Richard S Roden

Professor

1993 …2020

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2020

Bis-benzylidine Piperidone RA190 treatment of hepatocellular carcinoma via binding RPN13 and inhibiting NF-κB signaling

Soong, R. S., Anchoori, R. K., Roden, R. B. S., Cho, R. L., Chen, Y. C., Tseng, S. C., Huang, Y. L., Liao, P. C. & Shyu, Y. C., May 6 2020, In : BMC cancer. 20, 1, 386.

Research output: Contribution to journalArticle

Open Access

Infectivity of murine papillomavirus in the surgical byproducts of treated tail warts

Best, S. R., Esquivel, D., Mellinger-Pilgrim, R., Roden, R. B. S. & Pitman, M. J., Mar 1 2020, In : Laryngoscope. 130, 3, p. 712-717 6 p.

Research output: Contribution to journalArticle

Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties

Anchoori, R. K., Tan, M., Tseng, S. H., Peng, S., Soong, R. S., Algethami, A., Foran, P., Das, S., Wang, C., Wang, T. L., Liang, H., Hung, C. F. & Roden, R. B. S., Jan 1 2020, In : PloS one. 15, 1, e0227727.

Research output: Contribution to journalArticle

Open Access
2019

Incorporation of RG1 epitope into HPV16L1-VLP does not compromise L1-specific immunity

Schellenbacher, C., Huber, B., Skoll, M., Shafti-Keramat, S., Roden, R. S. & Kirnbauer, R., Jun 12 2019, In : Vaccine. 37, 27, p. 3529-3534 6 p.

Research output: Contribution to journalArticle

The estrogen receptor-alpha S118P variant does not affect breast cancer incidence or response to endocrine therapies

Button, B., Croessmann, S., Chu, D., Rosen, D. M., Zabransky, D. J., Dalton, W. B., Cravero, K., Kyker-Snowman, K., Waters, I., Karthikeyan, S., Christenson, E. S., Donaldson, J., Hunter, T., Dennison, L., Ramin, C., May, B., Roden, R., Petry, D., Armstrong, D. K., Visvanathan, K. & 1 others, Park, B. H., Apr 15 2019, In : Breast Cancer Research and Treatment. 174, 2, p. 401-412 12 p.

Research output: Contribution to journalArticle

2018

A Bayesian design for phase I cancer therapeutic vaccine trials

Wang, C., Rosner, G. & Roden, R. S., Jan 1 2018, (Accepted/In press) In : Statistics in Medicine.

Research output: Contribution to journalArticle

Covalent Rpn13-Binding Inhibitors for the Treatment of Ovarian Cancer

Anchoori, R., Jiang, R., Peng, S., Soong, R. S., Algethami, A., Rudek-Renaut, M., Anders, N., Hung, C-F., Chen, X., Lu, X., Kayode, O., Dyba, M., Walters, K. J. & Roden, R. S., Sep 30 2018, In : ACS Omega. 3, 9, p. 11917-11929 13 p.

Research output: Contribution to journalArticle

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L. V., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C., Goggins, M. S., Molin, M. D., Wang, T-L., Roden, R. S., Klein, A., Ptak, J., Dobbyn, L., Schaefer, J. & 22 others, Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H. L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., O'Broin-Lennon, A. M. & Papadopoulos, N., Feb 23 2018, In : Science. 359, 6378, p. 926-930 5 p.

Research output: Contribution to journalArticle

Epithelial boost enhances antigen expression by vaccinia virus for the generation of potent CD8+ T cell-mediated antitumor immunity following DNA priming vaccination

Qiu, J., Peng, S., Ma, Y., Yang, A., Farmer, E., Cheng, M. A., Roden, R. B. S., Wu, T. C., Chang, Y. N. & Hung, C. F., Dec 2018, In : Virology. 525, p. 205-215 11 p.

Research output: Contribution to journalArticle

Evaluation of osteopenia and osteoporosis in younger breast cancer survivors compared with cancer-free women: a prospective cohort study

Ramin, C., May, B. J., Roden, R. S., Orellana, M. M., Hogan, B. C., McCullough, M. S., Petry, D., Armstrong, D. K. & Visvanathan, K., Nov 13 2018, In : Breast cancer research : BCR. 20, 1, 1 p.

Research output: Contribution to journalArticle

Production and characterization of a novel HPV anti-L2 monoclonal antibody panel

Bywaters, S. M., Brendle, S. A., Biryukov, J., Wang, J. W., Walston, J., Milici, J., Roden, R. S., Meyers, C. & Christensen, N. D., Nov 1 2018, In : Virology. 524, p. 106-113 8 p.

