Ralph H Hruban

Professor

1984 …2020

Research output per year

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Research Output

2014

GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "Incipient IPMNs"

Matthaei, H., Wu, J., Dal Molin, M., Shi, C., Perner, S., Kristiansen, G., Lingohr, P., Kalff, J. C., Wolfgang, C. L., Kinzler, K. W., Vogelstein, B., Maitra, A. & Hruban, R. H., Mar 1 2014, In : American Journal of Surgical Pathology. 38, 3, p. 360-363 4 p.

Research output: Contribution to journalArticle

Having pancreatic cancer with tumoral loss of ATM and normal TP53 protein expression is associated with a poorer prognosis

Kim, H., Saka, B., Knight, S., Borges, M., Childs, E., Klein, A., Wolfgang, C., Herman, J., Adsay, V. N., Hruban, R. H. & Goggins, M., Apr 1 2014, In : Clinical Cancer Research. 20, 7, p. 1865-1872 8 p.

Research output: Contribution to journalArticle

Heterogeneity of pancreatic cancer metastases in a single patient revealed by quantitative proteomics

Kim, M. S., Zhong, Y., Yachida, S., Rajeshkumar, N. V., Abel, M. L., Marimuthu, A., Mudgal, K., Hruban, R. H., Poling, J. S., Tyner, J. W., Maitra, A., Iacobuzio-Donahue, C. A. & Pandey, A., Nov 1 2014, In : Molecular and Cellular Proteomics. 13, 11, p. 2803-2811 9 p.

Research output: Contribution to journalArticle

Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation

Lutz, E. R., Wu, A. A., Bigelow, E., Sharma, R., Mo, G., Soares, K., Solt, S., Dorman, A., Wamwea, A., Yager, A., Laheru, D., Wolfgang, C., Wang, J., Hruban, R. H., Anders, R. A., Jaffee, E. & Zheng, L., Jul 1 2014, In : Cancer immunology research. 2, 7, p. 616-631 16 p.

Research output: Contribution to journalArticle

Intraductal tubulopapillary neoplasm of the pancreas on fine needle aspiration: Case Report with Differential Diagnosis

Guan, H., Gurda, G., Lennon, A. M., Hruban, R. H. & Erozan, Y. S., Feb 1 2014, In : Diagnostic cytopathology. 42, 2, p. 156-160 5 p.

Research output: Contribution to journalArticle

Introduction

Hruban, R. H. & Klimstra, D. S., Nov 1 2014, In : Seminars in Diagnostic Pathology. 31, 6, p. 441-442 2 p.

Research output: Contribution to journalEditorial

Liver transplant patients have a risk of progression similar to that of sporadic patients with branch duct intraductal papillary mucinous neoplasms

Lennon, A. M., Victor, D., Zaheer, A., Ostovaneh, M. R., Jeh, J., Law, J. K., Rezaee, N., Molin, M. D., Ahn, Y. J., Wu, W., Khashab, M. A., Girotra, M., Ahuja, N., Makary, M. A., Weiss, M. J., Hirose, K., Goggins, M., Hruban, R. H., Cameron, A., Wolfgang, C. L. & 2 others, Singh, V. K. & Gurakar, A., Dec 1 2014, In : Liver Transplantation. 20, 12, p. 1462-1467 6 p.

Research output: Contribution to journalArticle

Long interspersed element-1 protein expression is a hallmark of many human cancers

Rodić, N., Sharma, R., Sharma, R., Zampella, J., Dai, L., Taylor, M. S., Hruban, R. H., Iacobuzio-Donahue, C. A., Maitra, A., Torbenson, M. S., Goggins, M., Shih, I. M., Duffield, A. S., Montgomery, E. A., Gabrielson, E., Netto, G. J., Lotan, T. L., De Marzo, A. M., Westra, W., Binder, Z. A. & 6 others, Orr, B. A., Gallia, G. L., Eberhart, C. G., Boeke, J. D., Harris, C. R. & Burns, K. H., May 2014, In : American Journal of Pathology. 184, 5, p. 1280-1286 7 p.

