., Apr 1 2017, In : PLoS One. 12, 4, e0174074.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Neurons
Toxicity
complement
neurodevelopment
Aplastic Anemia
Cyclophosphamide
Transplantation
Tissue Donors
Graft vs Host Disease
Graft vs Host Disease
Cyclophosphamide
Transplantation
Recurrence
Bone Marrow

Complementopathies

Baines, A. C. & Brodsky, R. A., 2017, (Accepted/In press) In : Blood Reviews.

Research output: Contribution to journalArticle

Paroxysmal Hemoglobinuria
Autoimmune Hemolytic Anemia
Complement Activation
Immune System
Infection

Eculizumab: Another breakthrough

Brodsky, R. A., Feb 23 2017, In : Blood. 129, 8, p. 922-923 2 p.

Research output: Contribution to journalComment/debate

Paroxysmal Hemoglobinuria
Complement Activation
Hemolysis
Conformations
Blood

Eculizumab cessation in atypical hemolytic uremic syndrome

Merrill, S., Brittingham, Z. D., Yuan, X., Moliterno, A. R., Sperati, C. J. & Brodsky, R. A., Jul 20 2017, In : Blood. 130, 3, p. 368-372 5 p.

Research output: Contribution to journalLetter

Antibodies, Monoclonal, Humanized
eculizumab
Graft vs Host Disease
Cyclophosphamide
Disease-Free Survival
Confidence Intervals
Transplants
Muscular Diseases
Cyclophosphamide
Stem Cells
Signal Recognition Particle
Therapeutics

Hypotonia and intellectual disability without dysmorphic features in a patient with PIGN-related disease

Thiffault, I., Zuccarelli, B., Welsh, H., Yuan, X., Farrow, E., Zellmer, L., Miller, N., Soden, S., Abdelmoity, A., Brodsky, R. A. & Saunders, C., Nov 2 2017, In : BMC Medical Genetics. 18, 1, 124.

Research output: Contribution to journalArticle

Muscle Hypotonia
Intellectual Disability
Glycosylphosphatidylinositols
Exome
Phenotype

In vitro evidence of complement activation in transplantation-associated thrombotic microangiopathy

Rotz, S. J., Luebbering, N., Dixon, B. P., Gavriilaki, E., Brodsky, R. A., Dandoy, C. E., Jodele, S. & Davies, S. M., Sep 12 2017, In : Blood Advances. 1, 20, p. 1632-1634 3 p.

Research output: Contribution to journalArticle

Thrombotic Microangiopathies
Complement Activation
Transplantation
In Vitro Techniques
Homologous Transplantation
Bone Marrow Transplantation
Systemic Lupus Erythematosus
Cyclophosphamide
Transplantation

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

Kanakry, C. G., Bolanos Meade, F. J., Kasamon, Y. L., Zahurak, M., Durakovic, N., Furlong, T., Mielcarek, M., Medeot, M., Gojo, I., Smith, B. D., Kanakry, J. A., Borrello, I. M., Brodsky, R. A., Gladstone, D., Huff, C. A., Matsui, W. H., Swinnen, L., Cooke, K. R., Ambinder, R. F., Fuchs, E. J. & 6 others, De Lima, M. J., Andersson, B. S., Varadhan, R., O'Donnell, P. V., Jones, R. J. & Luznik, L., Mar 9 2017, In : Blood. 129, 10, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

Busulfan
Immunosuppressive Agents
Cyclophosphamide
Immunosuppression
Grafts
Histocompatibility
Homologous Transplantation
Bone Marrow Transplantation
Tissue Donors
Allografts

Paroxysmal nocturnal haemoglobinuria

Hill, A., Dezern, A., Kinoshita, T. & Brodsky, R. A., May 18 2017, In : Nature Reviews Disease Primers. 3, 17028.

Research output: Contribution to journalReview article

Paroxysmal Hemoglobinuria
Complement Inactivating Agents
Hematopoietic Stem Cells
Glycosylphosphatidylinositols
Mutation

Paroxysmal Nocturnal Hemoglobinuria

Brodsky, R. A., Aug 15 2017, Hematology: Basic Principles and Practice. Elsevier Inc., p. 415-424 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Paroxysmal Hemoglobinuria
eculizumab

PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features

Teye, E. K., Sido, A., Xin, P., Finnberg, N. K., Gokare, P., Kawasawa, Y. I., Salzberg, A. C., Shimko, S., Bayerl, M., Ehmann, W. C., Claxton, D. F., Rybka, W. B., Drabick, J. J., Wang, H. G., Abraham, T., El-Deiry, W. S., Brodsky, R. A., J.Hohl, R. & Pu, J. J., 2017, In : Oncotarget. 8, 18, p. 29887-29905 19 p.

Research output: Contribution to journalArticle

Genomic Instability
Acute Myeloid Leukemia
Gene Expression
Protein Deficiency
M Phase Cell Cycle Checkpoints
Open Access
Cyclophosphamide
Graft vs Host Disease
Unrelated Donors
Transplantation
Bone Marrow

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

Yuan, X., Gavriilaki, E., Thanassi, J. A., Yang, G., Baines, A. C., Podos, S. D., Huang, Y., Huang, M. & Brodsky, R. A., Feb 28 2017, In : Haematologica. 102, 3, p. 466-475 10 p.

Research output: Contribution to journalArticle

Complement Factor D
Alternative Complement Pathway
Paroxysmal Hemoglobinuria
Hemolysis
Complement C5

Transplant-associated thrombotic microangiopathy: opening Pandora’s box

Gavriilaki, E., Sakellari, I., Anagnostopoulos, A. & Brodsky, R. A., Mar 13 2017, (Accepted/In press) In : Bone Marrow Transplantation.

Research output: Contribution to journalArticle

Thrombotic Microangiopathies
Transplants
Complement Activation
Cell Transplantation
Alternative Complement Pathway
2016

A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia

Braunstein, E., Li, R., Sobreira, N., Marosy, B., Hetrick, K., Doheny, K., Gocke, C., Valle, D., Brodsky, R. A. & Cheng, L., Jul 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Changing prognosis in paroxysmal nocturnal haemoglobinuria disease subcategories: an analysis of the International PNH Registry

on behalf of the PNH Registry, Sep 1 2016, In : Internal Medicine Journal. 46, 9, p. 1044-1053 10 p.

Research output: Contribution to journalArticle

Paroxysmal Hemoglobinuria
Registries
Aplastic Anemia
Hemolytic Anemia
Survival