Rexford S Ahima

Professor

1990 …2018
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Research Output 1990 2018

2018

Brain insulin resistance in type 2 diabetes and Alzheimer disease: Concepts and conundrums

Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H. Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., Holtzman, D. M. & Nathan, D. M. Mar 1 2018 In : Nature Reviews Neurology. 14, 3, p. 168-181 14 p.

Research output: Contribution to journalReview article

Type 2 Diabetes Mellitus
Dementia
Insulin Resistance
Alzheimer Disease
Brain
Paraganglioma
Brown Adipose Tissue
Pheochromocytoma

Hypertension, overweight/obesity, and diabetes among immigrants in the United States: An analysis of the 2010-2016 National Health Interview Survey

Commodore-Mensah, Y., Selvin, E., Aboagye, J., Turkson-Ocran, R. A., Li, X., Himmelfarb, C. D., Ahima, R. S. & Cooper, L. A. Jun 20 2018 In : BMC public health. 18, 1, 773

Research output: Contribution to journalReview article

Health Surveys
Obesity
Interviews
Hypertension
Central America
2017

Linking resistin, inflammation, and cardiometabolic diseases

Park, H. K., Kwak, M. K., Kim, H. J. & Ahima, R. S. 2017 In : Korean Journal of Internal Medicine. 32, 2, p. 239-247 9 p.

Research output: Contribution to journalReview article

Resistin
Inflammation
Insulin Resistance
Atherosclerosis
Cardiovascular Diseases

Neonatal GLP1R activation limits adult adiposity by durably altering hypothalamic architecture

Rozo, A. V., Babu, D. A., Suen, P. M. A., Groff, D. N., Seeley, R. J., Simmons, R. A., Seale, P., Ahima, R. S. & Stoffers, D. A. Jul 1 2017 In : Molecular Metabolism. 6, 7, p. 748-759 12 p.

Research output: Contribution to journalArticle

Adiposity
White Adipose Tissue
Obesity
Paraventricular Hypothalamic Nucleus
Energy Metabolism

Perilipin Staining Distinguishes Between Steatosis and Nonalcoholic Steatohepatitis in Adults and Children

Carr, R. M., Dhir, R., Mahadev, K., Comerford, M., Chalasani, N. P. & Ahima, R. S. Jan 1 2017 In : Clinical Gastroenterology and Hepatology. 15, 1, p. 145-147 3 p.

Research output: Contribution to journalShort survey

Staining and Labeling
Non-alcoholic Fatty Liver Disease
Perilipin-1

Synergistic Modulation of Inflammatory but not Metabolic Effects of High-Fat Feeding by CCR2 and CX3CR1

Zhang, H., Hinkle, C. C., O'Neill, S. M., Shi, J., Caughey, J., Lynch, E., Lynch, G., Gerelus, M., Tsai, A. S. D., Shah, R., Ferguson, J. F., Ahima, R. S. & Reilly, M. P. Aug 1 2017 In : Obesity. 25, 8, p. 1410-1420 11 p.

Research output: Contribution to journalArticle

C Chemokines
Chemokine Receptors
Fats
High Fat Diet
Macrophages
2016

Changes in Fasting and Prandial Gut and Adiposity Hormones Following Vertical Sleeve Gastrectomy or Roux-en-Y-Gastric Bypass: an 18-Month Prospective Study

Alamuddin, N., Vetter, M. L., Ahima, R. S., Hesson, L., Ritter, S., Minnick, A., Faulconbridge, L. F., Allison, K. C., Sarwer, D. B., Chittams, J., Williams, N. N., Hayes, M. R., Loughead, J. W., Gur, R. & Wadden, T. A. Dec 21 2016 (Accepted/In press) In : Obesity Surgery. p. 1-10 10 p.

Research output: Contribution to journalArticle

Gastric Bypass
Adiposity
Gastrectomy
Meals
Fasting

Diabetes, Hemoglobin A1C, and Regional Alzheimer Disease and Infarct Pathology

Pruzin, J. J., Schneider, J. A., Capuano, A. W., Leurgans, S. E., Barnes, L. L., Ahima, R. S., Arnold, S. E., Bennett, D. A. & Arvanitakis, Z. Oct 17 2016 (Accepted/In press) In : Alzheimer Disease and Associated Disorders.

