Richard S Roden

Professor

1993 …2020

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2013

Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity

Kang, T. H., Mao, C. P., Lee, S. Y., Chen, A., Lee, J. H., Kim, T. W., Alvarez, R. D., Roden, R. B. S., Pardoll, D., Hung, C. F. & Wu, T. C., Apr 15 2013, In : Cancer Research. 73, 8, p. 2493-2504 12 p.

Research output: Contribution to journalArticle

Efficacy of RG1-VLP vaccination against infections with genital and cutaneous human papillomaviruses

Schellenbacher, C., Kwak, K., Fink, D., Shafti-Keramat, S., Huber, B., Jindra, C., Faust, H., Dillner, J., Roden, R. B. S. & Kirnbauer, R., Dec 2013, In : Journal of Investigative Dermatology. 133, 12, p. 2706-2713 8 p.

Research output: Contribution to journalArticle

Evaluation of DNA from the papanicolaou test to detect ovarian and endometrial cancers

Kinde, I., Bettegowda, C., Wang, Y., Wu, J., Agrawal, N., Shih, I. M., Kurman, R., Dao, F., Levine, D. A., Giuntoli, R., Roden, R., Eshleman, J. R., Carvalho, J. P., Marie, S. K. N., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Diaz, L. A., Jan 9 2013, In : Science translational medicine. 5, 167, 167ra4.

Research output: Contribution to journalArticle

Immunohistochemical detection of human papillomavirus capsid proteins L1 and L2 in squamous intraepithelial lesions: Potential utility in diagnosis and management

Yemelyanova, A., Gravitt, P. E., Ronnett, B. M., Rositch, A. F., Ogurtsova, A., Seidman, J. & Roden, R. B. S., Feb 1 2013, In : Modern Pathology. 26, 2, p. 268-274 7 p.

Research output: Contribution to journalArticle

L2, the minor capsid protein of papillomavirus

Wang, J. W. & Roden, R. B. S., Oct 1 2013, In : Virology. 445, 1-2, p. 175-186 12 p.

Research output: Contribution to journalArticle

Multivalent Human Papillomavirus L1 DNA Vaccination Utilizing Electroporation

Kwak, K., Jiang, R., Jagu, S., Wang, J. W., Wang, C., Christensen, N. D. & Roden, R. B. S., Mar 25 2013, In : PloS one. 8, 3, e60507.

Research output: Contribution to journalArticle

Optimization of Multimeric Human Papillomavirus L2 Vaccines

Jagu, S., Kwak, K., Karanam, B., Huh, W. K., Damotharan, V., Chivukula, S. V. & Roden, R. B. S., Jan 31 2013, In : PloS one. 8, 1, e55538.

Research output: Contribution to journalArticle

Personalized chemotherapy profiling using cancer cell lines from selectable mice

Kamiyama, H., Rauenzahn, S., Shim, J. S., Karikari, C. A., Feldmann, G., Hua, L., Kamiyama, M., Schuler, F. W., Lin, M. T., Beaty, R. M., Karanam, B., Liang, H., Mullendore, M. E., Mo, G., Hidalgo, M., Jaffee, E., Hruban, R. H., Jinnah, H. A., Roden, R. B. S., Jimeno, A. & 3 others, Liu, J. O., Maitra, A. & Eshleman, J. R., Mar 1 2013, In : Clinical Cancer Research. 19, 5, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

Phylogenetic considerations in designing a broadly protective multimeric L2 vaccine

Jagu, S., Kwak, K., Schiller, J. T., Lowy, D. R., Kleanthous, H., Kalnin, K., Wang, C., Wang, H. K., Chow, L. T., Huh, W. K., Jaganathan, K. S., Chivukula, S. V. & Roden, R. B. S., Jun 1 2013, In : Journal of virology. 87, 11, p. 6127-6136 10 p.

Research output: Contribution to journalArticle

2012

Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate

Nieto, K., Weghofer, M., Sehr, P., Ritter, M., Sedlmeier, S., Karanam, B., Seitz, H., Müller, M., Kellner, M., Hörer, M., Michaelis, U., Roden, R. B. S., Gissmann, L. & Kleinschmidt, J. A., Jun 27 2012, In : PloS one. 7, 6, e39741.

