Richard S Roden

Professor

1993 …2020

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Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia

Daayana, S., Elkord, E., Winters, U., Pawlita, M., Roden, R., Stern, P. L. & Kitchener, H. C., Mar 1 2010, In : British journal of cancer. 102, 7, p. 1129-1136 8 p.

Research output: Contribution to journalArticle

Photonic approach to the selective inactivation of viruses with a near-infrared subpicosecond fiber laser

Tsen, K. T., Tsen, S. W. D., Fu, Q., Lindsay, S. M., Kibler, K., Jacobs, B., Wu, T. C., Karanam, B., Jagu, S., Roden, R. B. S., Hung, C. F., Sankey, O. F., Ramakrishna, B. & Kiang, J. G., 2009, In : Journal of biomedical optics. 14, 6, 064042.

Research output: Contribution to journalArticle

Phylogenetic considerations in designing a broadly protective multimeric L2 vaccine

Jagu, S., Kwak, K., Schiller, J. T., Lowy, D. R., Kleanthous, H., Kalnin, K., Wang, C., Wang, H. K., Chow, L. T., Huh, W. K., Jaganathan, K. S., Chivukula, S. V. & Roden, R. B. S., Jun 1 2013, In : Journal of virology. 87, 11, p. 6127-6136 10 p.

Research output: Contribution to journalArticle

Positively charged termini of the L2 minor capsid protein are necessary for papillomavirus infection

Roden, R. B. S., Day, P. M., Bronzo, B. K., Yutzy IV, W. H., Yang, Y., Lowy, D. R. & Schiller, J. T., 2001, In : Journal of virology. 75, 21, p. 10493-10497 5 p.

Research output: Contribution to journalArticle

Preparation and properties of a papillomavirus infectious intermediate and its utility for neutralization studies

Wang, J. W., Jagu, S., Kwak, K., Wang, C., Peng, S., Kirnbauer, R. & Roden, R. B. S., Jan 20 2014, In : Virology. 449, p. 304-316 13 p.

Research output: Contribution to journalArticle

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes

Heaphy, C. M., Subhawong, A. P., Hong, S. M., Goggins, M. G., Montgomery, E. A., Gabrielson, E., Netto, G. J., Epstein, J. I., Lotan, T. L., Westra, W. H., Shih, I. M., Iacobuzio-Donahue, C. A., Maitra, A., Li, Q. K., Eberhart, C. G., Taube, J. M., Rakheja, D., Kurman, R. J., Wu, T. C., Roden, R. B. & 5 others, Argani, P., De Marzo, A. M., Terracciano, L., Torbenson, M. & Meeker, A. K., Oct 1 2011, In : American Journal of Pathology. 179, 4, p. 1608-1615 8 p.

Research output: Contribution to journalArticle

Prevention of cancer by prophylactic human papillomavirus vaccines

Kwak, K., Yemelyanova, A. & Roden, R. B. S., Apr 1 2011, In : Current Opinion in Immunology. 23, 2, p. 244-251 8 p.

Research output: Contribution to journalArticle

Production and characterization of a novel HPV anti-L2 monoclonal antibody panel

Bywaters, S. M., Brendle, S. A., Biryukov, J., Wang, J. W., Walston, J., Milici, J., Roden, R. S., Meyers, C. & Christensen, N. D., Nov 1 2018, In : Virology. 524, p. 106-113 8 p.

Research output: Contribution to journalArticle

Production of furin-cleaved Papillomavirus pseudovirions and their use for in vitro neutralization assays of L1-or L2-specific antibodies

Wang, J. W., Kwak, K., Peng, S., Kemp, T., Pinto, L. & Roden, R. B. S., Jan 1 2015, In : Current Protocols in Microbiology. 2015, p. 14B.5.1-14B.5.26

Research output: Contribution to journalArticle

Prophylactic immunization with human papillomavirus vaccines induces oral immunity in mice

Ahn, J., Peng, S., Hung, C-F., Roden, R. S. & Best, S. R., Jan 1 2018, In : Laryngoscope. 128, 1, p. E16-E20

Research output: Contribution to journalArticle

Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2

Alphs, H. H., Gambhira, R., Karanam, B., Roberts, J. N., Jagu, S., Schiller, J. T., Zeng, W., Jackson, D. C. & Roden, R. B. S., Apr 15 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 15, p. 5850-5855 6 p.