Research output: Contribution to journalArticle

Alzheimer Disease
Hemoglobins
Odds Ratio
Confidence Intervals
Pathology

Editorial: Unlocking therapeutic potential of brown fat

Ahima, R. S. Mar 1 2016 In : Molecular Endocrinology. 30, 3, p. 275-277 3 p.

Research output: Contribution to journalEditorial

Brown Adipose Tissue
Thermogenesis
Therapeutics
Beige Adipose Tissue

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

Tomar, D. , Dong, Z. , Shanmughapriya, S. , Koch, D. A. , Thomas, T. , Hoffman, N. E. , Timbalia, S. A. , Goldman, S. J. , Breves, S. L. , Corbally, D. P. , Nemani, N. , Fairweather, J. P. , Cutri, A. R. , Zhang, X. , Song, J. , Jaña, F. , Huang, J. , Barrero, C. , Rabinowitz, J. E. , Luongo, T. S. & 15 others Schumacher, S. M., Rockman, M. E., Dietrich, A., Merali, S., Caplan, J., Stathopulos, P., Ahima, R. S., Cheung, J. Y., Houser, S. R., Koch, W. J., Patel, V., Gohil, V. M., Elrod, J. W., Rajan, S. & Madesh, M. May 24 2016 In : Cell Reports. 15, 8, p. 1673-1685 13 p.

Research output: Contribution to journalArticle

Autophagy
Mitochondrial Membranes
Cardiac Myocytes
Protein Binding
Scaffolds

Pathophysiology of lipid droplet proteins in liver diseases

Carr, R. M. & Ahima, R. S. Jan 15 2016 In : Experimental Cell Research. 340, 2, p. 187-192 6 p.

Research output: Contribution to journalReview article

Liver Diseases
Liver
Lipids
Alcoholic Liver Diseases
Proteins

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction

Kung, C. P., Leu, J. I. J., Basu, S., Khaku, S., Anokye-Danso, F., Liu, Q., George, D. L., Ahima, R. S. & Murphy, M. E. Mar 15 2016 In : Cell Reports. 14, 10, p. 2413-2425 13 p.

Research output: Contribution to journalArticle

Nutrition
Polymorphism
Metabolism
Obesity
Fats
2015

Connecting myokines and metabolism

Ahima, R. S. & Park, H. K. 2015 In : Endocrinology and Metabolism. 30, 3, p. 235-245 11 p.

Research output: Contribution to journalReview article

Skeletal Muscle
Muscles
Lipid Metabolism
Adipose Tissue
Homeostasis

Deletion of murine Arv1 results in a lean phenotype with increased energy expenditure

Lagor, W. R., Tong, F., Jarrett, K. E., Lin, W., Conlon, D. M., Smith, M., Wang, M. Y., Yenilmez, B. O., McCoy, M. G., Fields, D. W., O'Neill, S. M., Gupta, R., Kumaravel, A., Redon, V., Ahima, R. S., Sturley, S. L., Billheimer, J. T. & Rader, D. J. Oct 19 2015 In : Nutrition and Diabetes. 5, 10, e181

Research output: Contribution to journalArticle

Energy Metabolism
Phenotype
White Adipose Tissue
Enzymes
Lipids

Editorial: Rethinking the definition of diabetes for precision medicine

Ahima, R. S. Feb 27 2015 In : Molecular Endocrinology. 29, 3, p. 335-337 3 p.

Research output: Contribution to journalEditorial

Precision Medicine
Diabetes Mellitus

IL-15Rα is a determinant of muscle fuel utilization, and its loss protects against obesity

Loro, E., Seifert, E. L., Moffat, C., Romero, F., Mishra, M. K., Sun, Z., Krajacic, P., Anokye-Danso, F., Summer, R. S., Ahima, R. S. & Khurana, T. S. 2015 In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 309, 8, p. R835-R844

Research output: Contribution to journalArticle

Obesity
Interleukin-15
Muscles
Muscle Mitochondrion
Physiological Phenomena

Lipid droplet proteins and hepatic lipid metabolism

Imai, Y., Trevino, M. B. & Ahima, R. S. Jan 1 2015 Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer International Publishing, p. 165-188 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lipid Metabolism
Lipids
Liver
Proteins
Lipolysis

