Ralph H Hruban

Professor

1984 …2020

Research output per year

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Research Output

2011

The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting

Kern, S. E., Shi, C. & Hruban, R. H., Jan 2011, In : Journal of Pathology. 223, 2, p. 296-307 12 p.

Research output: Contribution to journalReview article

Transcriptomic biomarkers for the accurate diagnosis of myocarditis

Heidecker, B., Kittleson, M. M., Kasper, E. K., Wittstein, I. S., Champion, H. C., Russell, S. D., Hruban, R. H., Rodriguez, E. R., Baughman, K. L. & Hare, J. M., Mar 22 2011, In : Circulation. 123, 11, p. 1174-1184 11 p.

Research output: Contribution to journalArticle

Tumor engraftment in nude mice and enrichment in stroma-related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer

Garrido-Laguna, I., Uson, M., Rajeshkumar, N. V., Tan, A. C., De Oliveira, E., Karikari, C., Villaroel, M. C., Salomon, A., Taylor, G., Sharma, R., Hruban, R. H., Maitra, A., Laheru, D., Rubio-Viqueira, B., Jimeno, A. & Hidalgo, M., Sep 1 2011, In : Clinical Cancer Research. 17, 17, p. 5793-5800 8 p.

Research output: Contribution to journalArticle

Tumor-infiltrating neutrophils in pancreatic neoplasia

Reid, M. D., Basturk, O., Thirabanjasak, D., Hruban, R. H., Klimstra, D. S., Bagci, P., Altinel, D. & Adsay, V., Dec 1 2011, In : Modern Pathology. 24, 12, p. 1612-1619 8 p.

Research output: Contribution to journalArticle

Tumor size and location correlate with behavior of pancreatic serous cystic neoplasms

Khashab, M. A., Shin, E. J., Amateau, S., Canto, M. I., Hruban, R. H., Fishman, E. K., Cameron, J. L., Edil, B. H., Wolfgang, C. L., Schulick, R. D. & Giday, S., Aug 1 2011, In : American Journal of Gastroenterology. 106, 8, p. 1521-1526 6 p.

Research output: Contribution to journalArticle

Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas

Handra-Luca, A., Hong, S. M., Walter, K., Wolfgang, C., Hruban, R. & Goggins, M., Apr 12 2011, In : British journal of cancer. 104, 8, p. 1296-1302 7 p.

Research output: Contribution to journalArticle

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

Wu, J., Jiao, Y., Dal Molin, M., Maitra, A., De Wilde, R. F., Wood, L. D., Eshleman, J. R., Goggins, M. G., Wolfgang, C. L., Canto, M. I., Schulick, R. D., Edil, B. H., Choti, M. A., Adsay, V., Klimstra, D. S., Offerhaus, G. J. A., Klein, A. P., Kopelovich, L., Carter, H., Karchin, R. & 8 others, Allen, P. J., Schmidt, C. M., Naito, Y., Diaz, L. A., Kinzler, K. W., Papadopoulos, N., Hruban, R. H. & Vogelstein, B., Dec 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 52, p. 21188-21193 6 p.

Research output: Contribution to journalArticle

2010

Aberrant microRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma

Ryu, J. K., Hong, S. M., Karikari, C. A., Hruban, R. H., Goggins, M. G. & Maitra, A., Apr 2010, In : Pancreatology. 10, 1, p. 66-73 8 p.

Research output: Contribution to journalArticle

Adjuvant chemoradiation therapy for adenocarcinoma of the distal pancreas

Redmond, K. J., Wolfgang, C. L., Sugar, E. A., Ahn, J., Nathan, H., Laheru, D., Edil, B. H., Choti, M. A., Pawlik, T. M., Hruban, R. H., Cameron, J. L. & Herman, J. M., Dec 1 2010, In : Annals of Surgical Oncology. 17, 12, p. 3112-3119 8 p.

Research output: Contribution to journalArticle

Adjuvant Chemoradiotherapy After Pancreatic Resection for Invasive Carcinoma Associated With Intraductal Papillary Mucinous Neoplasm of the Pancreas

Swartz, M. J., Hsu, C. C., Pawlik, T. M., Winter, J., Hruban, R. H., Guler, M., Schulick, R. D., Cameron, J. L., Laheru, D. A., Wolfgang, C. L. & Herman, J. M., Mar 1 2010, In : International Journal of Radiation Oncology Biology Physics. 76, 3, p. 839-844 6 p.