Research output: Contribution to journalArticle

Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses

Kuhn, E., Wu, R. C., Guan, B., Wu, G., Zhang, J., Wang, Y., Song, L., Yuan, X., Wei, L., Roden, R. B. S., Kuo, K. T., Nakayama, K., Clarke, B., Shaw, P., Olvera, N., Kurman, R. J., Levine, D. A., Wang, T. L. & Shih, I. M., Oct 3 2012, In : Journal of the National Cancer Institute. 104, 19, p. 1503-1513 11 p.

Research output: Contribution to journalArticle

Murine skin and vaginal mucosa are similarly susceptible to infection by pseudovirions of different papillomavirus classifications and species

Handisurya, A., Day, P. M., Thompson, C. D., Buck, C. B., Kwak, K., Roden, R. B. S., Lowy, D. R. & Schiller, J. T., Nov 25 2012, In : Virology. 433, 2, p. 385-394 10 p.

Research output: Contribution to journalArticle

Ovarian cancer gene therapy using HPV-16 Pseudovirion carrying the HSV-tk gene

Hung, C. F., Chiang, A. J., Tsai, H. H., Pomper, M. G., Kang, T. H., Roden, R. R. & Wu, T. C., Jul 17 2012, In : PloS one. 7, 7, e40983.

Research output: Contribution to journalArticle

The high risk HPV16 L2 minor capsid protein has multiple transport signals that mediate its nucleocytoplasmic traffic

Mamoor, S., Onder, Z., Karanam, B., Kwak, K., Bordeaux, J., Crosby, L., Roden, R. B. S. & Moroianu, J., Jan 20 2012, In : Virology. 422, 2, p. 413-424 12 p.

Research output: Contribution to journalArticle

2011

A multimeric L2 vaccine for prevention of animal papillomavirus infections

Jagu, S., Malandro, N., Kwak, K., Yuan, H., Schlegel, R., Palmer, K. E., Huh, W. K., Campo, M. S. & Roden, R. B. S., Nov 10 2011, In : Virology. 420, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

Capsomer vaccines protect mice from vaginal challenge with human papillomavirus

Wu, W. H., Gersch, E., Kwak, K., Jagu, S., Karanam, B., Huh, W. K., Garcea, R. L. & Roden, R. B. S., Nov 1 2011, In : PloS one. 6, 10, e27141.

Research output: Contribution to journalArticle

Comparison of candidate serologic markers for type i and type II ovarian cancer

Lu, D., Kuhn, E., Bristow, R. E., Giuntoli, R. L., Kjær, S. K., Shih, I. M. & Roden, R. B. S., Sep 1 2011, In : Gynecologic oncology. 122, 3, p. 560-566 7 p.

Research output: Contribution to journalArticle

Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics

Tian, Y., Yao, Z., Roden, R. B. S. & Zhang, H., Dec 1 2011, In : Proteomics. 11, 24, p. 4677-4687 11 p.

Research output: Contribution to journalArticle

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes

Heaphy, C. M., Subhawong, A. P., Hong, S. M., Goggins, M. G., Montgomery, E. A., Gabrielson, E., Netto, G. J., Epstein, J. I., Lotan, T. L., Westra, W. H., Shih, I. M., Iacobuzio-Donahue, C. A., Maitra, A., Li, Q. K., Eberhart, C. G., Taube, J. M., Rakheja, D., Kurman, R. J., Wu, T. C., Roden, R. B. & 5 others, Argani, P., De Marzo, A. M., Terracciano, L., Torbenson, M. & Meeker, A. K., Oct 1 2011, In : American Journal of Pathology. 179, 4, p. 1608-1615 8 p.

Research output: Contribution to journalArticle

Prevention of cancer by prophylactic human papillomavirus vaccines

Kwak, K., Yemelyanova, A. & Roden, R. B. S., Apr 1 2011, In : Current Opinion in Immunology. 23, 2, p. 244-251 8 p.

Research output: Contribution to journalArticle

Stressing the ubiquitin-proteasome system without 20s proteolytic inhibition Selectively Kills cervical cancer cells

Anchoori, R. K., Khan, S. R., Sueblinvong, T., Felthauser, A., Iizuka, Y., Gavioli, R., Destro, F., Vogel, R. I., Peng, S., Roden, R. B. S. & Bazzaro, M., Sep 7 2011, In : PloS one. 6, 8, e23888.

Research output: Contribution to journalArticle

α,β-unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells

Bazzaro, M., Anchoori, R. K., Mudiam, M. K. R., Issaenko, O., Kumar, S., Karanam, B., Lin, Z., Isaksson Vogel, R., Gavioli, R., Destro, F., Ferretti, V., Roden, R. B. S. & Khan, S. R., Jan 27 2011, In : Journal of medicinal chemistry. 54, 2, p. 449-456 8 p.