Research output: Contribution to journalArticle

Prophylactic immunization with human papillomavirus vaccines induces oral immunity in mice

Ahn, J., Peng, S., Hung, C-F., Roden, R. S. & Best, S. R., Jan 1 2018, In : Laryngoscope. 128, 1, p. E16-E20

Research output: Contribution to journalArticle

Roles of Fc domain and exudation in L2 antibody-mediated protection against human papillomavirus

Wang, J. W., Wu, W. H., Huang, T. C., Wong, M., Kwak, K., Ozato, K., Hung, C. F. & Roden, R. B. S., Aug 1 2018, In : Journal of virology. 92, 15, e00572-18.

Research output: Contribution to journalArticle

The PD-1 and PD-L1 pathway in recurrent respiratory papillomatosis

Ahn, J., Bishop, J. A., Roden, R. S., Allen, C. T. & Best, S. R., Jan 1 2018, In : Laryngoscope. 128, 1, p. E27-E32

Research output: Contribution to journalArticle

2017

Immunologic responses to a novel DNA vaccine targeting human papillomavirus-11 E6E7

Ahn, J., Peng, S., Hung, C-F., Roden, R. S., Wu, T. C. & Best, S. R., 2017, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes

Kalnin, K., Chivukula, S., Tibbitts, T., Yan, Y., Stegalkina, S., Shen, L., Cieszynski, J., Costa, V., Sabharwal, R., Anderson, S. F., Christensen, N., Jagu, S., Roden, R. S. & Kleanthous, H., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Spontaneous and vaccine-induced clearance of Mus musculus papillomavirus 1 infection

Jiang, R. T., Wang, J. W., Peng, S., Huang, T. C., Wang, C., Cannella, F., Chang, Y. N., Viscidi, R. P., Best, S. R. A., Hung, C. F. & Roden, R. B. S., Aug 1 2017, In : Journal of virology. 91, 15, e00699-17.

Research output: Contribution to journalArticle

2016

Developments in L2-based human papillomavirus (HPV) vaccines

Schellenbacher, C., Roden, R. S. & Kirnbauer, R., Sep 12 2016, (Accepted/In press) In : Virus Research.

Research output: Contribution to journalArticle

Identification of anti-CA125 antibody responses in ovarian cancer patients by a novel deep sequence-coupled biopanning platform

Frietze, K. M., Roden, R. B. S., Lee, J. H., Shi, Y., Peabody, D. S. & Chackerian, B., Feb 2016, In : Cancer Immunology Research. 4, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell-Mediated Tumor Control in the Genital Tract

Sun, Y. Y., Peng, S., Han, L., Qiu, J., Song, L., Tsai, Y., Yang, B., Roden, R. B. S., Trimble, C. L., Hung, C. F. & Wu, T. C., Feb 1 2016, In : Clinical Cancer Research. 22, 3, p. 657-669 13 p.

Research output: Contribution to journalArticle

RPN13/ADRM1 inhibitor reverses immunosuppression by myeloid-derived suppressor cells

Soong, R. S., Anchoori, R. K., Yang, B., Yang, A., Tseng, S. H., He, L., Tsai, Y. C., Roden, R. B. S. & Hung, C. F., Jan 1 2016, In : Oncotarget. 7, 42, p. 68489-68502 14 p.

Research output: Contribution to journalArticle

Open Access

The proteasome ubiquitin receptor hrpn13 and its interacting deubiquitinating enzyme Uch37 are required for proper cell cycle progression

Randles, L., Anchoori, R., Roden, R. S. & Walters, K. J., Apr 15 2016, In : Journal of Biological Chemistry. 291, 16, p. 8773-8783 11 p.

Research output: Contribution to journalArticle

The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2

DeSmet, M., Kanginakudru, S., Rietz, A., Wu, W. H., Roden, R. S. & Androphy, E. J., Oct 1 2016, In : PLoS Pathogens. 12, 10, e1005934.

Research output: Contribution to journalArticle

2015

ADRM1-amplified metastasis gene in gastric cancer

Fejzo, M. S., Anderson, L., Chen, H. W., Anghel, A., Zhuo, J., Anchoori, R., Roden, R. & Slamon, D. J., Aug 1 2015, In : Genes Chromosomes and Cancer. 54, 8, p. 506-515 10 p.

Research output: Contribution to journalArticle

Capsid display of a conserved human papillomavirus L2 peptide in the adenovirus 5 hexon protein: A candidate prophylactic hpv vaccine approach

Wu, W. H., Alkutkar, T., Karanam, B., Roden, R. B., Ketner, G. & Ibeanu, O. A., Sep 11 2015, In : Virology Journal. 12, 1, 140.

