Ralph H Hruban

Professor

1984 …2020

Research output per year

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Research Output

Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer

Caldwell, M. E., Denicola, G. M., Martins, C. P., Jacobetz, M. A., Maitra, A., Hruban, R. H. & Tuveson, D. A., Mar 22 2012, In : Oncogene. 31, 12, p. 1599-1608 10 p.

Research output: Contribution to journalArticle

Central nervous system cancers in first-degree relatives and spouses

Grossman, S. A., Osman, M., Hruban, R. & Piantadosi, S., Jan 1 1999, In : Cancer Investigation. 17, 5, p. 299-308 10 p.

Research output: Contribution to journalArticle

Cerebral cysticercosis mimicking malignant glioma: A case report

Silver, S. A., Erozan, Y. S. & Hruban, R. H., Jan 1 1996, In : Acta cytologica. 40, 2, p. 351-357 7 p.

Research output: Contribution to journalArticle

Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays

Fukushima, N., Sato, N., Prasad, N., Leach, S. D., Hruban, R. H. & Goggins, M., Dec 2 2004, In : Oncogene. 23, 56, p. 9042-9051 10 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma: A spectrum of intrahepatic, perihilar, and distal tumors

Nakeeb, A., Pitt, H. A., Sohn, T. A., Coleman, J. A., Abrams, R. A., Piantadosi, S., Hruban, R. H., Lillemoe, K. D., Yeo, C. J. & Cameron, J. L., Oct 19 1996, In : Annals of surgery. 224, 4, p. 463-475 13 p.

Research output: Contribution to journalArticle

Cholecystectomy, liver resection, and pylorus-preserving pancreaticoduodenectomy for gallbladder cancer: Report of five cases

Doty, J. R., Cameron, J. L., Yeo, C. J., Campbell, K., Coleman, J. A. & Hruban, R. H., Jan 1 2002, In : Journal of Gastrointestinal Surgery. 6, 5, p. 776-780 5 p.

Research output: Contribution to journalArticle

Chondroid chordomas and low-grade chondrosarcomas of the craniospinal axis: An immunohistochemical analysis of 17 cases

Wojno, K. J., Hruban, R. H., Garin-Chesa, P. & Huvos, A. G., Dec 1 1992, In : American Journal of Surgical Pathology. 16, 12, p. 1144-1152 9 p.

Research output: Contribution to journalArticle

Chordomas with malignant spindle cell components: A DNA flow cytometric and immunohistochemical study with histogenetic implications

Hruban, R. H., Traganos, F., Reuter, V. E. & Huvos, A. G., Jan 1 1990, In : American Journal of Pathology. 137, 2, p. 435-447 13 p.

Research output: Contribution to journalArticle

Chromosomal abnormalities of adenocarcinoma of the pancreas: identifying early and late changes

Kowalski, J., Morsberger, L. A., Blackford, A., Hawkins, A., Yeo, C. J., Hruban, R. H. & Griffin, C. A., Oct 1 2007, In : Cancer Genetics and Cytogenetics. 178, 1, p. 26-35 10 p.

Research output: Contribution to journalArticle

Chromosome abnormalities in meningeal neoplasms: Do they correlate with histology?

Griffin, C. A., Hruban, R. H., Long, P. P., Miller, N., Volz, P., Carson, B. & Brem, H., Nov 1994, In : Cancer Genetics and Cytogenetics. 78, 1, p. 46-52 7 p.

Research output: Contribution to journalArticle

Chromosome abnormalities in pancreatic adenocarcinoma

Griffin, C. A., Long, P. P., Morsberger, L. A., Douna‐Issa, F., Hruban, R. H. & Yeo, C. J., Feb 1994, In : Genes, Chromosomes and Cancer. 9, 2, p. 93-100 8 p.

Research output: Contribution to journalArticle

Chromosome analysis of nine endocrine neoplasms of the pancreas

Long, P. P., Hruban, R. H., Lo, R., Yeo, C. J., Morsberger, L. A. & Griffin, C. A., Oct 1 1994, In : Cancer Genetics and Cytogenetics. 77, 1, p. 55-59 5 p.