Research output: Contribution to journalArticle

Protection of rabbits against challenge with rabbit papillomaviruses by immunization with the N terminus of human papillomavirus type 16 minor capsid antigen L2

Gambhira, R., Jagu, S., Karanam, B., Gravitt, P. E., Culp, T. D., Christensen, N. D. & Roden, R. B. S., Nov 1 2007, In : Journal of virology. 81, 21, p. 11585-11592 8 p.

Research output: Contribution to journalArticle

Role of L2 cysteines in papillomavirus infection and neutralization

Gambhira, R., Jagu, S., Karanam, B., Day, P. M. & Roden, R., Dec 28 2009, In : Virology Journal. 6, 176.

Research output: Contribution to journalArticle

Roles of Fc domain and exudation in L2 antibody-mediated protection against human papillomavirus

Wang, J. W., Wu, W. H., Huang, T. C., Wong, M., Kwak, K., Ozato, K., Hung, C. F. & Roden, R. B. S., Aug 1 2018, In : Journal of virology. 92, 15, e00572-18.

Research output: Contribution to journalArticle

RPN13/ADRM1 inhibitor reverses immunosuppression by myeloid-derived suppressor cells

Soong, R. S., Anchoori, R. K., Yang, B., Yang, A., Tseng, S. H., He, L., Tsai, Y. C., Roden, R. B. S. & Hung, C. F., 2016, In : Oncotarget. 7, 42, p. 68489-68502 14 p.

Research output: Contribution to journalArticle

Open Access

Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine

Harro, C. D., Pang, Y. Y. S., Roden, R. B. S., Hildesheim, A., Wang, Z., Reynolds, M. J., Mast, T. C., Robinson, R., Murphy, B. R., Karron, R. A., Dillner, J., Schiller, J. T. & Lowy, D. R., Feb 21 2001, In : Journal of the National Cancer Institute. 93, 4, p. 284-292 9 p.

Research output: Contribution to journalArticle

Open Access

Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer

Peng, S., Wang, J. W., Karanam, B., Wang, C., Huh, W. K., Alvarez, R. D., Pai, S. I., Hung, C. F., Wu, T. C. & Roden, R. B. S., Jan 5 2015, In : PloS one. 10, 1, e116389.

Research output: Contribution to journalArticle

Seroepidemiology of human papillomavirus 16 (HPV16) L2 and generation of L2-specific human chimeric monoclonal antibodies

Wang, J. W., Jagu, S., Wu, W. H., Viscidi, R. P., Macgregor-Das, A., Fogel, J. M., Kwak, K., Daayana, S., Kitchener, H., Stern, P. L., Gravitt, P. E., Trimble, C. L. & Roden, R. B. S., Jul 1 2015, In : Clinical and Vaccine Immunology. 22, 7, p. 806-816 11 p.

Research output: Contribution to journalArticle

Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells

Vogel, R. I., Coughlin, K., Scotti, A., Iizuka, Y., Anchoori, R., Roden, R. B. S., Marastoni, M. & Bazzaro, M., 2015, In : Oncotarget. 6, 6, p. 4159-4170 12 p.

Research output: Contribution to journalArticle

Open Access

Single-walled carbon nanotubes-mediated in vivo and in vitro delivery of siRNA into antigen-presenting cells

Yang, R., Yang, X., Zhang, Z., Zhang, Y., Wang, S., Cai, Z., Jia, Y., Ma, Y., Zheng, C., Lu, Y., Roden, R. & Chen, Y., Dec 2006, In : Gene Therapy. 13, 24, p. 1714-1723 10 p.

Research output: Contribution to journalArticle

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4

Ramos, P., Karnezis, A. N., Craig, D. W., Sekulic, A., Russell, M. L., Hendricks, W. P. D., Corneveaux, J. J., Barrett, M. T., Shumansky, K., Yang, Y., Shah, S. P., Prentice, L. M., Marra, M. A., Kiefer, J., Zismann, V. L., McEachron, T. A., Salhia, B., Prat, J., D'Angelo, E., Clarke, B. A. & 7 others, Pressey, J. G., Farley, J. H., Anthony, S. P., Roden, R. B. S., Cunliffe, H. E., Huntsman, D. G. & Trent, J. M., May 2014, In : Nature genetics. 46, 5, p. 427-429 3 p.

