Research Output 1970 2018

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2018

Diurnal variation of default mode network in patients with restless legs syndrome

Ku, J., Lee, Y. S., Chang, H. W., Earley, C. J., Allen, R. P. & Cho, Y. W. Jan 1 2018 In : Sleep Medicine. 41, p. 1-8 8 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Parietal Lobe
Circadian Rhythm
Arousal
Thalamus

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report

Allen, R. P., Picchietti, D. L., Auerbach, M., Cho, Y. W., Connor, J. R., Earley, C. J., Garcia-Borreguero, D., Kotagal, S., Manconi, M., Ondo, W., Ulfberg, J., Winkelman, J. W., On behalf of the & International Restless Legs Syndrome Study Group (IRLSSG) Jan 1 2018 In : Sleep Medicine. 41, p. 27-44 18 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Advisory Committees
Practice Guidelines
Consensus
Iron
2017

High prevalence of restless legs syndrome/Willis Ekbom Disease (RLS/WED) among people living at high altitude in the Indian Himalaya

Gupta, R., Ulfberg, J., Allen, R. P. & Goel, D. Jul 1 2017 In : Sleep Medicine. 35, p. 7-11 5 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Population
Leisure Activities
Varicose Veins
Peripheral Nervous System Diseases

Intervening leg movements disrupt PLMS sequences

Hiranniramol, K., Fulda, S., Skeba, P., Earley, C. J. & Allen, R. P. Jan 1 2017 In : Sleep. 40, 1

Research output: Research - peer-reviewArticle

Leg
Sleep
Periodicity

Prevalence of restless legs syndrome and associated factors in an otherwise healthy population: results from the Danish Blood Donor Study

Didriksen, M., Rigas, A. S., Nielsen, M. H., Burgdorf, K. S., Sørensen, E., Ullum, H., Allen, R. P., Burchell, B. J., Di Angelantonio, E., Di Angelantonio, E., Jennum, P., Jennum, P., Werge, T., Werge, T., Werge, T., Erikstrup, C. & Pedersen, O. B. Aug 1 2017 In : Sleep Medicine. 36, p. 55-61 7 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Blood Donors
Population
Iron
Life Style

Targeting hypersensitive corticostriatal terminals in restless legs syndrome

Yepes, G., Guitart, X., Rea, W., Newman, A. H., Allen, R. P., Earley, C. J., Quiroz, C. & Ferré, S. Dec 1 2017 In : Annals of Neurology. 82, 6, p. 951-960 10 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Glutamic Acid
pramipexole
Optogenetics
Hypersensitivity
2016

Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome

Quiroz, C., Gulyani, S., Ruiqian, W., Bonaventura, J., Cutler, R., Pearson, V., Allen, R. P., Earley, C. J., Mattson, M. P. & Ferré, S. Dec 1 2016 In : Neuropharmacology. 111, p. 160-168 9 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Purinergic P1 Receptors
Iron
Brain
Sleep

Animal models of RLS phenotypes

Allen, R. P., Donelson, N. C., Jones, B. C., Li, Y., Manconi, M., Rye, D. B., Sanyal, S. & Winkelmann, J. Mar 21 2016 (Accepted/In press) In : Sleep Medicine.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Animal Models
Phenotype
Genes
Iron
Restless Legs Syndrome
Iron
Brain
Substantia Nigra
Sleep

Clinical efficacy of ferric carboxymaltose treatment in patients with restless legs syndrome

Cho, Y. W., Allen, R. P. & Earley, C. J. Sep 1 2016 In : Sleep Medicine. 25, p. 16-23 8 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Therapeutics
ferric carboxymaltose
Placebos
Visual Analog Scale

Default mode network disturbances in restless legs syndrome/Willis–Ekbom disease

Ku, J., Lee, Y. S., Chang, H. W., Earley, C. J., Allen, R. P. & Cho, Y. W. Jul 1 2016 In : Sleep Medicine. 23, p. 6-11 6 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Parietal Lobe
Thalamus
Limbic Lobe
Asymptomatic Diseases

Defining morphology of periodic leg movements in sleep: an evidence-based definition of a minimum window of sustained activity

Skeba, P., Fulda, S., Hiranniramol, K., Earley, C. J. & Allen, R. P. Sep 21 2016 (Accepted/In press) In : Sleep and Breathing. p. 1-7 7 p.

