Richard Allen

Professor

1970 …2018
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Research Output 1970 2018

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Article
2018
Independent Living
Baltimore
Sleep Initiation and Maintenance Disorders
Longitudinal Studies
Anemia

Comparison of subjective sleep quality of long-term residents at low and high altitudes: SARAHA study

Gupta, R., Ulfberg, J., Allen, R. P. & Goel, D. Jan 15 2018 In : Journal of Clinical Sleep Medicine. 14, 1, p. 15-21 7 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Chronic Obstructive Pulmonary Disease
Sleep
Population
Odds Ratio

Diurnal variation of default mode network in patients with restless legs syndrome

Ku, J., Lee, Y. S., Chang, H. W., Earley, C. J., Allen, R. P. & Cho, Y. W. Jan 1 2018 In : Sleep Medicine. 41, p. 1-8 8 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Parietal Lobe
Circadian Rhythm
Arousal
Thalamus

Efficacy of ferric carboxymaltose (FCM) 500 mg dose for the treatment of Restless Legs Syndrome

Cho, Y. W., Allen, R. P. & Earley, C. J. Feb 1 2018 In : Sleep Medicine. 42, p. 7-12 6 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Placebos
Iron
Visual Analog Scale
Therapeutics

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report

Allen, R. P., Picchietti, D. L., Auerbach, M., Cho, Y. W., Connor, J. R., Earley, C. J., Garcia-Borreguero, D., Kotagal, S., Manconi, M., Ondo, W., Ulfberg, J., Winkelman, J. W., On behalf of the & International Restless Legs Syndrome Study Group (IRLSSG) Jan 1 2018 In : Sleep Medicine. 41, p. 27-44 18 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Advisory Committees
Practice Guidelines
Consensus
Iron

Pivotal role of adenosine neurotransmission in Restless Legs Syndrome

Ferré, S., Quiroz, C., Guitart, X., Rea, W., Seyedian, A., Moreno, E., Casadó-Anguera, V., Díaz-Ríos, M., Casadó, V., Clemens, S., Allen, R. P., Earley, C. J. & García-Borreguero, D. Jan 8 2018 In : Frontiers in Neuroscience. 11, JAN, 722

Research output: Contribution to journalArticle

Restless Legs Syndrome
Synaptic Transmission
Adenosine
Sleep
Leg

Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

Didriksen, M., Allen, R. P., Burchell, B. J., Thørner, L. W., Rigas, A. S., Di Angelantonio, E., Nielsen, M. H., Jennum, P. J., Werge, T., Erikstrup, C., Pedersen, O. B., Nielsen, K., Bruun, M. T., Burgdorf, K. S., Sørensen, E. & Ullum, H. May 1 2018 In : Sleep Medicine. 45, p. 124-131 8 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Blood Donors
Comorbidity
Population
Depressive Disorder

TOX3 Variants Are Involved in Restless Legs Syndrome and Parkinson’s Disease with Opposite Effects

Mohtashami, S., He, Q., Ruskey, J. A., Zhou, S., Dion, P. A., Allen, R. P., Earley, C. J., Fon, E. A., Xiong, L., Dupre, N., Dauvilliers, Y., Rouleau, G. A. & Gan-Or, Z. Mar 1 2018 In : Journal of Molecular Neuroscience. 64, 3, p. 341-345 5 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Parkinson Disease
Single Nucleotide Polymorphism
Genome-Wide Association Study
Gene Frequency
2017

High prevalence of restless legs syndrome/Willis Ekbom Disease (RLS/WED) among people living at high altitude in the Indian Himalaya

Gupta, R., Ulfberg, J., Allen, R. P. & Goel, D. Jul 1 2017 In : Sleep Medicine. 35, p. 7-11 5 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Leisure Activities
Varicose Veins
Peripheral Nervous System Diseases
Oceans and Seas

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis

23andMe Research Team Nov 1 2017 In : The Lancet Neurology. 16, 11, p. 898-907 10 p.

Research output: Contribution to journalArticle

Intervening leg movements disrupt PLMS sequences

Hiranniramol, K., Fulda, S., Skeba, P., Earley, C. J. & Allen, R. P. Jan 1 2017 In : Sleep. 40, 1

Research output: Contribution to journalArticle

Leg
Sleep
Periodicity
Polysomnography

Prevalence of restless legs syndrome and associated factors in an otherwise healthy population: results from the Danish Blood Donor Study

Didriksen, M., Rigas, A. S., Nielsen, M. H., Burgdorf, K. S., Sørensen, E., Ullum, H., Allen, R. P., Burchell, B. J., Di Angelantonio, E., Di Angelantonio, E., Jennum, P., Jennum, P., Werge, T., Werge, T., Werge, T., Erikstrup, C. & Pedersen, O. B. Aug 1 2017 In : Sleep Medicine. 36, p. 55-61 7 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Blood Donors
Population
Iron
Life Style

Targeting hypersensitive corticostriatal terminals in restless legs syndrome

Yepes, G., Guitart, X., Rea, W., Newman, A. H., Allen, R. P., Earley, C. J., Quiroz, C. & Ferré, S. Dec 1 2017 In : Annals of Neurology. 82, 6, p. 951-960 10 p.

