Ray-Whay Yen

2024

Tissue-location-specific transcription programs drive tumor dependencies in colon cancer

Yang, L., Tu, L., Bisht, S., Mao, Y., Petkovich, D., Thursby, S. J., Liang, J., Patel, N., Yen, R. W. C., Largent, T., Zahnow, C., Brock, M., Gabrielson, K., Salimian, K. J., Baylin, S. B. & Easwaran, H., Dec 2024, In: Nature communications. 15, 1, 1384.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Epigenetic therapy inhibits metastases by disrupting premetastatic niches

Lu, Z., Zou, J., Li, S., Topper, M. J., Tao, Y., Zhang, H., Jiao, X., Xie, W., Kong, X., Vaz, M., Li, H., Cai, Y., Xia, L., Huang, P., Rodgers, K., Lee, B., Riemer, J. B., Day, C. P., Yen, R. W. C., Cui, Y., & 28 othersWang, Y., Wang, Y., Zhang, W., Easwaran, H., Hulbert, A., Kim, K. B., Juergens, R. A., Yang, S. C., Battafarano, R. J., Bush, E. L., Broderick, S. R., Cattaneo, S. M., Brahmer, J. R., Rudin, C. M., Wrangle, J., Mei, Y., Kim, Y. J., Zhang, B., Wang, K. K. H., Forde, P. M., Margolick, J. B., Nelkin, B. D., Zahnow, C. A., Pardoll, D. M., Housseau, F., Baylin, S. B., Shen, L. & Brock, M. V., Mar 12 2020, In: Nature. 579, 7798, p. 284-290 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency

McLaughlin, L. J., Stojanovic, L., Kogan, A. A., Rutherford, J. L., Choi, E. Y., Yen, R. W. C., Xia, L., Zou, Y., Lapidus, R. G., Baylin, S. B., Topper, M. J. & Rassool, F. V., Jul 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17785-17795 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2019

Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf^V600E-Induced Tumorigenesis

Tao, Y., Kang, B., Petkovich, D. A., Bhandari, Y. R., In, J., Stein-O'Brien, G., Kong, X., Xie, W., Zachos, N., Maegawa, S., Vaidya, H., Brown, S., Chiu Yen, R. W., Shao, X., Thakor, J., Lu, Z., Cai, Y., Zhang, Y., Mallona, I., Peinado, M. A., & 6 othersZahnow, C. A., Ahuja, N., Fertig, E., Issa, J. P., Baylin, S. B. & Easwaran, H., Feb 11 2019, In: Cancer cell. 35, 2, p. 315-328.e6

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

Kong, X., Chen, J., Xie, W., Brown, S. M., Cai, Y., Wu, K., Fan, D., Nie, Y., Yegnasubramanian, S., Tiedemann, R. L., Tao, Y., Chiu Yen, R. W., Topper, M. J., Zahnow, C. A., Easwaran, H., Rothbart, S. B., Xia, L. & Baylin, S. B., Apr 15 2019, In: Cancer cell. 35, 4, p. 633-648.e7

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

2018

DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk

Xie, W., Kagiampakis, I., Pan, L., Zhang, Y. W., Murphy, L., Tao, Y., Kong, X., Kang, B., Xia, L., Carvalho, F. L. F., Sen, S., Chiu Yen, R. W., Zahnow, C. A., Ahuja, N., Baylin, S. B. & Easwaran, H., Feb 12 2018, In: Cancer cell. 33, 2, p. 309-321.e5

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

2017

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

Zhang, Y. W., Wang, Z., Xie, W., Cai, Y., Xia, L., Easwaran, H., Luo, J., Yen, R. W. C., Li, Y. & Baylin, S. B., Jan 19 2017, In: Molecular cell. 65, 2, p. 323-335 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes

Xia, L., Huang, W., Bellani, M., Seidman, M. M., Wu, K., Fan, D., Nie, Y., Cai, Y., Zhang, Y. W., Yu, L. R., Li, H., Zahnow, C. A., Xie, W., Chiu Yen, R. W., Rassool, F. V. & Baylin, S. B., May 8 2017, In: Cancer cell. 31, 5, p. 653-668.e7

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells

Cai, Y., Tsai, H. C., Yen, R. W. C., Zhang, Y. W., Kong, X., Wang, W., Xia, L. & Baylin, S. B., Apr 2017, In: Genome research. 27, 4, p. 533-544 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

