Richard Bryan Markham

Professor

1977 …2020

Research output per year

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Research Output

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Article
2020
Open Access
2019

HIV-2/SIV Vpx targets a novel functional domain of STING to selectively inhibit cGAS–STING-mediated NF-κB signalling

Su, J., Rui, Y., Lou, M., Yin, L., Xiong, H., Zhou, Z., Shen, S., Chen, T., Zhang, Z., Zhao, N., Zhang, W., Cai, Y., Markham, R., Zheng, S., Xu, R., Wei, W. & Yu, X. F., Dec 1 2019, In : Nature microbiology. 4, 12, p. 2552-2564 13 p.

Research output: Contribution to journalArticle

2018
2017

Disruption of MDA5-mediated innate immune responses by the 3C proteins of coxsackievirus A16, coxsackievirus A6, and enterovirus D68

Rui, Y., Su, J., Wang, H., Chang, J., Wang, S., Zheng, W., Cai, Y., Wei, W., Gordy, J., Markham, R. B., Kong, W., Zhang, W. & Yu, X. F., Jul 1 2017, In : Journal of Virology. 91, 13, e00546-17.

Research output: Contribution to journalArticle

Extended protection capabilities of an immature dendritic-cell targeting malaria sporozoite vaccine

Luo, K., Zavala, F. P., Gordy, J., Zhang, H. & Markham, R. B., Apr 25 2017, In : Vaccine. 35, 18, p. 2358-2364 7 p.

Research output: Contribution to journalArticle

Inhibition of Vpx-mediated SAMHD1 and Vpr-mediated host helicase transcription factor degradation by selective disruption of viral CRL4 (DCAF1) E3 ubiquitin ligase assembly

Wang, H., Guo, H., Su, J., Rui, Y., Zheng, W., Gao, W., Zhang, W., Li, Z., Liu, G., Markham, R. B., Wei, W. & Yu, X. F., May 1 2017, In : Journal of Virology. 91, 9, e00225-17.

Research output: Contribution to journalArticle

The poly-proline tail of SIVmac Vpx provides gain of function for resistance to a cryptic proteasome-dependent degradation pathway

Zhang, N., Guo, H., Yang, J., Liu, G., Li, S., Li, S., Wang, D., Li, R., Shu, C., Xu, H., Wei, Z., Huang, H., Zhang, S., Gao, P., Cen, S., Markham, R. B., Wang, Y., Yu, X. F. & Wei, W., Nov 1 2017, In : Virology. 511, p. 23-29 7 p.

Research output: Contribution to journalArticle

2016

Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations

Wei, W., Guo, H., Ma, M., Markham, R. & Yu, X. F., Jun 1 2016, In : EBioMedicine. 8, p. 230-236 7 p.

Research output: Contribution to journalArticle

2015

Analysis of enterovirus 68 strains from the 2014 North American outbreak reveals a new clade, indicating viral evolution

Du, J., Zheng, B., Zheng, W., Li, P., Kang, J., Hou, J., Markham, R., Zhao, K. & Yu, X. F., Dec 1 2015, In : PloS one. 10, 12, e0144208.

Research output: Contribution to journalArticle

Antiviral activity of a single-domain antibody immunotoxin binding to glycoprotein D of herpes simplex virus 2

Geoghegan, E. M., Zhang, H., Desai, P. J., Biragyn, A. & Markham, R. B., Jan 1 2015, In : Antimicrobial agents and chemotherapy. 59, 1, p. 527-535 9 p.

Research output: Contribution to journalArticle

HIV-1 Vpr suppresses the cytomegalovirus promoter in a CRL4(DCAF1) E3 ligase independent manner

Liu, X., Guo, H., Wang, H., Markham, R., Wei, W. & Yu, X. F., Apr 3 2015, In : Biochemical and Biophysical Research Communications. 459, 2, p. 214-219 6 p.

Research output: Contribution to journalArticle

2014

A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation

Wei, W., Guo, H., Liu, X., Zhang, H., Qian, L., Luo, K., Markham, R. B. & Yua, X. F., Jan 1 2014, In : Journal of virology. 88, 1, p. 745-751 7 p.

Research output: Contribution to journalArticle

Circulating HFMD-associated coxsackievirus A16 is genetically and phenotypically distinct from the prototype CV-A16

Wei, W., Guo, H., Li, J., Ren, S., Wei, Z., Bao, W., Hu, X., Zhao, K., Zhang, W., Zhou, Y., Sun, F., Markham, R. & Yu, X. F., Apr 15 2014, In : PloS one. 9, 4, e94746.

Research output: Contribution to journalArticle

Fusion of antigen to a dendritic cell targeting chemokine combined with adjuvant yields a malaria dna vaccine with enhanced protective capabilities

Luo, K., Zhang, H., Zavala, F., Biragyn, A., Espinosa, D. A. & Markham, R. B., Mar 5 2014, In : PloS one. 9, 3, e90413.

