Ralph H Hruban

Professor

1984 …2020

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2020

Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation

Park, S., Chu, L. C., Fishman, E. K., Yuille, A. L., Vogelstein, B., Kinzler, K. W., Horton, K. M., Hruban, R. H., Zinreich, E. S., Fadaei Fouladi, D., Shayesteh, S., Graves, J. & Kawamoto, S., Jan 2020, In : Diagnostic and Interventional Imaging. 101, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

A semicentennial of pancreatic pathology: the genetic revolution is here, but don't throw the baby out with the bath water!

Hruban, R. H., Klimstra, D. S., Zamboni, G. & Klöppel, G., Jan 2020, In : Human pathology. 95, p. 99-112 14 p.

Research output: Contribution to journalArticle

Assessing aneuploidy with repetitive element sequencing

Douville, C., Cohen, J. D., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Schoen, R. E., Tie, J., Gibbs, P., Goggins, M., Wolfgang, C. L., Wang, T. L., Shih, I. M., Karchin, R., Lennon, A. M., Hruban, R. H., Tomasetti, C., Bettegowda, C., Kinzler, K. W. & 2 others, Papadopoulos, N. & Vogelstein, B., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4858-4863 6 p.

Research output: Contribution to journalArticle

Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

Ardeljan, D., Steranka, J. P., Liu, C., Li, Z., Taylor, M. S., Payer, L. M., Gorbounov, M., Sarnecki, J. S., Deshpande, V., Hruban, R. H., Boeke, J. D., Fenyö, D., Wu, P. H., Smogorzewska, A., Holland, A. J. & Burns, K. H., Feb 1 2020, In : Nature Structural and Molecular Biology. 27, 2, p. 168-178 11 p.

Research output: Contribution to journalArticle

Detection of Circulating Tumor DNA in Patients with Pancreatic Cancer Using Digital Next-Generation Sequencing

Macgregor-Das, A., Yu, J., Tamura, K., Abe, T., Suenaga, M., Shindo, K., Borges, M., Koi, C., Kohi, S., Sadakari, Y., Dal Molin, M., Almario, J. A., Ford, M., Chuidian, M., Burkhart, R., He, J., Hruban, R. H., Eshleman, J. R., Klein, A. P., Wolfgang, C. L. & 2 others, Canto, M. I. & Goggins, M., Jun 2020, In : Journal of Molecular Diagnostics. 22, 6, p. 748-756 9 p.

Research output: Contribution to journalArticle

Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas

Felsenstein, M., Trujillo, M. A., Huang, B., Nanda, N., Jiang, Z., Jeong, Y. J., Pflüger, M., Goggins, M. G., Hruban, R. H., Thompson, E. D., Heaphy, C. M., Roberts, N. J. & Wood, L. D., Jul 1 2020, In : Laboratory Investigation. 100, 7, p. 1003-1013 11 p.

Research output: Contribution to journalArticle

Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups with Differing Risks of Liver Metastases

Pea, A., Yu, J., Marchionni, L., Noe, M., Luchini, C., Pulvirenti, A., De Wilde, R. F., Brosens, L. A., Rezaee, N., Javed, A., Chianchiano, P., Gobbo, S., Regi, P., Salvia, R., Bassi, C., He, J., Weiss, M. J., Cameron, J. L., Offerhaus, G. J. A., Hruban, R. H. & 5 others, Lawlor, R. T., Scarpa, A., Heaphy, C. M., Wood, L. D. & Wolfgang, C. L., Mar 1 2020, In : Annals of surgery. 271, 3, p. 566-573 8 p.

Research output: Contribution to journalArticle

Gene Variants That Affect Levels of Circulating Tumor Markers Increase Identification of Patients With Pancreatic Cancer

Abe, T., Koi, C., Kohi, S., Song, K. B., Tamura, K., Macgregor-Das, A., Kitaoka, N., Chuidian, M., Ford, M., Dbouk, M., Borges, M., He, J., Burkhart, R., Wolfgang, C. L., Klein, A. P., Eshleman, J. R., Hruban, R. H., Canto, M. I. & Goggins, M., May 2020, In : Clinical Gastroenterology and Hepatology. 18, 5, p. 1161-1169.e5

Research output: Contribution to journalArticle

Open Access

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Glasgow Precision Oncology Laboratory & Australian Pancreatic Cancer Genome Initiative, May 12 2020, In : Cell Reports. 31, 6, 107625.

