Ralph H Hruban

Professor

1984 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2013

Metastatic disease to the pancreas: Pathologic spectrum and CT patterns

Ahmed, S., Johnson, P. T., Hruban, R. & Fishman, E. K., Feb 1 2013, In : Abdominal Imaging. 38, 1, p. 144-153 10 p.

Research output: Contribution to journalArticle

Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts

Kanda, M., Knight, S., Topazian, M., Syngal, S., Farrell, J., Lee, J., Kamel, I., Lennon, A. M., Borges, M., Young, A., Fujiwara, S., Seike, J., Eshleman, J., Hruban, R. H., Canto, M. I. & Goggins, M., Jul 1 2013, In : Gut. 62, 7, p. 1024-1033 10 p.

Research output: Contribution to journalArticle

Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia

Kanda, M., Sadakari, Y., Borges, M., Topazian, M., Farrell, J., Syngal, S., Lee, J., Kamel, I., Lennon, A. M., Knight, S., Fujiwara, S., Hruban, R. H., Canto, M. I. & Goggins, M., Jun 2013, In : Clinical Gastroenterology and Hepatology. 11, 6, p. 719-730.e5

Research output: Contribution to journalArticle

PAM4 enzyme immunoassay alone and in combination with CA 19-9 for the detection of pancreatic adenocarcinoma

Gold, D. V., Gaedcke, J., Ghadimi, B. M., Goggins, M., Hruban, R. H., Liu, M., Newsome, G. & Goldenberg, D. M., Feb 1 2013, In : Cancer. 119, 3, p. 522-528 7 p.

Research output: Contribution to journalArticle

Pancreatic neuroendocrine tumor with cystlike changes: Evaluation with MDCT

Kawamoto, S., Johnson, P. T., Shi, C., Singhi, A. D., Hruban, R. H., Wolfgang, C. L., Edil, B. H. & Fishman, E. K., Mar 1 2013, In : American Journal of Roentgenology. 200, 3, p. W283-W290

Research output: Contribution to journalArticle

Personalized chemotherapy profiling using cancer cell lines from selectable mice

Kamiyama, H., Rauenzahn, S., Shim, J. S., Karikari, C. A., Feldmann, G., Hua, L., Kamiyama, M., Schuler, F. W., Lin, M. T., Beaty, R. M., Karanam, B., Liang, H., Mullendore, M. E., Mo, G., Hidalgo, M., Jaffee, E., Hruban, R. H., Jinnah, H. A., Roden, R. B. S., Jimeno, A. & 3 others, Liu, J. O., Maitra, A. & Eshleman, J. R., Mar 1 2013, In : Clinical Cancer Research. 19, 5, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

Phase 2 study of erlotinib combined with adjuvant chemoradiation and chemotherapy in patients with resectable pancreatic cancer

Herman, J. M., Fan, K. Y., Wild, A. T., Hacker-Prietz, A., Wood, L. D., Blackford, A. L., Ellsworth, S., Zheng, L., Le, D. T., De Jesus-Acosta, A., Hidalgo, M., Donehower, R. C., Schulick, R. D., Edil, B. H., Choti, M. A., Hruban, R. H., Pawlik, T. M., Cameron, J. L., Laheru, D. A. & Wolfgang, C. L., Jul 15 2013, In : International Journal of Radiation Oncology Biology Physics. 86, 4, p. 678-685 8 p.

Research output: Contribution to journalArticle

Prognosis of minimally invasive carcinoma arising in mucinous cystic neoplasms of the pancreas

Lewis, G. H., Wang, H., Bellizzi, A. M., Klein, A. P., Askin, F. B., Schwartz, L. E., Schulick, R. D., Wolfgang, C. L., Cameron, J. L., O'Reilly, E. M., Yu, K. H. & Hruban, R. H., Apr 1 2013, In : American Journal of Surgical Pathology. 37, 4, p. 601-605 5 p.