Research output: Contribution to journalArticle

Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein Responses

Coughlin, K., Anchoori, R., Iizuka, Y., Meints, J., MacNeill, L., Vogel, R. I., Orlowski, R. Z., Lee, M. K., Roden, R. B. S. & Bazzaro, M., Jun 15 2014, In : Clinical Cancer Research. 20, 12, p. 3174-3186 13 p.

Research output: Contribution to journalArticle

Spontaneous and vaccine-induced clearance of Mus musculus papillomavirus 1 infection

Jiang, R. T., Wang, J. W., Peng, S., Huang, T. C., Wang, C., Cannella, F., Chang, Y. N., Viscidi, R. P., Best, S. R. A., Hung, C. F. & Roden, R. B. S., Aug 1 2017, In : Journal of virology. 91, 15, e00699-17.

Research output: Contribution to journalArticle

Spontaneous regression of high-grade cervical dysplasia: Effects of human papillomavirus type and HLA phenotype

Trimble, C. L., Piantadosi, S., Gravitt, P., Ronnett, B., Pizer, E., Elko, A., Wilgus, B., Yutzy, W., Daniel, R., Shah, K., Peng, S., Hung, C., Roden, R., Wu, T. C. & Pardoll, D., Jul 1 2005, In : Clinical Cancer Research. 11, 13, p. 4717-4723 7 p.

Research output: Contribution to journalArticle

Stressing the ubiquitin-proteasome system without 20s proteolytic inhibition Selectively Kills cervical cancer cells

Anchoori, R. K., Khan, S. R., Sueblinvong, T., Felthauser, A., Iizuka, Y., Gavioli, R., Destro, F., Vogel, R. I., Peng, S., Roden, R. B. S. & Bazzaro, M., 2011, In : PloS one. 6, 8, e23888.

Research output: Contribution to journalArticle

Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties

Anchoori, R. K., Tan, M., Tseng, S. H., Peng, S., Soong, R. S., Algethami, A., Foran, P., Das, S., Wang, C., Wang, T. L., Liang, H., Hung, C. F. & Roden, R. B. S., 2020, In : PloS one. 15, 1, e0227727.

Research output: Contribution to journalArticle

Open Access

The estrogen receptor-alpha S118P variant does not affect breast cancer incidence or response to endocrine therapies

Button, B., Croessmann, S., Chu, D., Rosen, D. M., Zabransky, D. J., Dalton, W. B., Cravero, K., Kyker-Snowman, K., Waters, I., Karthikeyan, S., Christenson, E. S., Donaldson, J., Hunter, T., Dennison, L., Ramin, C., May, B., Roden, R., Petry, D., Armstrong, D. K., Visvanathan, K. & 1 others, Park, B. H., Apr 15 2019, In : Breast Cancer Research and Treatment. 174, 2, p. 401-412 12 p.

Research output: Contribution to journalArticle

The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis

Tesfaye, A., Di Cello, F., Hillion, J., Ronnett, B. M., Elbahloul, O., Ashfaq, R., Dhara, S., Prochownik, E., Tworkoski, K., Reeves, R., Roden, R., Ellenson, L. H., Huso, D. L. & Resar, L. M. S., May 1 2007, In : Cancer Research. 67, 9, p. 3998-4004 7 p.

Research output: Contribution to journalArticle

The high risk HPV16 L2 minor capsid protein has multiple transport signals that mediate its nucleocytoplasmic traffic

Mamoor, S., Onder, Z., Karanam, B., Kwak, K., Bordeaux, J., Crosby, L., Roden, R. B. S. & Moroianu, J., Jan 20 2012, In : Virology. 422, 2, p. 413-424 12 p.

Research output: Contribution to journalArticle

Open Access

The PD-1 and PD-L1 pathway in recurrent respiratory papillomatosis

Ahn, J., Bishop, J. A., Roden, R. S., Allen, C. T. & Best, S. R., Jan 1 2018, In : Laryngoscope. 128, 1, p. E27-E32

Research output: Contribution to journalArticle

The positively charged termini of L2 minor capsid protein required for bovine papillomavirus infection function separately in nuclear import and DNA binding

Fay, A., Yutzy IV, W. H., Roden, R. B. S. & Moroianu, J., Dec 1 2004, In : Journal of virology. 78, 24, p. 13447-13454 8 p.

Research output: Contribution to journalArticle

The proteasome ubiquitin receptor hrpn13 and its interacting deubiquitinating enzyme Uch37 are required for proper cell cycle progression

Randles, L., Anchoori, R., Roden, R. S. & Walters, K. J., Apr 15 2016, In : Journal of Biological Chemistry. 291, 16, p. 8773-8783 11 p.