Research output: Contribution to journalArticle

2010

Efficient delivery of DNA vaccines using human papillomavirus pseudovirions

Peng, S., Monie, A., Kang, T. H., Hung, C. F., Roden, R. & Wu, T. C., Dec 1 2010, In : Gene Therapy. 17, 12, p. 1453-1464 12 p.

Research output: Contribution to journalArticle

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma

Jones, S., Wang, T. L., Shih, I. M., Mao, T. L., Nakayama, K., Roden, R., Glas, R., Slamon, D., Diaz, L. A., Vogelstein, B., Kinzler, K. W., Velculescu, V. E. & Papadopoulos, N., Oct 8 2010, In : Science. 330, 6001, p. 228-231 4 p.

Research output: Contribution to journalArticle

In vivo mechanisms of vaccine-induced protection against HPV infection

Day, P. M., Kines, R. C., Thompson, C. D., Jagu, S., Roden, R. B., Lowy, D. R. & Schiller, J. T., Sep 16 2010, In : Cell Host and Microbe. 8, 3, p. 260-270 11 p.

Research output: Contribution to journalArticle

Papillomavirus infection requires γ secretase

Karanam, B., Peng, S., Li, T., Buck, C., Day, P. M. & Roden, R. B. S., Oct 1 2010, In : Journal of virology. 84, 20, p. 10661-10670 10 p.

Research output: Contribution to journalArticle

Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia

Daayana, S., Elkord, E., Winters, U., Pawlita, M., Roden, R., Stern, P. L. & Kitchener, H. C., Mar 1 2010, In : British journal of cancer. 102, 7, p. 1129-1136 8 p.

Research output: Contribution to journalArticle

Vaccination with multimeric L2 fusion protein and L1 VLP or capsomeres to broaden protection against HPV infection

Jagu, S., Kwak, K., Garcea, R. L. & Roden, R. B. S., Jun 17 2010, In : Vaccine. 28, 28, p. 4478-4486 9 p.

Research output: Contribution to journalArticle

2009

Chimeric L1-L2 virus-like particles as potential broad-spectrum human papillomavirus vaccines

Schellenbacher, C., Roden, R. & Kirnbauer, R., Oct 1 2009, In : Journal of virology. 83, 19, p. 10085-10095 11 p.

Research output: Contribution to journalArticle

Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer.

Li, J., Sherman-Baust, C. A., Tsai-Turton, M., Bristow, R. E., Roden, R. B. & Morin, P. J., 2009, In : BMC cancer. 9, 1 p.

Research output: Contribution to journalArticle

Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment

Lin, Z., Bazzaro, M., Wang, M. C., Chan, K. C., Peng, S. & Roden, R. B. S., Jan 15 2009, In : Clinical Cancer Research. 15, 2, p. 570-577 8 p.

Research output: Contribution to journalArticle

Concatenated multitype L2 fusion proteins as candidate prophylactic pan-human papillomavirus vaccines

Jagu, S., Karanam, B., Gambhira, R., Chivukula, S. V., Chaganti, R. J., Lowy, D. R., Schiller, J. T. & Roden, R. B. S., Jun 1 2009, In : Journal of the National Cancer Institute. 101, 11, p. 782-792 11 p.

Research output: Contribution to journalArticle

Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2

Lin, Z., Yemelyanova, A. V., Gambhira, R., Jagu, S., Meyers, C., Kirnbauer, R., Ronnett, B. M., Gravitt, P. E. & Roden, R. B. S., Jan 2009, In : American Journal of Pathology. 174, 1, p. 136-143 8 p.

Research output: Contribution to journalArticle

p53 autoantibodies, cytokine levels and ovarian carcinogenesis

Tsai-Turton, M., Santillan, A., Lu, D., Bristow, R. E., Chan, K. C., Shih, I. M. & Roden, R. B. S., Jul 1 2009, In : Gynecologic oncology. 114, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

Photonic approach to the selective inactivation of viruses with a near-infrared subpicosecond fiber laser

Tsen, K. T., Tsen, S. W. D., Fu, Q., Lindsay, S. M., Kibler, K., Jacobs, B., Wu, T. C., Karanam, B., Jagu, S., Roden, R. B. S., Hung, C. F., Sankey, O. F., Ramakrishna, B. & Kiang, J. G., Dec 1 2009, In : Journal of biomedical optics. 14, 6, 064042.