Topper, M. J., Vaz, M., Chiappinelli, K. B., DeStefano Shields, C. E., Niknafs, N., Yen, R. W. C., Wenzel, A., Hicks, J., Ballew, M., Stone, M., Tran, P. T., Zahnow, C. A., Hellmann, M. D., Anagnostou, V., Strissel, P. L., Strick, R., Velculescu, V. E. & Baylin, S. B., Nov 30 2017, In: Cell. 171, 6, p. 1284-1300.e21

Research output: Contribution to journal › Article › peer-review

Open Access

153 Scopus citations

2014

Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers

Li, H., Chiappinelli, K. B., Guzzetta, A. A., Easwaran, H., Yen, R. W. C., Vatapalli, R., Topper, M. J., Luo, J., Connolly, R. M., Azad, N. S., Stearns, V., Pardoll, D. M., Davidson, N., Jones, P. A., Slamon, D. J., Baylin, S. B., Zahnow, C. A. & Ahuja, N., 2014, In: Oncotarget. 5, 3, p. 587-598 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

250 Scopus citations

2013

Alterations of immune response of non-small cell lung cancer with Azacytidine

Wrangle, J., Wang, W., Koch, A., Easwaran, H., Mohammad, H. P., Vendetti, F., VanCriekinge, W., DeMeyer, T., Du, Z., Parsana, P., Rodgers, K., Yen, R. W., Zahnow, C. A., Taube, J. M., Brahmer, J. R., Tykodi, S. S., Easton, K., Carvajal, R. D., Jones, P. A., Laird, P. W., & 8 othersWeisenberger, D. J., Tsai, S., Juergens, R. A., Topalian, S. L., Rudin, C. M., Brock, M. V., Pardoll, D. & Baylin, S. B., Nov 2013, In: Oncotarget. 4, 11, p. 2067-2079 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

260 Scopus citations

2012

Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells

Tsai, H. C., Li, H., Van Neste, L., Cai, Y., Robert, C., Rassool, F. V., Shin, J. J., Harbom, K. M., Beaty, R., Pappou, E., Harris, J., Yen, R. W. C., Ahuja, N., Brock, M. V., Stearns, V., Feller-Kopman, D., Yarmus, L. B., Lin, Y. C., Welm, A. L., Issa, J. P., & 6 othersMinn, I., Matsui, W., Jang, Y. Y., Sharkis, S. J., Baylin, S. B. & Zahnow, C. A., Mar 20 2012, In: Cancer cell. 21, 3, p. 430-446 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

407 Scopus citations

2010

A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1

Zhang, W., Zeng, X., Briggs, K. J., Beaty, R., Simons, B., Chiu Yen, R. W., Tyler, M. A., Tsai, H. C., Ye, Y., Gesell, G. S., Herman, J. G., Baylin, S. B. & Watkins, D. N., Apr 2010, In: Oncogene. 29, 17, p. 2467-2476 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

2006

De novo CpG island methylation in human cancer cells

Jair, K. W., Bachman, K. E., Suzuki, H., Ting, A. H., Rhee, I., Yen, R. W. C., Baylin, S. B. & Schuebel, K. E., Jan 15 2006, In: Cancer Research. 66, 2, p. 682-692 11 p.

Research output: Contribution to journal › Article › peer-review

165 Scopus citations

2005

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

Wen, Y. C., Wang, D. H., RayWhay, C. Y., Luo, J., Gu, W. & Baylin, S. B., Nov 4 2005, In: Cell. 123, 3, p. 437-448 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

494 Scopus citations

2004

CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1

Ting, A. H., Jair, K. W., Suzuki, H., Yen, R. W. C., Baylin, S. B. & Schuebel, K. E., Jun 2004, In: Nature genetics. 36, 6, p. 582-584 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

Mammalian DNA methyltransferase 1: Inspiration for new directions

Ting, A. H., Jair, K. W., Suzuki, H., Yen, R. W. C., Baylin, S. B. & Schuebel, K. E., Aug 2004, In: Cell Cycle. 3, 8, p. 1022-1024 3 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

26 Scopus citations

2003

Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors

Chen, W. Y., Zeng, X., Carter, M. G., Morrell, C. N., Chiu Yen, R. W., Esteller, M., Watkins, D. N., Herman, J. G., Mankowski, J. L. & Baylin, S. B., Feb 1 2003, In: Nature genetics. 33, 2, p. 197-202 6 p.