Research output: Contribution to journalArticle

Cyclohexanecarboxylic Acids
Optogenetics
Corpus Striatum
Restless Legs Syndrome
Dopamine Agonists
2016

Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome

Quiroz, C., Gulyani, S., Ruiqian, W., Bonaventura, J., Cutler, R., Pearson, V., Allen, R. P., Earley, C. J., Mattson, M. P. & Ferré, S. Dec 1 2016 In : Neuropharmacology. 111, p. 160-168 9 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Purinergic P1 Receptors
Iron
Brain
Sleep

Animal models of RLS phenotypes

Allen, R. P., Donelson, N. C., Jones, B. C., Li, Y., Manconi, M., Rye, D. B., Sanyal, S. & Winkelmann, J. Mar 21 2016 (Accepted/In press) In : Sleep Medicine.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Animal Models
Phenotype
Genome-Wide Association Study
Iron
Restless Legs Syndrome
Iron
Brain
Substantia Nigra
Sleep

Case–Control and Family-Based Association Study of Specific PTPRD Variants in Restless Legs Syndrome

Gan-Or, Z., Zhou, S., Johnson, A., Montplaisir, J. Y., Allen, R. P., Earley, C. J., Desautels, A., Dion, P. A., Xiong, L. & Rouleau, G. A. Sep 1 2016 In : Movement Disorders Clinical Practice. 3, 5, p. 460-464 5 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Single Nucleotide Polymorphism
Haplotypes
Class 2 Receptor-Like Protein Tyrosine Phosphatases
Population

Clinical efficacy of ferric carboxymaltose treatment in patients with restless legs syndrome

Cho, Y. W., Allen, R. P. & Earley, C. J. Sep 1 2016 In : Sleep Medicine. 25, p. 16-23 8 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Placebos
Therapeutics
Visual Analog Scale
Iron

Default mode network disturbances in restless legs syndrome/Willis–Ekbom disease

Ku, J., Lee, Y. S., Chang, H. W., Earley, C. J., Allen, R. P. & Cho, Y. W. Jul 1 2016 In : Sleep Medicine. 23, p. 6-11 6 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Parietal Lobe
Thalamus
Asymptomatic Diseases
Gyrus Cinguli

Defining morphology of periodic leg movements in sleep: an evidence-based definition of a minimum window of sustained activity

Skeba, P., Fulda, S., Hiranniramol, K., Earley, C. J. & Allen, R. P. Sep 21 2016 (Accepted/In press) In : Sleep and Breathing. p. 1-7 7 p.

Research output: Contribution to journalArticle

Leg
Sleep
Guidelines
Muscles

Depth and distribution of symptoms in restless legs syndrome/ Willis-Ekbom disease

Yeh, P., Ondo, W. G., Picchietti, D. L., Steven Poceta, J., Allen, R. P., Davies, C. R., Wang, L., Shi, Y., Bagai, K. & Walters, A. S. 2016 In : Journal of Clinical Sleep Medicine. 12, 12, p. 1669-1680 12 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Leg
Arthritis
Joints
Muscle Cramp

Effects of rotigotine on daytime symptoms in patients with primary restless legs syndrome: A randomized, placebo-controlled study

Garcia-Borreguero, D., Allen, R., Hudson, J., Dohin, E., Grieger, F., Moran, K., Schollmayer, E., Smit, R. & Winkelman, J. Jan 2 2016 In : Current Medical Research and Opinion. 32, 1, p. 77-85 9 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Placebos
Immobilization
Maintenance
Transdermal Patch

Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: A combined task force of the IRLSSG, EURLSSG, and the RLS-foundation

Garcia-Borreguero, D., Silber, M. H., Winkelman, J. W., Högl, B., Bainbridge, J., Buchfuhrer, M., Hadjigeorgiou, G., Inoue, Y., Manconi, M., Oertel, W., Ondo, W., Winkelmann, J. & Allen, R. P. May 1 2016 In : Sleep Medicine. 21, p. 1-11 11 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Advisory Committees
Guidelines
Ligands
Therapeutics

Inter-movement interval as a primary stable measure of periodic limb movements of sleep

Skeba, P., Hiranniramol, K., Earley, C. J. & Allen, R. P. 2016 In : Sleep Medicine. 17, p. 138-143 6 p.