Metabolic effects of CX3CR1 deficiency in diet-induced obese mice

Shah, R., O'Neill, S. M., Hinkle, C., Caughey, J., Stephan, S., Lynch, E., Bermingham, K., Lynch, G., Ahima, R. S. & Reilly, M. P. Sep 22 2015 In : PLoS One. 10, 9, e0138317

Research output: Contribution to journalArticle

Obese Mice
Nutrition
Diet
Glucose
glucose

Pathway-based genome-wide association studies reveal that the Rac1 pathway is associated with plasma adiponectin levels

Li, W. D., Jiao, H., Wang, K., Yang, F., Grant, S. F. A., Hakonarson, H., Ahima, R. & Price, R. A. Aug 24 2015 In : Scientific Reports. 5, 13422

Research output: Contribution to journalArticle

Genome-Wide Association Study
Adiponectin
Cell Movement
Genes
Single Nucleotide Polymorphism

Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

Park, H. K. & Ahima, R. S. Jan 1 2015 In : Metabolism: clinical and experimental. 64, 1, p. 24-34 11 p.

Research output: Contribution to journalReview article

Leptin
Homeostasis
Congenital Generalized Lipodystrophy
Metabolic Diseases
Amenorrhea
2014

Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice

Carr, R. M., Peralta, G., Yin, X. & Ahima, R. S. May 15 2014 In : PLoS One. 9, 5, e97118

Research output: Contribution to journalArticle

adipophilin
ceramides
Glucose Intolerance
Ceramides
fatty liver

Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice

Roat, R., Rao, V., Doliba, N. M., Matschinsky, F. M., Tobias, J. W., Garcia, E., Ahima, R. S. & Imai, Y. Feb 5 2014 In : PLoS One. 9, 2, e86815

Research output: Contribution to journalArticle

Obese Mice
islets of Langerhans
High Fat Diet
high fat diet
Nutrition

Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action

Bang, S., Chen, Y., Ahima, R. S. & Kim, S. F. 2014 In : Molecular Endocrinology. 28, 7, p. 1186-1193 8 p.

Research output: Contribution to journalArticle

Metformin
AMP-Activated Protein Kinases
Liver
Biguanides
Glucose

Editorial: Molecular obesity research: Lessons learned?

Ahima, R. S. 2014 In : Molecular Endocrinology. 28, 6, p. 785-789 5 p.

Research output: Contribution to journalEditorial

Leptin
Energy Metabolism
Hypothalamus
Obesity
Research

Effect of isolated hyperglycemia on native mechanical and biologic shoulder joint properties in a rat model.

Thomas, S. J., Sarver, J. J., Yannascoli, S. M., Tucker, J. J., Kelly, J. D., Ahima, R. S., Barbe, M. F. & Soslowsky, L. J. 2014 In : Journal of Orthopaedic Research. 32, 11, p. 1464-1470 7 p.

Research output: Contribution to journalArticle

Shoulder Joint
Hyperglycemia
Tendons
Capsules
Mechanics

Leptin signaling

Park, H. K. & Ahima, R. S. 2014 In : F1000Prime Reports. 6, 73

Research output: Contribution to journalReview article

Leptin
Janus Kinase 2
Phosphatidylinositol 3-Kinase
Acetyl-CoA Carboxylase
Protein Phosphatase 2

Pancreatic islet neuropeptide Y overexpression has minimal effect on islet morphology and β-cell adaptation to high-fat diet

Machida, Y., Bruinsma, C., Hallinger, D. R., Roper, S. M., Garcia, E., Trevino, M. B., Nadler, J., Ahima, R. & Imai, Y. Dec 1 2014 In : Endocrinology. 155, 12, p. 4634-4640 7 p.

Research output: Contribution to journalArticle

Neuropeptide Y
High Fat Diet
Islets of Langerhans
Insulin
Diet

Targeting adipose tissue via systemic gene therapy

O'neill, S. M., Hinkle, C., Chen, S. J., Sandhu, A., Hovhannisyan, R., Stephan, S., Lagor, W. R., Ahima, R. S., Johnston, J. C. & Reilly, M. P. 2014 In : Gene Therapy. 21, 7, p. 653-661 9 p.

