Rana Rais

Assistant Professor

20082019
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Research Output 2008 2019

2019

A novel and potent brain penetrant inhibitor of extracellular vesicle release

Rojas, C., Sala, M., Thomas, A. G., Datta Chaudhuri, A., Yoo, S. W., Li, Z., Dash, R. P., Rais, R., Haughey, N., Nencka, R. & Slusher, B., Jan 1 2019, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase
Brain
Astrocytes
Animal Disease Models
Carbamates

Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b + cells and prevents depression-associated behaviors induced by chronic social defeat stress (Neuropsychopharmacology, (2019), 44, 4, (683-694), 10.1038/s41386-018-0177-7)

Zhu, X., Nedelcovych, M. T., Thomas, A. G., Hasegawa, Y., Moreno-Megui, A., Coomer, W., Vohra, V., Saito, A., Perez, G., Wu, Y., Alt, J., Prchalova, E., Tenora, L., Majer, P., Rais, R., Rojas, C., Slusher, B. & Kamiya, A., Jan 1 2019, In : Neuropsychopharmacology.

Research output: Contribution to journalComment/debate

Open Access
Glutaminase
Manuscripts
Brain

DCC-related developmental effects of abused- versus therapeutic-like amphetamine doses in adolescence

Cuesta, S., Restrepo-Lozano, J. M., Popescu, C., He, S., Reynolds, L. M., Israel, S., Hernandez, G., Rais, R., Slusher, B. & Flores, C., Jan 1 2019, In : Addiction Biology. e12791.

Research output: Contribution to journalArticle

Amphetamine
MicroRNAs
Dopamine
Therapeutics
Down-Regulation

Discovery of Benzamidine- And 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists

Prchalová, E., Hin, N., Thomas, A. G., Veeravalli, V., Ng, J., Alt, J., Rais, R., Rojas, C., Li, Z., Hihara, H., Aoki, M., Yoshizawa, K., Nishioka, T., Suzuki, S., Kopajtic, T., Chatrath, S., Liu, Q., Dong, X., Slusher, B. S. & Tsukamoto, T., Sep 26 2019, In : Journal of medicinal chemistry. 62, 18, p. 8631-8641 11 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
HEK293 Cells
Opioid Receptors
Sensory Receptor Cells
Analgesics

Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs

Dash, R. P., Tichý, T., Veeravalli, V., Lam, J., Alt, J., Wu, Y., Tenora, L., Majer, P., Slusher, B. & Rais, R., Oct 7 2019, In : Molecular Pharmaceutics. 16, 10, p. 4292-4301 10 p.

Research output: Contribution to journalArticle

Prodrugs
Biological Availability
2-(phosphonomethyl)pentanedioic acid
Glutamate Carboxypeptidase II
Pharmacokinetics

Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders

Nedelcovych, M. T., Kim, B. H., Zhu, X., Lovell, L. E., Manning, A. A., Kelschenbach, J., Hadas, E., Chao, W., Prchalová, E., Dash, R. P., Wu, Y., Alt, J., Thomas, A. G., Rais, R., Kamiya, A., Volsky, D. J. & Slusher, B., Jan 1 2019, In : Journal of Neuroimmune Pharmacology.

Research output: Contribution to journalArticle

Glutaminase
Glutamine
Norleucine
Glutamic Acid
HIV

Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice

Kim, B. H., Kelschenbach, J., Borjabad, A., Hadas, E., He, H., Potash, M. J., Nedelcovych, M. T., Rais, R., Haughey, N., McArthur, J. C., Slusher, B. & Volsky, D. J., May 1 2019, In : AIDS (London, England). 33, 6, p. 973-984 12 p.

Research output: Contribution to journalArticle

HIV
Insulin
Wounds and Injuries
Intranasal Administration
Therapeutics

Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold

Stepanek, O., Hin, N., Thomas, A. G., Dash, R. P., Alt, J., Rais, R., Rojas, C., Slusher, B. & Tsukamoto, T., May 15 2019, In : European Journal of Medicinal Chemistry. 170, p. 276-289 14 p.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase
Scaffolds
Metabolism
Plasmas
Ceramides

Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma

Hanaford, A. R., Alt, J., Rais, R., Wang, S. Z., Kaur, H., Thorek, D. L. J., Eberhart, C. G., Slusher, B., Martin, A. & Raabe, E., Oct 1 2019, In : Translational Oncology. 12, 10, p. 1314-1322 9 p.