Research output: Contribution to journalArticle

Chronic active myocarditis following acute Bartonella henselae infection (cat scratch disease)

Meininger, G. R., Nadasdy, T., Hruban, R. H., Bollinger, R. C., Baughman, K. L. & Hare, J. M., Sep 3 2001, In : American Journal of Surgical Pathology. 25, 9, p. 1211-1214 4 p.

Research output: Contribution to journalArticle

Circulating tumor cell phenotype predicts recurrence and survival in pancreatic adenocarcinoma

Poruk, K. E., Valero, V., Saunders, T., Blackford, A. L., Griffin, J. F., Poling, J., Hruban, R. H., Anders, R. A., Herman, J., Zheng, L., Rasheed, Z. A., Laheru, D. A., Ahuja, N., Weiss, M. J., Cameron, J. L., Goggins, M., Iacobuzio-Donahue, C. A., Wood, L. D. & Wolfgang, C. L., Nov 28 2016, In : Annals of surgery. 264, 6, p. 1073-1081 9 p.

Research output: Contribution to journalArticle

Circulating tumor DNA as a clinical test in resected pancreatic cancer

Groot, V. P., Mosier, S., Javed, A. A., Teinor, J. A., Gemenetzis, G., Ding, D., Haley, L. M., Yu, J., Burkhart, R. A., Hasanain, A., Debeljak, M., Kamiyama, H., Narang, A., Laheru, D. A., Zheng, L., Lin, M. T., Gocke, C. D., Fishman, E. K., Hruban, R. H., Goggins, M. G. & 7 others, Quintus Molenaar, I., Cameron, J. L., Weiss, M. J., Velculescu, V. E., He, J., Wolfgang, C. L. & Eshleman, J. R., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4973-4984 12 p.

Research output: Contribution to journalArticle

Classification, morphology, molecular pathogenesis, and outcome of premalignant lesions of the pancreas

Pittman, M. E., Rao, R. & Hruban, R. H., Dec 1 2017, In : Archives of Pathology and Laboratory Medicine. 141, 12, p. 1606-1614 9 p.

Research output: Contribution to journalArticle

Classification of pancreatic cysts in computed tomography images using a random forest and convolutional neural network ensemble

Dmitriev, K., Kaufman, A. E., Javed, A. A., Hruban, R. H., Fishman, E. K., O'Broin-Lennon, A. M. & Saltz, J. H., 2017, Medical Image Computing and Computer Assisted Intervention − MICCAI 2017 - 20th International Conference, Proceedings. Springer Verlag, Vol. 10435 LNCS. p. 150-158 9 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 10435 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: A consensus study

Furukawa, T., Klöppel, G., Volkan Adsay, N., Albores-Saavedra, J., Fukushima, N., Horii, A., Hruban, R. H., Kato, Y., Klimstra, D. S., Longnecker, D. S., Lüttges, J., Offerhaus, G. J. A., Shimizu, M., Sunamura, M., Suriawinata, A., Takaori, K. & Yonezawa, S., Nov 2005, In : Virchows Archiv. 447, 5, p. 794-799 6 p.

Research output: Contribution to journalArticle

Class III β-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia

Lee, K. M., Cao, D., Itami, A., Pour, P. M., Hruban, R. H., Maitra, A. & Ouellette, M. M., Oct 1 2007, In : Histopathology. 51, 4, p. 539-546 8 p.

Research output: Contribution to journalArticle

Clear cell endocrine pancreatic tumor mimicking renal cell carcinoma: A distinctive neoplasm of von Hippel-Lindau disease

Hoang, M. P., Hruban, R. H. & Albores-Saavedra, J., May 21 2001, In : American Journal of Surgical Pathology. 25, 5, p. 602-609 8 p.