Research output: Contribution to journalArticle

Open Access

Intraductal pancreatic cancer is less responsive than cancer in the stroma to neoadjuvant chemotherapy

Fujikura, K., Hutchings, D., Braxton, A. M., Zhu, Q., Laheru, D. A., Hruban, R. H., Thompson, E. D. & Wood, L. D., Jan 1 2020, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Multiple carcinomas and intraepithelial neoplasms in a case of familial pancreatic cancer: Rapid morphological changes in the pancreatic cyst and pathological lesions undetected by clinical images

Matsubayashi, H., Notohara, K., Hruban, R. H., Satoh, T., Kaneko, J., Sato, J., Ishiwatari, H., Ashida, R., Uesaka, K., Kiyozumi, Y. & Ono, H., Jan 1 2020, In : Internal Medicine. 59, 8, p. 1041-1046 6 p.

Research output: Contribution to journalArticle

Open Access

Pan-cancer analysis of whole genomes

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Feb 6 2020, In : Nature. 578, 7793, p. 82-93 12 p.

Research output: Contribution to journalArticle

Open Access

Pancreatic acinar cell carcinomas and mixed acinar-neuroendocrine carcinomas are more clinically aggressive than grade 1 pancreatic neuroendocrine tumours

Kim, J. Y., Brosnan-Cashman, J. A., Kim, J., An, S., Lee, K. B., Kim, H., Park, D. Y., Jang, K. T., Oh, Y. H., Hruban, R. H., Heaphy, C. M. & Hong, S. M., Apr 2020, In : Pathology. 52, 3, p. 336-347 12 p.

Research output: Contribution to journalArticle

Pancreatic Nerve Sheath Tumors: a Single Institutional Series and Systematic Review of the Literature

Javed, A. A., Wright, M. J., Hasanain, A., Chang, K., Burkhart, R. A., Hruban, R. H., Thompson, E., Fishman, E. K., Cameron, J. L., He, J., Wolfgang, C. L. & Weiss, M. J., Apr 1 2020, In : Journal of Gastrointestinal Surgery. 24, 4, p. 841-848 8 p.

Research output: Contribution to journalArticle

Primary pancreatic Ewing sarcoma: a cytomorphologic and histopathologic study of 13 cases

Miller, D. L., Roy-Chowdhuri, S., Illei, P. B., James, A., Hruban, R. H. & Ali, S. Z., Jan 1 2020, (Accepted/In press) In : Journal of the American Society of Cytopathology.

Research output: Contribution to journalArticle

Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct

Singhi, A. D., Wood, L. D., Parks, E., Torbenson, M. S., Felsenstein, M., Hruban, R. H., Nikiforova, M. N., Wald, A. I., Kaya, C., Nikiforov, Y. E., Favazza, L., He, J., McGrath, K., Fasanella, K. E., Brand, R. E., Lennon, A. M., Furlan, A., Dasyam, A. K., Zureikat, A. H., Zeh, H. J. & 3 others, Lee, K., Bartlett, D. L. & Slivka, A., Feb 2020, In : Gastroenterology. 158, 3, p. 573-582.e2

Research output: Contribution to journalArticle

Open Access
Open Access

Surgical Outcomes After Pancreatic Resection of Screening-Detected Lesions in Individuals at High Risk for Developing Pancreatic Cancer

Canto, M. I., Kerdsirichairat, T., Yeo, C. J., Hruban, R. H., Shin, E. J., Almario, J. A., Blackford, A., Ford, M., Klein, A. P., Javed, A. A., Lennon, A. M., Zaheer, A., Kamel, I. R., Fishman, E. K., Burkhart, R., He, J., Makary, M., Weiss, M. J., Schulick, R. D., Goggins, M. G. & 1 others, Wolfgang, C. L., May 1 2020, In : Journal of Gastrointestinal Surgery. 24, 5, p. 1101-1110 10 p.

Research output: Contribution to journalArticle

The Evolutionary Origins of Recurrent Pancreatic Cancer

Sakamoto, H., Attiyeh, M. A., Gerold, J. M., Makohon-Moore, A. P., Hayashi, A., Hong, J., Kappagantula, R., Zhang, L., Melchor, J. P., Reiter, J. G., Heyde, A., Bielski, C. M., Penson, A. V., Gönen, M., Chakravarty, D., O'Reilly, E. M., Wood, L. D., Hruban, R. H., Nowak, M. A., Socci, N. D. & 2 others, Taylor, B. S. & Iacobuzio-Donahue, C. A., Jun 1 2020, In : Cancer discovery. 10, 6, p. 792-805 14 p.