Research output: Contribution to journalArticle

Recent progress in pancreatic cancer

Wolfgang, C. L., Herman, J. M., Laheru, D. A., Klein, A. P., Erdek, M. A., Fishman, E. K. & Hruban, R. H., Sep 1 2013, In : CA Cancer Journal for Clinicians. 63, 5, p. 318-348 31 p.

Research output: Contribution to journalReview article

Serum miR-1290 as a marker of pancreatic cancer-response

Li, A., Yu, J., Kim, H., Wolfgang, C. L., Canto, M. I., Hruban, R. H. & Goggins, M., Sep 15 2013, In : Clinical Cancer Research. 19, 18, p. 5252-5253 2 p.

Research output: Contribution to journalLetter

TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine

Kinde, I., Munari, E., Faraj, S. F., Hruban, R. H., Schoenberg, M., Bivalacqua, T., Allaf, M., Springer, S., Wang, Y., Diaz, L. A., Kinzler, K. W., Vogelstein, B., Papadopoulos, N. & Netto, G. J., Dec 15 2013, In : Cancer Research. 73, 24, p. 7162-7167 6 p.

Research output: Contribution to journalArticle

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

Killela, P. J., Reitman, Z. J., Jiao, Y., Bettegowda, C., Agrawal, N., Diaz, L. A., Friedman, A. H., Friedman, H., Gallia, G. L., Giovanella, B. C., Grollman, A. P., He, T. C., He, Y., Hruban, R. H., Jallo, G. I., Mandahl, N., Meeker, A. K., Mertens, F., Netto, G. J., Ahmed Rasheed, B. & 17 others, Riggins, G. J., Rosenquist, T. A., Schiffman, M., Shih, I. M., Theodorescu, D., Torbenson, M. S., Velculescu, V. E., Wang, T. L., Wentzensen, N., Wood, L. D., Zhang, M., McLendon, R. E., Bigner, D. D., Kinzler, K. W., Vogelstein, B., Papadopoulos, N. & Yan, H., Apr 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. 6021-6026 6 p.

Research output: Contribution to journalArticle

The Diagnosis and Surgical Treatment of Pancreatoblastoma in Adults: A Case Series and Review of the Literature

Salman, B., Brat, G., Yoon, Y. S., Hruban, R. H., Singhi, A. D., Fishman, E. K., Herman, J. M. & Wolfgang, C. L., Dec 1 2013, In : Journal of Gastrointestinal Surgery. 17, 12, p. 2153-2161 9 p.

Research output: Contribution to journalReview article

Young Patients Undergoing Resection of Pancreatic Cancer Fare Better than their Older Counterparts

He, J., Edil, B. H., Cameron, J. L., Schulick, R. D., Hruban, R. H., Herman, J. M., Zheng, L., Iacobuzio-Donahue, C., Ahuja, N., Pawlik, T. M. & Wolfgang, C. L., Jan 1 2013, In : Journal of Gastrointestinal Surgery. 17, 2, p. 339-344 6 p.

Research output: Contribution to journalArticle

2012

A monoclonal antibody-GDNF fusion protein is not neuroprotective and is associated with proliferative pancreatic lesions in parkinsonian monkeys

Ohshima-Hosoyama, S., Simmons, H. A., Goecks, N., Joers, V., Swanson, C. R., Bondarenko, V., Velotta, R., Brunner, K., Wood, L. D., Hruban, R. H. & Emborg, M. E., Jun 20 2012, In : PloS one. 7, 6, e39036.