Research output: Research - peer-reviewArticle

Leg
Sleep
Guidelines
Muscles

Depth and distribution of symptoms in restless legs syndrome/ Willis-Ekbom disease

Yeh, P., Ondo, W. G., Picchietti, D. L., Steven Poceta, J., Allen, R. P., Davies, C. R., Wang, L., Shi, Y., Bagai, K. & Walters, A. S. 2016 In : Journal of Clinical Sleep Medicine. 12, 12, p. 1669-1680 12 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Leg
Arthritis
Joints
Muscle Cramp

Effects of rotigotine on daytime symptoms in patients with primary restless legs syndrome: A randomized, placebo-controlled study

Garcia-Borreguero, D., Allen, R., Hudson, J., Dohin, E., Grieger, F., Moran, K., Schollmayer, E., Smit, R. & Winkelman, J. Jan 2 2016 In : Current Medical Research and Opinion. 32, 1, p. 77-85 9 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Placebos
N 0437
Immobilization
Therapeutics

Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: A combined task force of the IRLSSG, EURLSSG, and the RLS-foundation

Garcia-Borreguero, D., Silber, M. H., Winkelman, J. W., Högl, B., Bainbridge, J., Buchfuhrer, M., Hadjigeorgiou, G., Inoue, Y., Manconi, M., Oertel, W., Ondo, W., Winkelmann, J. & Allen, R. P. May 1 2016 In : Sleep Medicine. 21, p. 1-11 11 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Advisory Committees
Guidelines
Therapeutics
Ligands

Inter-movement interval as a primary stable measure of periodic limb movements of sleep

Skeba, P., Hiranniramol, K., Earley, C. J. & Allen, R. P. 2016 In : Sleep Medicine. 17, p. 138-143 6 p.

Research output: Research - peer-reviewArticle

Sleep
Extremities
Leg
Restless Legs Syndrome
Biological Phenomena

Iron and restless legs syndrome: Treatment, genetics and pathophysiology

Connor, J. R., Patton, S. M., Oexle, K. & Allen, R. Mar 18 2016 (Accepted/In press) In : Sleep Medicine.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Iron
Therapeutics
Brain
Hypoxia

Practice guideline summary: Treatment of restless legs syndrome in adults

Winkelman, J. W., Armstrong, M. J., Allen, R. P., Chaudhuri, K. R., Ondo, W., Trenkwalder, C., Zee, P. C., Gronseth, G. S., Gloss, D. & Zesiewicz, T. Dec 13 2016 In : Neurology. 87, 24, p. 2585-2593 9 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Practice Guidelines
Therapeutics
cabergoline
ropinirole

Restless legs syndrome associated with major diseases

Trenkwalder, C., Allen, R., Högl, B., Paulus, W. & Winkelmann, J. Apr 5 2016 In : Neurology. 86, 14, p. 1336-1343 8 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Deficiency Diseases
Narcolepsy
Iron-Deficiency Anemias
Kidney Diseases

World Association of Sleep Medicine (WASM) 2016 standards for recording and scoring leg movements in polysomnograms developed by a joint task force from the International and the European Restless Legs Syndrome Study Groups (IRLSSG and EURLSSG)

Ferri, R., Fulda, S., Manconi, M., Allen, R. P., Zucconi, M., Ferini-Strambi, L., Bruni, O., Chokroverty, S., Frauscher, B., Garcia-Borreguero, D., Hirshkowitz, M., Högl, B., Inoue, Y., Jahangir, A., Marcus, C. L., Picchietti, D. L., Plazzi, G., Winkelman, J. W. & Zak, R. S. Oct 1 2016 In : Sleep Medicine. 26, p. 86-95 10 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Advisory Committees
Leg
Sleep
Joints
2015

A comparison of MRI tissue relaxometry and ROI methods used to determine regional brain iron concentrations in restless legs syndrome

Moon, H. J., Chang, Y., Lee, Y. S., Song, H., Chang, H. W., Ku, J., Allen, R. P., Earley, C. J. & Cho, Y. W. Jan 1 2015 In : Medical Devices: Evidence and Research. 8, p. 341-350 10 p.