Research output: Contribution to journalArticle

Open Access
Medulloblastoma
Prodrugs
Glutamine
Brain
Growth

Return to articles asapprevarticlenext investigation of novel primary and secondary pharmacophores and 3-substitution in the linking chain of a series of highly selective and bitopic dopamine d3 receptor antagonists and partial agonists

Shaik, A. B., Kumar, V., Bonifazi, A., Guerrero, A. M., Cemaj, S. L., Gadiano, A., Lam, J., Xi, Z. X., Rais, R., Slusher, B. S. & Newman, A. H., Jan 1 2019, (Accepted/In press) In : Journal of medicinal chemistry.

Research output: Contribution to journalArticle

Metabolome
Dopamine Antagonists
Opioid Analgesics
Substance-Related Disorders
Dopamine

The highly selective dopamine D3R antagonist, R-VK4-40 attenuates oxycodone reward and augments analgesia in rodents

Jordan, C. J., Humburg, B., Rice, M., Bi, G. H., You, Z. B., Shaik, A. B., Cao, J., Bonifazi, A., Gadiano, A., Rais, R., Slusher, B., Newman, A. H. & Xi, Z. X., Nov 1 2019, In : Neuropharmacology. 158, 107597.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Oxycodone
Dopamine Antagonists
Reward
Analgesia

The NAAG'ing Concerns of Modeling Human Alzheimer's Disease in Mice

Hollinger, K., Alt, J., Rais, R., Kaplin, A. I. & Slusher, B., Jan 1 2019, In : Journal of Alzheimer's Disease. 68, 3, p. 939-945 7 p.

Research output: Contribution to journalArticle

Glutamate Carboxypeptidase II
Glutamic Acid
Alzheimer Disease
Brain
Neurodegenerative Diseases

The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D3 Receptor (D3R) Selective Agonists

Battiti, F. O., Cemaj, S. L., Guerrero, A. M., Shaik, A. B., Lam, J., Rais, R., Slusher, B., Deschamps, J. R., Imler, G. H., Newman, A. H. & Bonifazi, A., Jun 19 2019, In : Journal of medicinal chemistry. 62, 13, p. 6287-6314 28 p.

Research output: Contribution to journalArticle

Drug Design
Ligands
Dopamine D2 Receptors
Liver Microsomes
Dopamine

Tumor-Targeted Delivery of 6-Diazo-5-oxo- l -norleucine (DON) Using Substituted Acetylated Lysine Prodrugs

Tenora, L., Alt, J., Dash, R. P., Gadiano, A. J., Novotná, K., Veeravalli, V., Lam, J., Kirkpatrick, Q. R., Lemberg, K. M., Majer, P., Rais, R. & Slusher, B., Apr 11 2019, In : Journal of medicinal chemistry. 62, 7, p. 3524-3538 15 p.

Research output: Contribution to journalArticle

Diazooxonorleucine
Prodrugs
Lysine
Neoplasms
Glutamine
2018

Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats

Tunstall, B. J., Ho, C. P., Cao, J., Vendruscolo, J. C. M., Schmeichel, B. E., Slack, R. D., Tanda, G., Gadiano, A. J., Rais, R., Slusher, B., Koob, G. F., Newman, A. H. & Vendruscolo, L. F., Mar 15 2018, In : Neuropharmacology. 131, p. 96-103 8 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Self Administration
Methamphetamine
Pharmaceutical Preparations
Wakefulness-Promoting Agents

Chirality and neuropsychiatric drugs: an update on stereoselective disposition and clinical pharmacokinetics of bupropion

Dash, R. P., Rais, R. & Srinivas, N. R., Sep 2 2018, In : Xenobiotica. 48, 9, p. 945-957 13 p.