Research output: Contribution to journalArticle

Clinicopathologic analysis of ampullary neoplasms in 450 patients: Implications for surgical strategy and long-term prognosis

Winter, J. M., Cameron, J. L., Olino, K., Herman, J. M., de Jong, M. C., Hruban, R. H., Wolfgang, C. L., Eckhauser, F., Edil, B. H., Choti, M. A., Schulick, R. D. & Pawlik, T. M., Feb 1 2010, In : Journal of Gastrointestinal Surgery. 14, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

CT features of pulmonary artery sarcoma: Critical aid to a challenging diagnosis

Singla Long, S., Johnson, P. T., Hruban, R. H. & Fishman, E. K., Mar 1 2010, In : Emergency Radiology. 17, 2, p. 153-155 3 p.

Research output: Contribution to journalArticle

Detection of early-stage pancreatic adenocarcinoma

Gold, D. V., Goggins, M., Modrak, D. E., Newsome, G., Liu, M., Shi, C., Hruban, R. H. & Goldenberg, D. M., Nov 1 2010, In : Cancer Epidemiology Biomarkers and Prevention. 19, 11, p. 2786-2794 9 p.

Research output: Contribution to journalArticle

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., Velculescu, V. E., Kinzler, K. W., Vogelstein, B. & Iacobuzio-Donahue, C. A., Oct 28 2010, In : Nature. 467, 7319, p. 1114-1117 4 p.

Research output: Contribution to journalArticle

EUS-guided tattooing before laparoscopic distal pancreatic resection (with video)

Lennon, A. M., Newman, N., Makary, M. A., Edil, B. H., Shin, E. J., Khashab, M. A., Hruban, R. H., Wolfgang, C. L., Schulick, R. D., Giday, S. & Canto, M. I., Nov 1 2010, In : Gastrointestinal endoscopy. 72, 5, p. 1089-1094 6 p.

Research output: Contribution to journalArticle

Histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreas

Poultsides, G. A., Reddy, S., Cameron, J. L., Hruban, R. H., Pawlik, T. M., Ahuja, N., Jain, A., Edil, B. H., Iacobuzio-Donahue, C. A., Schulick, R. D. & Wolfgang, C. L., Mar 1 2010, In : Annals of surgery. 251, 3, p. 470-476 7 p.

Research output: Contribution to journalArticle

Importance of age of onset in pancreatic cancer kindreds

Brune, K. A., Lau, B., Palmisano, E., Canto, M., Goggins, M. G., Hruban, R. H. & Klein, A. P., Jan 1 2010, In : Journal of the National Cancer Institute. 102, 2, p. 119-126 8 p.

Research output: Contribution to journalArticle

In vivo and in vitro propagation of intraductal papillary mucinous neoplasms

Kamiyama, H., Kamiyama, M., Hong, S. M., Karikari, C. A., Lin, M. T., Borges, M. W., Griffith, M., Young, A., Norris-Kirby, A., Lubek, C., Mizuma, M., Feldmann, G., Shi, C., Liang, H., Goggins, M. G., Maitra, A., Hruban, R. H. & Eshleman, J. R., May 1 2010, In : Laboratory Investigation. 90, 5, p. 665-673 9 p.

Research output: Contribution to journalArticle

Mixed epithelial and stromal tumor of the kidney: Radiologic- pathologic correlation

Chu, L. C., Hruban, R. H., Horton, K. M. & Fishman, E. K., Oct 1 2010, In : Radiographics. 30, 6, p. 1541-1551 11 p.

Research output: Contribution to journalArticle

Multiple endocrine neoplasms and serous cysts of the pancreas in a patient with von hippel-lindau disease

Matsubayashi, H., Uesaka, K., Kanemoto, H., Sugiura, T., Mizuno, T., Sasaki, K., Ono, H. & Hruban, R., Sep 1 2010, In : Journal of Gastrointestinal Cancer. 41, 3, p. 197-202 6 p.

Research output: Contribution to journalArticle

Outcomes of Adjuvant Chemoradiation After Pancreaticoduodenectomy With Mesenterico-Portal Vein Resection for Adenocarcinoma of the Pancreas

Hristov, B., Reddy, S., Lin, S. H., Cameron, J. L., Pawlik, T. M., Hruban, R. H., Swartz, M. J., Edil, B. H., Kemp, C., Wolfgang, C. L. & Herman, J. M., Jan 1 2010, In : International Journal of Radiation Oncology Biology Physics. 76, 1, p. 176-180 5 p.

Research output: Contribution to journalArticle

P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

Yamakuchi, M., Lotterman, C. D., Bao, C., Hruban, R. H., Karim, B., Mendell, J. T., Huso, D. & Lowenstein, C. J., Apr 6 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6334-6339 6 p.

Research output: Contribution to journalArticle

Pancreas

Hruban, R. H. & Guler, M., Dec 1 2010, Differential Diagnosis in Surgical Pathology. Elsevier Inc., p. 445-459 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pancreatic duct stenosis secondary to small endocrine neoplasms: A manifestation of serotonin production?