Research output: Contribution to journalArticle

Molecular pathology of pancreatic cancer

Wood, L. D., Adsay, N. V. & Hruban, R. H., May 1 2014, Molecular Surgical Pathology. Springer New York, p. 17-42 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups

Simbolo, M., Fassan, M., Ruzzenente, A., Mafficini, A., Wood, L. D., Corbo, V., Melisi, D., Malleo, G., Vicentini, C., Malpeli, G., Antonello, D., Sperandio, N., Capelli, P., Tomezzoli, A., Iacono, C., Lawlor, R. T., Bassi, C., Hruban, R. H., Guglielmi, A., Tortora, G. & 2 others, de Braud, F. & Scarpa, A., 2014, In : Oncotarget. 5, 9, p. 2839-2852 14 p.

Research output: Contribution to journalArticle

Open Access

Overexpression of Lymphoid Enhancer-Binding Factor 1 (LEF1) in solid-pseudopapillary neoplasms of the pancreas

Singhi, A. D., Lilo, M., Hruban, R. H., Cressman, K. L., Fuhrer, K. & Seethala, R. R., Oct 1 2014, In : Modern Pathology. 27, 10, p. 1355-1363 9 p.

Research output: Contribution to journalArticle

Pancreatic Cancer Database: An integrative resource for pancreatic cancer

Thomas, J. K., Kim, M. S., Balakrishnan, L., Nanjappa, V., Raju, R., Marimuthu, A., Radhakrishnan, A., Muthusamy, B., Khan, A. A., Sakamuri, S., Tankala, S. G., Singal, M., Nair, B., Sirdeshmukh, R., Chatterjee, A., Keshava Prasad, T. S., Maitra, A., Gowda, H., Hruban, R. H. & Pandey, A., Aug 2014, In : Cancer Biology and Therapy. 15, 8, p. 963-967 5 p.

Research output: Contribution to journalArticle

PIK3CA mutations in mucinous cystic neoplasms of the pancreas

Garcia-Carracedo, D., Chen, Z. M., Qiu, W., Huang, A. S., Tang, S. M., Hruban, R. H. & Su, G. H., Mar 1 2014, In : Pancreas. 43, 2, p. 245-249 5 p.

Research output: Contribution to journalArticle

Poorly differentiated neuroendocrine carcinomas of the pancreas: A clinicopathologic analysis of 44 cases

Basturk, O., Tang, L., Hruban, R. H., Adsay, V., Yang, Z., Krasinskas, A. M., Vakiani, E., La Rosa, S., Jang, K. T., Frankel, W. L., Liu, X., Zhang, L., Giordano, T. J., Bellizzi, A. M., Chen, J. H., Shi, C., Allen, P., Reidy, D. L., Wolfgang, C. L., Saka, B. & 3 others, Rezaee, N., Deshpande, V. & Klimstra, D. S., Apr 2014, In : American Journal of Surgical Pathology. 38, 4, p. 437-447 11 p.

Research output: Contribution to journalArticle

Resection of Isolated Renal Cell Carcinoma Metastases of the Pancreas: Outcomes from the Johns Hopkins Hospital

Tosoian, J. J., Cameron, J. L., Allaf, M. E., Hruban, R. H., Nahime, C. B., Pawlik, T. M., Pierorazio, P. M., Reddy, S. & Wolfgang, C. L., Mar 1 2014, In : Journal of Gastrointestinal Surgery. 18, 3, p. 542-548 7 p.

Research output: Contribution to journalArticle

Role of a Multidisciplinary Clinic in the Management of Patients with Pancreatic Cysts: A Single-Center Cohort Study

Lennon, A. M., Manos, L. L., Hruban, R. H., Ali, S. Z., Fishman, E. K., Kamel, I. R., Raman, S. P., Zaheer, A., Hutfless, S., Salamone, A., Kiswani, V., Ahuja, N., Makary, M. A., Weiss, M. J., Hirose, K., Goggins, M. & Wolfgang, C. L., Oct 1 2014, In : Annals of Surgical Oncology. 21, 11, p. 3668-3674 7 p.

Research output: Contribution to journalArticle

Solid-pseudopapillary neoplasm of the pancreas: Cytomorphologic findings and literature review

Bhatnagar, R., Olson, M. T., Fishman, E. K., Hruban, R. H., Lennon, A. M. & Ali, S. Z., Nov 7 2014, In : Acta cytologica. 58, 4, p. 347-355 9 p.