Research output: Contribution to journalReview article

Bupropion
Pharmacokinetics
Chirality
Pharmaceutical Preparations
Metabolites

Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects

You, Z. B., Bi, G. H., Galaj, E., Kumar, V., Cao, J., Gadiano, A., Rais, R., Slusher, B., Gardner, E. L., Xi, Z. X. & Newman, A. H., Jan 1 2018, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Oxycodone
Self Administration
Dopamine Antagonists
Opioid Analgesics

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

Rojas, C., Barnaeva, E., Thomas, A. G., Hu, X., Southall, N., Marugan, J., Chaudhuri, A. D., Yoo, S. W., Hin, N., Stepanek, O., Wu, Y., Zimmermann, S. C., Gadiano, A. G., Tsukamoto, T., Rais, R., Haughey, N., Ferrer, M. & Slusher, B., Dec 1 2018, In : Scientific Reports. 8, 1, 17715.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase
Encephalitis
Astrocytes
Communication
Brain

Ghrelin agonist HM01 attenuates chemotherapy-induced neurotoxicity in rodent models

Chiorazzi, A., Wozniak, K. M., Rais, R., Wu, Y., Gadiano, A. J., Farah, M. H., Liu, Y., Canta, A., Alberti, P., Rodriguez-Menendez, V., Meregalli, C., Fumagalli, G., Monza, L., Pozzi, E., Vornov, J. J., Polydefkis, M. J., Pietra, C., Slusher, B. & Cavaletti, G., Dec 5 2018, In : European Journal of Pharmacology. 840, p. 89-103 15 p.

Research output: Contribution to journalArticle

oxaliplatin
Ghrelin
Nerve Fibers
Rodentia
Neural Conduction

Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease

Soomro, I., Sun, Y., Li, Z., Diggs, L., Hatzivassiliou, G., Thomas, A. G., Rais, R., Slusher, B., Somlo, S. & Skolnik, E. Y., Jan 1 2018, In : Nephrology Dialysis Transplantation. 33, 8, p. 1343-1353 11 p.

Research output: Contribution to journalArticle

Glutaminase
Autosomal Dominant Polycystic Kidney
Glutamine
Cysts
Growth

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

Zhu, X., Nedelcovych, M. T., Thomas, A. G., Hasegawa, Y., Moreno-Megui, A., Coomer, W., Vohra, V., Saito, A., Perez, G., Wu, Y., Alt, J., Prchalova, E., Tenora, L., Majer, P., Rais, R., Rojas, C., Slusher, B. & Kamiya, A., Jan 1 2018, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Glutaminase
Major Depressive Disorder
Glutamic Acid
Microglia
Depression

NaV1.1 inhibition can reduce visceral hypersensitivity

Salvatierra, J., Castro, J., Erickson, A., Li, Q., Braz, J., Gilchrist, J., Grundy, L., Rychkov, G. Y., Deiteren, A., Rais, R., King, G. F., Slusher, B., Basbaum, A., Pasricha, P. J., Brierley, S. M. & Bosmans, F., Jun 7 2018, In : JCI insight. 3, 11

Research output: Contribution to journalArticle

Open Access
Chronic Pain
Abdominal Pain
Hypersensitivity
NAV1.1 Voltage-Gated Sodium Channel
Drug Hypersensitivity

N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs

Zimmermann, S. C., Tichý, T., Vávra, J., Dash, R. P., Slusher, C. E., Gadiano, A. J., Wu, Y., Jančařík, A., Tenora, L., Monincová, L., Prchalová, E., Riggins, G. J., Majer, P., Slusher, B. & Rais, R., May 10 2018, In : Journal of Medicinal Chemistry. 61, 9, p. 3918-3929 12 p.

Research output: Contribution to journalArticle

Mebendazole
Prodrugs
Solubility
Biological Availability
Dogs

Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse

Nedelcovych, M. T., Gadiano, A. J., Wu, Y., Manning, A. A., Thomas, A. G., Khuder, S. S., Yoo, S. W., Xu, J., McArthur, J. C., Haughey, N., Volsky, D. J., Rais, R. & Slusher, B., Apr 18 2018, In : ACS Chemical Neuroscience. 9, 4, p. 809-816 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Insulin
Brain
Plasmas
Blood Glucose

Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition

Dash, R. P., Rais, R. & Srinivas, N. R., May 4 2018, In : Xenobiotica. 48, 5, p. 442-451 10 p.