Research output: Contribution to journalArticle

Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins

Wei, W., Guo, H., Gao, Q., Markham, R. & Yua, X. F., Jan 2014, In : Journal of virology. 88, 1, p. 583-591 9 p.

Research output: Contribution to journalArticle

2009

Multiple-infection and recombination in HIV-1 within a longitudinal cohort of women

Templeton, A. R., Kramer, M. G., Jarvis, J., Kowalski, J., Gange, S., Schneider, M. F., Shao, Q., Zhang, G. W., Yeh, M. F., Tsai, H. L., Zhang, H. & Markham, R. B., Jun 3 2009, In : Retrovirology. 6, 54.

Research output: Contribution to journalArticle

Relationship of injection drug use, antiretroviral therapy resistance, and genetic diversity in the HIV-1 pol gene

Kowalski, J., Gange, S. J., Schneider, M. F., Tsai, H. L., Templeton, A., Shao, Q., Zhang, G. W., Yeh, M. F., Young, M. & Markham, R. B., Apr 1 2009, In : Journal of acquired immune deficiency syndromes. 50, 4, p. 381-389 9 p.

Research output: Contribution to journalArticle

2006

Lactobacilli-expressed single-chain variable fragment (scFv) specific for intercellular adhesion molecule 1 (ICAM-1) blocks cell-associated HIV-1 transmission across a cervical epithelial monolayer

Chancey, C. J., Khanna, K. V., Seegers, J. F. M. L., Zhang, G. W., Hildreth, J., Langan, A. & Markham, R. B., May 1 2006, In : Journal of Immunology. 176, 9, p. 5627-5636 10 p.

Research output: Contribution to journalArticle

Open Access
2005

Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse model

Olmsted, S. S., Khanna, K. V., Ng, E. M., Whitten, S. T., Johnson, O. N., Markham, R. B., Cone, R. A. & Moench, T. R., Sep 30 2005, In : BMC infectious diseases. 5, 79.

Research output: Contribution to journalArticle

2004

Selection in context: Patterns of natural selection in the glycoprotein 120 region of human immunodeficiency virus 1 within infected individuals

Templeton, A. R., Reichert, R. A., Weisstein, A. E., Yu, X. F. & Markham, R. B., Aug 1 2004, In : Genetics. 167, 4, p. 1547-1561 15 p.

Research output: Contribution to journalArticle

2003

Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans

Duggal, P., An, P., Beaty, T. H., Strathdee, S. A., Farzadegan, H., Markham, R. B., Johnson, L., O'Brien, S. J., Vlahov, D. & Winkler, C. A., Jun 1 2003, In : Genes and immunity. 4, 4, p. 245-250 6 p.

Research output: Contribution to journalArticle

Requirement for the second coding exon of Tat in the optimal replication of macrophage-tropic HIV-1

Neuveut, C., Scoggins, R. M., Camerini, D., Markham, R. B. & Jeang, K. T., 2003, In : Journal of biomedical science. 10, 6, p. 651-660 10 p.

Research output: Contribution to journalArticle

2002

Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent

Khanna, K. V., Whaley, K. J., Zeitlin, L., Moench, T. R., Mehrazar, K., Cone, R. A., Liao, Z., Hildreth, J. E. K., Hoen, T. E., Shultz, L. & Markham, R. B., Jan 1 2002, In : Journal of Clinical Investigation. 109, 2, p. 205-211 7 p.

Research output: Contribution to journalArticle

Open Access
2000

Differences among HIV-1 variants in their ability to elicit secretion of TNF-α

Khanna, K. V., Yu, X. F., Ford, D. H., Ratner, L., Hildreth, J. K. & Markham, R. B., Feb 1 2000, In : Journal of Immunology. 164, 3, p. 1408-1415 8 p.

Research output: Contribution to journalArticle

1999

The effect of drug-injection behavior on genetic evolution of HIV-1

Carneiro, M., Yu, X. F., Lyles, C., Templeton, A., Weisstein, A. E., Safaeian, M., Farzadegan, H., Vlahov, D. & Markham, R. B., Dec 1 1999, In : Journal of Infectious Diseases. 180, 4, p. 1025-1032 8 p.

Research output: Contribution to journalArticle

1998
Open Access

Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline

Markham, R. B., Wang, W. C., Weisstein, A. E., Wang, Z., Munoz, A., Templeton, A., Margolick, J., Vlahov, D., Quinn, T., Farzadegan, H. & Yu, X. F., Oct 13 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 21, p. 12568-12573 6 p.

Research output: Contribution to journalArticle

Potential relationships between the presence of HIV, macrophages, and astrogliosis in SCID mice with HIV encephalitis

Avgeropoulos, N. G., Burris, G. W., Ohlandt, G. W., Wesselingh, S. L., Markham, R. B. & Tyor, W. R., Jul 1 1998, In : Journal of Neuro-AIDS. 2, 1, p. 1-20 20 p.

