Richard L Huganir

Professor

1979 …2020

Research output per year

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Research Output

2020

Contribution of D1R-expressing neurons of the dorsal dentate gyrus and Cav1.2 channels in extinction of cocaine conditioned place preference

Burgdorf, C. E., Bavley, C. C., Fischer, D. K., Walsh, A. P., Martinez-Rivera, A., Hackett, J. E., Zallar, L. J., Ireton, K. E., Hofmann, F., Hell, J. W., Huganir, R. L. & Rajadhyaksha, A. M., Jan 1 2020, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Cortical Synaptic AMPA Receptor Plasticity during Motor Learning

Roth, R. H., Cudmore, R. H., Tan, H. L., Hong, I., Zhang, Y. & Huganir, R. L., Mar 4 2020, In : Neuron. 105, 5, p. 895-908.e5

Research output: Contribution to journalArticle

Lamina-specific AMPA receptor dynamics following visual deprivation in vivo

Tan, H. L., Roth, R. H., Graves, A. R., Cudmore, R. H. & Huganir, R. L., Mar 3 2020, In : eLife. 9

Research output: Contribution to journalArticle

Open Access

Low-Dose Perampanel Rescues Cortical Gamma Dysregulation Associated With Parvalbumin Interneuron GluA2 Upregulation in Epileptic Syngap1+/− Mice

Sullivan, B. J., Ammanuel, S., Kipnis, P. A., Araki, Y., Huganir, R. L. & Kadam, S. D., May 1 2020, In : Biological psychiatry. 87, 9, p. 829-842 14 p.

Research output: Contribution to journalArticle

Open Access

Signature Fragment Ions of Biotinylated Peptides

Renuse, S., Madugundu, A. K., Jung, J. H., Byeon, S. K., Goldschmidt, H. L., Tahir, R., Meyers, D., Kim, D. I., Cutler, J., Kim, K. P., Wu, X., Huganir, R. L. & Pandey, A., Feb 5 2020, In : Journal of the American Society for Mass Spectrometry. 31, 2, p. 394-404 11 p.

Research output: Contribution to journalArticle

Subunit-Specific Augmentation of AMPA Receptor Ubiquitination by Phorbol Ester

Widagdo, J., Kerk, J. W., Guntupalli, S., Huganir, R. L. & Anggono, V., Jan 1 2020, (Accepted/In press) In : Cellular and molecular neurobiology.

Research output: Contribution to journalArticle

SynGAP splice variants display heterogeneous spatio-temporal expression and subcellular distribution in the developing mammalian brain

Gou, G., Roca-Fernandez, A., Kilinc, M., Serrano, E., Reig-Viader, R., Araki, Y., Huganir, R. L., de Quintana-Schmidt, C., Rumbaugh, G. & Bayés, À., Jan 1 2020, (Accepted/In press) In : Journal of Neurochemistry.

Research output: Contribution to journalArticle

Open Access

Twenty years of syngap research: From synapses to cognition

Gamache, T. R., Araki, Y. & Huganir, R. L., Feb 19 2020, In : Journal of Neuroscience. 40, 8, p. 1596-1605 10 p.

Research output: Contribution to journalReview article

Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity

Yong, A. J. H., Tan, H. L., Zhu, Q., Bygrave, A. M., Johnson, R. C. & Huganir, R. L., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4948-4958 11 p.

Research output: Contribution to journalArticle

2019

Affected Sib-Pair Analyses Identify Signaling Networks Associated With Social Behavioral Deficits in Autism

Pirooznia, M., Niranjan, T., Chen, Y. C., Tunc, I., Goes, F. S., Avramopoulos, D., Potash, J. B., Huganir, R. L., Zandi, P. P. & Wang, T., Nov 27 2019, In : Frontiers in Genetics. 10, 1186.

Research output: Contribution to journalArticle

Open Access

Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation

Zhang, W., Chuang, Y. A., Na, Y., Ye, Z., Yang, L., Lin, R., Zhou, J., Wu, J., Qiu, J., Savonenko, A., Leahy, D. J., Huganir, R., Linden, D. J. & Worley, P. F., Jul 11 2019, In : Molecular cell. 75, 1, p. 13-25.e5

Research output: Contribution to journalArticle

Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

Itoh, K., Murata, D., Kato, T., Yamada, T., Araki, Y., Saito, A., Adachi, Y., Igarashi, A., Li, S., Pletnikov, M., Huganir, R. L., Watanabe, S., Kamiya, A., Iijima, M. & Sesaki, H., Oct 2019, In : eLife. 8, e44739.

Research output: Contribution to journalArticle

Open Access

Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum

Mejias, R., Chiu, S-L., Han, M., Rose, R., Gil-Infante, A., Zhao, Y., Huganir, R. L. & Wang, T., Dec 1 2019, In : Neurobiology of Disease. 132, 104602.