Research output: Contribution to journalArticle

ATM mutations in patients with hereditary pancreatic cancer

Roberts, N. J., Jiao, Y., Yu, J., Kopelovich, L., Petersen, G. M., Bondy, M. L., Gallinger, S., Schwartz, A. G., Syngal, S., Cote, M. L., Axilbund, J., Schulick, R., Ali, S. Z., Eshleman, J. R., Velculescu, V. E., Goggins, M., Vogelstein, B., Papadopoulos, N., Hruban, R. H., Kinzler, K. W. & 1 others, Klein, A. P., Jan 1 2012, In : Cancer discovery. 2, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

Beyond renal cell carcinoma: Rare and unusual renal masses

Raman, S. P., Hruban, R. H. & Fishman, E. K., Oct 1 2012, In : Abdominal Imaging. 37, 5, p. 873-884 12 p.

Research output: Contribution to journalArticle

Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer

Caldwell, M. E., Denicola, G. M., Martins, C. P., Jacobetz, M. A., Maitra, A., Hruban, R. H. & Tuveson, D. A., Mar 22 2012, In : Oncogene. 31, 12, p. 1599-1608 10 p.

Research output: Contribution to journalArticle

Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors

Yachida, S., White, C. M., Naito, Y., Zhong, Y., Brosnan, J. A., Macgregor-Das, A. M., Morgan, R. A., Saunders, T., Laheru, D. A., Herman, J. M., Hruban, R. H., Klein, A. P., Jones, S., Velculescu, V., Wolfgang, C. L. & Iacobuzio-Donahue, C. A., Nov 15 2012, In : Clinical Cancer Research. 18, 22, p. 6339-6347 9 p.

Research output: Contribution to journalArticle

Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas

Matthaei, H., Norris, A. L., Tsiatis, A. C., Olino, K., Hong, S. M., Dal Molin, M., Goggins, M. G., Canto, M., Horton, K. M., Jackson, K. D., Capelli, P., Zamboni, G., Bortesi, L., Furukawa, T., Egawa, S., Ishida, M., Ottomo, S., Unno, M., Motoi, F., Wolfgang, C. L. & 6 others, Edil, B. H., Cameron, J. L., Eshleman, J. R., Schulick, R. D., Maitra, A. & Hruban, R. H., Feb 1 2012, In : Annals of surgery. 255, 2, p. 326-333 8 p.

Research output: Contribution to journalArticle

Clinicopathologic comparison of high-dose-rate endorectal brachytherapy versus conventional chemoradiotherapy in the neoadjuvant setting for resectable stages II and III low rectal cancer

Smith, J. A., Wild, A. T., Singhi, A., Raman, S. P., Qiu, H., Kumar, R., Hacker-Prietz, A., Hruban, R. H., Kamel, I. R., Efron, J., Wick, E. C., Azad, N. S., Diaz, L. A., Le, Y., Armour, E. P., Gearhart, S. L. & Herman, J. M., Sep 18 2012, In : International Journal of Surgical Oncology. 2012, 406568.

Research output: Contribution to journalArticle

Comparison of conventional and 3-dimensional computed tomography against histopathologic examination in determining pancreatic adenocarcinoma tumor size: Implications for radiation therapy planning

Qiu, H., Wild, A. T., Wang, H., Fishman, E. K., Hruban, R. H., Laheru, D. A., Kumar, R., Hacker-Prietz, A., Tuli, R., Tryggestad, E., Schulick, R. D., Cameron, J. L., Edil, B. H., Pawlik, T. M., Wolfgang, C. L. & Herman, J. M., Aug 1 2012, In : Radiotherapy and Oncology. 104, 2, p. 167-172 6 p.

Research output: Contribution to journalArticle

CT of splenosis: Patterns and pitfalls

Lake, S. T., Johnson, P. T., Kawamoto, S., Hruban, R. H. & Fishman, E. K., Dec 1 2012, In : American Journal of Roentgenology. 199, 6, p. W686-W693

Research output: Contribution to journalReview article

Cystic pancreatic neuroendocrine tumors: a clinicopathologic study.

Singhi, A. D., Chu, L. C., Tatsas, A. D., Shi, C., Ellison, T. A., Fishman, E. K., Kawamoto, S., Schulick, R. D., Wolfgang, C. L., Hruban, R. H. & Edil, B. H., Nov 2012, In : The American journal of surgical pathology. 36, 11, p. 1666-1673 8 p.