Research output: Contribution to journalArticle

Genetic Therapy
Adipose Tissue
Dependovirus
Leptin
Reporter Genes
2013

Adiponectin/Resistin

Ahima, R. S. 2013 Handbook of Biologically Active Peptides. Elsevier Inc., p. 1045-1048 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Resistin
Adiponectin

Resistin in Rodents and Humans

Park, H. K. & Ahima, R. S. Dec 2013 In : Diabetes and Metabolism Journal. 37, 6, p. 404-414 11 p.

Research output: Contribution to journalReview article

Resistin
Rodentia
Insulin Resistance
Type 2 Diabetes Mellitus
Atherosclerosis

Systematic review of clinical studies related to pork intake and metabolic syndrome or its components

Stettler, N., Murphy, M. M., Barraj, L. M., Smith, K. M. & Ahima, R. S. Sep 24 2013 In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 6, p. 347-357 11 p.

Research output: Contribution to journalArticle

Meat
Insulin
Eggs
Meals
Glucose

Temporal effects of ethanol consumption on energy homeostasis, hepatic steatosis, and insulin sensitivity in mice

Carr, R. M., Dhir, R., Yin, X., Agarwal, B. & Ahima, R. S. Jul 2013 In : Alcoholism: Clinical and Experimental Research. 37, 7, p. 1091-1099 9 p.

Research output: Contribution to journalArticle

Insulin Resistance
Homeostasis
Ethanol
Insulin
Liver

The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design

Patterson, R. E. , Colditz, G. A. , Hu, F. B. , Schmitz, K. H. , Ahima, R. S. , Brownson, R. C. , Carson, K. R. , Chavarro, J. E. , Chodosh, L. A. , Gehlert, S. , Gill, J. , Glanz, K. , Haire-Joshu, D. , Herbst, K. L. , Hoehner, C. M. , Hovmand, P. S. , Irwin, M. L. , Jacobs, L. A. , James, A. S. , Jones, L. W. & 25 others Kerr, J., Kibel, A. S., King, I. B., Ligibel, J. A., Meyerhardt, J. A., Natarajan, L., Neuhouser, M. L., Olefsky, J. M., Proctor, E. K., Redline, S., Rock, C. L., Rosner, B., Sarwer, D. B., Schwartz, J. S., Sears, D. D., Sesso, H. D., Stampfer, M. J., Subramanian, S. V., Taveras, E. M., Tchou, J., Thompson, B., Troxel, A. B., Wessling-Resnick, M., Wolin, K. Y. & Thornquist, M. D. Apr 2013 In : Cancer Causes and Control. 24, 4, p. 695-704 10 p.

Research output: Contribution to journalArticle

Research
Neoplasms
Organized Financing
Exercise
Survivors

The health risk of obesity - Better metrics imperative

Ahima, R. S. & Lazar, M. A. 2013 In : Science. 341, 6148, p. 856-858 3 p.

Research output: Contribution to journalReview article

Obesity
Mortality
Health
2012

Alteration of hypothalamic cellular dynamics in obesity

Lee, E. B. & Ahima, R. S. Jan 3 2012 In : Journal of Clinical Investigation. 122, 1, p. 22-25 4 p.

Research output: Contribution to journalComment/debate

Obesity
Hypothalamus
Aptitude
Neurogenesis
Brain

Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression

Imai, Y., Boyle, S., Varela, G. M., Caron, E., Yin, X., Dhir, R., Dhir, R., Graham, M. J. & Ahima, R. S. Nov 15 2012 In : Physiological Genomics. 44, 22, p. 1125-1131 7 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Lipid Metabolism
Gene Expression
Liver
High Fat Diet

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Sun, Z., Miller, R. A., Patel, R. T., Chen, J., Dhir, R., Wang, H., Zhang, D., Graham, M. J., Unterman, T. G., Shulman, G. I., Sztalryd, C., Bennett, M. J., Ahima, R. S., Birnbaum, M. J. & Lazar, M. A. Jun 2012 In : Nature Medicine. 18, 6, p. 934-942 9 p.

Research output: Contribution to journalArticle

Gluconeogenesis
Lipids
Liver
Insulin
Insulin Resistance

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

Lu, M., Wan, M., Leavens, K. F., Chu, Q., Monks, B. R., Fernandez, S., Ahima, R. S., Ueki, K., Kahn, C. R. & Birnbaum, M. J. Mar 2012 In : Nature Medicine. 18, 3, p. 388-395 8 p.