Research output: Research - peer-reviewArticle

Magnetic resonance imaging
Brain
Tissue
Iron
Restless Legs Syndrome

Analysis of functional GLO1 variants in the BTBD9 locus and restless legs syndrome

Gan-Or, Z., Zhou, S., Ambalavanan, A., Leblond, C. S., Xie, P., Johnson, A., Spiegelman, D., Allen, R. P., Earley, C. J., Desautels, A., Montplaisir, J. Y., Dion, P. A., Xiong, L. & Rouleau, G. A. Sep 1 2015 In : Sleep Medicine. 16, 9, p. 1151-1155 5 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Exome
Genetic Loci
Nucleic Acid Regulatory Sequences
Genome-Wide Association Study

Augmentation of restless leg syndrome (Willis-Ekbom disease) during long-term dopaminergic treatment

Garcia-Borreguero, D., Benitez, A., Kohnen, R. & Allen, R. Jan 1 2015 In : Postgraduate Medicine. 127, 7, p. 716-725 10 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Therapeutics
Dopamine Agonists
Disease Progression
Primary Health Care

Co-registration of magnetic resonance spectroscopy and transcranial magnetic stimulation

Hone-Blanchet, A., Salas, R. E., Celnik, P., Kalloo, A., Schar, M., Puts, N. A. J., Harris, A. D., Barker, P. B., Fecteau, S., Earley, C. J., Allen, R. P. & Edden, R. A. Mar 5 2015 In : Journal of Neuroscience Methods. 242, p. 52-57 6 p.

Research output: Research - peer-reviewArticle

Transcranial Magnetic Stimulation
Magnetic Resonance Spectroscopy
Neurotransmitter Agents
Motor Cortex
Hand

Diagnostic accuracy of behavioral, activity, ferritin, and clinical indicators of restless legs syndrome

Richards, K. C., Bost, J. E., Rogers, V. E., Hutchison, L. C., Beck, C. K., Bliwise, D. L., Kovach, C. R., Cuellar, N. & Allen, R. P. Mar 1 2015 In : Sleep. 38, 3, p. 371-380 10 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Ferritins
Odds Ratio
Leg
Sleep

Gray matter alteration in patients with restless legs syndrome: A voxel-based morphometry study

Chang, Y., Chang, H. W., Song, H., Ku, J., Earley, C. J., Allen, R. P. & Cho, Y. W. Jan 1 2015 In : Clinical Imaging. 39, 1, p. 20-25 6 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Gray Matter
Parahippocampal Gyrus
Parietal Lobe
Cerebellum

MATPLM1, A MATLAB script for scoring of periodic limb movements: Preliminary validation with visual scoring

Huang, A. S., Skeba, P., Yang, M. S., Sgambati, F. P., Earley, C. J. & Allen, R. P. Dec 1 2015 In : Sleep Medicine. 16, 12, p. 1541-1549 9 p.

Research output: Research - peer-reviewArticle

Sleep
Extremities
Restless Legs Syndrome
Sleep Apnea Syndromes
Leg

Prevalence and clinical characteristics of patients with restless legs syndrome with painful symptoms

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P. Jun 1 2015 In : Sleep Medicine. 16, 6, p. 775-778 4 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Sleep
Pain
Polysomnography
Ferritins

Response to "Characterization of the painful restless legs syndrome"

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P. Jul 1 2015 In : Sleep Medicine. 16, 7, p. 898 1 p.