Research output: Contribution to journalArticle

Sleep
Extremities
Leg
Restless Legs Syndrome
Biological Phenomena

Iron and restless legs syndrome: Treatment, genetics and pathophysiology

Connor, J. R., Patton, S. M., Oexle, K. & Allen, R. Mar 18 2016 (Accepted/In press) In : Sleep Medicine.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Iron
Therapeutics
Brain
Dietary Iron

Practice guideline summary: Treatment of restless legs syndrome in adults

Winkelman, J. W., Armstrong, M. J., Allen, R. P., Chaudhuri, K. R., Ondo, W., Trenkwalder, C., Zee, P. C., Gronseth, G. S., Gloss, D. & Zesiewicz, T. Dec 13 2016 In : Neurology. 87, 24, p. 2585-2593 9 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Practice Guidelines
Sleep
ferrous sulfate
Levodopa

Restless legs syndrome associated with major diseases

Trenkwalder, C., Allen, R., Högl, B., Paulus, W. & Winkelmann, J. Apr 5 2016 In : Neurology. 86, 14, p. 1336-1343 8 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Deficiency Diseases
Narcolepsy
Iron-Deficiency Anemias
Kidney Diseases

World Association of Sleep Medicine (WASM) 2016 standards for recording and scoring leg movements in polysomnograms developed by a joint task force from the International and the European Restless Legs Syndrome Study Groups (IRLSSG and EURLSSG)

Ferri, R., Fulda, S., Manconi, M., Allen, R. P., Zucconi, M., Ferini-Strambi, L., Bruni, O., Chokroverty, S., Frauscher, B., Garcia-Borreguero, D., Hirshkowitz, M., Högl, B., Inoue, Y., Jahangir, A., Marcus, C. L., Picchietti, D. L., Plazzi, G., Winkelman, J. W. & Zak, R. S. Oct 1 2016 In : Sleep Medicine. 26, p. 86-95 10 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Advisory Committees
Leg
Sleep
Joints
2015

A comparison of MRI tissue relaxometry and ROI methods used to determine regional brain iron concentrations in restless legs syndrome

Moon, H. J., Chang, Y., Lee, Y. S., Song, H., Chang, H. W., Ku, J., Allen, R. P., Earley, C. J. & Cho, Y. W. Jan 1 2015 In : Medical Devices: Evidence and Research. 8, p. 341-350 10 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Magnetic resonance imaging
Brain
Iron
Tissue

Analysis of functional GLO1 variants in the BTBD9 locus and restless legs syndrome

Gan-Or, Z., Zhou, S., Ambalavanan, A., Leblond, C. S., Xie, P., Johnson, A., Spiegelman, D., Allen, R. P., Earley, C. J., Desautels, A., Montplaisir, J. Y., Dion, P. A., Xiong, L. & Rouleau, G. A. Sep 1 2015 In : Sleep Medicine. 16, 9, p. 1151-1155 5 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Exome
Genetic Loci
Nucleic Acid Regulatory Sequences
Genome-Wide Association Study

Augmentation of restless leg syndrome (Willis-Ekbom disease) during long-term dopaminergic treatment

Garcia-Borreguero, D., Benitez, A., Kohnen, R. & Allen, R. Jan 1 2015 In : Postgraduate Medicine. 127, 7, p. 716-725 10 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Therapeutics
Dopamine Agonists
Disease Progression
Primary Health Care

Co-registration of magnetic resonance spectroscopy and transcranial magnetic stimulation

Hone-Blanchet, A., Salas, R. E., Celnik, P., Kalloo, A., Schar, M., Puts, N. A. J., Harris, A. D., Barker, P. B., Fecteau, S., Earley, C. J., Allen, R. P. & Edden, R. A. Mar 5 2015 In : Journal of Neuroscience Methods. 242, p. 52-57 6 p.

Research output: Contribution to journalArticle

Transcranial Magnetic Stimulation
Magnetic Resonance Spectroscopy
Neurotransmitter Agents
Motor Cortex
Hand

Diagnostic accuracy of behavioral, activity, ferritin, and clinical indicators of restless legs syndrome

Richards, K. C., Bost, J. E., Rogers, V. E., Hutchison, L. C., Beck, C. K., Bliwise, D. L., Kovach, C. R., Cuellar, N. & Allen, R. P. Mar 1 2015 In : Sleep. 38, 3, p. 371-380 10 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Ferritins
Odds Ratio
Leg
Sleep

Gray matter alteration in patients with restless legs syndrome: A voxel-based morphometry study

Chang, Y., Chang, H. W., Song, H., Ku, J., Earley, C. J., Allen, R. P. & Cho, Y. W. Jan 1 2015 In : Clinical Imaging. 39, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Parahippocampal Gyrus
Parietal Lobe
Cerebellum
Gray Matter

MATPLM1, A MATLAB script for scoring of periodic limb movements: Preliminary validation with visual scoring

Huang, A. S., Skeba, P., Yang, M. S., Sgambati, F. P., Earley, C. J. & Allen, R. P. Dec 1 2015 In : Sleep Medicine. 16, 12, p. 1541-1549 9 p.