Research output: Contribution to journalArticle

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

Zhang, M., Wang, Y., Jones, S., Sausen, M., McMahon, K., Sharma, R., Wang, Q., Belzberg, A. J., Chaichana, K., Gallia, G. L., Gokaslan, Z. L., Riggins, G. J., Wolinksy, J. P., Wood, L. D., Montgomery, E. A., Hruban, R. H., Kinzler, K. W., Papadopoulos, N., Vogelstein, B. & Bettegowda, C., Nov 5 2014, In : Nature genetics. 46, 11, p. 1170-1172 3 p.

Research output: Contribution to journalArticle

Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas

Amato, E., Molin, M. D., Mafficini, A., Yu, J., Malleo, G., Rusev, B., Fassan, M., Antonello, D., Sadakari, Y., Castelli, P., Zamboni, G., Maitra, A., Salvia, R., Hruban, R. H., Bassi, C., Capelli, P., Lawlor, R. T., Goggins, M. & Scarpa, A., Jul 2014, In : Journal of Pathology. 233, 3, p. 217-227 11 p.

Research output: Contribution to journalArticle

The great mimickers: Castleman disease

Bonekamp, D., Hruban, R. H. & Fishman, E. K., Jun 2014, In : Seminars in Ultrasound, CT and MRI. 35, 3, p. 263-271 9 p.

Research output: Contribution to journalArticle

The impact of postoperative complications on the administration of adjuvant therapy following pancreaticoduodenectomy for adenocarcinoma

Wu, W., He, J., Cameron, J. L., Makary, M., Soares, K., Ahuja, N., Rezaee, N., Herman, J., Zheng, L., Laheru, D., Choti, M. A., Hruban, R. H., Pawlik, T. M., Wolfgang, C. L. & Weiss, M. J., Sep 2014, In : Annals of surgical oncology. 21, 9, p. 2873-2881 9 p.

Research output: Contribution to journalArticle

The tail of neuroendocrine tumors from lung to pancreas: Two rare case reports

Soni, A., Dogeas, E., Juluri, K. R., Wolfgang, C. L., Hruban, R. H. & Weiss, M. J., 2014, In : International Journal of Surgery Case Reports. 5, 8, p. 537-539 3 p.

Research output: Contribution to journalArticle

Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions: The Papanicolaou Society of Cytopathology Guidelines

Layfield, L., Ehya, H., Filie, A., Hruban, R., Jhala, N., Joseph, L., Vielh, P. & Pitman, M., Jan 1 2014, In : CytoJournal. 11, SUPPL. 1, 1 p.

Research output: Contribution to journalArticle

Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions: The papanicolaou society of cytopathology guidelines for pancreatobiliary cytology

Layfield, L. J., Ehya, H., Filie, A. C., Hruban, R. H., Jhala, N., Joseph, L., Vielh, P. & Pitman, M. B., Apr 2014, In : Diagnostic cytopathology. 42, 4, p. 351-362 12 p.

Research output: Contribution to journalArticle

Whole-exome sequencing of pancreatic neoplasms with acinar differentiation

Jiao, Y., Yonescu, R., Offerhaus, G. J. A., Klimstra, D. S., Maitra, A., Eshleman, J. R., Herman, J. G., Poh, W., Pelosof, L., Wolfgang, C. L., Vogelstein, B., Kinzler, K. W., Hruban, R. H., Papadopoulos, N. & Wood, L. D., Mar 1 2014, In : Journal of Pathology. 232, 4, p. 428-435 8 p.

Research output: Contribution to journalArticle

2013

Acinar cell carcinoma of the pancreas: Clinical and cytomorphologic characteristics

Toll, A. D., Hruban, R. H. & Ali, S. Z., Jun 26 2013, In : Korean Journal of Pathology. 47, 2, p. 93-99 7 p.

Research output: Contribution to journalReview article

Acinar cell cystadenoma of the pancreas a benign neoplasm or non-neoplastic ballooning of acinar and ductal epithelium?

Singhi, A. D., Norwood, S., Liu, T. C., Sharma, R., Wolfgang, C. L., Schulick, R. D., Zeh, H. J. & Hruban, R. H., Sep 1 2013, In : American Journal of Surgical Pathology. 37, 9, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

Advancements in pancreatic neuroendocrine tumors

Sadaria, M. R., Hruban, R. H. & Edil, B. H., Sep 4 2013, In : Expert Review of Gastroenterology and Hepatology. 7, 5, p. 477-490 14 p.