Research output: Contribution to journalReview article

Lysosphingolipid Receptors
Pharmacokinetics
Modulators
Autoimmune Diseases
Pharmaceutical Preparations

Stereoselective and nonstereoselective pharmacokinetics of rabeprazole–an overview

Dash, R. P., Rais, R. & Srinivas, N. R., Apr 3 2018, In : Xenobiotica. 48, 4, p. 422-432 11 p.

Research output: Contribution to journalReview article

Rabeprazole
Pharmacokinetics
Pharmaceutical Preparations
Proton Pump Inhibitors
Enantiomers

Therapeutics discovery: From bench to first in-human trials

Al-Hujaily, E. M., Khatlani, T., Alehaideb, Z., Ali, R., Almuzaini, B., Alrfaei, B. M., Iqbal, J., Islam, I., Malik, S., Marwani, B. A., Massadeh, S., Muzaini, B., Nehdi, A., Alsomaie, B., Debasi, B., Bushnak, I., Noibi, S., Hussain, S., Wajid, W. A., Armand, J. P. & 7 others, Gul, S., Oyarzabal, J., Rais, R., Bountra, C., Alaskar, A., Al Knawy, B. & Boudjelal, M., Mar 1 2018, In : Biomedical Reports. 8, 3, p. 275-282 8 p.

Research output: Contribution to journalArticle

Drug Discovery
Saudi Arabia
Clinical Trials
Clinical Trials, Phase I
Therapeutics

We're not "don" yet: Optimal dosing and prodrug delivery of 6-diazo-5-oxo-L-norleucine

Lemberg, K. M., Vornov, J. J., Rais, R. & Slusher, B., Sep 1 2018, In : Molecular Cancer Therapeutics. 17, 9, p. 1824-1832 9 p.

Research output: Contribution to journalReview article

Diazooxonorleucine
Prodrugs
Glutamine
Neoplasms
Nausea
2017

A review of bioanalytical quantitative methods for selected sphingosine 1-phosphate receptor modulators

Dash, R. P., Srinivas, N. R. & Rais, R., 2017, (Accepted/In press) In : Biomedical Chromatography.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Modulators
Pharmaceutical Preparations
Liquid chromatography
Liquids

Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain

Rais, R., Vávra, J., Tichý, T., Dash, R. P., Gadiano, A. J., Tenora, L., Monincová, L., Bařinka, C., Alt, J., Zimmermann, S. C., Slusher, C. E., Wu, Y., Wozniak, K., Majer, P., Tsukamoto, T. & Slusher, B., Sep 28 2017, In : Journal of Medicinal Chemistry. 60, 18, p. 7799-7809 11 p.

Research output: Contribution to journalArticle

Glutamate Carboxypeptidase II
Prodrugs
Neuralgia
Esters
Benzoic Acid

Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs

Nedelcovych, M., Dash, R. P., Tenora, L., Zimmermann, S. C., Gadiano, A. J., Garrett, C., Alt, J., Hollinger, K., Pommier, E., Jančařík, A., Rojas, C., Thomas, A. G., Wu, Y., Wozniak, K., Majer, P., Slusher, B. & Rais, R., Oct 2 2017, In : Molecular Pharmaceutics. 14, 10, p. 3248-3257 10 p.

Research output: Contribution to journalArticle

Intranasal Administration
Prodrugs
Esters
Brain
Glutamate Carboxypeptidase II

Key Pharmacokinetic Essentials of Fixed-Dosed Combination Products: Case Studies and Perspectives

Dash, R. P., Rais, R. & Srinivas, N. R., Aug 8 2017, (Accepted/In press) In : Clinical Pharmacokinetics. p. 1-8 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Patient Compliance
Pharmaceutical Preparations
Therapeutics

N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo- l -norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders

Nedelcovych, M. T., Tenora, L., Kim, B. H., Kelschenbach, J., Chao, W., Hadas, E., Jančařík, A., Prchalová, E., Zimmermann, S. C., Dash, R. P., Gadiano, A. J., Garrett, C., Furtmüller, G., Oh, B. C., Brandacher, G., Alt, J., Majer, P., Volsky, D. J., Rais, R. & Slusher, B., Aug 24 2017, In : Journal of Medicinal Chemistry. 60, 16, p. 7136-7198 63 p.