Research output: Contribution to journalArticle

Sex differences in HIV-1 viral load and progression to AIDS

Farzadegan, H., Hoover, D. R., Astemborski, J., Lyles, C. M., Margolick, J. B., Markham, R. B., Quinn, T. C. & Vlahov, D., Nov 7 1998, In : Lancet. 352, 9139, p. 1510-1514 5 p.

Research output: Contribution to journalArticle

1997

N-acetyl-cysteine and L-2-oxathiazolidine-4-carboxylic acid enhance contact-dependent growth of HIV in resting peripheral blood mononuclear cells (PBMC) in vitro and increase recovery of HIV from human-PBMC SCID mice

Chen, P., Bauer, G., Mitchell, J., Factor, R., Markham, R. & Schwartz, D. H., Jan 20 1997, In : AIDS. 11, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

1996
Open Access

Selective transmission of human immunodeficiency virus type 1 variants to SCID mice reconstituted with human peripheral blood mononuclear cells

Markham, R. B., Schwartz, D. H., Templeton, A., Margolick, J. B., Farzadegan, H., Vlahov, D. & Yu, X. F., Oct 1996, In : Journal of virology. 70, 10, p. 6947-6954 8 p.

Research output: Contribution to journalArticle

Open Access

The presence of HIV in SCID MICE with HIV encephalitis correlates with gliosis

Avgeropouios, N., Burris, G., Qhlandt, G., Wesselingh, S., Gendelman, H., Markham, R. & Tyor, W., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1074

Research output: Contribution to journalArticle

1995
Open Access

HIV-1 p17 synthetic peptide vaccine HGP-30: induction of immune response in human subjects and preliminary evidence of protection against HIV challenge in SCID mice.

Sarin, P. S., Mora, C. A., Naylor, P. H., Markham, R., Schwartz, D., Kahn, J., Heseltine, P., Gazzard, B., Youle, M. & Rios, A., May 1995, In : Cellular and molecular biology (Noisy-le-Grand, France). 41, 3, p. 401-407 7 p.

Research output: Contribution to journalArticle

Nef and LTR Sequence Variation from Sequentially Derived Human Immunodeficiency Virus Type 1 Isolates

McNearney, T., Hornickova, Z., Templeton, A., Birdwell, A., Markham, R., Saah, A. & Ratner, L., Apr 1 1995, In : Virology. 208, 1, p. 388-398 11 p., 71166.

Research output: Contribution to journalArticle

1994

Cytotoxic and humoral immune responses to HIV-1 p17 synthetic peptide HGP-30 in human volunteers

Sarin, P. S., Markham, R., Naylor, P. H., Kahn, J., Heseltine, P., Gazzard, B., Youle, M., Rios, A. & Goldstein, A. L., Oct 19 1994, In : Vaccine Research. 3, 1, p. 49-57 9 p.

Research output: Contribution to journalArticle

Maternal IgG1 and IgA antibody to V3 loop consensus sequence and maternal-infant HIV-1 transmission

Markham, R. B., Gomez, J., Halsey, N. A., Coberly, J., Ruff, A., Holt, E., Hoover, D., Quinn, T. C., Desormeaux, J. & Boulos, R., Feb 12 1994, In : The Lancet. 343, 8894, p. 390-391 2 p.

Research output: Contribution to journalArticle

1993

A model of human immunodeficiency virus encephalitis in scid mice

Tyor, W. R., Power, C., Gendelman, H. E. & Markham, R. B., Sep 15 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 18, p. 8658-8662 5 p.

Research output: Contribution to journalArticle

Open Access

Biologic effects after a single dose of poly(I):poly(C12U) in healthy volunteers

Hendrix, C. W., Margolick, J. B., Petty, B. G., Markham, R. B., Nerhood, L., Farzadegan, H., Ts'o, P. O. P. & Lietman, P. S., Jan 1 1993, In : Antimicrobial agents and chemotherapy. 37, 3, p. 429-435 7 p.

Research output: Contribution to journalArticle

Open Access
Open Access
1992

Lack of association between maternal antibodies to v3 loop peptides and maternal-infant HIV-1 transmission

Halsey, N. A., Markham, R., Wahren, B., Boulos, R., Rossi, P. & Wigzell, H., Feb 1992, In : Journal of acquired immune deficiency syndromes. 5, 2, p. 153-157 5 p.

Research output: Contribution to journalArticle

Mouse model for exoerythrocytic stages of Plasmodium falciparum malaria parasite

Sacci, J. B., Schriefer, M. E., Resau, J. H., Wirtz, R. A., Detolla, L. J., Markham, R. B. & Azad, A. F., 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 9, p. 3701-3705 5 p.

Research output: Contribution to journalArticle

Open Access

Relationship of human immunodeficiency virus type 1 sequence heterogeneity to stage of disease

McNearney, T., Hornickova, Z., Markham, R., Birdwell, A., Arens, M., Saah, A. & Ratner, L., Jan 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 21, p. 10247-10251 5 p.

Research output: Contribution to journalArticle

Open Access