Research output: Contribution to journalArticle

Role of L2 cysteines in papillomavirus infection and neutralization

Gambhira, R., Jagu, S., Karanam, B., Day, P. M. & Roden, R., Dec 28 2009, In : Virology Journal. 6, 176.

Research output: Contribution to journalArticle

Tissue-spanning redox gradient-dependent assembly of native human papillomavirus type 16 virions

Conway, M. J., Alam, S., Ryndock, E. J., Cruz, L., Christensen, N. D., Roden, R. B. S. & Meyers, C., Oct 1 2009, In : Journal of virology. 83, 20, p. 10515-10526 12 p.

Research output: Contribution to journalArticle

Vaccination with HPV16 L2E6E7 fusion protein in GPI-0100 adjuvant elicits protective humoral and cell-mediated immunity

Karanam, B., Gambhira, R., Peng, S., Jagu, S., Kim, D. J., Ketner, G. W., Stern, P. L., Adams, R. J. & Roden, R. B. S., Feb 11 2009, In : Vaccine. 27, 7, p. 1040-1049 10 p.

Research output: Contribution to journalArticle

2008

Generation and characterization of a preventive and therapeutic HPV DNA vaccine

Kim, D., Gambhira, R., Karanam, B., Monie, A., Hung, C. F., Roden, R. & Wu, T. C., Jan 17 2008, In : Vaccine. 26, 3, p. 351-360 10 p.

Research output: Contribution to journalArticle

Human papillomavirus screening and vaccines for cancer prevention: What is on the horizon?

Trimble, C. L., Gravitt, P. & Roden, R. B. S., May 1 2008, In : Therapy. 5, 3, p. 295-303 9 p.

Research output: Contribution to journalArticle

Mechanisms of human papillomavirus type 16 neutralization by L2 cross-neutralizing and L1 type-specific antibodies

Day, P. M., Gambhira, R., Roden, R. B. S., Lowy, D. R. & Schiller, J. T., May 1 2008, In : Journal of virology. 82, 9, p. 4638-4646 9 p.

Research output: Contribution to journalArticle

News and EFIS

Roden, R. B. S., Gravitt, P. & Wu, T. C., Feb 1 2008, In : European Journal of Immunology. 38, 2, p. 323-326 4 p.

Research output: Contribution to journalArticle

Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2

Alphs, H. H., Gambhira, R., Karanam, B., Roberts, J. N., Jagu, S., Schiller, J. T., Zeng, W., Jackson, D. C. & Roden, R. B. S., Apr 15 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 15, p. 5850-5855 6 p.

Research output: Contribution to journalArticle

Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor

Bazzaro, M., Lin, Z., Santillan, A., Lee, M. K., Wang, M. C., Chan, K. C., Bristow, R. E., Mazitschek, R., Bradner, J. & Roden, R. B. S., Nov 15 2008, In : Clinical Cancer Research. 14, 22, p. 7340-7347 8 p.

Research output: Contribution to journalArticle

2007

A papillomavirus-like particle (VLP) vaccine displaying HPV16 L2 epitopes induces cross-neutralizing antibodies to HPV11

Slupetzky, K., Gambhira, R., Culp, T. D., Shafti-Keramat, S., Schellenbacher, C., Christensen, N. D., Roden, R. B. S. & Kirnbauer, R., Mar 1 2007, In : Vaccine. 25, 11, p. 2001-2010 10 p.

Research output: Contribution to journalArticle

A protective and broadly cross-neutralizing epitope of human papillomavirus L2

Gambhira, R., Karanam, B., Jagu, S., Roberts, J. N., Buck, C. B., Bossis, I., Alphs, H., Culp, T., Christensen, N. D. & Roden, R. B. S., Dec 1 2007, In : Journal of virology. 81, 24, p. 13927-13931 5 p.

Research output: Contribution to journalArticle

HPV16 L1 capsid protein expressed from viable adenovirus recombinants elicits neutralizing antibody in mice

Berg, M., Gambhira, R., Siracusa, M., Hoiczyk, E., Roden, R. & Ketner, G., Apr 30 2007, In : Vaccine. 25, 17, p. 3501-3510 10 p.

Research output: Contribution to journalArticle

Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility

Bazzaro, M., Santillan, A., Lin, Z., Tang, T., Lee, M. K., Bristow, R. E., Shih, I. M. & Roden, R. B. S., Nov 2007, In : American Journal of Pathology. 171, 5, p. 1640-1649 10 p.

Research output: Contribution to journalArticle