Research output: Contribution to journal › Article › peer-review

183 Scopus citations

2002

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

Rhee, I., Bachman, K. E., Park, B. H., Jair, K. W., Yen, R. W. C., Schuebel, K. E., Cui, H., Feinberg, A. P., Lengauer, C., Kinzler, K. W., Baylin, S. B. & Vogelstein, B., Apr 8 2002, In: Nature. 416, 6880, p. 552-556 5 p.

Research output: Contribution to journal › Article › peer-review

976 Scopus citations

2000

CpG methylation is maintained in human cancer cells lacking DNMT1

Rhee, I., Jalr, K. W., Yen, R. W. C., Lengauer, C., Herman, J. G., Kinzler, K. W., Vogelstein, B., Baylin, S. B. & Schuebel, K. E., Apr 27 2000, In: Nature. 404, 6781, p. 1003-1007 5 p.

Research output: Contribution to journal › Article › peer-review

350 Scopus citations

1996

De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase

Vertino, P. M., Yen, R. W. C., Gao, J. & Baylin, S. B., 1996, In: Molecular and cellular biology. 16, 8, p. 4555-4565 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

237 Scopus citations

Expression of prokaryotic HhaI DNA methyltransferase is transforming and lethal to NIH 3T3 cells

Wu, J., Herman, J. G., Wilson, G., Lee, R. Y., Yen, R. W. C., Mabry, M., De Bustros, A., Nelkin, B. D. & Baylin, S. B., Feb 1 1996, In: Cancer Research. 56, 3, p. 616-622 7 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

New 5' regions of the murine and human genes for DNA (cytosine-5)- methyltransferase

Yoder, J. A., Yen, R. W. C., Vertino, P. M., Bestor, T. H. & Baylin, S. B., 1996, In: Journal of Biological Chemistry. 271, 49, p. 31092-31097 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

1992

Isolation and characterization of the cDNA encoding human DNA methyltransferase

Yen, R. W. C., Vertino, P. M., Nelkin, B. D., Yu, J. J., El-deiry, W., Cumaraswamy, A., Lennon, G. G., Trask, B. J., Celano, P. & Baylin, S. B., May 11 1992, In: Nucleic acids research. 20, 9, p. 2287-2291 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

199 Scopus citations

1991

Abnormal patterns of DNA methylation in human neoplasia: Potential consequences for tumor progression

Baylin, S. B., Makos, M., Wu, J., Yen, R. W. C., De Bustros, A., Vertino, P. & Nelkin, B. D., 1991, In: Cancer Cells. 3, 10, p. 383-390 8 p.

Research output: Contribution to journal › Review article › peer-review

214 Scopus citations

High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer

El-Deiry, W. S., Nelkin, B. D., Celano, P., Yen, R. W. C., Falco, J. P., Hamilton, S. R. & Baylin, S. B., 1991, In: Proceedings of the National Academy of Sciences of the United States of America. 88, 8, p. 3470-3474 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

287 Scopus citations

1989

Differentiation of Human Variant Small Cell Lung Cancer Cell Lines to a Classic Morphology by Retinoic Acid

Doyle, L. A., Giangiulo, D., Hussaii, A., Park, H. J., Yen, R. W. C. & Borges, M., Dec 1 1989, In: Cancer Research. 49, 23, p. 6745-6751 7 p.

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Potentiation of Interferon Induction of Class I Major Histocompatibility Complex Antigen Expression by Human Tumor Necrosis Factor in Small Cell Lung Cancer Cell Lines

Marley, G. M., Doyle, L. A., Ordóñez, J. V., Sisk, A., Hussain, A. & Yen, R. W. C., May 15 1989, In: Cancer Research. 49, 22, p. 6232-6236 5 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

1985

Characterization of differentiation-inducer-resistant HL-60 cells

Gallagher, R. E., Bilello, P. A., Ferrari, A. C., Chang, C. S., Yen, R. W. C., Nickols, W. A. & Muly, E. C., 1985, In: Leukemia Research. 9, 8, p. 967-975,977-986

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

1984

Cytotoxic and Cytodifferentiative Components of 6-Thioguanine Resistance in HL-60 Cells Containing Acquired Double Minute Chromosomes

Gallagher, R. E., Ferrari, A. C., Zulich, A. W., Yen, R. W. C. & Testa, J. R., Jun 1 1984, In: Cancer Research. 44, 6, p. 2642-2653 12 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Ray-Whay Yen

Research output

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