Research output: Contribution to journalArticle

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., Hussain, N. K., Imig, C., de Jong, A. P. H., Jung, H., Kohansalnodehi, M., Kramarz, B., Lipstein, N., Lovering, R. C., MacGillavry, H., Mariano, V. & 53 others, Mi, H., Ninov, M., Osumi-Sutherland, D., Pielot, R., Smalla, K. H., Tang, H., Tashman, K., Toonen, R. F. G., Verpelli, C., Reig-Viader, R., Watanabe, K., van Weering, J., Achsel, T., Ashrafi, G., Asi, N., Brown, T. C., De Camilli, P., Feuermann, M., Foulger, R. E., Gaudet, P., Joglekar, A., Kanellopoulos, A., Malenka, R., Nicoll, R. A., Pulido, C., de Juan-Sanz, J., Sheng, M., Südhof, T. C., Tilgner, H. U., Bagni, C., Bayés, À., Biederer, T., Brose, N., Chua, J. J. E., Dieterich, D. C., Gundelfinger, E. D., Hoogenraad, C., Huganir, R. L., Jahn, R., Kaeser, P. S., Kim, E., Kreutz, M. R., McPherson, P. S., Neale, B. M., O'Connor, V., Posthuma, D., Ryan, T. A., Sala, C., Feng, G., Hyman, S. E., Thomas, P. D., Smit, A. B. & Verhage, M., Jul 17 2019, In : Neuron. 103, 2, p. 217-234.e4

Research output: Contribution to journalArticle

Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas

Li, L., Fan, Y., Huang, X., Luo, J., Zhong, L., Shu, X. S., Lu, L., Xiang, T., Chan, A. T. C., Yeo, W., Chen, C., Chan, W. Y., Huganir, R. L. & Tao, Q., Nov 22 2019, In : iScience. 21, p. 1-18 18 p.

Research output: Contribution to journalArticle

Open Access
2018

BioSITe: A Method for Direct Detection and Quantitation of Site-Specific Biotinylation

Kim, D. I., Cutler, J. A., Na, C-H., Reckel, S., Renuse, S., Madugundu, A. K., Tahir, R., Goldschmidt, H. L., Reddy, K. L., Huganir, R. L., Wu, X., Zachara, N. E., Hantschel, O. & Pandey, A., Feb 2 2018, In : Journal of Proteome Research. 17, 2, p. 759-769 11 p.

Research output: Contribution to journalArticle

Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover

Heo, S., Diering, G. H., Na, C-H., Nirujogi, R. S., Bachman, J. L., Pandey, A. & Huganir, R. L., Apr 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 16, p. E3827-E3836

Research output: Contribution to journalArticle

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

Yamada, T., Murata, D., Adachi, Y., Itoh, K., Kameoka, S., Igarashi, A., Kato, T., Araki, Y., Huganir, R. L., Dawson, T. M., Yanagawa, T., Okamoto, K., Iijima, M. & Sesaki, H., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

Lin, E. Y. S., Silvian, L. F., Marcotte, D. J., Banos, C. C., Jow, F., Chan, T. R., Arduini, R. M., Qian, F., Baker, D. P., Bergeron, C., Hession, C. A., Huganir, R. L., Borenstein, C. F., Enyedy, I., Zou, J., Rohde, E., Wittmann, M., Kumaravel, G., Rhodes, K. J., Scannevin, R. H. & 2 others, Dunah, A. W. & Guckian, K. M., Dec 1 2018, In : Scientific Reports. 8, 1, 13438.

Research output: Contribution to journalArticle

Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains

Zhang, L., Zhang, P., Wang, G., Zhang, H., Zhang, Y., Yu, Y., Zhang, M., Xiao, J., Crespo, P., Hell, J. W., Lin, L., Huganir, R. L. & Zhu, J. J., May 16 2018, In : Neuron. 98, 4, p. 783-800.e4

Research output: Contribution to journalArticle

Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities

Mehta, S., Zhang, Y., Roth, R. H., Zhang, J. F., Mo, A., Tenner, B., Huganir, R. L. & Zhang, J., Oct 1 2018, In : Nature Cell Biology. 20, 10, p. 1215-1225 11 p.

Research output: Contribution to journalArticle

The AMPA Receptor Code of Synaptic Plasticity

Diering, G. H. & Huganir, R. L., Oct 24 2018, In : Neuron. 100, 2, p. 314-329 16 p.

Research output: Contribution to journalReview article

2017

BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method

Lim, C. S., Kang, X., Mirabella, V., Zhang, H., Bu, Q., Araki, Y., Hoang, E. T., Wang, S., Shen, Y., Choi, S., Kaang, B. K., Chang, Q., Pang, Z. P., Huganir, R. L. & Zhu, J. J., Mar 15 2017, In : Genes & development. 31, 6, p. 537-552 16 p.