Research output: Contribution to journalArticle

Open Access

Three-dimensional analysis of extrahepatic cholangiocarcinoma and tumor budding

Yoshizawa, T., Hong, S. M., Jung, D. J., Noë, M., Kiemen, A., Wu, P. H., Wirtz, D., Hruban, R. H., Wood, L. D. & Oshima, K., Aug 1 2020, In : Journal of Pathology. 251, 4, p. 400-410 11 p.

Research output: Contribution to journalArticle

Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion

Hong, S. M., Jung, D. J., Kiemen, A., Gaida, M. M., Yoshizawa, T., Braxton, A. M., Noë, M., Lionheart, G., Oshima, K., Thompson, E. D., Burkhart, R., Wu, P. H., Wirtz, D., Hruban, R. H. & Wood, L. D., Apr 1 2020, In : Modern Pathology. 33, 4, p. 639-647 9 p.

Research output: Contribution to journalArticle

2019

Added value of apparent diffusion coefficient in distinguishing between serous and mucin-producing pancreatic cystic neoplasms

Pandey, P., Pandey, A., Shao, N., Varzaneh, F. N., Ghasabeh, M. A., Zharghampour, M., Khoshpouri, P., Fouladi, D., Eng, J., O'Broin-Lennon, A. M., Canto, M., Hruban, R. H. & Kamel, I. R., Jan 1 2019, In : European Radiology.

Research output: Contribution to journalArticle

A multimodality test to guide the management of patients with a pancreatic cyst

Springer, S., Masica, D. L., Molin, M. D., Douville, C., Thoburn, C. J., Afsari, B., Li, L., Cohen, J. D., Thompson, E., Allen, P. J., Klimstra, D. S., Schattner, M. A., Max Schmidt, C., Yip-Schneider, M., Simpson, R. E., Castillo, C. F. D., Mino-Kenudson, M., Brugge, W., Brand, R. E., Singhi, A. D. & 40 others, Scarpa, A., Lawlor, R., Salvia, R., Zamboni, G., Hong, S. M., Hwang, D. W., Jang, J. Y., Kwon, W., Swan, N., Geoghegan, J., Falconi, M., Crippa, S., Doglioni, C., Paulino, J., Schulick, R. D., Edil, B. H., Park, W., Yachida, S., Hijioka, S., Van Hooft, J., He, J., Weiss, M. J., Burkhart, R., Makary, M., Canto, M. I., Goggins, M. G., Ptak, J., Dobbyn, L., Schaefer, J., Sillman, N., Popoli, M., Klein, A. P., Tomasetti, C., Karchin, R., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Wolfgang, C. L., Hruban, R. H. & Lennon, A. M., Jul 17 2019, In : Science translational medicine. 11, 501, eaav4772.

Research output: Contribution to journalArticle

Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience

Chu, L. C. H., Park, S., Kawamoto, S., Wang, Y., Zhou, Y., Shen, W., Zhu, Z., Xia, Y., Xie, L., Liu, F., Yu, Q., Fouladi, D. F., Shayesteh, S., Zinreich, E. S., Graves, J. S., Horton, K. M., Yuille, A. L., Hruban, R. H., Kinzler, K. W., Vogelstein, B. & 1 others, Fishman, E. K., Jan 1 2019, In : Journal of the American College of Radiology.

Research output: Contribution to journalArticle

Biphenotypic Differentiation of Pancreatic Cancer in 3-Dimensional Culture

Matsushita, Y., Smith, B., Delannoy, M., Trujillo, M. A., Chianchiano, P., McMillan, R., Kamiyama, H., Liang, H., Thompson, E. D., Hruban, R. H., Matsui, W., Wood, L. D., Roberts, N. J. & Eshleman, J. R., Oct 1 2019, In : Pancreas. 48, 9, p. 1225-1231 7 p.

Research output: Contribution to journalArticle

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Australian Pancreatic Genome Initiative (APGI), Dec 1 2019, In : Nature communications. 10, 1, 3637.

Research output: Contribution to journalArticle

Open Access

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

Tomasetti, C., Poling, J., Roberts, N. J., London, N. R., Pittman, M. E., Haffner, M. C., Rizzo, A., Baras, A., Karim, B., Kim, A., Heaphy, C. M., Meeker, A. K., Hruban, R. H., Iacobuzio-Donahue, C. A. & Vogelstein, B., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20482-20488 7 p.