Research output: Contribution to journalArticle

Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adeno-associated virus-like particle immunogen displaying L2 17-36 epitopes

Jagu, S., Karanam, B., Wang, J. W., Zayed, H., Weghofer, M., Brendle, S. A., Balogh, K. K., Tossi, K. P., Roden, R. B. S. & Christensen, N. D., Oct 13 2015, In : Vaccine. 33, 42, p. 5553-5563 11 p.

Research output: Contribution to journalArticle

GATA-3 expression in trophoblastic tissues: An immunohistochemical study of 445 cases, including diagnostic utility

Banet, N., Gown, A. M., Shih, I. M., Li, Q. K., Roden, R. B. S., Nucci, M. R., Cheng, L., Przybycin, C. G., Nasseri-Nik, N., Wu, L. S. F., Netto, G. J., Ronnett, B. M. & Vang, R., Jan 20 2015, In : American Journal of Surgical Pathology. 39, 1, p. 101-108 8 p.

Research output: Contribution to journalArticle

Immunologic Control of Mus musculus Papillomavirus Type 1

Wang, J. W., Jiang, R., Peng, S., Chang, Y. N., Hung, C. F. & Roden, R. B. S., Jan 1 2015, In : PLoS pathogens. 11, 10, e1005243.

Research output: Contribution to journalArticle

Production of furin-cleaved Papillomavirus pseudovirions and their use for in vitro neutralization assays of L1-or L2-specific antibodies

Wang, J. W., Kwak, K., Peng, S., Kemp, T., Pinto, L. & Roden, R. B. S., Jan 1 2015, In : Current Protocols in Microbiology. 2015, p. 14B.5.1-14B.5.26

Research output: Contribution to journalArticle

Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer

Peng, S., Wang, J. W., Karanam, B., Wang, C., Huh, W. K., Alvarez, R. D., Pai, S. I., Hung, C. F., Wu, T. C. & Roden, R. B. S., Jan 5 2015, In : PloS one. 10, 1, e116389.

Research output: Contribution to journalArticle

Seroepidemiology of human papillomavirus 16 (HPV16) L2 and generation of L2-specific human chimeric monoclonal antibodies

Wang, J. W., Jagu, S., Wu, W. H., Viscidi, R. P., Macgregor-Das, A., Fogel, J. M., Kwak, K., Daayana, S., Kitchener, H., Stern, P. L., Gravitt, P. E., Trimble, C. L. & Roden, R. B. S., Jul 1 2015, In : Clinical and Vaccine Immunology. 22, 7, p. 806-816 11 p.

Research output: Contribution to journalArticle

Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells

Vogel, R. I., Coughlin, K., Scotti, A., Iizuka, Y., Anchoori, R., Roden, R. B. S., Marastoni, M. & Bazzaro, M., Jan 1 2015, In : Oncotarget. 6, 6, p. 4159-4170 12 p.

Research output: Contribution to journalArticle

Open Access
2014

Control of HPV-associated tumors by innovative therapeutic HPV DNA vaccine in the absence of CD4+ T cells

Peng, S., Song, L., Knoff, J., Wang, J. W., Chang, Y. N., Hannaman, D., Wu, T. C., Alvarez, R. D., Roden, R. B. S. & Hung, C. F., Mar 4 2014, In : Cell and Bioscience. 4, 1, 11.

Research output: Contribution to journalArticle

Detection of somatic TP53 mutations in tampons of patients with high-grade serous ovarian cancer

Erickson, B. K., Kinde, I., Dobbin, Z. C., Wang, Y., Martin, J. Y., Alvarez, R. D., Conner, M. G., Huh, W. K., Roden, R. B. S., Kinzler, K. W., Papadopoulos, N., Vogelstein, B., Diaz, L. A. & Landen, C. N., Jan 1 2014, In : Obstetrics and gynecology. 124, 5, p. 881-885 5 p.

Research output: Contribution to journalArticle

Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors

Wu, C. Y., Yang, L. H., Yang, H. Y., Knoff, J., Peng, S., Lin, Y. H., Wang, C., Alvarez, R. D., Pai, S. I., Roden, R. B. S., Hung, C. F. & Wu, T. C., Feb 11 2014, In : Clinical Cancer Research. 20, 3, p. 644-657 14 p.