Research output: Contribution to journalArticle

Duodenal adenocarcinoma: Clinicopathologic analysis and implications for treatment

Poultsides, G. A., Huang, L. C., Cameron, J. L., Tuli, R., Lan, L., Hruban, R. H., Pawlik, T. M., Herman, J. M., Edil, B. H., Ahuja, N., Choti, M. A., Wolfgang, C. L. & Schulick, R. D., Jun 1 2012, In : Annals of surgical oncology. 19, 6, p. 1928-1935 8 p.

Research output: Contribution to journalArticle

Early Mortality Risk Score: Identification of Poor Outcomes Following Upfront Surgery for Resectable Pancreatic Cancer

Hsu, C. C., Wolfgang, C. L., Laheru, D. A., Pawlik, T. M., Swartz, M. J., Winter, J. M., Robinson, R., Edil, B. H., Narang, A. K., Choti, M. A., Hruban, R. H., Cameron, J. L., Schulick, R. D. & Herman, J. M., Apr 1 2012, In : Journal of Gastrointestinal Surgery. 16, 4, p. 753-761 9 p.

Research output: Contribution to journalArticle

Erratum: Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: A consensus study (Virchows Archiv (2005) 447 (794-799) DOI: 10.1007/s00428-005-0039-7)

Furukawa, T., Klöppel, G., Adsay, V., Albores-Saavedra, J., Fukushima, N., Horii, A., Hruban, R. H., Kato, Y., Klimstra, D. S., Longnecker, D. S., Lüttges, J., Offerhaus, G. J. A., Shimizu, M., Sunamura, M., Suriawinata, A., Takaori, K. & Yonezawa, S., Sep 1 2012, In : Virchows Archiv. 461, 3, 1 p.

Research output: Contribution to journalComment/debate

Evaluation of predictive variables in locally advanced pancreatic adenocarcinoma patients receiving definitive chemoradiation

Rudra, S., Narang, A. K., Pawlik, T. M., Wang, H., Jaffee, E. M., Zheng, L., Le, D. T., Cosgrove, D., Hruban, R. H., Fishman, E. K., Tuli, R., Laheru, D. A., Wolfgang, C. L., Diaz, L. A. & Herman, J. M., Apr 1 2012, In : Practical Radiation Oncology. 2, 2, p. 77-85 9 p.

Research output: Contribution to journalArticle

Factors influencing survival in patients undergoing palliative bypass for pancreatic adenocarcinoma

Gray, P. J., Wang, J., Pawlik, T. M., Edil, B. H., Schulick, R., Hruban, R. H., Dao, H., Cameron, J., Wolfgang, C. & Herman, J. M., Jul 1 2012, In : Journal of Surgical Oncology. 106, 1, p. 66-71 6 p.

Research output: Contribution to journalArticle

Fine-needle aspiration of intrapancreatic accessory spleen: Cytomorphologic features and differential diagnosis

Tatsas, A. D., Owens, C. L., Siddiqui, M. T., Hruban, R. H. & Ali, S. Z., Aug 25 2012, In : Cancer Cytopathology. 120, 4, p. 261-268 8 p.

Research output: Contribution to journalArticle

Frequent detection of pancreatic lesions in asymptomatic high-risk individuals

Canto, M. I., Hruban, R. H., Fishman, E. K., Kamel, I. R., Schulick, R., Zhang, Z., Topazian, M., Takahashi, N., Fletcher, J., Petersen, G., Klein, A. P., Axilbund, J., Griffin, C., Syngal, S., Saltzman, J. R., Mortele, K. J., Lee, J., Tamm, E., Vikram, R., Bhosale, P. & 3 others, Margolis, D., Farrell, J. & Goggins, M., Apr 2012, In : Gastroenterology. 142, 4, p. 796-804 9 p.