Research output: Contribution to journalArticle

Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke

Li, R., Faden, D. L., Fakhry, C., Langelier, C., Jiao, Y., Wang, Y., Wilkerson, M. D., Pedamallu, C. S., Old, M., Lang, J., Loyo, M., Ahn, S. M., Tan, M., Gooi, Z., Chan, J., Richmon, J., Wood, L. D., Hruban, R. H., Bishop, J., Westra, W. H. & 11 others, Chung, C. H., Califano, J., Gourin, C. G., Bettegowda, C., Meyerson, M., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Derisi, J. L., Koch, W. M. & Agrawal, N., Nov 2015, In : Head and Neck. 37, 11, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

Clinical and radiographic gastrointestinal abnormalities in McCune-Albright syndrome

Robinson, C., Estrada, A., Zaheer, A., Singh, V. K., Wolfgang, C. L., Goggins, M. G., Hruban, R. H., Wood, L. D., Noë, M., Montgomery, E. A., Guthrie, L. C., Lennon, A. M., Boyce, A. M. & Collins, M. T., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 11, p. 4293-4303 11 p.

Research output: Contribution to journalArticle

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

Sausen, M., Phallen, J., Adleff, V., Jones, S., Leary, R. J., Barrett, M. T., Anagnostou, V., Parpart-Li, S., Murphy, D., Li, Q. K., Hruban, C. A., Scharpf, R. B., White, J. R., O'Dwyer, P. J., Allen, P. J., Eshleman, J., Thompson, C. B., Klimstra, D. S., Linehan, D. C., Maitra, A. & 6 others, Hruban, R. H., Diaz, L. A., Von Hoff, D. D., Johansen, J. S., Drebin, J. A. & Velculescu, V. E., Jul 7 2015, In : Nature Communications. 6, 7686.

Research output: Contribution to journalArticle

Clinical importance of familial pancreatic cancer registry in Japan: A report from kick-off meeting at international symposium on pancreas cancer 2012

Wada, K., Takaori, K., Traverso, L. W., Hruban, R. H., Furukawa, T., Brentnall, T. A., Hatori, T., Sano, K., Takada, T., Majima, Y. & Shimosegawa, T., Aug 1 2013, In : Journal of Hepato-Biliary-Pancreatic Sciences. 20, 6, p. 557-566 10 p.

Research output: Contribution to journalArticle

Clinical importance of precursor lesions in the pancreas

Hruban, R. H., Takaori, K., Canto, M., Fishman, E. K., Campbell, K., Brune, K., Kern, S. E. & Goggins, M., May 1 2007, In : Journal of Hepato-Biliary-Pancreatic Surgery. 14, 3, p. 255-263 9 p.

Research output: Contribution to journalArticle

Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors

Yachida, S., White, C. M., Naito, Y., Zhong, Y., Brosnan, J. A., Macgregor-Das, A. M., Morgan, R. A., Saunders, T., Laheru, D. A., Herman, J. M., Hruban, R. H., Klein, A. P., Jones, S., Velculescu, V., Wolfgang, C. L. & Iacobuzio-Donahue, C. A., Nov 15 2012, In : Clinical Cancer Research. 18, 22, p. 6339-6347 9 p.

Research output: Contribution to journalArticle

Clinical value of K-ras codon 12 analysis and endobiliary brush cytology for the diagnosis of malignant extrahepatic bile duct stenosis

Sturm, P. D. J., Rauws, E. A. J., Hruban, R. H., Caspers, E., Ramsoekh, T. B., Huibregtse, K., Noorduyn, L. A. & Offerhaus, G. J. A., Mar 1 1999, In : Clinical Cancer Research. 5, 3, p. 629-635 7 p.

Research output: Contribution to journalArticle

Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas

Matthaei, H., Norris, A. L., Tsiatis, A. C., Olino, K., Hong, S. M., Dal Molin, M., Goggins, M. G., Canto, M., Horton, K. M., Jackson, K. D., Capelli, P., Zamboni, G., Bortesi, L., Furukawa, T., Egawa, S., Ishida, M., Ottomo, S., Unno, M., Motoi, F., Wolfgang, C. L. & 6 others, Edil, B. H., Cameron, J. L., Eshleman, J. R., Schulick, R. D., Maitra, A. & Hruban, R. H., Feb 1 2012, In : Annals of surgery. 255, 2, p. 326-333 8 p.