Research output: Contribution to journalArticle

Sleep
Extremities
Restless Legs Syndrome
Sleep Apnea Syndromes
Leg

Prevalence and clinical characteristics of patients with restless legs syndrome with painful symptoms

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P. Jun 1 2015 In : Sleep Medicine. 16, 6, p. 775-778 4 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Sleep
Pain
Polysomnography
Ferritins

Response to "Characterization of the painful restless legs syndrome"

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P. Jul 1 2015 In : Sleep Medicine. 16, 7, p. 898 1 p.

Research output: Contribution to journalArticle

Nocturnal Myoclonus Syndrome
Restless Legs Syndrome
Pain

Response to the letter "Characterization of the painful restless legs syndrome"

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P. Nov 1 2015 In : Sleep Medicine. 16, 11, p. 1448 1 p., 2862

Research output: Contribution to journalArticle

Nocturnal Myoclonus Syndrome
Restless Legs Syndrome
Pain

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology

Allen, R. P. Sep 1 2015 In : Sleep Medicine Clinics. 10, 3, p. 207-214 8 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Dopamine
Iron
Brain
Down-Regulation
2014

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)

Earley, C. J., Connor, J., Garcia-Borreguero, D., Jenner, P., Winkelman, J., Zee, P. C. & Allen, R. Nov 1 2014 In : Sleep Medicine. 15, 11, p. 1288-1301 14 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Homeostasis
Iron
Brain
Animal Models

Altered white matter integrity in primary restless legs syndrome patients: Diffusion tensor imaging study

Chang, Y., Paik, J. S., Lee, H. J., Chang, H. W., Moon, H. J., Allen, R. P., Earley, C. J. & Cho, Y. W. 2014 In : Neurological Research. 36, 8, p. 769-774 6 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Diffusion Tensor Imaging
Anisotropy
Corpus Callosum
Brain
Restless Legs Syndrome
Depression
Cognition
Anxiety

Comparison of pregabalin with pramipexole for restless legs syndrome

Allen, R. P., Chen, C., Garcia-Borreguero, D., Polo, O., DuBrava, S., Miceli, J., Knapp, L. & Winkelman, J. W. 2014 In : New England Journal of Medicine. 370, 7, p. 621-631 11 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Placebos
Therapeutics
pramipexole
Pregabalin

Diurnal variations in brain iron concentrations in BXD RI mice

Unger, E. L., Jones, B. C., Bianco, L. E., Allen, R. P. & Earley, C. J. Mar 28 2014 In : Neuroscience. 263, p. 54-59 6 p.

Research output: Contribution to journalArticle

Iron
Mesencephalon
Brain
Inbred Strains Mice
Spleen
Restless Legs Syndrome
Thalamus
Magnetic Resonance Imaging
Parahippocampal Gyrus
Temporal Lobe

Increased use-dependent plasticity in chronic insomnia

Salas, R. E., Galea, J. M., Gamaldo, A. A., Gamaldo, C. E., Allen, R. P., Smith, M. T., Cantarero, G., Lam, B. D. & Celnik, P. A. Mar 1 2014 In : Sleep. 37, 3, p. 535-544 10 p.

Research output: Contribution to journalArticle

Sleep Initiation and Maintenance Disorders
Neuronal Plasticity
Sleep
Phantom Limb
Aptitude

In memoriam Ralf Kohnen, PhD, professor of clinical psychology

Trenkwalder, C., Benes, H. & Allen, R. P. Jun 1 2014 In : Sleep Medicine. 15, 6, p. 603-604 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Restless Legs Syndrome
Clinical Psychology
Germany

Low brain iron effects and reversibility on striatal dopamine dynamics

Unger, E. L., Bianco, L. E., Jones, B. C., Allen, R. P. & Earley, C. J. 2014 In : Experimental Neurology. 261, p. 462-468 7 p.

Research output: Contribution to journalArticle

Corpus Striatum
Dopamine
Iron
Brain
Mesencephalon

Pregabalin versus pramipexole: Effects on sleep disturbance in restless legs syndrome

Garcia-Borreguero, D., Patrick, J., DuBrava, S., Becker, P. M., Lankford, A., Chen, C., Miceli, J., Knapp, L. & Allen, R. P. Apr 1 2014 In : Sleep. 37, 4, p. 635-643 9 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Sleep
Placebos
Polysomnography
Arousal