Research output: Contribution to journalArticle

Open Access

Circulating tumor DNA as a clinical test in resected pancreatic cancer

Groot, V. P., Mosier, S., Javed, A. A., Teinor, J. A., Gemenetzis, G., Ding, D., Haley, L. M., Yu, J., Burkhart, R. A., Hasanain, A., Debeljak, M., Kamiyama, H., Narang, A., Laheru, D. A., Zheng, L., Lin, M. T., Gocke, C. D., Fishman, E. K., Hruban, R. H., Goggins, M. G. & 7 others, Quintus Molenaar, I., Cameron, J. L., Weiss, M. J., Velculescu, V. E., He, J., Wolfgang, C. L. & Eshleman, J. R., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4973-4984 12 p.

Research output: Contribution to journalArticle

Deleterious germline mutations are a risk factor for neoplastic progression among high-risk individuals undergoing pancreatic surveillance

Abe, T., Blackford, A. L., Tamura, K., Ford, M., McCormick, P., Chuidian, M., Almario, J. A., Borges, M., Lennon, A. M., Shin, E. J., Klein, A. P., Hruban, R. H., Canto, M. I. & Goggins, M., Jan 1 2019, In : Journal of Clinical Oncology. 37, 13, p. 1070-1080 11 p.

Research output: Contribution to journalArticle

Follow-up of incidentally detected pancreatic cystic neoplasms: Do baseline MRI and CT features predict cyst growth?

Pandey, P., Pandey, A., Luo, Y., Ghasabeh, M. A., Khoshpouri, P., Ameli, S., O'Broin-Lennon, A. M., Canto, M., Hruban, R. H., Goggins, M. S., Wolfgang, C. & Kamel, I. R., 2019, In : RADIOLOGY. 292, 3, p. 647-654 8 p.

Research output: Contribution to journalArticle

Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants

Hutchings, D., Jiang, Z., Skaro, M., Weiss, M. J., Wolfgang, C. L., Makary, M. A., He, J., Cameron, J. L., Zheng, L., Klimstra, D. S., Brand, R. E., Singhi, A. D., Goggins, M., Klein, A. P., Roberts, N. J. & Hruban, R. H., Dec 1 2019, In : Modern Pathology. 32, 12, p. 1806-1813 8 p.

Research output: Contribution to journalArticle

Intraductal Papillary Mucinous Neoplasms Arise From Multiple Independent Clones, Each With Distinct Mutations

Fischer, C. G., Beleva Guthrie, V., Braxton, A. M., Zheng, L., Wang, P., Song, Q., Griffin, J. F., Chianchiano, P. E., Hosoda, W., Niknafs, N., Springer, S., Dal Molin, M., Masica, D., Scharpf, R. B., Thompson, E. D., He, J., Wolfgang, C. L., Hruban, R. H., Roberts, N. J., Lennon, A. M. & 3 others, Jiao, Y., Karchin, R. & Wood, L. D., Oct 2019, In : Gastroenterology. 157, 4, p. 1123-1137.e22

Research output: Contribution to journalArticle

Multiple KRAS mutations in the non-mucinous epithelial lining in the majority of mucinous cystic neoplasms of the pancreas

An, S., Kim, M. J., Kim, S. J., Sung, Y. N., Kim, Y. W., Song, K. B., Hwang, D. W., Kim, S. C., Hruban, R. H. & Hong, S. M., Oct 1 2019, In : Histopathology. 75, 4, p. 559-567 9 p.

Research output: Contribution to journalArticle

Pancreatic cancer arising in the remnant pancreas is not always a relapse of the preceding primary

Luchini, C., Pea, A., Yu, J., He, J., Salvia, R., Riva, G., Weiss, M. J., Bassi, C., Cameron, J. L., Hruban, R. H., Goggins, M., Wolfgang, C. L., Scarpa, A., Wood, L. D. & Lawlor, R. T., May 1 2019, In : Modern Pathology. 32, 5, p. 659-665 7 p.

Research output: Contribution to journalArticle

Prevalence of Germline Mutations Associated With Cancer Risk in Patients With Intraductal Papillary Mucinous Neoplasms

Skaro, M., Nanda, N., Gauthier, C., Felsenstein, M., Jiang, Z., Qiu, M., Shindo, K., Yu, J., Hutchings, D., Javed, A. A., Beckman, R., He, J., Wolfgang, C., Thompson, E., Hruban, R. H., Klein, A., Goggins, M. S., Wood, L. D. & Roberts, N., May 1 2019, In : Gastroenterology. 156, 6, p. 1905-1913 9 p.