Research output: Contribution to journalArticle

Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity

Cui, Y., Brosnan, J. A., Blackford, A. L., Sur, S., Hruban, R. H., Kinzler, K. W., Vogelstein, B., Maitra, A., Diaz, L. A., Iacobuzio-Donahue, C. A. & Eshleman, J. R., Dec 1 2012, In : Clinical Cancer Research. 18, 23, p. 6519-6530 12 p.

Research output: Contribution to journalArticle

Genetic basis of pancreas cancer development and progression: Insights from whole-exome and whole-genome sequencing

Iacobuzio-Donahue, C. A., Velculescu, V. E., Wolfgang, C. L. & Hruban, R. H., Aug 15 2012, In : Clinical Cancer Research. 18, 16, p. 4257-4265 9 p.

Research output: Contribution to journalArticle

Genome-wide CpG island profiling of intraductal papillary mucinous neoplasms of the pancreas

Hong, S. M., Omura, N., Vincent, A., Li, A., Knight, S., Yu, J., Hruban, R. H. & Goggins, M., Feb 1 2012, In : Clinical Cancer Research. 18, 3, p. 700-712 13 p.

Research output: Contribution to journalArticle

Genome-wide somatic copy number alterations in low-grade panINs and IPMNs from individuals with a family history of pancreatic cancer

Hong, S. M., Vincent, A., Kanda, M., Leclerc, J., Omura, N., Borges, M., Klein, A. P., Canto, M. I., Hruban, R. H. & Goggins, M., Aug 15 2012, In : Clinical Cancer Research. 18, 16, p. 4303-4312 10 p.

Research output: Contribution to journalArticle

GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct

Matthaei, H., Wu, J., Dal Molin, M., Debeljak, M., Lingohr, P., Katabi, N., Klimstra, D. S., Adsay, N. V., Eshleman, J. R., Schulick, R. D., Kinzler, K. W., Vogelstein, B., Hruban, R. H. & Maitra, A., Oct 2012, In : HPB. 14, 10, p. 677-683 7 p.

Research output: Contribution to journalArticle

Human correlates of provocative questions in pancreatic pathology

McDonald, O. G., Maitra, A. & Hruban, R. H., Nov 1 2012, In : Advances in anatomic pathology. 19, 6, p. 351-362 12 p.

Research output: Contribution to journalReview article

Intraductal papillary mucinous neoplasm

Shi, C. & Hruban, R. H., Jan 1 2012, In : Human pathology. 43, 1, p. 1-16 16 p.

Research output: Contribution to journalArticle

Intrapancreatic accessory spleen: CT appearance and differential diagnosis

Kawamoto, S., Johnson, P. T., Hall, H., Cameron, J. L., Hruban, R. H. & Fishman, E. K., Oct 1 2012, In : Abdominal Imaging. 37, 5, p. 812-827 16 p.

Research output: Contribution to journalArticle

Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors

De Wilde, R. F., Heaphy, C. M., Maitra, A., Meeker, A. K., Edil, B. H., Wolfgang, C. L., Ellison, T. A., Schulick, R. D., Molenaar, I. Q., Valk, G. D., Vriens, M. R., Rinkes, I. H. M. B., Offerhaus, G. J. A., Hruban, R. H. & Matsukuma, K. E., Jul 1 2012, In : Modern Pathology. 25, 7, p. 1033-1039 7 p.

Research output: Contribution to journalArticle

Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas

Dal Molin, M., Hong, S. M., Hebbar, S., Sharma, R., Scrimieri, F., De Wilde, R. F., Mayo, S. C., Goggins, M., Wolfgang, C. L., Schulick, R. D., Lin, M. T., Eshleman, J. R., Hruban, R. H., Maitra, A. & Matthaei, H., Apr 1 2012, In : Human pathology. 43, 4, p. 585-591 7 p.