Shi, C., Siegelman, S. S., Kawamoto, S., Wolfgang, C. L., Schulick, R. D., Maitra, A. & Hruban, R. H., Oct 1 2010, In : RADIOLOGY. 257, 1, p. 107-114 8 p.

Research output: Contribution to journalArticle

Preferential expression of MUC6 in oncocytic and pancreatobiliary types of intraductal papillary neoplasms highlights a pyloropancreatic pathway, distinct from the intestinal pathway, in pancreatic carcinogenesis

Basturk, O., Khayyata, S., Klimstra, D. S., Hruban, R. H., Zamboni, G., Coban, I. & Adsay, N. V., Mar 1 2010, In : American Journal of Surgical Pathology. 34, 3, p. 364-370 7 p.

Research output: Contribution to journalArticle

Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)

Carter, H., Samayoa, J., Hruban, R. H. & Karchin, R., Sep 15 2010, In : Cancer Biology and Therapy. 10, 6, p. 582-587 6 p.

Research output: Contribution to journalArticle

Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients

Voong, K. R., Davison, J., Pawlik, T. M., Uy, M. O., Hsu, C. C., Winter, J., Hruban, R. H., Laheru, D., Rudra, S., Swartz, M. J., Nathan, H., Edil, B. H., Schulick, R., Cameron, J. L., Wolfgang, C. L. & Herman, J. M., Jan 1 2010, In : Human pathology. 41, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

Sclerosing mesenteritis involving the pancreas: A mimicker of pancreatic cancer

Scudiere, J. R., Shi, C., Hruban, R. H., Herman, J. M., Fishman, E. K., Schulick, R. D., Wolfgang, C. L., Makary, M. A., Thornton, K., Montgomery, E. & Horton, K. M., Apr 1 2010, In : American Journal of Surgical Pathology. 34, 4, p. 447-453 7 p.

Research output: Contribution to journalArticle

Solid serous adenoma of the pancreas: Clinicopathologic features and differential diagnosis

Lam-Himlin, D. M. & Hruban, R. H., Nov 1 2010, In : Pathology Case Reviews. 15, 6, p. 215-218 4 p.

Research output: Contribution to journalReview article

Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer

Liby, K. T., Royce, D. B., Risingsong, R., Williams, C. R., Maitra, A., Hruban, R. H. & Sporn, M. B., Nov 1 2010, In : Cancer Prevention Research. 3, 11, p. 1427-1434 8 p.

Research output: Contribution to journalArticle

Update on familial pancreatic cancer

Hruban, R. H., Canto, M. I., Goggins, M., Schulick, R. & Klein, A. P., Sep 1 2010, In : Advances in surgery. 44, 1, p. 293-311 19 p.

Research output: Contribution to journalReview article

2009

Absence of deleterious palladin mutations in patients with familial pancreatic cancer

Klein, A. P., Borges, M., Griffith, M., Brune, K., Hong, S. M., Omura, N., Hruban, R. H. & Goggins, M., Apr 1 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 4, p. 1328-1330 3 p.

Research output: Contribution to journalArticle

Absence of germline BRCA1 mutations in familial pancreatic cancer patients

Axilbund, J. E., Argani, P., Kamiyama, M., Palmisano, E., Raben, M., Borges, M., Brune, K. A., Goggins, M., Hruban, R. H. & Klein, A. P., Jan 2009, In : Cancer Biology and Therapy. 8, 2, p. 131-135 5 p.

Research output: Contribution to journalArticle

Open Access

A compendium of potential biomarkers of pancreatic cancer

Harsha, H. C., Kandasamy, K., Ranganathan, P., Rani, S., Ramabadran, S., Gollapudi, S., Balakrishnan, L., Dwivedi, S. B., Telikicherla, D., Selvan, L. D. N., Goel, R., Mathivanan, S., Marimuthu, A., Kashyap, M., Vizza, R. F., Mayer, R. J., DeCaprio, J. A., Srivastava, S., Hanash, S. M., Hruban, R. H. & 1 others, Pandey, A., Apr 1 2009, In : PLoS medicine. 6, 4, e1000046.

Research output: Contribution to journalArticle

Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma

Brody, J. R., Costantino, C. L., Potoczek, M., Cozzitorto, J., McCue, P., Yeo, C. J., Hruban, R. H. & Witkiewicz, A. K., May 1 2009, In : Modern Pathology. 22, 5, p. 651-659 9 p.

Research output: Contribution to journalArticle

Adult pancreatic hemangioma: Case report and literature review

Mundinger, G. S., Gust, S., Micchelli, S. T., Fishman, E. K., Hruban, R. H. & Wolfgang, C. L., Dec 1 2009, In : Gastroenterology Research and Practice. 839730.