Research output: Contribution to journalArticle

Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood

Eissa, M. A. L., Lerner, L., Abdelfatah, E., Shankar, N., Canner, J. K., Hasan, N. M., Yaghoobi, V., Huang, B., Kerner, Z., Takaesu, F., Wolfgang, C., Kwak, R., Ruiz, M., Tam, M., Pisanic, T. R., Iacobuzio-Donahue, C., Hruban, R. H., He, J., Wang, T. H., Wood, L. D. & 2 others, Sharma, A. & Ahuja, N., Apr 5 2019, In : Clinical Epigenetics. 11, 1, 59.

Research output: Contribution to journalArticle

Open Access

Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

Kuboki, Y., Fischer, C. G., Beleva Guthrie, V., Huang, W., Yu, J., Chianchiano, P., Hosoda, W., Zhang, H., Zheng, L., Shao, X., Thompson, E. D., Waters, K., Poling, J., He, J., Weiss, M. J., Wolfgang, C. L., Goggins, M. G., Hruban, R. H., Roberts, N. J., Karchin, R. & 1 others, Wood, L. D., Jan 1 2019, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Surveillance for pancreatic cancer in high-risk individuals

International CAncer of the Pancreas Screening (CAPS) Consortium, Oct 1 2019, In : BJS open. 3, 5, p. 656-665 10 p.

Research output: Contribution to journalArticle

Open Access

Survival in Locally Advanced Pancreatic Cancer after Neoadjuvant Therapy and Surgical Resection

Gemenetzis, G., Groot, V. P., Blair, A. B., Laheru, D. A., Zheng, L., Narang, A. K., Fishman, E. K., Hruban, R. H., Yu, J., Burkhart, R. A., Cameron, J. L., Weiss, M. J., Wolfgang, C. L. & He, J., Aug 1 2019, In : Annals of surgery. 270, 2, p. 340-347 8 p.

Research output: Contribution to journalArticle

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice

Engle, D. D., Tiriac, H., Rivera, K. D., Pommier, A., Whalen, S., Oni, T. E., Alagesan, B., Lee, E. J., Yao, M. A., Lucito, M. S., Spielman, B., Silva, B. D., Schoepfer, C., Wright, K., Creighton, B., Afinowicz, L., Yu, K. H., Grützmann, R., Aust, D., Gimotty, P. A. & 8 others, Pollard, K. S., Hruban, R. H., Goggins, M. G., Pilarsky, C., Park, Y., Pappin, D. J., Hollingsworth, M. A. & Tuveson, D. A., Jan 1 2019, In : Science. 364, 6446, p. 1156-1162 7 p.

Research output: Contribution to journalArticle

Open Access

Well-differentiated Pancreatic Neuroendocrine Tumor in a Patient with Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM)

Noë, M., Hackeng, W. M., De Leng, W. W. J., Vergeer, M., Vleggaar, F. P., Morsink, F. H. M., Wood, L. D., Hruban, R. H., Offerhaus, G. J. A. & Brosens, L. A. A., Sep 1 2019, In : American Journal of Surgical Pathology. 43, 9, p. 1297-1302 6 p.

Research output: Contribution to journalArticle

Why is pancreatic cancer so deadly? The pathologist's view

Hruban, R. H., Gaida, M. M., Thompson, E., Hong, S. M., Noë, M., Brosens, L. A. A., Jongepier, M., Offerhaus, G. J. A. & Wood, L. D., Jun 2019, In : Journal of Pathology. 248, 2, p. 131-141 11 p.

Research output: Contribution to journalArticle

2018

A "clearer" View of Pancreatic Pathology: A Review of Tissue Clearing and Advanced Microscopy Techniques

Hong, S. M., Noë, M., Hruban, C. A., Thompson, E., Wood, L. D. & Hruban, R. H., Jan 1 2018, (Accepted/In press) In : Advances in Anatomic Pathology.

Research output: Contribution to journalArticle

Are pancreatic IPMN volumes measured on MRI images more reproducible than diameters? An assessment in a large single-institution cohort

Pandey, P., Pandey, A., Varzaneh, F. N., Ghasabeh, M. A., Fouladi, D., Khoshpouri, P., Shao, N., Zarghampour, M., Hruban, R. H., Canto, M., O'Broin-Lennon, A. M. & Kamel, I. R., Feb 5 2018, (Accepted/In press) In : European Radiology. p. 1-11 11 p.

Research output: Contribution to journalArticle