Research output: Contribution to journalReview article

Clinical importance of familial pancreatic cancer registry in Japan: A report from kick-off meeting at international symposium on pancreas cancer 2012

Wada, K., Takaori, K., Traverso, L. W., Hruban, R. H., Furukawa, T., Brentnall, T. A., Hatori, T., Sano, K., Takada, T., Majima, Y. & Shimosegawa, T., Aug 1 2013, In : Journal of Hepato-Biliary-Pancreatic Sciences. 20, 6, p. 557-566 10 p.

Research output: Contribution to journalArticle

Clinicopathological correlates of activating gnas mutations in intraductal papillary mucinous neoplasm (IPMN) of the pancreas

Dal Molin, M., Matthaei, H., Wu, J., Blackford, A., Debeljak, M., Rezaee, N., Wolfgang, C. L., Butturini, G., Salvia, R., Bassi, C., Goggins, M. G., Kinzler, K. W., Vogelstein, B., Eshleman, J. R., Hruban, R. H. & Maitra, A., Nov 1 2013, In : Annals of Surgical Oncology. 20, 12, p. 3802-3808 7 p.

Research output: Contribution to journalArticle

Correlation of Smad4 status with outcomes in patients receiving erlotinib combined with adjuvant chemoradiation and chemotherapy after resection for pancreatic adenocarcinoma

Herman, J. M., Fan, K. Y., Wild, A. T., Wood, L. D., Blackford, A. L., Donehower, R. C., Hidalgo, M., Schulick, R. D., Edil, B. H., Choti, M. A., Hruban, R. H., Pawlik, T. M., Cameron, J. L., Laheru, D. A., Iacobuzio-Donahue, C. A. & Wolfgang, C. L., Nov 1 2013, In : International Journal of Radiation Oncology Biology Physics. 87, 3, p. 458-459 2 p.

Research output: Contribution to journalArticle

CT of gallbladder cancer and its mimics: A pattern-based approach

Deshmukh, S. D., Johnson, P. T., Sheth, S., Hruban, R. & Fishman, E. K., Jun 1 2013, In : Abdominal Imaging. 38, 3, p. 527-536 10 p.

Research output: Contribution to journalArticle

Efficacy of dimethylaminoparthenolide and sulindac in combination with gemcitabine in a genetically engineered mouse model of pancreatic cancer

Yip-Schneider, M. T., Wu, H., Hruban, R. H., Lowy, A. M., Crooks, P. A. & Schmidt, C. M., Jan 1 2013, In : Pancreas. 42, 1, p. 160-167 8 p.

Research output: Contribution to journalArticle

Erratum: The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma (Nature (2012) 486 (266-270) DOI: 10.1038/nature11114)

Pérez-Mancera, P. A., Rust, A. G., Van Der Weyden, L., Kristiansen, G., Li, A., Sarver, A. L., Silverstein, K. A. T., Grützmann, R., Aust, D., Rümmele, P., Knösel, T., Herd, C., Stemple, D. L., Kettleborough, R., Brosnan, J. A., Li, A., Morgan, R., Knight, S., Yu, J., Stegeman, S. & 17 others, Collier, L. S., Ten Hoeve, J. J., De Ridder, J., Klein, A. P., Goggins, M., Hruban, R. H., Chang, D. K., Biankin, A. V., Grimmond, S. M., Initiative, A. P. C. G., Wessels, L. F. A., Wood, S. A., Iacobuzio-Donahue, C. A., Pilarsky, C., Largaespada, D. A., Adams, D. J. & Tuveson, D. A., Feb 21 2013, In : Nature. 494, 7437, 1 p.

Research output: Contribution to journalComment/debate

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

Jiao, Y., Pawlik, T. M., Anders, R. A., Selaru, F. M., Streppel, M. M., Lucas, D. J., Niknafs, N., Guthrie, V. B., Maitra, A., Argani, P., Offerhaus, G. J. A., Roa, J. C., Roberts, L. R., Gores, G. J., Popescu, I., Alexandrescu, S. T., Dima, S., Fassan, M., Simbolo, M., Mafficini, A. & 16 others, Capelli, P., Lawlor, R. T., Ruzzenente, A., Guglielmi, A., Tortora, G., De Braud, F., Scarpa, A., Jarnagin, W., Klimstra, D., Karchin, R., Velculescu, V. E., Hruban, R. H., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Wood, L. D., Dec 1 2013, In : Nature genetics. 45, 12, p. 1470-1473 4 p.