Research output: Contribution to journalArticle

Diazooxonorleucine
Prodrugs
Glutamine
HIV
Swine
Pharmacokinetics
Brain
norbuprenorphine

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders

Zou, M. F., Cao, J., Abramyan, A. M., Kopajtic, T., Zanettini, C., Guthrie, D. A., Rais, R., Slusher, B., Shi, L., Loland, C. J. & Newman, A. H., Dec 28 2017, In : Journal of Medicinal Chemistry. 60, 24, p. 10172-10187 16 p.

Research output: Contribution to journalArticle

Tropanes
Dopamine Plasma Membrane Transport Proteins
Structure-Activity Relationship
Cocaine
Therapeutics
2016

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., Neisser, M., Nguyen, C., Lee, R., Park, J. K., Reyes, J., Hartung, T., Rojas, C., Rais, R., Tsukamoto, T., Semenza, G. L. & 3 others, Hanes, J. S., Slusher, B. & Le Thi, Q. H., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. E5328-E5336

Research output: Contribution to journalArticle

Glutaminase
Metformin
Pancreatic Neoplasms
Nanoparticles
Neoplasms

D-amino-acid oxidase inhibition increases D-serine plasma levels in mouse but not in monkey or dog

Rojas, C., Alt, J., Ator, N. A., Thomas, A. G., Wu, Y., Hin, N., Wozniak, K., Ferraris, D., Rais, R., Tsukamoto, T. & Slusher, B., May 1 2016, In : Neuropsychopharmacology. 41, 6, p. 1610-1619 10 p.

Research output: Contribution to journalArticle

D-Amino-Acid Oxidase
Serine
Haplorhini
Dogs
Rodentia

D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold

Hin, N., Duvall, B., Berry, J. F., Ferraris, D. V., Rais, R., Alt, J., Rojas, C., Slusher, B. & Tsukamoto, T., Apr 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 8, p. 2088-2091 4 p.

Research output: Contribution to journalArticle

D-Amino-Acid Oxidase
Scaffolds
Serine
Oxidoreductases
Derivatives

Discovery of 6-Diazo-5-oxo- l -norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

Rais, R., Jančařík, A., Tenora, L., Nedelcovych, M., Alt, J., Englert, J., Rojas, C., Le Thi, Q. H., Elgogary, A., Tan, J., Monincová, L., Pate, K., Adams, R. J., Ferraris, D., Powell, J., Majer, P. & Slusher, B., Sep 22 2016, In : Journal of Medicinal Chemistry. 59, 18, p. 8621-8633 13 p.

Research output: Contribution to journalArticle

Diazooxonorleucine
Prodrugs
Glioblastoma
Haplorhini
Glutamine

Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA)

Majer, P., Jančařík, A., Krečmerová, M., Tichý, T., Tenora, L., Wozniak, K., Wu, Y., Pommier, E., Ferraris, D., Rais, R. & Slusher, B., Mar 24 2016, In : Journal of Medicinal Chemistry. 59, 6, p. 2810-2819 10 p.

Research output: Contribution to journalArticle

Glutamate Carboxypeptidase II
Organophosphonates
Prodrugs
Acids
Neurological Models

Highly selective dopamine D3 receptor (D3R) antagonists and partial agonists based on eticlopride and the D3R crystal structure: New leads for opioid dependence treatment

Kumar, V., Bonifazi, A., Ellenberger, M. P., Keck, T. M., Pommier, E., Rais, R., Slusher, B., Gardner, E., You, Z. B., Xi, Z. X. & Newman, A. H., Aug 25 2016, In : Journal of Medicinal Chemistry. 59, 16, p. 7634-7650 17 p.