Research output: Research - peer-reviewArticle

Nocturnal Myoclonus Syndrome
Restless Legs Syndrome
Pain

Response to the letter "Characterization of the painful restless legs syndrome"

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P. Nov 1 2015 In : Sleep Medicine. 16, 11, p. 1448 1 p., 2862

Research output: Research - peer-reviewArticle

Nocturnal Myoclonus Syndrome
Restless Legs Syndrome
Pain

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology

Allen, R. P. Sep 1 2015 In : Sleep Medicine Clinics. 10, 3, p. 207-214 8 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Dopamine
Iron
Brain
Down-Regulation
2014

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)

Earley, C. J., Connor, J., Garcia-Borreguero, D., Jenner, P., Winkelman, J., Zee, P. C. & Allen, R. Nov 1 2014 In : Sleep Medicine. 15, 11, p. 1288-1301 14 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Homeostasis
Iron
Brain
Animal Models

Altered white matter integrity in primary restless legs syndrome patients: Diffusion tensor imaging study

Chang, Y., Paik, J. S., Lee, H. J., Chang, H. W., Moon, H. J., Allen, R. P., Earley, C. J. & Cho, Y. W. 2014 In : Neurological Research. 36, 8, p. 769-774 6 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Diffusion Tensor Imaging
White Matter
Anisotropy
Brain
Restless Legs Syndrome
Depression
Cognition
Anxiety

Comparison of pregabalin with pramipexole for restless legs syndrome

Allen, R. P., Chen, C., Garcia-Borreguero, D., Polo, O., DuBrava, S., Miceli, J., Knapp, L. & Winkelman, J. W. 2014 In : New England Journal of Medicine. 370, 7, p. 621-631 11 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
pramipexole
Pregabalin
Placebos
Therapeutics

Diurnal variations in brain iron concentrations in BXD RI mice

Unger, E. L., Jones, B. C., Bianco, L. E., Allen, R. P. & Earley, C. J. Mar 28 2014 In : Neuroscience. 263, p. 54-59 6 p.

Research output: Research - peer-reviewArticle

Iron
Brain
Mesencephalon
Inbred Strains Mice
Spleen
Restless Legs Syndrome
Thalamus
Magnetic Resonance Imaging
Parahippocampal Gyrus
Temporal Lobe

Increased use-dependent plasticity in chronic insomnia

Salas, R. E., Galea, J. M., Gamaldo, A. A., Gamaldo, C. E., Allen, R. P., Smith, M. T., Cantarero, G., Lam, B. D. & Celnik, P. A. Mar 1 2014 In : Sleep. 37, 3, p. 535-544 10 p.

Research output: Research - peer-reviewArticle

Sleep Initiation and Maintenance Disorders
Neuronal Plasticity
Sleep
Phantom Limb
Aptitude

In memoriam Ralf Kohnen, PhD, professor of clinical psychology

Trenkwalder, C., Benes, H. & Allen, R. P. Jun 1 2014 In : Sleep Medicine. 15, 6, p. 603-604 2 p.

Research output: Research - peer-reviewArticle

21st Century History
20th Century History
Restless Legs Syndrome
Clinical Psychology
Germany

Low brain iron effects and reversibility on striatal dopamine dynamics

Unger, E. L., Bianco, L. E., Jones, B. C., Allen, R. P. & Earley, C. J. 2014 In : Experimental Neurology. 261, p. 462-468 7 p.