Research output: Contribution to journalArticle

Clinicopathological correlates of activating gnas mutations in intraductal papillary mucinous neoplasm (IPMN) of the pancreas

Dal Molin, M., Matthaei, H., Wu, J., Blackford, A., Debeljak, M., Rezaee, N., Wolfgang, C. L., Butturini, G., Salvia, R., Bassi, C., Goggins, M. G., Kinzler, K. W., Vogelstein, B., Eshleman, J. R., Hruban, R. H. & Maitra, A., Nov 1 2013, In : Annals of Surgical Oncology. 20, 12, p. 3802-3808 7 p.

Research output: Contribution to journalArticle

Clinicopathologic analysis of ampullary neoplasms in 450 patients: Implications for surgical strategy and long-term prognosis

Winter, J. M., Cameron, J. L., Olino, K., Herman, J. M., de Jong, M. C., Hruban, R. H., Wolfgang, C. L., Eckhauser, F., Edil, B. H., Choti, M. A., Schulick, R. D. & Pawlik, T. M., Feb 1 2010, In : Journal of Gastrointestinal Surgery. 14, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

Clinicopathologic comparison of high-dose-rate endorectal brachytherapy versus conventional chemoradiotherapy in the neoadjuvant setting for resectable stages II and III low rectal cancer

Smith, J. A., Wild, A. T., Singhi, A., Raman, S. P., Qiu, H., Kumar, R., Hacker-Prietz, A., Hruban, R. H., Kamel, I. R., Efron, J., Wick, E. C., Azad, N. S., Diaz, L. A., Le, Y., Armour, E. P., Gearhart, S. L. & Herman, J. M., Sep 18 2012, In : International Journal of Surgical Oncology. 2012, 406568.

Research output: Contribution to journalArticle

Coagulation markers predicting cardiac transplant rejection

Segal, J. B., Kasper, E. K., Rohde, C., Bray, P. F., Baldwin, W. M., Resar, J. R., Hruban, R. H. & Kickler, T. S., Jan 1 2001, In : Transplantation. 72, 2, p. 233-237 5 p.

Research output: Contribution to journalArticle

Colloid carcinomas of the pancreas and periampullary region [2]

Wilentz, R. E., Seidel, G., Iacobuzio-Donahue, C. A. & Hruban, R. H., Jan 1 2002, In : American Journal of Surgical Pathology. 26, 7, p. 952-953 2 p.

Research output: Contribution to journalLetter

Colloid cysts of the third ventricle: Immunohistochemical evidence for nonneuroepithelial differentiation

Tsuchida, T., Hruban, R. H., Carson, B. S. & Phillips, P. C., Jul 1992, In : Human pathology. 23, 7, p. 811-816 6 p.

Research output: Contribution to journalArticle

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

Cohen, J. D., Javed, A. A., Thoburn, C., Wong, F., Tie, J., Gibbs, P., Schmidt, C. M., Yip-Schneider, M. T., Allen, P. J., Schattner, M., Brand, R. E., Singhi, A. D., Petersen, G. M., Hong, S. M., Kim, S. C., Falconi, M., Doglioni, C., Weiss, M. J., Ahuja, N., He, J. & 20 others, Makary, M. A., Maitra, A., Hanash, S. M., Dal Molin, M., Wang, Y., Li, L., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Goggins, M. S., Hruban, R. H., Wolfgang, C., Klein, A., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & O'Broin-Lennon, A. M., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10202-10207 6 p.

Research output: Contribution to journalArticle

Comparison of conventional and 3-dimensional computed tomography against histopathologic examination in determining pancreatic adenocarcinoma tumor size: Implications for radiation therapy planning

Qiu, H., Wild, A. T., Wang, H., Fishman, E. K., Hruban, R. H., Laheru, D. A., Kumar, R., Hacker-Prietz, A., Tuli, R., Tryggestad, E., Schulick, R. D., Cameron, J. L., Edil, B. H., Pawlik, T. M., Wolfgang, C. L. & Herman, J. M., Aug 1 2012, In : Radiotherapy and Oncology. 104, 2, p. 167-172 6 p.

Research output: Contribution to journalArticle

Comparison of rejection in the atrioventricular node and bundles with the working myocardium in transplanted hearts

Chang, A. C., Hruban, R. H., Levin, H. R., Baughman, K. L., Baumgartner, W. A., Reitz, B. A. & Hutchins, G. M., Dec 1 1991, In : Journal of Heart and Lung Transplantation. 10, 6, p. 915-920 6 p.