Research output: Contribution to journalArticle

eticlopride
Dopamine D3 Receptors
Oxycodone
Dopamine Antagonists
Opioid Analgesics

Local enema treatment to inhibit FOLH1/GCPII as a novel therapy for inflammatory bowel disease

Date, A. A., Rais, R., Babu, T., Ortiz, J., Kanvinde, P., Thomas, A. G., Zimmermann, S. C., Gadiano, A. J., Halpert, G., Slusher, B. & Ensign-Hodges, L., Nov 24 2016, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

Enema
Inflammatory Bowel Diseases
Colitis
Therapeutics
2-(phosphonomethyl)pentanedioic acid

Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors

Cao, J., Slack, R. D., Bakare, O. M., Burzynski, C., Rais, R., Slusher, B., Kopajtic, T., Bonifazi, A., Ellenberger, M. P., Yano, H., He, Y., Bi, G. H., Xi, Z. X., Loland, C. J. & Newman, A. H., Dec 8 2016, In : Journal of Medicinal Chemistry. 59, 23, p. 10676-10691 16 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
sulfoxide
Piperazines
Cocaine-Related Disorders
Methamphetamine
D-Amino-Acid Oxidase
Alanine
Haplorhini
Oral Administration
Cerebrospinal Fluid

Property-Guided Synthesis of Aza-Tricyclic Indolines: Development of Gold Catalysis En Route

Barbour, P. M., Wang, W., Chang, L., Pickard, K. L., Rais, R., Slusher, B. & Wang, X., 2016, (Accepted/In press) In : Advanced Synthesis and Catalysis.

Research output: Contribution to journalArticle

Antibiotics
Gold
Catalysis
Methicillin
Anti-Bacterial Agents

Still NAAG'ing After All These Years: The Continuing Pursuit of GCPII Inhibitors

Vornov, J. J., Hollinger, K., Jackson, P. F., Wozniak, K. M., Farah, M. H., Majer, P., Rais, R. & Slusher, B., 2016, (Accepted/In press) In : Advances in Pharmacology.

Research output: Contribution to journalArticle

Glutamate Carboxypeptidase II
N-Methyl-D-Aspartate Receptors
Neurotransmitter Agents
Glutamic Acid
Presynaptic Receptors

Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity

Novakova, Z., Wozniak, K., Jancarik, A., Rais, R., Wu, Y., Pavlicek, J., Ferraris, D., Havlinova, B., Ptacek, J., Vavra, J., Hin, N., Rojas, C., Majer, P., Slusher, B., Tsukamoto, T. & Barinka, C., May 26 2016, In : Journal of Medicinal Chemistry. 59, 10, p. 4539-4550 12 p.

Research output: Contribution to journalArticle

Glutamate Carboxypeptidase II
Glutarates
Hydroxamic Acids
Neuralgia
Structure-Activity Relationship
2015

6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel d -Amino Acid Oxidase Inhibitors

Hin, N., Duvall, B., Ferraris, D., Alt, J., Thomas, A. G., Rais, R., Rojas, C., Wu, Y., Wozniak, K. M., Slusher, B. & Tsukamoto, T., Sep 24 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7258-7272 15 p.

Research output: Contribution to journalArticle

Serine
Oxidoreductases
Amino Acids
Inhibitory Concentration 50
Oral Administration

Gastrointestinal delivery of propofol from fospropofol: Its bioavailability and activity in rodents and human volunteers

Wozniak, K. M., Vornov, J. J., Mistry, B. M., Wu, Y., Rais, R. & Slusher, B., May 29 2015, In : Journal of Translational Medicine. 13, 1, 170.

Research output: Contribution to journalArticle

Propofol
Biological Availability
Volunteers
Rodentia
Pharmacokinetics

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice

Boateng, C. A., Bakare, O. M., Zhan, J., Banala, A. K., Burzynski, C., Pommier, E., Keck, T. M., Donthamsetti, P., Javitch, J. A., Rais, R., Slusher, B., Xi, Z. X. & Newman, A. H., Jul 23 2015, In : Journal of Medicinal Chemistry. 58, 15, p. 6195-6213 19 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Self Administration
Heroin
Knockout Mice
Substance-Related Disorders