Research output: Contribution to journalArticle

Immune Responses in Macaques to a Prototype Recombinant Adenovirus Live Oral Human Papillomavirus 16 Vaccine

Berg, M. G., Adams, R. J., Gambhira, R., Siracusa, M. C., Scott, A. L., Roden, R. B. S. & Ketner, G., Sep 2014, In : Clinical and Vaccine Immunology. 21, 9, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

Impact of inhibitors and L2 antibodies upon the infectivity of diverse alpha and beta human papillomavirus types

Kwak, K., Jiang, R., Wang, J. W., Jagu, S., Kirnbauer, R. & Roden, R. B. S., May 9 2014, In : PloS one. 9, 5, e97232.

Research output: Contribution to journalArticle

Low doses of flagellin-L2 multimer vaccines protect against challenge with diverse papillomavirus genotypes

Kalnin, K., Tibbitts, T., Yan, Y., Stegalkina, S., Shen, L., Costa, V., Sabharwal, R., Anderson, S. F., Day, P. M., Christensen, N., Schiller, J. T., Jagu, S., Roden, R. B. S., Almond, J. & Kleanthous, H., Jun 12 2014, In : Vaccine. 32, 28, p. 3540-3547 8 p.

Research output: Contribution to journalArticle

Measurement of neutralizing serum antibodies of patients vaccinated with human papillomavirus L1 or L2-based immunogens using furin-cleaved HPV pseudovirions

Wang, J. W., Jagu, S., Wang, C., Kitchener, H. C., Daayana, S., Stern, P. L., Pang, S., Day, P. M., Huh, W. K. & Roden, R. B. S., Jul 7 2014, In : PloS one. 9, 7, e101576.

Research output: Contribution to journalArticle

Preparation and properties of a papillomavirus infectious intermediate and its utility for neutralization studies

Wang, J. W., Jagu, S., Kwak, K., Wang, C., Peng, S., Kirnbauer, R. & Roden, R. B. S., Jan 20 2014, In : Virology. 449, p. 304-316 13 p.

Research output: Contribution to journalArticle

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4

Ramos, P., Karnezis, A. N., Craig, D. W., Sekulic, A., Russell, M. L., Hendricks, W. P. D., Corneveaux, J. J., Barrett, M. T., Shumansky, K., Yang, Y., Shah, S. P., Prentice, L. M., Marra, M. A., Kiefer, J., Zismann, V. L., McEachron, T. A., Salhia, B., Prat, J., D'Angelo, E., Clarke, B. A. & 7 others, Pressey, J. G., Farley, J. H., Anthony, S. P., Roden, R. B. S., Cunliffe, H. E., Huntsman, D. G. & Trent, J. M., May 2014, In : Nature genetics. 46, 5, p. 427-429 3 p.

Research output: Contribution to journalArticle

Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein Responses

Coughlin, K., Anchoori, R., Iizuka, Y., Meints, J., MacNeill, L., Vogel, R. I., Orlowski, R. Z., Lee, M. K., Roden, R. B. S. & Bazzaro, M., Jun 15 2014, In : Clinical Cancer Research. 20, 12, p. 3174-3186 13 p.

Research output: Contribution to journalArticle

Toll-like receptor agonist imiquimod facilitates antigen-specific CD8+ T-cell accumulation in the genital tract leading to tumor control through IFNγ

Soong, R. S., Song, L., Trieu, J., Knoff, J., He, L., Tsai, Y. C., Huh, W., Chang, Y. N., Cheng, W. F., Roden, R. B. S., Wu, T. C., Trimble, C. L. & Hung, C. F., Nov 1 2014, In : Clinical Cancer Research. 20, 21, p. 5456-5467 12 p.

Research output: Contribution to journalArticle

2013

A bis-Benzylidine Piperidone Targeting Proteasome Ubiquitin Receptor RPN13/ADRM1 as a Therapy for Cancer

Anchoori, R. K., Karanam, B., Peng, S., Wang, J. W., Jiang, R., Tanno, T., Orlowski, R. Z., Matsui, W., Zhao, M., Rudek, M. A., Hung, C. F., Chen, X., Walters, K. J. & Roden, R. B. S., Dec 9 2013, In : Cancer cell. 24, 6, p. 791-805 15 p.

Research output: Contribution to journalArticle

Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity

Kang, T. H., Mao, C. P., Lee, S. Y., Chen, A., Lee, J. H., Kim, T. W., Alvarez, R. D., Roden, R. B. S., Pardoll, D., Hung, C. F. & Wu, T. C., Apr 15 2013, In : Cancer Research. 73, 8, p. 2493-2504 12 p.

Research output: Contribution to journalArticle