Research output: Research - peer-reviewArticle

Corpus Striatum
Dopamine
Iron
Brain
Mesencephalon

Pregabalin versus pramipexole: Effects on sleep disturbance in restless legs syndrome

Garcia-Borreguero, D., Patrick, J., DuBrava, S., Becker, P. M., Lankford, A., Chen, C., Miceli, J., Knapp, L. & Allen, R. P. Apr 1 2014 In : Sleep. 37, 4, p. 635-643 9 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Sleep
Pregabalin
pramipexole
Placebos

Response to intravenous iron in patients with iron deficiency anemia (IDA) and restless leg syndrome (Willis-Ekbom disease)

Mehmood, T., Auerbach, M., Earley, C. J. & Allen, R. P. Dec 1 2014 In : Sleep Medicine. 15, 12, p. 1473-1476 4 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Iron-Deficiency Anemias
Iron
Surveys and Questionnaires
Hemoglobins

Restless legs syndrome/Willis Ekbom disease: Evaluation and treatment

Allen, R. P. 2014 In : International Review of Psychiatry. 26, 2, p. 248-262 15 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Therapeutics
Psychiatry
Depression
Anxiety Disorders

Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: Updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria - history, rationale, description, and significance

Allen, R. P., Picchietti, D. L., Garcia-Borreguero, D., Ondo, W. G., Walters, A. S., Winkelman, J. W., Zucconi, M., Ferri, R., Trenkwalder, C. & Lee, H. B. 2014 In : Sleep Medicine. 15, 8, p. 860-873 14 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Consensus
History
Research
Education

Review of diagnostic instruments for the restless legs syndrome/willis-ekbom disease (RLS/WED): Critique and recommendations

Walters, A. S. , Frauscher, B. , Allen, R. , Benes, H. , Chaudhuri, K. R. , Garcia-Borreguero, D. , Lee, H. B. , Picchietti, D. L. , Trenkwalder, C. , Martinez-Martin, P. , Stebbins, G. T. , Schrag, A. , Cubo, E. , Goetz, C. G. , Hall, D. , Luo, S. , Marsh, L. , Post, B. , Sampaio, C. , Weintraub, D. & 1 others MDS Committee on Rating Scales Development 2014 In : Journal of Clinical Sleep Medicine. 10, 12, p. 1343-1349 7 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Advisory Committees
Interviews
Pediatrics
Research

Review of quality of life instruments for the restless legs syndrome/willis-ekbom disease (RLS/WED): Critique and recommendations

Walters, A. S. , Frauscher, B. , Allen, R. , Benes, H. , Chaudhuri, K. R. , Garcia-Borreguero, D. , Lee, H. B. , Picchietti, D. L. , Trenkwalder, C. , Martinez-Martin, P. , Stebbins, G. T. , Schrag, A. , Cubo, E. , Goetz, C. G. , Hall, D. , Luo, S. , Marsh, L. , Post, B. , Sampaio, C. , Weintraub, D. & 1 others MDS Committee on Rating Scales Development 2014 In : Journal of Clinical Sleep Medicine. 10, 12, p. 1351-1357 7 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Quality of Life
Advisory Committees
Therapeutic Human Experimentation
Genetic Research

The author replies

Allen, R. P. 2014 In : New England Journal of Medicine. 370, 21, p. 2050-2051 2 p.

Research output: Research - peer-reviewArticle

Benzothiazoles
Restless Legs Syndrome
Dopamine Agonists
Anticonvulsants
gamma-Aminobutyric Acid

Valid measures of periodic leg movements (PLMs) during a suggested immobilization test using the PAM-RL leg activity monitors require adjusting detection parameters for noise and signal in each recording

Yang, M. S., Montplaisir, J., Desautels, A., Winkelman, J. W., Cramer Bornemann, M. A., Earley, C. J. & Allen, R. P. Jan 2014 In : Sleep Medicine. 15, 1, p. 132-137 6 p.

Research output: Research - peer-reviewArticle

Wakefulness
Immobilization
Noise
Leg
Electromyography
2013

Association of restless legs syndrome variants in Korean patients with restless legs syndrome

Kim, M. K., Cho, Y. W., Shin, W. C., Cho, J. W., Shon, Y. M., Kim, J. H., Yang, K. I., Earley, C. J. & Allen, R. P. Dec 1 2013 In : Sleep. 36, 12, p. 1787-1791 5 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Odds Ratio
Genome-Wide Association Study
Population
Genetic Epistasis