Research output: Contribution to journalArticle

An algorithmic approach to the diagnosis of pancreatic neoplasms

Klimstra, D. S., Pitman, M. B. & Hruban, R. H., Mar 1 2009, In : Archives of Pathology and Laboratory Medicine. 133, 3, p. 454-464 11 p.

Research output: Contribution to journalReview article

Assessment of "gene-environment" interaction in cases of familial and sporadic pancreatic cancer

Yeo, T. P., Hruban, R. H., Brody, J., Brune, K., Fitzgerald, S. & Yeo, C. J., Jul 1 2009, In : Journal of Gastrointestinal Surgery. 13, 8, p. 1487-1494 8 p.

Research output: Contribution to journalArticle

Depth of tumor invasion better predicts prognosis than the current American Joint Committee on Cancer T classification for distal bile duct carcinoma

Hong, S. M., Pawlik, T. M., Cho, H. J., Aggarwal, B., Goggins, M., Hruban, R. H. & Anders, R. A., Aug 1 2009, In : Surgery. 146, 2, p. 250-257 8 p.

Research output: Contribution to journalArticle

DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer

Lacobuzio-Donahue, C. A., Fu, B., Yachida, S., Luo, M., Abe, H., Henderson, C. M., Vilardell, F., Wang, Z., Keller, J. W., Banerjee, P., Herman, J. M., Cameron, J. L., Yeo, C. J., Halushka, M. K., Eshleman, J. R., Raben, M., Klein, A. P., Hruban, R. H., Hidalgo, M. & Laheru, D., Apr 10 2009, In : Journal of Clinical Oncology. 27, 11, p. 1806-1813 8 p.

Research output: Contribution to journalArticle

Elevated cancer mortality in the relatives of patients with pancreatic cancer

Wang, L., Brune, K. A., Visvanathan, K., Laheru, D., Herman, J., Wolfgang, C., Schulick, R., Cameron, J. L., Goggins, M., Hruban, R. H. & Klein, A. P., Nov 1 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 11, p. 2829-2834 6 p.

Research output: Contribution to journalArticle

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C. H., Palmisano, E., Brune, K., Jaffee, E. M., Iacobuzio-Donahue, C. A., Maitra, A., Parmigiani, G., Kern, S. E., Velculescu, V. E., Kinzler, K. W., Vogelstein, B., Eshleman, J. R., Goggins, M. & Klein, A. P., Apr 10 2009, In : Science. 324, 5924, 1 p.

Research output: Contribution to journalArticle

Familial pancreatic cancer

Shi, C., Hruban, R. H. & Klein, A. P., Mar 1 2009, In : Archives of Pathology and Laboratory Medicine. 133, 3, p. 365-374 10 p.

Research output: Contribution to journalReview article

Genetic mutations associated with Cigarette smoking in pancreatic cancer

Blackford, A., Parmigiani, G., Kensler, T. W., Wolfgang, C., Jones, S., Zhang, X., Parsons, D. W., Lin, J. C. H., Leary, R. J., Eshleman, J. R., Goggins, M., Jaffee, E. M., Iacobuzio-Donahue, C. A., Maitra, A., Klein, A., Cameron, J. L., Olino, K., Schulick, R., Winter, J., Vogelstein, B. & 3 others, Velculescu, V. E., Kinzler, K. W. & Hruban, R. H., Apr 15 2009, In : Cancer Research. 69, 8, p. 3681-3688 8 p.

Research output: Contribution to journalArticle

Increased prevalence of precursor lesions in familial pancreatic cancer patients

Shi, C., Klein, A. P., Goggins, M., Maitra, A., Canto, M., Ali, S., Schulick, R., Palmisano, E. & Hruban, R. H., Dec 15 2009, In : Clinical Cancer Research. 15, 24, p. 7737-7743 7 p.

Research output: Contribution to journalArticle

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., Frese, K. K., DeNicola, G., Feig, C., Combs, C., Winter, S. P., Ireland-Zecchini, H., Reichelt, S., Howat, W. J., Chang, A., Dhara, M. & 17 others, Wang, L., Rückert, F., Grützmann, R., Pilarsky, C., Izeradjene, K., Hingorani, S. R., Huang, P., Davies, S. E., Plunkett, W., Egorin, M., Hruban, R. H., Whitebread, N., McGovern, K., Adams, J., Iacobuzio-Donahue, C., Griffiths, J. & Tuveson, D. A., Jun 12 2009, In : Science. 324, 5933, p. 1457-1461 5 p.

Research output: Contribution to journalArticle