Research output: Contribution to journalArticle

Dynamic imaging of AMPA receptor trafficking in vitro and in vivo

Roth, R. H., Zhang, Y. & Huganir, R. L., Aug 1 2017, In : Current Opinion in Neurobiology. 45, p. 51-58 8 p.

Research output: Contribution to journalReview article

Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens

Martínez-Rivera, A., Hao, J., Tropea, T. F., Giordano, T. P., Kosovsky, M., Rice, R. C., Lee, A., Huganir, R. L., Striessnig, J., Addy, N. A., Han, S. & Rajadhyaksha, A. M., Feb 14 2017, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Extinction of contextual cocaine memories requires Cav1.2 within D1R-expressing cells and recruits hippocampal Cav1.2-dependent signaling mechanisms

Burgdorf, C. E., Schierberl, K. C., Lee, A. S., Fischer, D. K., Van Kempen, T. A., Mudragel, V., Huganir, R. L., Milner, T. A., Glass, M. J. & Rajadhyaksha, A. M., Dec 6 2017, In : Journal of Neuroscience. 37, 49, p. 11894-11911 18 p.

Research output: Contribution to journalArticle

GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

Guntupalli, S., Jang, S. E., Zhu, T., Huganir, R. L., Widagdo, J. & Anggono, V., May 19 2017, In : Journal of Biological Chemistry. 292, 20, p. 8186-8194 9 p.

Research output: Contribution to journalArticle

GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors

Chiu, S-L., Diering, G. H., Ye, B., Takamiya, K., Chen, C. M., Jiang, Y., Niranjan, T., Schwartz, C. E., Wang, T. & Huganir, R. L., Mar 22 2017, In : Neuron. 93, 6, p. 1405-1419.e8

Research output: Contribution to journalArticle

Homer1a drives homeostatic scaling-down of excitatory synapses during sleep

Diering, G. H., Nirujogi, R. S., Roth, R. H., Worley, P. F., Pandey, A. & Huganir, R. L., Feb 3 2017, In : Science. 355, 6324, p. 511-515 5 p.

Research output: Contribution to journalArticle

Inflammation-induced GluA1 trafficking and membrane insertion of Ca2 + permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A

Wigerblad, G., Huie, J. R., Yin, H. Z., Leinders, M., Pritchard, R. A., Koehrn, F. J., Xiao, W. H., Bennett, G. J., Huganir, R. L., Ferguson, A. R., Weiss, J. H., Svensson, C. I. & Sorkin, L. S., Jul 1 2017, In : Experimental Neurology. 293, p. 144-158 15 p.

Research output: Contribution to journalArticle

Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylation at GluA2-S880

Han, M., Mejias, R., Chiu, S-L., Rose, R., Adamczyk, A., Huganir, R. L. & Wang, T., Mar 15 2017, In : Behavioural Brain Research. 321, p. 176-184 9 p.

Research output: Contribution to journalArticle

Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons

Wang, Q., Chiu, S. L., Koropouli, E., Hong, I., Mitchell, S., Easwaran, T. P., Hamilton, N. R., Gustina, A. S., Zhu, Q., Ginty, D. D., Huganir, R. L. & Kolodkin, A. L., Dec 6 2017, In : Neuron. 96, 5, p. 1084-1098.e7

Research output: Contribution to journalArticle

O-GlcNAc transferase regulates excitatory synapse maturity

Lagerlöf, O., Hart, G. W. & Huganir, R. L., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1684-1689 6 p.

Research output: Contribution to journalArticle

Phosphatidic acid-producing enzymes regulating the synaptic vesicle cycle: Role for PLD?

Barber, C. N., Huganir, R. L. & Raben, D. M., 2017, (Accepted/In press) In : Advances in Biological Regulation.

Research output: Contribution to journalArticle

Selective phosphorylation of AMPA receptor contributes to the network of long-term potentiation in the anterior cingulate cortex

Song, Q., Zheng, H. W., Li, X. H., Huganir, R. L., Kuner, T., Zhuo, M. & Chen, T., Aug 30 2017, In : Journal of Neuroscience. 37, 35, p. 8534-8548 15 p.

Research output: Contribution to journalArticle

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice

Chen, C. M., Orefice, L. L., Chiu, S-L., LeGates, T. A., Hattar, S., Huganir, R. L., Zhao, H., Xu, B. & Kuruvilla, R., Jan 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 4, p. E619-E628

Research output: Contribution to journalArticle

2016

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

Tracy, T. E., Sohn, P. D., Minami, S. S., Wang, C., Min, S. W., Li, Y., Zhou, Y., Le, D., Lo, I., Ponnusamy, R., Cong, X., Schilling, B., Ellerby, L. M., Huganir, R. L. & Gan, L., Apr 20 2016, In : Neuron. 90, 2, p. 245-260 16 p.