Research output: Contribution to journalArticle

Microcystic serous cystadenoma of the pancreas with subtotal cystic degeneration: Another neoplastic mimic of pancreatic pseudocyst

Panarelli, N. C., Park, K. J., Hruban, R. H. & Klimstra, D. S., May 1 2012, In : American Journal of Surgical Pathology. 36, 5, p. 726-731 6 p.

Research output: Contribution to journalArticle

MicroRNA alterations of pancreatic intraepithelial neoplasias

Yu, J., Li, A., Hong, S. M., Hruban, R. H. & Goggins, M., Feb 15 2012, In : Clinical Cancer Research. 18, 4, p. 981-992 12 p.

Research output: Contribution to journalArticle

miRNA biomarkers in cyst fluid augment the diagnosis and management of pancreatic cysts

Matthaei, H., Wylie, D., Lloyd, M. B., Molin, M. D., Kemppainen, J., Mayo, S. C., Wolfgang, C. L., Schulick, R. D., Langfield, L., Andruss, B. F., Adai, A. T., Hruban, R. H., Szafranska-Schwarzbach, A. E. & Maitra, A., Sep 1 2012, In : Clinical Cancer Research. 18, 17, p. 4713-4724 12 p.

Research output: Contribution to journalArticle

Pancreas

Klimstra, D. S., Hruban, R. H. & Pitman, M. B., Jul 16 2012, Histology for Pathologists: Fourth Edition. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M. C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A. M., Wu, J., Chang, D. K., Cowley, M. J., Gardiner, B. B., Song, S., Harliwong, I., Idrisoglu, S., Nourse, C., Nourbakhsh, E., Manning, S., Wani, S. & 106 others, Gongora, M., Pajic, M., Scarlett, C. J., Gill, A. J., Pinho, A. V., Rooman, I., Anderson, M., Holmes, O., Leonard, C., Taylor, D., Wood, S., Xu, Q., Nones, K., Fink, J. L., Christ, A., Bruxner, T., Cloonan, N., Kolle, G., Newell, F., Pinese, M., Mead, R. S., Humphris, J. L., Kaplan, W., Jones, M. D., Colvin, E. K., Nagrial, A. M., Humphrey, E. S., Chou, A., Chin, V. T., Chantrill, L. A., Mawson, A., Samra, J. S., Kench, J. G., Lovell, J. A., Daly, R. J., Merrett, N. D., Toon, C., Epari, K., Nguyen, N. Q., Barbour, A., Zeps, N., Kakkar, N., Zhao, F., Wu, Y. Q., Wang, M., Muzny, D. M., Fisher, W. E., Brunicardi, F. C., Hodges, S. E., Reid, J. G., Drummond, J., Chang, K., Han, Y., Lewis, L. R., Dinh, H., Buhay, C. J., Beck, T., Timms, L., Sam, M., Begley, K., Brown, A., Pai, D., Panchal, A., Buchner, N., De Borja, R., Denroche, R. E., Yung, C. K., Serra, S., Onetto, N., Mukhopadhyay, D., Tsao, M. S., Shaw, P. A., Petersen, G. M., Gallinger, S., Hruban, R. H., Maitra, A., Iacobuzio-Donahue, C. A., Schulick, R. D., Wolfgang, C. L., Morgan, R. A., Lawlor, R. T., Capelli, P., Corbo, V., Scardoni, M., Tortora, G., Tempero, M. A., Mann, K. M., Jenkins, N. A., Perez-Mancera, P. A., Adams, D. J., Largaespada, D. A., Wessels, L. F. A., Rust, A. G., Stein, L. D., Tuveson, D. A., Copeland, N. G., Musgrove, E. A., Scarpa, A., Eshleman, J. R., Hudson, T. J., Sutherland, R. L., Wheeler, D. A., Pearson, J. V., McPherson, J. D., Gibbs, R. A. & Grimmond, S. M., Nov 15 2012, In : Nature. 491, 7424, p. 399-405 7 p.

Research output: Contribution to journalArticle