Research output: Contribution to journalArticle

Metabolism
Liver
Insulin
Gene expression
Nutrients

Maternal obesity associated with inflammation in their children

Leibowitz, K. L., Moore, R. H., Ahima, R. S., Stunkard, A. J., Stallings, V. A., Berkowitz, R. I., Chittams, J. L., Faith, M. S. & Stettler, N. Feb 2012 In : World Journal of Pediatrics. 8, 1, p. 76-79 4 p.

Research output: Contribution to journalArticle

C-Reactive Protein
Obesity
Mothers
Inflammation
Pregnancy

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

Lamming, D. W., Ye, L., Katajisto, P., Goncalves, M. D., Saitoh, M., Stevens, D. M., Davis, J. G., Salmon, A. B., Richardson, A., Ahima, R. S., Guertin, D. A., Sabatini, D. M. & Baur, J. A. Mar 30 2012 In : Science. 335, 6076, p. 1638-1643 6 p.

Research output: Contribution to journalArticle

Sirolimus
Insulin Resistance
Glucose
Insulin
Gluconeogenesis

Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice

Carr, R. M., Patel, R. T., Rao, V., Dhir, R., Graham, M. J., Crooke, R. M. & Ahima, R. S. Apr 15 2012 In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 302, 8

Research output: Contribution to journalArticle

Homeostasis
Glucose
Antisense Oligonucleotides
Liver
Adipocytes
2011

Adipokines in health and disease

Ahima, R. S. & Goncalves, M. D. 2011 Metabolic Basis of Obesity. Springer New York, p. 69-88 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Adipokines
Obesity
Health
Body Mass Index
Pediatric Obesity

Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling

Miller, R. A., Chu, Q., Le Lay, J., Scherer, P. E., Ahima, R. S., Kaestner, K. H., Foretz, M., Viollet, B. & Birnbaum, M. J. Jun 1 2011 In : Journal of Clinical Investigation. 121, 6, p. 2518-2528 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Adiponectin
Hepatocytes
Gene Expression
Glucose

Bariatric surgery: Metabolic benefits beyond weight loss

Ahima, R. S. & Sabri, A. Sep 2011 In : Gastroenterology. 141, 3, p. 793-795 3 p.

Research output: Contribution to journalReview article

Postprandial Period
Bariatric Surgery
Gastric Bypass
Gastrectomy
Intestines

Biology of adipose tissue

Collins, S., Ahima, R. S. & Kahn, B. B. Nov 3 2011 Joslin's Diabetes Mellitus: Fourteenth Edition. Wolters Kluwer Health Adis (ESP), p. 207-226 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Adipose Tissue

Classical hormones linked to obesity

Park, H. K. & Ahima, R. S. 2011 Metabolic Basis of Obesity. Springer New York, p. 139-154 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Polycystic Ovary Syndrome
Abdominal Obesity
Cushing Syndrome
Obesity
Hyperinsulinism

Digging deeper into obesity

Ahima, R. S. Jun 1 2011 In : Journal of Clinical Investigation. 121, 6, p. 2076-2079 4 p.

Research output: Contribution to journalReview article

Obesity
Sleep Apnea Syndromes
Weight Loss
Heart Diseases
Pharmacology

Estrogen sulfotransferase is expressed in subcutaneous adipose tissue of obese humans in association with TNF-α and SOCS3

Ahima, R. S., Stanley, T. L., Khor, V. K., Zanni, M. V. & Grinspoon, S. K. Jul 1 2011 In : Journal of Clinical Endocrinology and Metabolism. 96, 7

Research output: Contribution to journalArticle

Subcutaneous Fat
Tumor Necrosis Factor-alpha
Association reactions
Tissue
Cytokines

Fractalkine is a novel human adipochemokine associated with type 2 diabetes

Shah, R., Hinkle, C. C., Ferguson, J. F., Mehta, N. N., Li, M., Qu, L., Lu, Y., Putt, M. E., Ahima, R. S. & Reilly, M. P. May 2011 In : Diabetes. 60, 5, p. 1512-1518 7 p.

Research output: Contribution to journalArticle

Chemokine CX3CL1
Adipocytes
Type 2 Diabetes Mellitus
Monocytes
Endotoxemia