Research output: Contribution to journalArticle

DGKθ Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses

Goldschmidt, H. L., Tu-Sekine, B., Volk, L., Anggono, V., Huganir, R. L. & Raben, D. M., Jan 12 2016, In : Cell Reports. 14, 2, p. 200-207 8 p.

Research output: Contribution to journalArticle

Differential vesicular sorting of AMPA and GABAA receptors

Gu, Y., Chiu, S. L., Liu, B., Wu, P. H., Delannoy, M., Lin, D. T., Wirtz, D. & Huganir, R. L., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E922-E931

Research output: Contribution to journalArticle

Essential roles of AMPA receptor GluA1 phosphorylation and presynaptic HCN channels in fast-Acting antidepressant responses of ketamine

Zhang, K., Xu, T., Yuan, Z., Wei, Z., Yamaki, V. N., Huang, M., Huganir, R. L. & Cai, X., Dec 13 2016, In : Science signaling. 9, 458, ra123.

Research output: Contribution to journalArticle

Extensive phosphorylation of AMPA receptors in neurons

Diering, G. H., Heo, S., Hussain, N. K., Liu, B. & Huganir, R. L., Aug 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 33, p. E4920-E4927

Research output: Contribution to journalArticle

Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold

Noseda, R., Guerrero-Valero, M., Alberizzi, V., Previtali, S. C., Sherman, D. L., Palmisano, M., Huganir, R. L., Nave, K. A., Cuenda, A., Feltri, M. L., Brophy, P. J. & Bolino, A., Apr 12 2016, In : PLoS biology. 14, 4, e1002440.

Research output: Contribution to journalArticle

Mapping homeostatic synaptic plasticity using cable properties of dendrites

Queenan, B. N., Lee, K. J., Tan, H., Huganir, R. L., Vicini, S. & Pak, D. T. S., Feb 19 2016, In : Neuroscience. 315, p. 206-216 11 p.

Research output: Contribution to journalArticle

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity

Zeng, M., Shang, Y., Araki, Y., Guo, T., Huganir, R. L. & Zhang, M., Aug 25 2016, In : Cell. 166, 5, p. 1163-1175.e12

Research output: Contribution to journalArticle

Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity

Olivito, L., Saccone, P., Perri, V., Bachman, J. L., Fragapane, P., Mele, A., Huganir, R. L. & De Leonibus, E., Jan 1 2016, In : Brain Structure and Function. 221, 1, p. 591-603 13 p.

Research output: Contribution to journalArticle

Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites

Na, Y., Park, S., Lee, C., Kim, D. K., Park, J. M., Sockanathan, S., Huganir, R. L. & Worley, P. F., Aug 3 2016, In : Neuron. 91, 3, p. 561-573 13 p.

Research output: Contribution to journalArticle

Role for neonatal D-serine signaling: Prevention of physiological and behavioral deficits in adult Pick1 knockout mice

Nomura, J., Jaaro-Peled, H., Lewis, E., Nuñez-Abades, P., Huppe-Gourgues, F., Cash-Padgett, T., Emiliani, F., Kondo, M. A., Furuya, A., Landek-Salgado, M. A., Ayhan, Y., Kamiya, A., Takumi, T., Huganir, R., Pletnikov, M., O'Donnell, P. & Sawa, A., Mar 1 2016, In : Molecular psychiatry. 21, 3, p. 386-393 8 p.

Research output: Contribution to journalArticle

The nutrient sensor OGT in PVN neurons regulates feeding

Lagerlöf, O., Slocomb, J. E., Hong, I., Aponte, Y., Blackshaw, S., Hart, G. W. & Huganir, R. L., Mar 18 2016, In : Science. 351, 6279, p. 1293-1296 4 p.

Research output: Contribution to journalArticle

To the Cloud! A Grassroots Proposal to Accelerate Brain Science Discovery

Vogelstein, J. T., Mensh, B., Häusser, M., Spruston, N., Evans, A. C., Kording, K., Amunts, K., Ebell, C., Muller, J., Telefont, M., Hill, S., Koushika, S. P., Calì, C., Valdés-Sosa, P. A., Littlewood, P. B., Koch, C., Saalfeld, S., Kepecs, A., Peng, H., Halchenko, Y. O. & 15 others, Kiar, G., Poo, M. M., Poline, J. B., Milham, M. P., Schaffer, A. P., Gidron, R., Okano, H., Calhoun, V. D., Chun, M., Kleissas, D. M., Vogelstein, R. J., Perlman, E., Burns, R., Huganir, R. & Miller, M. I., Nov 2 2016, In : Neuron. 92, 3, p. 622-627 6 p.

Research output: Contribution to journalShort survey