Research output: Contribution to journalArticle

Exomic sequencing of four rare central nervous system tumor types

Bettegowda, C., Agrawal, N., Jiao, Y., Wang, Y., Wood, L. D., Rodriguez, F. J., Hruban, R. H., Gallia, G. L., Binder, Z. A., Riggins, C. J., Salmasi, V., Riggins, G. J., Reitman, Z. J., Rasheed, A., Keir, S., Shinjo, S., Marie, S., McLendon, R., Jallo, G., Vogelstein, B. & 4 others, Bigner, D., Yan, H., Kinzler, K. W. & Papadopoulos, N., Apr 2013, In : Oncotarget. 4, 4, p. 572-583 12 p.

Research output: Contribution to journalArticle

Open Access

Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS

Agrawal, N., Jiao, Y., Sausen, M., Leary, R., Bettegowda, C., Roberts, N. J., Bhan, S., Ho, A. S., Khan, Z., Bishop, J., Westra, W. H., Wood, L. D., Hruban, R. H., Tufano, R. P., Robinson, B., Dralle, H., Toledo, S. P. A., Toledo, R. A., Morris, L. G. T., Ghossein, R. A. & 8 others, Fagin, J. A., Chan, T. A., Velculescu, V. E., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Nelkin, B. D. & Ball, D. W., Feb 1 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 2, p. E364-E369

Research output: Contribution to journalArticle

Grading of well-differentiated pancreatic Neuroendocrine tumors is improved by the inclusion of both ki67 Proliferative index and mitotic rate

McCall, C. M., Shi, C., Cornish, T. C., Klimstra, D. S., Tang, L. H., Basturk, O., Mun, L. J., Ellison, T. A., Wolfgang, C. L., Choti, M. A., Schulick, R. D., Edil, B. H. & Hruban, R. H., Nov 1 2013, In : American Journal of Surgical Pathology. 37, 11, p. 1671-1677 7 p.

Research output: Contribution to journalArticle

Groove pancreatitis: Spectrum of imaging findings and radiology-pathology correlation

Raman, S. P., Salaria, S. N., Hruban, R. H. & Fishman, E. K., Jul 1 2013, In : American Journal of Roentgenology. 201, 1, p. W29-W39

Research output: Contribution to journalReview article

Hepatic adenomatosis: Spectrum of imaging findings

Raman, S. P., Hruban, R. H. & Fishman, E. K., Jun 1 2013, In : Abdominal Imaging. 38, 3, p. 474-481 8 p.

Research output: Contribution to journalReview article

Histopathologic findings of multifocal pancreatic intraductal papillary mucinous neoplasms on CT

Raman, S. P., Kawamoto, S., Blackford, A., Hruban, R. H., O'Brien-Lennon, A. M., Wolfgang, C. L., Rezaee, N., Edil, B. & Fishman, E. K., Mar 1 2013, In : American Journal of Roentgenology. 200, 3, p. 563-569 7 p.

Research output: Contribution to journalArticle

International cancer of the pancreas screening (CAPS) consortium summit on the management of patients with increased risk for familial pancreatic cancer

Canto, M. I., Harinck, F., Hruban, R. H., Offerhaus, G. J., Poley, J. W., Kamel, I., Nio, Y., Schulick, R. S., Bassi, C., Kluijt, I., Levy, M. J., Chak, A., Fockens, P., Goggins, M. & Bruno, M., Mar 1 2013, In : Gut. 62, 3, p. 339-347 9 p.

Research output: Contribution to journalArticle

Is it necessary to follow patients after resection of a benign pancreatic intraductal papillary mucinous neoplasm?

He, J., Cameron, J. L., Ahuja, N., Makary, M. A., Hirose, K., Choti, M. A., Schulick, R. D., Hruban, R. H., Pawlik, T. M. & Wolfgang, C. L., Apr 2013, In : Journal of the American College of Surgeons. 216, 4, p. 657-665 9 p.

Research output: Contribution to journalArticle

Management of pancreatic cysts: A multidisciplinary approach

Law, J. K., Hruban, R. H. & Lennon, A. M., Sep 1 2013, In : Current opinion in gastroenterology. 29, 5, p. 509-516 8 p.

Research output: Contribution to journalReview article