Research output: Contribution to journalArticle

Complement as a mediator of allograft injury: An inflammatory view

Baldwin, W. M., Samaniego, M., Qian, Z., Ota, H., Wasowska, B. A., Sanfilippo, F. & Hruban, R. H., Jan 2000, In : Transplantation Reviews. 14, 1, p. 41-51 11 p.

Research output: Contribution to journalArticle

Complement as a mediator of vascular inflammation and activation in allografts.

Baldwin, W. M., Qian, Z., Ota, H., Samaniego, M., Wasowska, B., Sanfilippo, F. & Hruban, R. H., Aug 2000, In : The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 19, 8, p. 723-730 8 p.

Research output: Contribution to journalReview article

Complement deposition in early cardiac transplant biopsies is associated with ischemic injury and subsequent rejection episodes

Baldwin, W. M., Samaniego-Picota, M., Kasper, E. K., Clark, A. M., Czader, M., Rohde, C., Zachary, A. A., Sanfilippo, F. & Hruban, R. H., Sep 27 1999, In : Transplantation. 68, 6, p. 894-900 7 p.

Research output: Contribution to journalArticle

Comprehensive proteomic analysis of human pancreatic juice

Grønborg, M., Bunkenborg, J., Kristiansen, T. Z., Jensen, O. N., Yeo, C. J., Hruban, R. H., Maitra, A., Goggins, M. G. & Pandey, A., Sep 1 2004, In : Journal of proteome research. 3, 5, p. 1042-1055 14 p.

Research output: Contribution to journalArticle

Computed tomography of inflation-fixed lungs: The beaded septum sign of pulmonary metastases

Ren, H., Hruban, R. H., Kuhlman, J. E., Fishman, E. K., Wheeler, P. S., Zerhouni, E. A. & Hutchins, G. M., Jan 1 1989, In : Journal of computer assisted tomography. 13, 3, p. 411-416 6 p.

Research output: Contribution to journalArticle

Computed tomography of rounded atelectasis

Ren, H., Hruban, R. H., Kuhlman, J. E., Fishman, E. K., Wheeler, P. S., Zerhouni, E. A. & Hutchins, G. M., Jan 1 1988, In : Journal of computer assisted tomography. 12, 6, p. 1031-1034 4 p.

Research output: Contribution to journalArticle

Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: Evidence of homozygous deletion in a noninvasive precursor lesion

Hustinx, S. R., Leoni, L. M., Yeo, C. J., Brown, P. N., Goggins, M., Kern, S. E., Hruban, R. H. & Maitra, A., Jul 1 2005, In : Modern Pathology. 18, 7, p. 959-963 5 p.

Research output: Contribution to journalArticle

Congenital bronchopulmonary foregut malformations. Intralobar and extralobar pulmonary sequestrations communicating with the foregut

Hruban, R. H., Shumway, S. J., Orel, S. B., Dumler, J. S., Baker, R. R. & Hutchins, G. M., Jan 1 1989, In : American journal of clinical pathology. 91, 4, p. 403-409 7 p.

Research output: Contribution to journalArticle

Consistent Chromosome Abnormalities in Adenocarcinoma of the Pancreas

Griffin, C. A., Hruban, R. H., Morsberger, L. A., Ellingham, T., Long, P. P., Jaffee, E. M., Hauda, K. M., Bohlander, S. K. & Yeo, C. J., Jun 1 1995, In : Cancer Research. 55, 11, p. 2394-2399 6 p.

Research output: Contribution to journalArticle

Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification

Chen, S., Auletta, T., Dovirak, O., Hutter, C., Kuntz, K., El-ftesi, S., Kendall, J., Han, H., Von Hoff, D. D., Ashfaq, R., Maitra, A., Iacobuzio-Donahue, C. A., Hruban, R. H. & Lucito, R., Nov 2008, In : Cancer Biology and Therapy. 7, 11, p. 1793-1802 10 p.

Research output: Contribution to journalArticle