Research output: Contribution to journalArticle

The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2

DeSmet, M., Kanginakudru, S., Rietz, A., Wu, W. H., Roden, R. & Androphy, E. J., Oct 2016, In : PLoS pathogens. 12, 10, e1005934.

Research output: Contribution to journalArticle

Tissue-spanning redox gradient-dependent assembly of native human papillomavirus type 16 virions

Conway, M. J., Alam, S., Ryndock, E. J., Cruz, L., Christensen, N. D., Roden, R. B. S. & Meyers, C., Oct 1 2009, In : Journal of virology. 83, 20, p. 10515-10526 12 p.

Research output: Contribution to journalArticle

Toll-like receptor agonist imiquimod facilitates antigen-specific CD8+ T-cell accumulation in the genital tract leading to tumor control through IFNγ

Soong, R. S., Song, L., Trieu, J., Knoff, J., He, L., Tsai, Y. C., Huh, W., Chang, Y. N., Cheng, W. F., Roden, R. B. S., Wu, T. C., Trimble, C. L. & Hung, C. F., Nov 1 2014, In : Clinical Cancer Research. 20, 21, p. 5456-5467 12 p.

Research output: Contribution to journalArticle

Two antibodies that neutralize papillomavirus by different mechanisms show distinct binding patterns at 13 Å resolution

Booy, F. P., Roden, R. B. S., Greenstone, H. L., Schiller, J. T. & Trus, B. L., Aug 7 1998, In : Journal of molecular biology. 281, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle

Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis

Bazzaro, M., Lee, M. K., Zoso, A., Stirling, W. L. H., Santillan, A., Shih, I. M. & Roden, R. B. S., Apr 1 2006, In : Cancer Research. 66, 7, p. 3754-3763 10 p.

Research output: Contribution to journalArticle

Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor

Bazzaro, M., Lin, Z., Santillan, A., Lee, M. K., Wang, M. C., Chan, K. C., Bristow, R. E., Mazitschek, R., Bradner, J. & Roden, R. B. S., Nov 15 2008, In : Clinical Cancer Research. 14, 22, p. 7340-7347 8 p.

Research output: Contribution to journalArticle

Vaccination of healthy volunteers with human papillomavirus type 16 L2E7E6 fusion protein induces serum antibody that neutralizes across papillomavirus species

Gambhira, R., Gravitt, P. E., Bossis, I., Stern, P. L., Viscidi, R. P. & Roden, R. B. S., Dec 1 2006, In : Cancer Research. 66, 23, p. 11120-11124 5 p.

Research output: Contribution to journalArticle

Vaccination to prevent and treat cervical cancer

Roden, R. B. S., Ling, M. & Wu, T. C., Aug 2004, In : Human pathology. 35, 8, p. 971-982 12 p.

Research output: Contribution to journalArticle

Vaccination with HPV16 L2E6E7 fusion protein in GPI-0100 adjuvant elicits protective humoral and cell-mediated immunity

Karanam, B., Gambhira, R., Peng, S., Jagu, S., Kim, D. J., Ketner, G. W., Stern, P. L., Adams, R. J. & Roden, R. B. S., Feb 11 2009, In : Vaccine. 27, 7, p. 1040-1049 10 p.

Research output: Contribution to journalArticle

Vaccination with multimeric L2 fusion protein and L1 VLP or capsomeres to broaden protection against HPV infection

Jagu, S., Kwak, K., Garcea, R. L. & Roden, R. B. S., Jun 17 2010, In : Vaccine. 28, 28, p. 4478-4486 9 p.

Research output: Contribution to journalArticle

Vaccines against human papillomavirus

Lin, Y. Y., Alphs, H., Hung, C. F., Roden, R. B. S. & Wu, T. C., Jun 7 2007, In : Frontiers in Bioscience. 12, 1, p. 246-264 19 p.

Research output: Contribution to journalArticle

α,β-unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells

Bazzaro, M., Anchoori, R. K., Mudiam, M. K. R., Issaenko, O., Kumar, S., Karanam, B., Lin, Z., Isaksson Vogel, R., Gavioli, R., Destro, F., Ferretti, V., Roden, R. B. S. & Khan, S. R., Jan 27 2011, In : Journal of medicinal chemistry. 54, 2, p. 449-456 8 p.

Research output: Contribution to journalArticle